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prof. dr. M.C. (Marianne C.) Verhaar

Full Professor

  • Nephrology

prof. dr. M.C. (Marianne C.) Verhaar

Biography

The research of Marianne Verhaar focuses on renal and vascular regeneration and involves translational studies from basic cell studies to animal experiments and clinical trials. Het general aim is to improve care for the patient with chronic kidney disease by developing new strategies to enhance protective mechanisms against microvascular dysfunction, atherosclerotic disease and chronic kidney disease, to enhance vascular and renal regeneration and to improve renal replacement therapies. Specific interests of her group are: mechanisms underlying increased cardiovascular risk in chronic kidney disease, the realation between chronic kidney disease, microvascular dysfunction and heart failure, the role of (bone marrow-derived) stem and progenitor cells or cellular products in vascular and renal regeneration and their therapeutic potential in patients with cardiovascular and chronic kidney disease; development of renal organoids and search for renal stem cells using specific stem cell markers; investigate the potential of induced pluripotent stem cells for renal regeneration; development of a wearable artificial kidney.

Side Activities

  • Expert panel – The scientific challenge “Lab-Grown Organ Replacement “German Federal Ministry of Education and Research (BMBF) 2019-

    Scientific board Dutch Kidney Foundation 2019-

    European Renal Association – European Dialysis and Transplant Association (ERA-EDTA) Continuous Education and Professional Development (CEPD) Committee (Chair) 2019-

    ERA-EDTA Scientific Advisory Board 2019-

    ERA-EDTA EUropean REnal and CArdiovascular Medicine (EURECA-m) Working Group 2015-2019

    Scientific Committee of the ERA-EDTA Berlin Meeting 2021

    Scientific Committee of the ERA-EDTA Milan Meeting 2020

    French National Research Agency (ANR) University Hospital institute Selection Committee (Chair) 2017-

    Scientific Forum of the Netherlands Heart Institute 2016-

    Science Europe Scientific Advisory Committee 2015-2018

    ZonMw Programme Committee Innovational Research Incentives Scheme Veni 2010-2018

    NWO Innovational Research Incentives Scheme Vidi (interdivisional) 2014

    ZonMw Programme Committee Translational Research 2010-2020

    International Review Board Academy of Finland, 2011 & 2015

    Review Committee Regenerative Medicine proposals European Committee, 2009

    Visiting professor at Renal Research Institute, New York Medical College, department of Nephrology (Prof. dr. M.S. Goligorsky) (2009)

Fellowship and Awards

  • NWO Vidi & ASPASIA grant (2008)

    NWO Veni grant (2002)

    Jaarprijs Vasculaire Biologie, Nederlandse Vereniging voor Cardiologie (1998)

Research Output (266)

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Pei Jiayi, Harakalova Magdalena, Treibel Thomas A, Lumbers R Thomas, Boukens Bastiaan J, Efimov Igor R, van Dinter Jip T, González Arantxa, López Begoña, El Azzouzi Hamid, van den Dungen Noortje, van Dijk Christian G M, Krebber Merle M, den Ruijter Hester M, Pasterkamp Gerard, Duncker Dirk J, Nieuwenhuis Edward E S, de Weger Roel, Huibers Manon M, Vink Aryan, Moore Jason H, Moon James C, Verhaar Marianne C, Kararigas Georgios, Mokry Michal, Asselbergs Folkert W, Cheng Caroline 14 jul 2020, In: Clinical Epigenetics. 12 18 p.

Validation of randomized controlled trial-derived models for the prediction of postintervention outcomes in chronic limb-threatening ischemia

Wijnand Joep G J, van Koeverden Ian D, Teraa Martin, Spreen Marlon I, Mali Willem P T M, van Overhagen Hans, Pasterkamp Gerard, de Borst Gert J, Conte Michael S, Gremmels Hendrik, Verhaar Marianne C 1 mrt 2020, In: Journal of Vascular Surgery. 71 , p. 869-879 11 p.

Applicability of Transcutaneous Oxygen Tension Measurement in the Assessment of Chronic Limb-Threatening Ischemia

Leenstra Bernard, Wijnand Joep, Verhoeven Bart, Koning Olivier, Teraa Martin, Verhaar Marianne C, de Borst Gert J mrt 2020, In: Angiology. 71 , p. 208-216 9 p.

Unbound Plasma, Total Plasma, and Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

Sikma Maaike A., Van Maarseveen Erik M., Hunault Claudine C., Moreno Javier M., Van de Graaf Ed A., Kirkels Johannes H., Verhaar Marianne C., Grutters Jan C., Kesecioglu Jozef, De Lange Dylan W., Huitema Alwin D. R. 16 dec 2019, In: Clinical Pharmacokinetics. 59 , p. 771-780 10 p.

Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis:The SMART-MR Study

Zwartbol M. H. T., Geerlings M. I., Ghaznawi R., Hendrikse J., van der Kolk A. G., Asselbergs F. W., Nathoe H. M., de Borst G. J., Bots M. L., Emmelot M. H., de Jong P. A., Leiner T., Lely A. T., van der Kaaij N. P., Kappelle L. J., Ruigrok Y. M., Verhaar M. C., Visseren F. L. J., Westerink J., 5 dec 2019, In: American Journal of Neuroradiology. 40 , p. 2016-2022 7 p.

A Pro-Inflammatory Biomarker-Profile Predicts Amputation-Free Survival in Patients with Severe Limb Ischemia

Gremmels Hendrik, Teraa Martin, de Jager Saskia C.A., Pasterkamp Gerard, de Borst Gert J., Verhaar Marianne C. 1 dec 2019, In: Scientific Reports. 9

High Variability of Whole-Blood Tacrolimus Pharmacokinetics Early After Thoracic Organ Transplantation

Sikma Maaike A, Hunault Claudine C, Van Maarseveen Erik M, Huitema Alwin D R, Van de Graaf Ed A, Kirkels Johannes H, Verhaar Marianne C, Grutters Jan C, Kesecioglu Jozef, De Lange Dylan W 19 nov 2019, In: European journal of drug metabolism and pharmacokinetics. 45 , p. 123-134 12 p.

The association between chronic kidney disease, falls, and fractures:a systematic review and meta-analysis

Goto N A, Weststrate A C G, Oosterlaan F M, Verhaar M C, Willems H C, Emmelot-Vonk M H, Hamaker M E 12 nov 2019, In: Osteoporosis International. 31 , p. 13-29 17 p.

Transcriptome analysis reveals microvascular endothelial cell-dependent pericyte differentiation

Brandt Maarten M, van Dijk Christian G M, Maringanti Ranganath, Chrifi Ihsan, Kramann Rafael, Verhaar Marianne C, Duncker Dirk J, Mokry Michal, Cheng Caroline 30 okt 2019, In: Scientific Reports. 9

Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients

Heidt Sebastiaan, Haasnoot Geert W., Witvliet Marian D., van der Linden-van Oevelen Marissa J.H., Kamburova Elena G., Wisse Bram W., Joosten Irma, Allebes Wil A., van der Meer Arnold, Hilbrands Luuk B., Baas Marije C., Spierings Eric, Hack Cornelis E., van Reekum Franka E., van Zuilen Arjan D., Verhaar Marianne C., Bots Michiel L., Drop Adriaan C.A.D., Plaisier Loes, Seelen Marc A.J., Sanders Jan Stephan, Hepkema Bouke G., Lambeck Annechien J.A., Bungener Laura B., Roozendaal Caroline, Tilanus Marcel G.J., Voorter Christina E., Wieten Lotte, van Duijnhoven Elly M., Gelens Marielle A.C.J., Christiaans Maarten H.L., van Ittersum Frans J., Nurmohamed Shaikh A., Lardy Neubury M., Swelsen Wendy, van der Pant Karlijn A.M.I., van der Weerd Neelke C., ten Berge Ineke J.M., Bemelman Frederike J., Hoitsma Andries, van der Boog Paul J.M., de Fijter Johan W., Betjes Michiel G.H., Otten Henny G., Roelen Dave L., Claas Frans H.J. okt 2019, In: American Journal of Transplantation. 19 , p. 2926-2933 8 p.

All Research Output (266)