dr. M.D.I. (Mervyn) Vergouwen
dr. M.D.I. (Mervyn) Vergouwen
- Neurologen
Research Programs
Biography
Biography
Mervyn Vergouwen obtained his PhD degree at the University of Amsterdam / Academic Medical Center in 2009. The title of his PhD was ‘Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage – the role of coagulation and fibrinolysis’. From 2009-2010 he did a clinical/research stroke fellowship at the University of Toronto, Canada. After his return to the Netherlands, he worked as a postdoc at the Laboratory of Experimental Vascular Medicine at the Academic Medical Center to study the role of microthrombosis in the pathogenesis of delayed cerebral ischemia after subarachnoid hemorrhage in a mouse model. In 2011 he accepted a position as a staff neurologist at the UMC Utrecht and joined Prof. Gabriel Rinkel’s research group on aneurysmal subarachnoid hemorrhage.
His research focuses on unruptured intracranial aneurysms, diagnosis of (aneurysmal) subarachnoid hemorrhage, and brain injury after subarachnoid hemorrhage. This includes all processes that occur in the (sub)acute setting, including the initial hemorrhage and subsequent in-hospital complications (such as rebleeding, delayed cerebral ischemia, hydrocephalus, and infections), and the relationship of these processes with micro- and macrostructural brain injury, disability, and cognitive impairment.
His work was published in >100 publications and to date (December 2018) has been cited >3500 times.
Mervyn Vergouwen is the president-elect of the 15th International Conference on SubArachnoid Hemorrhage (ISAH) 2019 and co-PI of the Prospective Randomized Open-label Trial to Evaluate risk faCTor management in patients with Unruptured intracranial aneurysms (PROTECT-U).
Research line
Unruptured intracranial aneurysms - Subarachnoid hemorrhage
Most recent key publications
1: Backes D, Rinkel GJ, Greving JP, Velthuis BK, Murayama Y, Takao H, Ishibashi T, Igase M, terBrugge KG, Agid R, Jääskeläinen JE, Lindgren AE, Koivisto T, von und zu Fraunberg M, Matsubara S, Moroi J, Wong GK, Abrigo JM, Igase K, Matsumoto K, Wermer MJ, van Walderveen MA, Algra A, Vergouwen MD. The ELAPSS score for prediction of risk of growth of unruptured intracranial aneurysms. Neurology 2017; Mar 31. [Epub ahead of print].
2: Backes D, Rinkel GJ, Laban KG, Algra A, Vergouwen MD. Patient- and aneurysm-specific risk factors for intracranial aneurysm growth - a systematic review and meta-analysis. Stroke 2016;47:951-957.
3: Vergouwen MD, Jong-Tjien-Fa A, Algra A, Rinkel GJ. Time trends in causes of death after aneurysmal subarachnoid hemorrhage: a hospital-based study. Neurology 2016;86:59-63.
4: Etminan N, Brown RD, Beseoglu K, Juvela S, Raymond J, Morita A, Torner JC, Derdeyn CP, Raabe A, Mocco J, Korja M, Abdulazim A, Amin-Hanjani S, Salman RA, Barrow DL, Bederson J, Bonafe A, Dumont A, Fiorella DH, Gruber A, Hankey G, Hasan DM, Hoh BL, Jabbour P, Kasuya H., Kelly ME, Kirkpatrick PJ, Knuckey N, Koivisto T, Krings T, Lawton MT, Marotta TR, Mayer SA, Mee E, Molyneux A, Morgan MK, Mori K, Murayama Y, Nagahiro S, Nakayama N, Niemelä M, Knuckey N, Ogilvy CS, Mendes-Perreira V, Pierot L, Rabinstein AA, Roos YB, Rinne J, Rosenwasser RH, Ronkainen A, Schaller K, Seifert V, Solomon RA, Spears J, Steiger HJ, Vergouwen MD, Wanke I, Wermer MJH, Wong GK, Wong JH, Zipfel GF, Connolly ES, Steinmetz H, Lanzino G, Pasqualin A, Rüfenacht D, LeRoux P, Vajkoczy P, McDougall C, Hänggi D, Rinkel GJ, Macdonald RL. The Unruptured Intracranial Aneurysm Treatment Score: A multidisciplinary consensus. Neurology 2015;85:881-889.
5: Backes D, Rinkel GJ, van der Schaaf IC, Nij Bijvank JA, Verweij BH, Visser-Meily JM, Post MW, Algra A, Vergouwen MD. Recovery to pre-interventional functioning, return-to-work and life satisfaction after treatment of unruptured aneurysms. Stroke 2015;46:1607-1612.
6: Blok KM, Rinkel GJ, Majoie CB, Hendrikse J, Braaksma M, Tijssen CC, Wong YY, Hofmeijer J, Extercatte J, Kerklaan B, Schreuder TH, ten Holter S, Verheul F, Harlaar L, Pruissen MO, Kwa VI, Brouwers PJ, Remmers MJ, Schonewille WJ, Kruyt ND, Vergouwen MD. CT within 6 hours to rule out subarachnoid hemorrhage in nonacademic hospitals. Neurology 2015;84:1927-1932.
7: Backes D, Vergouwen MD, Velthuis BK, van der Schaaf IC, Bor AS, Algra A, Rinkel GJ. Difference in characteristics between ruptured and unruptured aneurysms in patients with multiple intracranial aneurysms. Stroke 2014;45:1299-1303.
8: Cremers CH, van der Schaaf IC, Wensink E, Greving JP, Rinkel GJ, Velthuis BK, Vergouwen MD. CT perfusion and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Cereb Blood Flow Metab 2014;34:200-207.
9: Backes D, Rinkel GJ, Kemperman H, Linn FH, Vergouwen MD. Time-dependent test characteristics of head CT in patients suspected of non-traumatic subarachnoid hemorrhage. Stroke 2012;43:2115-2119.
10: Diringer MN, Bleck TP, Claude Hemphill J 3rd, Menon D, Shutter L, Vespa P, Bruder N, Connolly ES Jr, Citerio G, Gress D, Hänggi D, Hoh BL, Lanzino G, Le Roux P, Rabinstein A, Schmutzhard E, Stocchetti N, Suarez JI, Treggiari M, Tseng MY, Vergouwen MD, Wolf S, Zipfel G. Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society’s Multidisciplinary Consensus Conference. Neurocrit Care 2011;15:211-240.
11: Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, Mendelow AD, Juvela S, Yonas H, Terbrugge KG, Macdonald RL, Diringer MN, Broderick JP, Dreier JP, Roos YB. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies - Proposal of a multidisciplinary research group. Stroke 2010;41:2391-2395.
12: Vergouwen MD, Meijers JC, Geskus RB, Coert BA, Horn J, Stroes ES, van der Poll T, Vermeulen M, Roos YB. Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage - a double-blind, placebo-controlled randomized trial. J Cereb Blood Flow Metab 2009;29:1444-1453.
13: Vergouwen MD, Vermeulen M, Coert BA, Stroes ES, Roos YB. Microthrombosis after aneurysmal subarachnoid hemorrhage - an additional explanation for delayed cerebral ischemia. J Cereb Blood Flow Metab 2008;28:1761-1770.
14: Vergouwen MD, Vermeulen M, Roos YB. Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage - a systematic review. Lancet Neurol 2006;5:1029-1032.
Fellowship and Awards
1: Jacob Jongbloed Talent Society (2014)
2: Netherlands Heart Foundation Dr. E. Dekker postdoc personal grant (2011)
3: Niels Stensen award for stroke fellowship in Toronto, Canada (2009)
Research Output (171)
Galea Ian, Bandyopadhyay Soham, Bulters Diederik, Humar Rok, Hugelshofer Michael, Schaer Dominik J., Abdulazim Amr, Alalade Andrew F., Alexander Sheila A., Amaro Sergi, Amin-Hanjani Sepideh, Andersen Christopher R., Anderson Craig, Anstey Matthew H., Balla József, Bankole Nourou Dine Adeniran, Bellapart Judith, Bhagat Hemant, Blackburn Spiros L., Brechmann Markus, Buehler P. W., Burkhardt Jan Karl, Chen Yujie, Cohen Jeremy, Cooper P. David, Coulthard Liam G., Cuadrado-Godia Elisa, Dalton Joan, Delaney Anthony, Doré Sylvain, Downer Jonathan, Dye Justin, Fernandez-Perez Isabel, Flower Oliver, Fülesdi Béla, Gaastra Ben, Gaberel Thomas, Galea James, Gankpe Gbetoho Fortuné, Garland Patrick, Gentinetta Thomas, Gram Magnus, Graversen Jonas Heilskov, Grover Patrick J., Guisado-Alonso Daniel, Hasan David, Helmy Adel, Regli Luca, Ruigrok Ynte Marije, Vergouwen Mervyn D.I. 1 Jul 2023, In: Stroke. 54 , p. 1930-1942 13 p.
Tack R. W.P., Lindgren A., Vergouwen M. D.I., van der Zwan A., van der Schaaf I., Rinkel G. J.E. 15 Mar 2023, In: Journal of the Neurological Sciences. 446
Tjerkstra Maud A, Müller Marcella C A, Coert Bert A, Hoefnagels Friso W A, Vergouwen Mervyn D I, van Vliet Peter, Ooms Lizzy, Rinkel Gabriël J E, Slooter Arjen J C, Moojen Wouter A, Jellema Korné, Vandertop W Peter, Verbaan Dagmar 2023, In: European Journal of Neurology. 30 , p. 2278-2287 10 p.
Etminan Nima, Vergouwen Mervyn D.I., Rinkel Gabriel J.E. 2023, In: European Stroke Journal. 8 , p. 602-603 2 p.
Tjerkstra Maud A, Post Rene, Germans Menno R, Vergouwen Mervyn D I, Jellema Korné, Koot Radboud W, Kruyt Nyika D, Willems Peter W A, Wolfs Jasper F C, de Beer Frits C, Kieft Hans, Nanda Dharmin, van der Pol Bram, Roks Gerwin, de Beer Frank, Halkes Patricia H A, Reichman Loes J A, Brouwers Paul J A M, Van den Berg-Vos Renske M, Kwa Vincent I H, van der Ree Taco C, Bronner Irene, Bienfait Henri P, Boogaarts Hieronymus, Klijn Catharina Jm, van den Berg René, Coert Bert A, Horn Janneke, Majoie Charles B L M, Rinkel Gabriël J E, Roos Yvo B W M, Vandertop William, Verbaan Dagmar 20 Oct 2022, In: Neurology. 99 , p. E2605-E2614
Koopman Inez, van Wijngaarden Philippine B., Rinkel Gabriel J.E., Vergouwen Mervyn D.I. 13 Oct 2022, In: Frontiers in Neurology. 13 , p. 1016111
Algra Annemijn M., Greving Jacoba P., De Winkel Jordi, Kurtelius Arttu, Laban Kamil, Verbaan Dagmar, Van Den Berg René, Vandertop William, Lindgren Antti, Krings Timo, Woo Peter Y.M., Wong George K.C., Roozenbeek Bob, Van Es Adriaan C.G.M., Dammers Ruben, Etminan Nima, Boogaarts Hieronymus, Van Doormaal Tristan, Van Der Zwan Albert, Van Der Schaaf Irene C., Rinkel Gabriël J.E., Vergouwen Mervyn D.I. 2 Sep 2022, In: Neurology. 99 , p. E1725-E1737
Algra Annemijn M, Greving Jacoba P, Wermer Marieke J H, van Walderveen Marianne A A, van der Schaaf Irene C, van der Zwan Albert, Visser-Meily Johanna, Rinkel Gabriël J E, Vergouwen Mervyn D I 5 Jul 2022, In: Neurology. 99 , p. E1715-E1724
van Os Hendrikus J A, Verbaan Dagmar, Ruigrok Ynte M, Dennesen Paul, Müller Marcella C A, Coert Bert A, Vergouwen Mervyn D I, Wermer Marieke J H 6 May 2022, In: Stroke. 53 , p. 2075-2077 3 p.
Timmins Kimberley, Kuijf Hugo, Vergouwen Mervyn, Ruigrok Ynte, Velthuis Birgitta, van der Schaaf Irene Mar 2022, In: American Journal of Neuroradiology. 43 , p. 416-421 6 p.