dr. M.D.I. (Mervyn) Vergouwen

dr. M.D.I. (Mervyn) Vergouwen

Associate Professor - medical
dr. M.D.I. (Mervyn) Vergouwen
  • Neurologen

Research Programs



Mervyn Vergouwen obtained his PhD degree at the University of Amsterdam / Academic Medical Center in 2009. The title of his PhD was ‘Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage – the role of coagulation and fibrinolysis’. From 2009-2010 he did a clinical/research stroke fellowship at the University of Toronto, Canada. After his return to the Netherlands, he worked as a postdoc at the Laboratory of Experimental Vascular Medicine at the Academic Medical Center to study the role of microthrombosis in the pathogenesis of delayed cerebral ischemia after subarachnoid hemorrhage in a mouse model. In 2011 he accepted a position as a staff neurologist at the UMC Utrecht and joined Prof. Gabriel Rinkel’s research group on aneurysmal subarachnoid hemorrhage.

His research focuses on unruptured intracranial aneurysms, diagnosis of (aneurysmal) subarachnoid hemorrhage, and brain injury after subarachnoid hemorrhage. This includes all processes that occur in the (sub)acute setting, including the initial hemorrhage and subsequent in-hospital complications (such as rebleeding, delayed cerebral ischemia, hydrocephalus, and infections), and the relationship of these processes with micro- and macrostructural brain injury, disability, and cognitive impairment.

His work was published in >100 publications and to date (December 2018) has been cited >3500 times.

Mervyn Vergouwen is the president-elect of the 15th International Conference on SubArachnoid Hemorrhage (ISAH) 2019 and co-PI of the Prospective Randomized Open-label Trial to Evaluate risk faCTor management in patients with Unruptured intracranial aneurysms (PROTECT-U).

Research line

Unruptured intracranial aneurysms - Subarachnoid hemorrhage

Most recent key publications

1: Backes D, Rinkel GJ, Greving JP, Velthuis BK, Murayama Y, Takao H, Ishibashi T, Igase M, terBrugge KG, Agid R, Jääskeläinen JE, Lindgren AE, Koivisto T, von und zu Fraunberg M, Matsubara S, Moroi J, Wong GK, Abrigo JM, Igase K, Matsumoto K, Wermer MJ, van Walderveen MA, Algra A, Vergouwen MD. The ELAPSS score for prediction of risk of growth of unruptured intracranial aneurysms. Neurology 2017; Mar 31. [Epub ahead of print].

2: Backes D, Rinkel GJ, Laban KG, Algra A, Vergouwen MD. Patient- and aneurysm-specific risk factors for intracranial aneurysm growth - a systematic review and meta-analysis. Stroke 2016;47:951-957.

3: Vergouwen MD, Jong-Tjien-Fa A, Algra A, Rinkel GJ. Time trends in causes of death after aneurysmal subarachnoid hemorrhage: a hospital-based study. Neurology 2016;86:59-63.

4: Etminan N, Brown RD, Beseoglu K, Juvela S, Raymond J, Morita A, Torner JC, Derdeyn CP, Raabe A, Mocco J, Korja M, Abdulazim A, Amin-Hanjani S, Salman RA, Barrow DL, Bederson J, Bonafe A, Dumont A, Fiorella DH, Gruber A, Hankey G, Hasan DM, Hoh BL, Jabbour P, Kasuya H., Kelly ME, Kirkpatrick PJ, Knuckey N, Koivisto T, Krings T, Lawton MT, Marotta TR, Mayer SA, Mee E, Molyneux A, Morgan MK, Mori K, Murayama Y, Nagahiro S, Nakayama N, Niemelä M, Knuckey N, Ogilvy CS, Mendes-Perreira V, Pierot L, Rabinstein AA, Roos YB, Rinne J, Rosenwasser RH, Ronkainen A, Schaller K, Seifert V, Solomon RA, Spears J, Steiger HJ, Vergouwen MD, Wanke I, Wermer MJH, Wong GK, Wong JH, Zipfel GF, Connolly ES, Steinmetz H, Lanzino G, Pasqualin A, Rüfenacht D, LeRoux P, Vajkoczy P, McDougall C, Hänggi D, Rinkel GJ, Macdonald RL. The Unruptured Intracranial Aneurysm Treatment Score: A multidisciplinary consensus. Neurology 2015;85:881-889.  

5: Backes D, Rinkel GJ, van der Schaaf IC, Nij Bijvank JA, Verweij BH, Visser-Meily JM, Post MW, Algra A, Vergouwen MD. Recovery to pre-interventional functioning, return-to-work and life satisfaction after treatment of unruptured aneurysms. Stroke 2015;46:1607-1612.

6: Blok KM, Rinkel GJ, Majoie CB, Hendrikse J, Braaksma M, Tijssen CC, Wong YY, Hofmeijer J, Extercatte J, Kerklaan B, Schreuder TH, ten Holter S, Verheul F, Harlaar L, Pruissen MO, Kwa VI, Brouwers PJ, Remmers MJ, Schonewille WJ, Kruyt ND, Vergouwen MD. CT within 6 hours to rule out subarachnoid hemorrhage in nonacademic hospitals. Neurology 2015;84:1927-1932.

7: Backes D, Vergouwen MD, Velthuis BK, van der Schaaf IC, Bor AS, Algra A, Rinkel GJ. Difference in characteristics between ruptured and unruptured aneurysms in patients with multiple intracranial aneurysms. Stroke 2014;45:1299-1303.

8: Cremers CH, van der Schaaf IC, Wensink E, Greving JP, Rinkel GJ, Velthuis BK, Vergouwen MD. CT perfusion and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Cereb Blood Flow Metab 2014;34:200-207.

9: Backes D, Rinkel GJ, Kemperman H, Linn FH, Vergouwen MD. Time-dependent test characteristics of head CT in patients suspected of non-traumatic subarachnoid hemorrhage. Stroke 2012;43:2115-2119.

10: Diringer MN, Bleck TP, Claude Hemphill J 3rd, Menon D, Shutter L, Vespa P, Bruder N, Connolly ES Jr, Citerio G, Gress D, Hänggi D, Hoh BL, Lanzino G, Le Roux P, Rabinstein A, Schmutzhard E, Stocchetti N, Suarez JI, Treggiari M, Tseng MY, Vergouwen MD, Wolf S, Zipfel G. Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society’s Multidisciplinary Consensus Conference. Neurocrit Care 2011;15:211-240.

11: Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, Mendelow AD, Juvela S, Yonas H, Terbrugge KG, Macdonald RL, Diringer MN, Broderick JP, Dreier JP, Roos YB. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies - Proposal of a multidisciplinary research group. Stroke 2010;41:2391-2395.

12: Vergouwen MD, Meijers JC, Geskus RB, Coert BA, Horn J, Stroes ES, van der Poll T, Vermeulen M, Roos YB. Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage - a double-blind, placebo-controlled randomized trial. J Cereb Blood Flow Metab 2009;29:1444-1453.

13: Vergouwen MD, Vermeulen M, Coert BA, Stroes ES, Roos YB. Microthrombosis after aneurysmal subarachnoid hemorrhage - an additional explanation for delayed cerebral ischemia. J Cereb Blood Flow Metab 2008;28:1761-1770.

14: Vergouwen MD, Vermeulen M, Roos YB. Effect of nimodipine on outcome in patients with traumatic subarachnoid haemorrhage - a systematic review. Lancet Neurol 2006;5:1029-1032.

Fellowship and Awards

1: Jacob Jongbloed Talent Society (2014)
2: Netherlands Heart Foundation Dr. E. Dekker postdoc personal grant (2011)
3: Niels Stensen award for stroke fellowship in Toronto, Canada (2009)

Research Output (176)

Outcomes Associated With Intracranial Aneurysm Treatments Reported as Safe, Effective, or Durable:A Systematic Review and Meta-Analysis

Volovici Victor, Verploegh Iris S., Satoer Djaina, Vrancken Peeters Noëlle J.M.C., Sadigh Yasmin, Vergouwen Mervyn D.I., Schouten Joost W., Bruggeman Gavin, Pisica Dana, Yildirim Gizem, Cozar Ayca, Muller Femke, Zidaru Ana Maria, Gori Kelsey, Tzourmpaki Nefeli, Schnell Esther, Thioub Mbaye, Kicielinski Kimberly, van Doormaal Pieter Jan, Velinov Nikolay, Boutarbouch Mahjouba, Lawton Michael T., Lanzino Giuseppe, Amin-Hanjani Sepideh, Dammers Ruben, Meling Torstein R. 5 Sep 2023, In: JAMA network open. 6 , p. e2331798

Glial cell response and microthrombosis in aneurysmal subarachnoid hemorrhage patients:An autopsy study

Koopman Inez, Van Dijk Bart J., Zuithoff Nicolaas P.A., Sluijs Jacqueline A., Van Der Kamp Marije J., Baldew Zelonna A.V., Frijns Catharina J.M., Rinkel Gabriel J.E., Hol Elly M., Vergouwen Mervyn D.I. 21 Jul 2023, In: Journal of Neuropathology and Experimental Neurology. 82 , p. 798-805 8 p.

Haptoglobin Treatment for Aneurysmal Subarachnoid Hemorrhage:Review and Expert Consensus on Clinical Translation

Galea Ian, Bandyopadhyay Soham, Bulters Diederik, Humar Rok, Hugelshofer Michael, Schaer Dominik J., Abdulazim Amr, Alalade Andrew F., Alexander Sheila A., Amaro Sergi, Amin-Hanjani Sepideh, Andersen Christopher R., Anderson Craig, Anstey Matthew H., Balla József, Bankole Nourou Dine Adeniran, Bellapart Judith, Bhagat Hemant, Blackburn Spiros L., Brechmann Markus, Buehler P. W., Burkhardt Jan Karl, Chen Yujie, Cohen Jeremy, Cooper P. David, Coulthard Liam G., Cuadrado-Godia Elisa, Dalton Joan, Delaney Anthony, Doré Sylvain, Downer Jonathan, Dye Justin, Fernandez-Perez Isabel, Flower Oliver, Fülesdi Béla, Gaastra Ben, Gaberel Thomas, Galea James, Gankpe Gbetoho Fortuné, Garland Patrick, Gentinetta Thomas, Gram Magnus, Graversen Jonas Heilskov, Grover Patrick J., Guisado-Alonso Daniel, Hasan David, Helmy Adel, Regli Luca, Ruigrok Ynte Marije, Vergouwen Mervyn D.I. 1 Jul 2023, In: Stroke. 54 , p. 1930-1942 13 p.

Emergency Medical Management of Aneurysmal Subarachnoid Hemorrhage

Vergouwen Mervyn D I, Rinkel Gabriel J E 21 Jun 2023, In: Neurocritical Care. 39 , p. 51-58 8 p.

Lumbar puncture for treating acute hydrocephalus after aneurysmal subarachnoid haemorrhage

Tack R. W.P., Lindgren A., Vergouwen M. D.I., van der Zwan A., van der Schaaf I., Rinkel G. J.E. 15 Mar 2023, In: Journal of the Neurological Sciences. 446

Clinical response following hypertension induction for clinical delayed cerebral ischemia following subarachnoid hemorrhage:A retrospective, multicenter, cohort study

Tjerkstra Maud A, Müller Marcella C A, Coert Bert A, Hoefnagels Friso W A, Vergouwen Mervyn D I, van Vliet Peter, Ooms Lizzy, Rinkel Gabriël J E, Slooter Arjen J C, Moojen Wouter A, Jellema Korné, Vandertop W Peter, Verbaan Dagmar 2023, In: European Journal of Neurology. 30 , p. 2278-2287 10 p.

Safety and pharmacodynamic efficacy of eculizumab in aneurysmal subarachnoid hemorrhage (CLASH):A phase 2a randomized clinical trial

Koopman Inez, Tack Reinier Wp, Wunderink Herman F, Bruns Anke Hw, van der Schaaf Irene C, Cianci Daniela, Gelderman Kyra A, van de Ridder Inge M, Hol Elly M, Rinkel Gabriel Je, Vergouwen Mervyn DI 2023, In: European Stroke Journal. 8 , p. 1097-1106 10 p.

In reply

Etminan Nima, Vergouwen Mervyn D.I., Rinkel Gabriel J.E. 2023, In: European Stroke Journal. 8 , p. 602-603 2 p.

Aneurysm treatment within 6 h versus 6–24 h after rupture in patients with subarachnoid hemorrhage

Vergouwen Mervyn D.I., Germans Menno R., Post René, Tjerkstra Maud A., Coert Bert A., Rinkel Gabriel J.E., Peter Vandertop William, Verbaan Dagmar 2023, In: European Stroke Journal. 8 , p. 802-807 6 p.

Tranexamic Acid After Aneurysmal Subarachnoid Hemorrhage:Post-Hoc Analysis of the ULTRA Trial

Tjerkstra Maud A, Post Rene, Germans Menno R, Vergouwen Mervyn D I, Jellema Korné, Koot Radboud W, Kruyt Nyika D, Willems Peter W A, Wolfs Jasper F C, de Beer Frits C, Kieft Hans, Nanda Dharmin, van der Pol Bram, Roks Gerwin, de Beer Frank, Halkes Patricia H A, Reichman Loes J A, Brouwers Paul J A M, Van den Berg-Vos Renske M, Kwa Vincent I H, van der Ree Taco C, Bronner Irene, Bienfait Henri P, Boogaarts Hieronymus, Klijn Catharina Jm, van den Berg René, Coert Bert A, Horn Janneke, Majoie Charles B L M, Rinkel Gabriël J E, Roos Yvo B W M, Vandertop William, Verbaan Dagmar 20 Oct 2022, In: Neurology. 99 , p. E2605-E2614

All research output

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