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prof. dr. M.C. (Marianne C.) Verhaar

prof. dr. M.C. (Marianne C.) Verhaar

Full Professor
prof. dr. M.C. (Marianne C.) Verhaar

Biography

Biography

The research of Marianne Verhaar focuses on renal and vascular regeneration and involves translational studies from basic cell studies to animal experiments and clinical trials. Het general aim is to improve care for the patient with chronic kidney disease by developing new strategies to enhance protective mechanisms against microvascular dysfunction, atherosclerotic disease and chronic kidney disease, to enhance vascular and renal regeneration and to improve renal replacement therapies. Specific interests of her group are: mechanisms underlying increased cardiovascular risk in chronic kidney disease, the realation between chronic kidney disease, microvascular dysfunction and heart failure, the role of (bone marrow-derived) stem and progenitor cells or cellular products in vascular and renal regeneration and their therapeutic potential in patients with cardiovascular and chronic kidney disease; development of renal organoids and search for renal stem cells using specific stem cell markers; investigate the potential of induced pluripotent stem cells for renal regeneration; development of a wearable artificial kidney.

Side Activities

Expert panel – The scientific challenge “Lab-Grown Organ Replacement “German Federal Ministry of Education and Research (BMBF) 2019-

Scientific board Dutch Kidney Foundation 2019-

European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Continuous Education and Professional Development (CEPD) Committee (Chair) 2019-

ERA-EDTA Scientific Advisory Board 2019-

ERA-EDTA EUropean REnal and CArdiovascular Medicine (EURECA-m) Working Group 2015-2019

Scientific Committee of the ERA-EDTA Berlin Meeting 2021

Scientific Committee of the ERA-EDTA Milan Meeting 2020

French National Research Agency (ANR) University Hospital institute Selection Committee (Chair) 2017-

Scientific Forum of the Netherlands Heart Institute 2016-

Science Europe Scientific Advisory Committee 2015-2018

ZonMw Programme Committee Innovational Research Incentives Scheme Veni 2010-2018

NWO Innovational Research Incentives Scheme Vidi (interdivisional) 2014

ZonMw Programme Committee Translational Research 2010-2020

International Review Board Academy of Finland, 2011 & 2015

Review Committee Regenerative Medicine proposals European Committee, 2009

Visiting professor at Renal Research Institute, New York Medical College, department of Nephrology (Prof. dr. M.S. Goligorsky) (2009)

Fellowship and Awards

NWO Vidi & ASPASIA grant (2008)

NWO Veni grant (2002)

Jaarprijs Vasculaire Biologie, Nederlandse Vereniging voor Cardiologie (1998)

Research Output (295)

The Global Limb Anatomic Staging System (GLASS) for CLTI:Improving Inter-Observer Agreement

Wijnand Joep G J, Zarkowsky Devin, Wu Bian, van Haelst Steven T W, Vonken Evert-Jan P A, Sorrentino Thomas A, Pallister Zachary, Chung Jayer, Mills Joseph L, Teraa Martin, Verhaar Marianne C, de Borst Gert J, Conte Michael S 4 aug 2021, In: Journal of Clinical medicine. 10 , p. 1-9

Mildly Increased Renin Expression in the Absence of Kidney Injury in the Murine Transverse Aortic Constriction Model

Wesseling Marian, Mulder Eva, Brans Maike A D, Kapteijn Daniek M C, Bulthuis Marian, Pasterkamp Gerard, Verhaar Marianne C, Danser A H Jan, van Goor Harry, Joles Jaap A, de Jager Saskia C A 15 jun 2021, In: Frontiers in Pharmacology. 12 , p. 1-11

Progression of coronary artery calcification in conventional hemodialysis, nocturnal hemodialysis, and kidney transplantation

Jansz Thijs T, Özyilmaz Akin, van Reekum Franka E, Boereboom Franciscus T J, de Jong Pim A, Verhaar Marianne C, van Jaarsveld Brigit C dec 2020, In: PLoS ONE. 15 , p. 1-12 12 p.

Evaluation of a system for sorbent-assisted peritoneal dialysis in a uremic pig model

van Gelder Maaike K, de Vries Joost C, Simonis Frank, Monninkhof Anneke S, Hazenbrink Diënty H M, Ligabue Giulia, Giovanella Silvia, Joles Jaap A, Verhaar Marianne C, Bajo Rubio Maria A, Selgas Rafael, Cappelli Gianni, Gerritsen Karin G F dec 2020, In: Physiological Reports [E]. 8 14 p.

Plasma Methylglyoxal Levels Are Associated With Amputations and Mortality in Severe Limb Ischemia Patients With and Without Diabetes

Hanssen Nordin M J, Teraa Martin, Scheijen Jean L J M, Van de Waarenburg Marjo, Gremmels Hendrik, Stehouwer Coen D A, Verhaar Marianne C, Schalkwijk Casper G 3 nov 2020, In: Diabetes Care. 44 , p. 157-163 7 p.

Bleeding risk of haemodialysis and peritoneal dialysis patients

van Eck van der Sluijs Anita, Abrahams Alferso C, Rookmaaker Maarten B, Verhaar Marianne C, Bos Willem Jan W, Blankestijn Peter J, Dekker Friedo W, van Diepen Merel, Ocak Gurbey 1 nov 2020, In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 36 , p. 170-175 6 p.

Dosage reduction of low weight heparin in patients with renal dysfunction:Effects on anti-Xa levels and clinical outcomes

Hornung Paul, Khairoun Meriem, Dekker Friedo W, Kaasjager Karin A H, Huisman Albert, Jakulj Lily, Bos Willem Jan W, Rosendaal Frits R, Verhaar Marianne C, Ocak Gurbey 1 okt 2020, In: PLoS ONE. 15 , p. 1-14

Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Extracellular Matrix Remodeling during Left Ventricular Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction:A Systematic Review and Meta-Analysis

Krebber Merle M, van Dijk Christian G M, Vernooij Robin W M, Brandt Maarten M, Emter Craig A, Rau Christoph D, Fledderus Joost O, Duncker Dirk J, Verhaar Marianne C, Cheng Caroline, Joles Jaap A 14 sep 2020, In: International journal of molecular sciences. 21 , p. 1-22 22 p.

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Pei Jiayi, Harakalova Magdalena, Treibel Thomas A, Lumbers R Thomas, Boukens Bastiaan J, Efimov Igor R, van Dinter Jip T, González Arantxa, López Begoña, El Azzouzi Hamid, van den Dungen Noortje, van Dijk Christian G M, Krebber Merle M, den Ruijter Hester M, Pasterkamp Gerard, Duncker Dirk J, Nieuwenhuis Edward E S, de Weger Roel, Huibers Manon M, Vink Aryan, Moore Jason H, Moon James C, Verhaar Marianne C, Kararigas Georgios, Mokry Michal, Asselbergs Folkert W, Cheng Caroline 14 jul 2020, In: Clinical Epigenetics. 12 18 p.

Drugs Commonly Applied to Kidney Patients May Compromise Renal Tubular Uremic Toxins Excretion

Mihaila Silvia M, Faria João, Stefens Maurice F J, Stamatialis Dimitrios, Verhaar Marianne C, Gerritsen Karin G F, Masereeuw Rosalinde 12 jun 2020, In: Toxins. 12 16 p.

All research output

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