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dr. S.J. Vastert

dr. S.J. Vastert

Associate Professor
dr. S.J. Vastert
  • Laboratory for Translational Immunology (LTI)
  • Immuno/reuma onderzoek 5

Biography

Biography

Bas is a pediatric rheumatologist in the “EULAR center of excellence in rheumatology" Wilhelmina Children’s Hospital Utrecht. Besides being an esteemed clinician in the field of Pediatric Rheumatology, he has developed into a translational researcher, with a PhD on mechanisms of disease and therapy in severe JIA in 2013. From 2015, he has been starting a translational research group together with Jorg van Loosdregt, molecular biologist. They currently supervise 5 PhD students, 1 post-doc and 2 technicians together, within the Center of Translational Immunology in Utrecht (v Loosdregt-Vastert group). Their labgroup aims to translate cutting edge science into clinical benefit for patients and their research focusses on systemic JIA and on development of novel treatment strategies for JIA. Bas is currently leading a multi-center prospective trial implementing a biomarker driven stop-strategy for rIL-1RA therapy in systemic JIA in the Netherlands (the ESTIS trial).

In addition, as a designated Young Investigator, Bas is the Dutch lead for all translational laboratory studies within UCAN CAN DU (major infrastructural research project 2017-2021 in Canada and the Netherlands).

Key words: Translational research in childhood arthritis, biology of systemic JIA, (regulation of) auto-inflammation, regulation of autoimmune inflammation, epigenetics.

Side Activities

  • member editoreal board van Pediatric Rheumatology Online Journal
  • associate editor Rheumatology

Fellowship and Awards

- 2007: Young investigator Meeting, Pediatric rheumatology European Society: Award for best basic abstract .

- 2014: Wilhelmina Research Fund (co-applicant), € 150 000 : Dissecting the complex role of S100-proteins in systemic juvenile idiopathic arthritis.

- 2015: ZonMW Rational Pharmacotherapy grant, € 340 000 : Biomarker guided treatment and stop strategy for rIL-1RA therapy in systemic JIA.

- 2016-2019: Wilhelmina Kinderziekenhuis Fonds, Rosenberg foundation / Vrienden WKZ (€340 000): Modulation of Treg in JIA by Nicotinamide. Principal Investigator, no overlap.

- 2016-2021: ZonMW grant, Rational Pharmacotherapy for implementation of biomarker guided tapering strategy of rIL-1RA in systemic JIA (€340 000 + €190 000 contribution Sobi). Principal Investigator, clinical trial, no overlap.

- 2017-2021: UCAN CAN DU: (8,0 mln Can$). Canada – Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic diseases. Young Investigator, NL lead for laboratory studies within UCAN CAN DU. (PI: R. Yeung, NM Wulffraat, co-PI JF Swart, S. Benseler).   

 

Research Output (118)

Tissue-Resident Memory T Cells in Chronic Inflammation-Local Cells with Systemic Effects?

Samat Anoushka Ashok Kumar, van der Geest Jolijn, Vastert Sebastiaan J, van Loosdregt Jorg, van Wijk Femke 16 feb 2021, In: Cells. 10 18 p.

How autoinflammation may turn into autoimmune inflammation:Insights from monogenetic and complex IL-1 mediated auto-inflammatory diseases

ter Haar N. M., Jansen M. H.A., Frenkel J. F., Vastert S. J. okt 2020, In: Clinical Immunology. 219 8 p.

Whole Transcriptome Analysis Reveals Heterogeneity in B Cell Memory Populations in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis

Wennink Roos A.W., Pandit Aridaman, Haasnoot Anne Mieke J.W., Hiddingh Sanne, Kalinina Ayuso Viera, Wulffraat Nico M., Vastert Bas J., Radstake Timothy R.D.J., de Boer Joke H., Kuiper Jonas J.W. 17 sep 2020, In: Frontiers in Immunology. 11

Aiming high:quantifying inflammation in systemic onset juvenile idiopathic arthritis (sJIA), a multi-faceted and complex inflammatory disease

Murray Grainne M, Vastert Sebastiaan J, Ramanan Athimalaipet V 26 aug 2020, In: Rheumatology (Oxford, England). 59 , p. 3124-3126 3 p.

Proceedings from the 2<sup>nd</sup>Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019

Canna Scott W., Schulert Grant S., De Jesus Adriana, Pickering Alex, Brunner Hermine, Gadina Massimo, Levine Stewart, Goldbach-Mansky Raphaela, Boutelle Jonathan, Sinha Rashmi, Debenedetti Fabrizio, Grom Alexei, Gottlieb Beth, Yeung Rae, Riskalla Mona, Prahalad Sampath, Alehashemi Sara, Chandrakasan Shan, Vastert Bas, Kimura Yuki, Carlson Anna, Schumacher Emily, Minerva Regina, Pierce Jonathan, Pierce Kate, Martinez Zulayka, Cupp Kari, Bush Leah, Costello Wendy, Delgaizo Vincent, 15 jul 2020, In: Pediatric Rheumatology. 18 15 p.

The Patient and Parent Perspective on Methotrexate in Recent Juvenile Idiopathic Arthritis Guidelines:Comment on the Article by Ringold et al

Schoemaker Casper G., Wulffraat Nico M., Vastert Sebastiaan J. 1 jun 2020, In: Arthritis and Rheumatology. 72 , p. 1039-1040 2 p.

European consensus-based recommendations for the diagnosis and treatment of rare paediatric vasculitides – the SHARE initiative:This is a correction to: Rheumatology, Volume 58, Issue 4, April 2019, Pages 656–671, https://doi.org/10.1093/rheumatology/key322

De Graeff Nienke, Groot Noortje, Brogan Paul, Ozen Seza, Avcin Tadej, Bader-Meunier Brigitte, Dolezalova Pavla, Feldman Brian M., Kone-Paut Isabelle, Lahdenne Pekka, Marks Stephen D., McCann Liza, Pilkington Clarissa, Ravelli Angelo, Van Royen Annet, Uziel Yosef, Vastert Bas, Wulffraat Nico, Kamphuis Sylvia, Beresford Michael W. apr 2020, In: Rheumatology (United Kingdom). 59 , p. 919 1 p.

Tocilizumab as an Effective Treatment Option in Children with Refractory Intermediate and Panuveitis

Wennink Roos A W, Ayuso Viera Kalinina, de Vries Lieuwe A, Vastert Sebastiaan J, de Boer Joke H 14 feb 2020, In: Ocular Immunology and Inflammation. 29 , p. 21-25 5 p.

Anakinra in children and adults with Still's disease

Vastert Sebastiaan J., Jamilloux Yvan, Quartier Pierre, Ohlman Sven, Osterling Koskinen Lisa, Kullenberg Torbjörn, Franck-Larsson Karin, Fautrel Bruno, De Benedetti Fabrizio 1 nov 2019, In: Rheumatology (United Kingdom). 58 , p. VI9-VI22

Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis

Gohar Faekah, Mcardle Angela, Jones Melissa, Callan Niamh, Hernandez Belinda, Kessel Christoph, Miranda-Garcia Maria, Lavric Miha, Holzinger Dirk, Pretzer Carolin, Lainka Elke, Vastert Sebastiaan J., De Roock Sytze, Fitzgerald Oliver, Pennington Stephen R., Foell Dirk 1 aug 2019, In: Annals of the Rheumatic Diseases. 78 , p. 1107-1113 7 p.

All research output

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