dr. J.J.C. (Joost) Verhoeff

dr. J.J.C. (Joost) Verhoeff

Associate Professor - medical
dr. J.J.C. (Joost) Verhoeff
  • Department of Radiotherapy



View my YouTube research presentation (in Dutch):

MRI-geleide radiotherapie in Utrecht: Harder, Better, Faster, Stronger


Performing research is expensive. If you want to support us to speed things up, please contact me.

T. 088 - 75 588 00 E.


My lab's mission is to redefine Standard Radiotherapy

As radiation oncologists, we want to treat cancer patients with high precision radiotherapy. The UMC Utrecht has the right team and right machinery for this (3x MRI-linac, 10x CT-linac). My lab's goal is to design the best cancer treatment for each patient. Some patients want to live as long as possible regardless of treatment side effects, others want quality of life. To find balance is key.

The UMC Utrecht department of Radiation Oncology is a terrific place to do clinical research, as it is even the birthplace of the MRI-linac. Next, the Radiation Oncology department harbours 2 1.5T MRI systems, a 3.0T MRI, a 7.0T MRI and a MRI/PET scanner.

Joost Verhoeff subspecialized in treatment of brain tumors, lung cancer and cardiac SBRT. About half of his time he spends on research as associate professor.


Brain tumors:

- Increasing quality of life by compact but extremely precise focused radiation treatment

- Increasing overall survival by combining better treatment modalities

- Principal Investigator of ZonMW funded GOLD trial (dutch info), 30x2Gy+TMZ versus 6x6Gy+TMZ for primary GBM (responsible researcher drs. Arthur van der Boog)

- Principal Investigator of KWF funded RISinG trial (dutch info), 10x3.5Gy versus 4x7.5Gy for recurrent GBM (responsible researcher drs. Arthur van der Boog)


Brain metastases:

- Finding best treatments for each specific patient: personalized medicine.

- Increasing quality of life by incorporating MR-guided treatment post operative (MRI-linac)

- Coimbra brain metastasis prospective cohort (website, (responsible researcher drs. Fia Cialdella)


Lung cancer:

- Better predicting patient survival and toxicity by smart analyses

- Increasing quality of life by incorporating MR-guided treatment (MR-Linac)

- U-color prospective cohort, for all lung cancer patients that receive radiotherapy


Cardiac Ablative SBRT:

- In the lead of a consortium of 30 European hospitals we develop strategies to treat Ventricular Tachycardia in the framework (Principal Investigator, EU H2020 grant).



- Szabolcs David PhD (brain tumors, imaging)
- Jacqueline Pomp MD PhD, radiation oncologist, (lung cancer and deep learning)
- Peter van Rossum MD PhD MSc, resident radiation oncologist (MRI-linac, epidemiology, lung cancer)


PhD students:

- Eva van Grinsven MSc (neuro-psychology, brain tumors)
- Arthur van der Boog BS (brain tumors, clinical trials)
- Belle van Duin MD (melanoma, imaging, pathology)
- Fia Cialdella MD (brain metastases, neuro-oncology)


Residents radiation oncology performing research:

- Joyce Lodeweges MD (lung cancer)
- Max Peters MD PhD MSc (epidemiology, lung cancer)
- Pim Damen MD (immunotherapies)
- Emma Wolters MD PhD (neuro oncology)
- Rosa Sleddering MD (neuro oncology)


Students (medical, biomedical, informatics):

- Michelle Sierts (MR-Linac for brain tumors)
- Karlijn Smitt (brain tumors)
- Lucie Egberink (lung cancer)
- Myra van Laar (lung cancer)

Former group members (medical, biomedical, informatics):

- Steven Nagtegaal MD PhD (brain tumors, cognitive changes)
- Wouter van Amsterdam MD PhD (deep learning, lung cancer)
- Selena Huisman (brain tumor imaging)
- Victor Wasser (brain tumor imaging)
- Salah Gasle (brain tumor imaging)
- Mathijs Tomassen (lung cancer)
- Sjors Witteveen (lung cancer)
- Hajo Boersma (psychiatric disorders and radiotherapy)
- Hugo van Joolingen (lung cancer)
- Anne van der Tuin (MR-Linac for lung cancer)
- Eva Swinkels (lung cancer)
- Marnix Rading MD (lung cancer)
- Laura Merckel MD PhD (MRI-linac lung cancer)
- Bas Arends (deep learning for spine tumor treatment)
- Jasper Hennecken (spinal imaging)
- Céline Bogers (lung cancer)
- Eliza van Wulfften Palthe (brain metastases)
- Anouk Steennis (brain tumors)
- Ali Ghannam (brain metastases cohort)
- Emma Nessen (brain metastases)
- Marc Pijper (lung cancer)
- Cathalijne Post (brain tumors)
- Robin Schuijlenburg (brain tumors)
- Merel Kraak (lung cancer)
- Suzanne Vellinga (lung cancer)
- Netanja Harlianto (lung cancer)
- Yannic Hanekamp (Covid treatment)
- Sjors Wagemakers (pain meassurement)
- Max van Essen (brain tumors)
- Chris Hammerstein (survival analyses)




Full list of publications on PubMed: click here (automatic list is incomplete)

Research Output (138)

STereotactic Arrhythmia Radioablation:current status of the art. The old world and the new world connected

Trombetta Mark, Verhoeff Joost 6 Jan 2023, In: Journal of Radiotherapy in Practice. 22 4 p.

Occurrence, Risk Factors, and Consequences of Postoperative Ischemia After Glioma Resection:A Retrospective Study

van der Boog Arthur T J, Rados Matea, Akkermans Annemarie, Dankbaar Jan Willem, Kizilates Ufuk, Snijders Tom J, Hendrikse Jeroen, Verhoeff Joost J C, Hoff Reinier G, Robe Pierre A 1 Jan 2023, In: Neurosurgery. 92 , p. 125-136 12 p.

The impact of etiology in lesion-symptom mapping - A direct comparison between tumor and stroke

van Grinsven E E, Smits A R, van Kessel E, Raemaekers M A H, de Haan E H F, Huenges Wajer I M C, Ruijters V J, Philippens M E P, Verhoeff J J C, Ramsey N F, Robe P A J T, Snijders T J, van Zandvoort M J E Jan 2023, In: NeuroImage. Clinical. 37

Dosimetric feasibility of direct post-operative MR-Linac-based stereotactic radiosurgery for resection cavities of brain metastases

Seravalli Enrica, Sierts Michelle, Brand Eric, Maspero Matteo, David Szabolcs, Philippens Mariellen E P, Voormolen Eduward H J, Verhoeff Joost J C 30 Dec 2022, In: Radiotherapy & Oncology. 179

Screening for long-term complications in brain tumor care, thinking one step ahead

Compter Annette, Verhoeff Joost J C Dec 2022, In: Neuro-Oncology Practice. 9 , p. 459-460 2 p.

Imaging standardisation in metastatic colorectal cancer:A joint EORTC-ESOI-ESGAR expert consensus recommendation

Unterrainer Marcus, Deroose Christophe M., Herrmann Ken, Moehler Markus, Blomqvist Lennart, Cannella Roberto, Caramella Caroline, Caruso Damiano, Chouhan Manil D., Denecke Timm, De la Pinta Carolina, De Geus-Oei Lioe Fee, Dulskas Audrius, Eisenblätter Michel, Foley Kieran G., Gourtsoyianni Sofia, Lecouvet Frederic E., Lopci Egesta, Maas Monique, Obmann Markus M., Oprea-Lager Daniela E., Verhoeff Joost J.C., Santiago Ines, Terraz Sylvain, D'Anastasi Melvin, Regge Daniele, Laghi Andrea, Beets-Tan Regina G.H., Heinemann Volker, Lordick Florian, Smyth Elizabeth C., Ricke Jens, Kunz Wolfgang G., , , Nov 2022, In: European Journal of Cancer. 176 , p. 193-206 14 p.

Long-term Local Control and Overall Survival After Radiotherapy in Oligoprogressive Patients During Treatment With Checkpoint Inhibitors

Damen Pim J J, Suijkerbuijk Karijn P M, VAN Lindert Anne S R, Eppinga Wietse S C, El Sharouni Sherif Y, Verhoeff Joost J C Oct 2022, In: Anticancer Research. 42 , p. 4795-4804 10 p.

Imaging to predict checkpoint inhibitor outcomes in cancer. A systematic review

Ter Maat Laurens S, van Duin Isabella A J, Elias Sjoerd G, van Diest Paul J, Pluim Josien P W, Verhoeff Joost J C, de Jong Pim A, Leiner Tim, Veta Mitko, Suijkerbuijk Karijn P M 9 Sep 2022, In: European Journal of Cancer. 175 , p. 60-76 17 p.


van Grinsven E. E., Smits A. R., van Kessel E., Raemaekers M., de Haan E. H. F., Huenges-Wajer I. M. C., Ruijters V. J., Philippens M. E. P., Verhoeff J. J. C., Ramsey N. F., Robe P. A. J. T., Snijders T. J., van Zandvoort M. J. E. 5 Sep 2022, In: Neuro-oncology. 24 , p. ii24


Van der Boog A. T. J., David S., Nagtegaal S. H. J., Bruil D. E., Cialdella F., Snijders T., Robe P. A. J., Verhoeff J. J. C. 5 Sep 2022, In: Neuro-oncology. 24

All research output

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