prof. dr. M.C. (Marianne C.) Verhaar

prof. dr. M.C. (Marianne C.) Verhaar

Full Professor
prof. dr. M.C. (Marianne C.) Verhaar



Trained as a medical doctor and internist-nephrologist, and with a strong pre-clinical background, Marianne Verhaar consistently combines her clinical practice with extensive basic, translational, and clinical research. After her Cum Laude PhD in Vascular Biology and next to her work as consultant nephrologist, she established the research laboratory for Regenerative Nephrology and Vascular Biology within the department of Nephrology and Hypertension at the UMC Utrecht. In 2009, she was appointed as professor of Experimental Nephrology, and since 2014 she has assumed the position of head of the department of Nephrology and Hypertension at the UMC Utrecht. She is co-founder and current chair of the Regenerative Medicine & Stem Cells strategic programme, one of the six prominent "spearhead" programs implemented throughout UMC Utrecht. Additionally, she played a key part in initiating the successful Strategic Alliance in Regenerative Medicine (RM) between UMC Utrecht, Eindhoven University of Technology (TU/e) and Utrecht University (UU), and serves as the director of the collaborative Master’s Program RM and Technology, jointly offered by UMC Utrecht, TU/e and UU.

Verhaar is an internationally established researcher operating at the forefront of regenerative nephrology and integrating vascular biology. She has (co-)authored >350 peer-reviewed papers, and has received numerous research grants, including the prestigious NWO VENI, VIDI and ASPASIA grants, and two large NWO Translational Adult Stem cell (TAS) grants for her research into new applications for adult stem cells. With her guidance, 42 PhD students have completed their research and have gone on to hold diverse positions both nationally and internationally. Verhaar is internationally and highly respected for her contributions to the field. She serves as a member of key (inter)national committees, including the Scientific Advisory Board of the Dutch Kidney Foundation; the Scientific Advisory Board of the European Renal Association (ERA); and holds the chair position of the CME committee of the ERA. Furthermore, she serves as chair of the ‘Investments for the Future’ ANR evaluation committee, overseeing the selection process of French University Hospital Institutes. She is a frequently asked speaker and an elected member of AcademiaNet for Outstanding Female Scientists and Scholars; International Fellow of the American Heart Association (FAHA); and Distinguished Fellow of the European Renal Association (FERA).


Verhaar’s research covers the complete spectrum from fundamental research to clinical trials. She leads a diverse, interdisciplinary team of ~40 researchers, committed to finding solutions for patients with cardiovascular and chronic kidney disease, particularly by developing new vascular and renal regenerative treatments. A recent breakthrough achieved by her team involves the successful generation of organoids derived from adult kidney tissue and cells isolated from human urine. These adult-derived human kidney organoids present a novel technology for modeling human kidney diseases. Furthermore, they serve as a unique resource for the generation of transplantable kidney tissue and the advancement of bioartificial kidney development. Verhaar's research group is actively involved in the development of innovative technology to enable the realization of an implantable (bio)artificial kidney that offers more effective, physiological, and affordable functional kidney replacement therapy than currently  existing options. Collaborating with the Dutch Kidney Foundation, multiple academic centers, and private partners, Verhaar's group has successfully developed a prototype for a portable artificial kidney that is scheduled to undergo testing in a first-in-human clinical trial in the near future. Furthermore, Verhaar's group investigates in situ tissue engineering techniques specifically targeting small-diameter arteries and vascular grafts used in hemodialysis access.

She and her group lead and actively participate in several (inter)national consortia, including projects on regenerative nephrology and development of the wearable artificial kidney. Verhaar was one of the six main applicants of the NWO Gravitation grant Materials-Driven Regeneration and leads the Kidney Moonshot in the Regenerative Medicine Crossing Borders initiative. She also leads the national multicentre Dutch CardioVascular Alliance consortium RECONNEXT – on the cardio-renal connection- and the international consortia EC Horizon 2020 Pathfinder-open KIDNEW – investigating breakthrough technologies for an implantable artificial kidney-  and EC Horizon 2020 Marie S. Curie COFUND doctorate project RESCUE - offering 30 PhD positions on REgenerative Medicine & Stem Cells in UtrEcht.

Side Activities

Board activities

  • Scientific Forum of the Netherlands Heart Institute (2016-2019)
  • Wetenschappelijke Raad Nierstichting (2019- )
  • Scientific Advisory Board European Renal Association (ERA) (2019- )
  • ERA Continuing Medical Education Committee (chair) (2019- )
  • Scientific Committee ERA Scientific Congress (2019- )
  • Agence National de la Recherche (ANR), Selection Committee of University Hospital institutes (IHU) (chair) (2017- )
  • Expert panel – The scientific challenge “Lab-Grown Organ Replacement “German Federal Ministry of Education and Research (BMBF) (2019- )
  • Strategic Advisory Board Regenerative Medicine Crossing Borders (RegMedXB) (2020- )
  • Kidney Moonshot leader RegMedXB (2020- )
  • Nationaal Actieprogramma: Tafel 1 Regeneratieve Geneeskunde + Stamcel Therapie (2020- )
  • Advisory Board werkgroep Living Technologies Eindhoven-Wageningen-UU-UMC Utrecht (EWUU) Alliantie (2021- )


  • Nederlandse Internisten Vereniging
  • Nederlandse Federatie voor Nefrologie
  • Dutch Cardio Vascular Alliance
  • Regenerative Medicine Crossing Borders
  • European Renal Association
  • ERA- EUropean REnal and CArdiovascular Medicine (EURECA-m) Working Group
  • American Society of Nephrology
  • American Heart Association

Fellowship and Awards

Dirkzwager-Assink Award

NWO Vidi & ASPASIA grant (2008)

NWO Veni grant (2002)

Jaarprijs Vasculaire Biologie, Nederlandse Vereniging voor Cardiologie (1998)

Research Output (349)

Author Correction:Transcriptomic profile comparison reveals conservation of ionocytes across multiple organs

Pou Casellas Carla, Pleguezuelos-Manzano Cayetano, Rookmaaker Maarten B, Verhaar Marianne C, Clevers Hans 21 Jun 2023, In: Scientific Reports. 13

Evidence for pharmacological interventions to reduce cardiovascular risk for patients with chronic kidney disease:a study protocol of an evidence map

Colombijn Julia M.T., Idema Demy L., van der Braak Kim, Spijker Rene, Meijvis Sabine C.A., Bots Michiel L., Hooft Lotty, Verhaar Marianne C., Vernooij Robin W.M. 12 Nov 2022, In: Systematic Reviews. 11

A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles

Nguyen Vivian V.T., Ye Shicheng, Gkouzioti Vasiliki, van Wolferen Monique E., Yengej Fjodor Yousef, Melkert Dennis, Siti Sofia, de Jong Bart, Besseling Paul J., Spee Bart, van der Laan Luc J.W., Horland Reyk, Verhaar Marianne C., van Balkom Bas W.M. 1 Nov 2022, In: Journal of Extracellular Vesicles. 11

The Ethical Implications of Tissue Engineering for Regenerative Purposes:A Systematic Review

de Kanter Anne-Floor Johanna, Jongsma Karin Rolanda, Verhaar Marianne C, Bredenoord Annelien L 16 Sep 2022, In: Tissue engineering. Part B, Reviews. 29 , p. 167-187 21 p.

Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids

Martinez-Silgado Adriana, Yousef Yengej Fjodor A., Puschhof Jens, Geurts Veerle, Boot Charelle, Geurts Maarten H., Rookmaaker Maarten B., Verhaar Marianne C., Beumer Joep, Clevers Hans 16 Sep 2022, In: STAR protocols. 3

A Uremic Pig Model for Peritoneal Dialysis

de Vries Joost C., van Gelder Maaike K., Monninkhof Anneke S., Ahmed Sabbir, Hazenbrink Diënty H.M., Nguyen Tri Q., de Kort Gèrard A.P., Vonken Evert Jan P.A., Vaessen Koen R.D., Joles Jaap A., Verhaar Marianne C., Gerritsen Karin G.F. 14 Sep 2022, In: Toxins. 14

Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids

Lindoso Rafael Soares, Yousef Yengej Fjodor A., Voellmy Franziska, Altelaar Maarten, Mancheño Juncosa Estela, Tsikari Theano, Ammerlaan Carola M.E., Van Balkom Bas W.M., Rookmaaker Maarten B., Verhaar Marianne C., Masereeuw Rosalinde 15 Jul 2022, In: Journal of Nanobiotechnology. 20

Deep learning body-composition analysis of clinically acquired CT-scans estimates creatinine excretion with high accuracy in patients and healthy individuals

Pieters Tobias T., Veldhuis W. B., Moeskops P., de Vos B. D., Verhaar M. C., Haitjema S., Huitema A. D.R., Rookmaaker M. B. 30 May 2022, In: Scientific Reports. 12

Lifestyle changes and kidney function:A 10-year follow-up study in patients with manifest cardiovascular disease

Østergaard Helena Bleken, Demirhan Imre, Westerink Jan, Verhaar Marianne C, Asselbergs Folkert W, de Borst Gert J, Kappelle L Jaap, Visseren Frank L J, van der Leeuw Joep, 17 May 2022, In: European Journal of Clinical Investigation. 52

Chronic kidney disease and atrial fibrillation:A dangerous combination

Ocak Gurbey, Khairoun Meriem, Khairoun Othman, Bos Willem Jan W, Fu Edouard L, Cramer Maarten J, Westerink Jan, Verhaar Marianne C, Visseren Frank L, Apr 2022, In: PLoS ONE. 17 , p. 1-13

All research output

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