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dr. J.J.C. (Joost) Verhoeff

dr. J.J.C. (Joost) Verhoeff

Associate Professor - medical
dr. J.J.C. (Joost) Verhoeff
  • Department of Radiotherapy

Research Programs

Strategic Program Cancer

Biography

Biography

View my YouTube research presentation (in Dutch):

MRI-geleide radiotherapie in Utrecht: Harder, Better, Faster, Stronger https://youtu.be/aJerM2wQoKI?t=152

 

Performing research is expensive. If you want to support us to speed things up, please contact me.

T. 088 - 75 588 00 E. j.j.c.verhoeff-10@umcutrecht.nl

 

My lab's mission is to redefine Standard Radiotherapy

As radiation oncologists, we want to treat cancer patients with high precision radiotherapy. The UMC Utrecht has the right team and right machinery for this (3x MRI-linac, 10x CT-linac). My lab's goal is to design the best cancer treatment for each patient. Some patients want to live as long as possible regardless of treatment side effects, others want quality of life. To find balance is key.

The UMC Utrecht department of Radiation Oncology is a terrific place to do clinical research, as it is even the birthplace of the MRI-linac. Next, the Radiation Oncology department harbours 2 1.5T MRI systems, a 3.0T MRI, a 7.0T MRI and a MRI/PET scanner.

Joost Verhoeff subspecialized in treatment of brain tumors, lung cancer and cardiac SBRT. About half of his time he spends on research as associate professor.

 

Brain tumors:

- Increasing quality of life by compact but extremely precise focused radiation treatment

- Increasing overall survival by combining better treatment modalities

- Principal Investigator of ZonMW funded GOLD trial (dutch info), 30x2Gy+TMZ versus 6x6Gy+TMZ for primary GBM (responsible researcher drs. Arthur van der Boog)

- Principal Investigator of KWF funded RISinG trial (dutch info), 10x3.5Gy versus 4x7.5Gy for recurrent GBM (responsible researcher drs. Arthur van der Boog)

 

Brain metastases:

- Finding best treatments for each specific patient: personalized medicine.

- Increasing quality of life by incorporating MR-guided treatment post operative (MRI-linac)

- Coimbra brain metastasis prospective cohort (website) (responsible researcher drs. Fia Cialdella)

 

Lung cancer:

- Better predicting patient survival and toxicity by smart analyses

- Increasing quality of life by incorporating MR-guided treatment (MR-Linac)

- U-color prospective cohort, for all lung cancer patients that receive radiotherapy

 

Cardiac Ablative SBRT:

- In the lead of a consortium of 30 European hospitals we develop strategies to treat Ventricular Tachycardia in the STOPSTORM.eu framework (Principal Investigator, EU H2020 grant).

 

Postdocs:

- Szabolcs David PhD (brain tumors, imaging)
- Jacqueline Pomp MD PhD, radiation oncologist, (lung cancer and deep learning)
- Peter van Rossum MD PhD MSc, resident radiation oncologist (MRI-linac, epidemiology, lung cancer)

 

PhD students:

- Steven Nagtegaal MD (brain tumors, cognitive changes)
- Wouter van Amsterdam MD (deep learning, lung cancer)
- Eva van Grinsven MSc (neuro-psychology, brain tumors)
- Arthur van der Boog BS (brain tumors, clinical trials)
- Belle van Duin MD (melanoma, imaging, pathology)
- Fia Cialdella MD (brain metastases, neuro-oncology)

 

Residents radiation oncology performing research:

- Joyce Lodeweges MD (lung cancer)
- Max Peters MD PhD MSc (epidemiology, lung cancer)
- Pim Damen MD (immunotherapies)

 

Students (medical, biomedical, informatics):

- Selena Huisman (brain tumor imaging)
- Victor Wasser (brain tumor imaging)
- Salah Gasle (brain tumor imaging)
- Michelle Sierts (MR-Linac for brain tumors)
- Karlijn Smitt (brain tumors)
- Mathijs Tomassen (lung cancer)
- Lucie Egberink (lung cancer)
- Myra van Laar (lung cancer)

Former group members (medical, biomedical, informatics):

- Sjors Witteveen (lung cancer)
- Hajo Boersma (psychiatric disorders and radiotherapy)
- Hugo van Joolingen (lung cancer)
- Anne van der Tuin (MR-Linac for lung cancer)
- Eva Swinkels (lung cancer)
- Marnix Rading MD (lung cancer)
- Laura Merckel MD PhD (MRI-linac lung cancer)
- Bas Arends (deep learning for spine tumor treatment)
- Jasper Hennecken (spinal imaging)
- Céline Bogers (lung cancer)
- Eliza van Wulfften Palthe (brain metastases)
- Anouk Steennis (brain tumors)
- Ali Ghannam (brain metastases cohort)
- Emma Nessen (brain metastases)
- Marc Pijper (lung cancer)
- Cathalijne Post (brain tumors)
- Robin Schuijlenburg (brain tumors)
- Merel Kraak (lung cancer)
- Suzanne Vellinga (lung cancer)
- Netanja Harlianto (lung cancer)
- Yannic Hanekamp (Covid treatment)
- Sjors Wagemakers (pain meassurement)
- Max van Essen (brain tumors)
- Chris Hammerstein (survival analyses)

 

 

 

Full list of publications on PubMed: click here (automatic list is incomplete)

Research Output (118)

Towards mid-position based Stereotactic Body Radiation Therapy using online magnetic resonance imaging guidance for central lung tumours

Ligtenberg Hans, Hackett Sara L., Merckel Laura G., Snoeren Louk, Kontaxis Charis, Zachiu Cornel, Bol Gijsbert H., Verhoeff Joost J.C., Fast Martin F. Jul 2022, In: Physics and Imaging in Radiation Oncology. 23 , p. 24-31 8 p.

In Reply to Chow and Simone

Damen Pim J.J., Kroese Tiuri E., Peters Max, Lin Steven H., Verhoeff Joost J.C., van Rossum Peter S.N. 1 May 2022, In: International Journal of Radiation Oncology Biology Physics. 113 , p. 236-237 2 p.

Conventional MRI Criteria to Differentiate Progressive Disease from Treatment-Induced Effects in High-Grade (WHO Grade 3-4) Gliomas

Flies Christina M, van Leuken Karlijn H, Voorde Marlies Ten, Verhoeff Joost J C, De Vos Filip Y F, Seute Tatjana, Robe Pierre A, Witkamp Theodoor D, Hendrikse Jeroen, Dankbaar Jan Willem, Snijders Tom J 18 Apr 2022, In: Neurology. 99 , p. e77-e88

Individual treatment effect estimation in the presence of unobserved confounding using proxies:a cohort study in stage III non-small cell lung cancer

van Amsterdam Wouter A C, Verhoeff Joost J C, Harlianto Netanja I, Bartholomeus Gijs A, Puli Aahlad Manas, de Jong Pim A, Leiner Tim, van Lindert Anne S R, Eijkemans Marinus J C, Ranganath Rajesh 7 Apr 2022, In: Scientific Reports. 12

ASO Visual Abstract:Non-small Cell Lung Cancer Patients with a High Predicted Risk of Irradical Resection-can Chemoradiotherapy Offer Similar Survival?

van Joolingen W Hugo, Rasing Marnix J A, Peters Max, van Lindert Anne S R, de Heer Linda M, Aarts Mieke J, Verhoeff Joost J C, van Rossum Peter S N Mar 2022, In: Annals of Surgical Oncology. 29 , p. 1815-1815 1 p.

The overall survival impact of prophylactic cranial irradiation in limited-stage small-cell lung cancer:A systematic review and meta-analysis

Tomassen Mathijs L., Pomp Jacquelien, van der Stap Janneke, van Lindert Anne S.R., Peters Max, Belderbos José S.A., De Ruysscher Dirk K.M., Lin Steven H., Verhoeff Joost J.C., van Rossum Peter S.N. Mar 2022, In: Clinical and translational radiation oncology. 33 , p. 145-152 8 p.

First experimental exploration of real-time cardiorespiratory motion management for future stereotactic arrhythmia radioablation treatments on the MR-linac

Akdag Osman, Borman Pim T S, Woodhead Peter L, Uijtewaal Prescilla, Mandija Stefano, van Asselen Bram, Verhoeff Joost J C, Raaymakers Bas W, Fast Martin F 21 Feb 2022, In: Physics in medicine and biology. 67 , p. 1-14

Quality of Life After Stereotactic Body Radiation Therapy Versus Conventional Radiation Therapy in Patients With Bone Metastases

Pielkenrood Bart J, Gal Roxanne, Kasperts Nicolien, Verhoeff Joost Jc, Bartels Marcia Mtj, Seravalli Enrica, van der Linden Yvette M, Monninkhof Evelyn M, Verlaan Jorrit-Jan, van der Velden Joanne M, Verkooijen Helena M 10 Jan 2022, In: International Journal of Radiation Oncology Biology Physics. 112 , p. 1203-1215 13 p.

Feasibility of cardiac-synchronized quantitative T1 and T2 mapping on a hybrid 1.5 Tesla magnetic resonance imaging and linear accelerator system

Akdag Osman, Mandija Stefano, van Lier Astrid L H M W, Borman PTS, Schakel Tim, Alberts Eveline, van der Heide Oscar, Hassink Rutger J, Verhoeff Joost J C, Mohamed Hoesein Firdaus A A, Raaymakers Bas W, Fast Martin F Jan 2022, In: Physics and Imaging in Radiation Oncology. 21 , p. 153-159 7 p.

Metastasis directed stereotactic radiotherapy in NSCLC patients progressing under targeted- or immunotherapy:efficacy and safety reporting from the 'TOaSTT' database

Kroeze Stephanie G C, Schaule Jana, Fritz Corinna, Kaul David, Blanck Oliver, Kahl Klaus H, Roeder Falk, Siva Shankar, Verhoeff Joost J C, Adebahr Sonja, Schymalla Markus M, Glatzer Markus, Szuecs Marcella, Geier Michael, Skazikis Georgios, Sackerer Irina, Lohaus Fabian, Eckert Franziska, Guckenberger Matthias Dec 2021, In: Radiation Oncology [E]. 16 9 p.

All research output

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