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prof. dr. M.C. (Marianne C.) Verhaar

prof. dr. M.C. (Marianne C.) Verhaar

Full Professor
prof. dr. M.C. (Marianne C.) Verhaar

Biography

Biography

The research of Marianne Verhaar focuses on renal and vascular regeneration and involves translational studies from basic cell studies to animal experiments and clinical trials. Het general aim is to improve care for the patient with chronic kidney disease by developing new strategies to enhance protective mechanisms against microvascular dysfunction, atherosclerotic disease and chronic kidney disease, to enhance vascular and renal regeneration and to improve renal replacement therapies. Specific interests of her group are: mechanisms underlying increased cardiovascular risk in chronic kidney disease, the realation between chronic kidney disease, microvascular dysfunction and heart failure, the role of (bone marrow-derived) stem and progenitor cells or cellular products in vascular and renal regeneration and their therapeutic potential in patients with cardiovascular and chronic kidney disease; development of renal organoids and search for renal stem cells using specific stem cell markers; investigate the potential of induced pluripotent stem cells for renal regeneration; development of a wearable artificial kidney.

Side Activities

Expert panel – The scientific challenge “Lab-Grown Organ Replacement “German Federal Ministry of Education and Research (BMBF) 2019-

Scientific board Dutch Kidney Foundation 2019-

European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Continuous Education and Professional Development (CEPD) Committee (Chair) 2019-

ERA-EDTA Scientific Advisory Board 2019-

ERA-EDTA EUropean REnal and CArdiovascular Medicine (EURECA-m) Working Group 2015-2019

Scientific Committee of the ERA-EDTA Berlin Meeting 2021

Scientific Committee of the ERA-EDTA Milan Meeting 2020

French National Research Agency (ANR) University Hospital institute Selection Committee (Chair) 2017-

Scientific Forum of the Netherlands Heart Institute 2016-

Science Europe Scientific Advisory Committee 2015-2018

ZonMw Programme Committee Innovational Research Incentives Scheme Veni 2010-2018

NWO Innovational Research Incentives Scheme Vidi (interdivisional) 2014

ZonMw Programme Committee Translational Research 2010-2020

International Review Board Academy of Finland, 2011 & 2015

Review Committee Regenerative Medicine proposals European Committee, 2009

Visiting professor at Renal Research Institute, New York Medical College, department of Nephrology (Prof. dr. M.S. Goligorsky) (2009)

Fellowship and Awards

NWO Vidi & ASPASIA grant (2008)

NWO Veni grant (2002)

Jaarprijs Vasculaire Biologie, Nederlandse Vereniging voor Cardiologie (1998)

Research Output (323)

GFR estimation is complicated by a high incidence of non-steady-state serum creatinine concentrations at the emergency department

Niemantsverdriet M. S.A., Pieters T. T., Hoefer I. E., Verhaar M. C., Joles J. A., van Solinge W. W., Tiel Groenestege W. M., Haitjema S., Rookmaaker M. B. dec 2021, In: PLoS ONE. 16

T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Peereboom Emma T M, Matern Benedict M, Tomosugi Toshihide, Niemann Matthias, Drylewicz Julia, Joosten Irma, Allebes Wil A, van der Meer Arnold, Hilbrands Luuk B, Baas Marije C, van Reekum Franka E, Verhaar Marianne C, Kamburova Elena G, Seelen Marc A J, Sanders Jan Stephan, Hepkema Bouke G, Lambeck Annechien J, Bungener Laura B, Roozendaal Caroline, Tilanus Marcel G J, Voorter Christien E, Wieten Lotte, van Duijnhoven Elly M, Gelens Mariëlle A C J, Christiaans Maarten H L, van Ittersum Frans J, Nurmohamed Azam, Lardy Neubury M, Swelsen Wendy, van der Pant Karlijn A, van der Weerd Neelke C, Ten Berge Ineke J M, Bemelman Fréderike J, de Vries Aiko P J, de Fijter Johan W, Betjes Michiel G H, Roelen Dave L, Claas Frans H, Otten Henny G, Heidt Sebastiaan, van Zuilen Arjan D, Kobayashi Takaaki, Geneugelijk Kirsten, Spierings Eric 18 nov 2021, In: Frontiers in Immunology. 12 , p. 1-13

Protein-Bound Uremic Toxins Induce Reactive Oxygen Species-Dependent and Inflammasome-Mediated IL-1β Production in Kidney Proximal Tubule Cells

Mihajlovic Milos, Krebber Merle M, Yang Yi, Ahmed Sabbir, Lozovanu Valeria, Andreeva Daria, Verhaar Marianne C, Masereeuw Rosalinde 26 sep 2021, In: Biomedicines. 9 , p. 1-24

Renal Biology Driven Macro- and Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies

Vermue IJsbrand M, Begum Runa, Castilho Miguel, Rookmaaker Maarten B, Masereeuw Rosalinde, Bouten Carlijn V C, Verhaar Marianne C, Cheng Caroline 7 sep 2021, In: ACS Biomaterials Science and Engineering. 7 , p. 4679-4693 15 p.

Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors

van de Wouw Jens, Sorop Oana, van Drie Ruben W.A., Joles Jaap A., Danser A. H.Jan, Verhaar Marianne C., Merkus Daphne, Duncker Dirk J. 26 aug 2021, In: Basic Research in Cardiology. 116 , p. 1-21

Correction to "Reactivity of (Vicinal) Carbonyl Compounds with Urea"

Driest Piet J, Jong Jacobus A W, Smakman Robert, Moret Marc-Etienne, Verhaar Marianne C, Hennink Wim E, Gerritsen Karin G F, van Nostrum Cornelus F 10 aug 2021, In: ACS omega. 6 , p. 20719-20721 3 p.

The Global Limb Anatomic Staging System (GLASS) for CLTI:Improving Inter-Observer Agreement

Wijnand Joep G J, Zarkowsky Devin, Wu Bian, van Haelst Steven T W, Vonken Evert-Jan P A, Sorrentino Thomas A, Pallister Zachary, Chung Jayer, Mills Joseph L, Teraa Martin, Verhaar Marianne C, de Borst Gert J, Conte Michael S 4 aug 2021, In: Journal of Clinical medicine. 10 , p. 1-9

Safety Of Electro-Oxidation For Urea Removal In A Wearable Artificial Kidney Is Compromised By Formation Of Glucose Degradation Products

van Gelder Maaike K, Vollenbroek Jeroen C, Lentferink Babette H, Hazenbrink Diënty H M, Besseling Paul J, Simonis Frank, Giovanella Silvia, Ligabue Giulia, Bajo Rubio Maria A, Cappelli Gianni, Joles Jaap A, Verhaar Marianne C, Gerritsen Karin G F 23 jul 2021, In: Artificial Organs. 45 , p. 1422-1428 7 p.

Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

Jamalpoor Amer, van Gelder Charlotte Agh, Yousef Yengej Fjodor A, Zaal Esther A, Berlingerio Sante P, Veys Koenraad R, Pou Casellas Carla, Voskuil Koen, Essa Khaled, Ammerlaan Carola Me, Rega Laura Rita, van der Welle Reini En, Lilien Marc R, Rookmaaker Maarten B, Clevers Hans, Klumperman Judith, Levtchenko Elena, Berkers Celia R, Verhaar Marianne C, Altelaar Maarten, Masereeuw Rosalinde, Janssen Manoe J 24 jun 2021, In: Embo Molecular Medicine. 13 , p. 1-20

All research output

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