dr. J.J.C. (Joost) Verhoeff

dr. J.J.C. (Joost) Verhoeff

Associate Professor - medical
dr. J.J.C. (Joost) Verhoeff
  • Radiotherapy (research)
  • Department of Radiotherapy

Research Programs

Strategic Program Cancer



View my YouTube research presentation (in Dutch):

MRI-geleide radiotherapie in Utrecht: Harder, Better, Faster, Stronger


My lab's mission is to redefine Standard Radiotherapy

As radiation oncologists, we want to treat cancer patients with high precision radiotherapy. The UMC Utrecht has the right team and right machinery for this (3x MRI-linac, 10x CT-linac). My lab's goal is to design the best cancer treatment for each patient. Some patients want to live as long as possible regardless of treatment side effects, others want quality of life. To find balance is key.

The UMC Utrecht department of Radiation Oncology is a terrific place to do clinical research, as it is even the birthplace of the MRI-linac. Next, the Radiation Oncology department harbours 2 1.5T MRI systems, a 3.0T MRI, a 7.0T MRI and a MRI/PET scanner.

Joost Verhoeff subspecialized in treatment of brain tumors, lung cancer and cardiac SBRT. About half of his time he spends on research as associate professor.


Brain tumors:

- Increasing quality of life by compact but extremely precise focused radiation treatment

- Increasing overall survival by combining better treatment modalities

- Principal Investigator of ZonMW funded GOLD trial (dutch info), 30x2Gy+TMZ versus 6x6Gy+TMZ for primary GBM (responsible researcher drs. Arthur van der Boog)

- Principal Investigator of KWF funded RISinG trial (dutch info), 10x3.5Gy versus 4x7.5Gy for recurrent GBM (responsible researcher drs. Arthur van der Boog)


Brain metastases:

- Finding best treatments for each specific patient: personalized medicine.

- Increasing quality of life by incorporating MR-guided treatment post operative (MRI-linac)

- Coimbra brain metastasis prospective cohort (website) (responsible researcher drs. Fia Cialdella)


Lung cancer:

- Better predicting patient survival and toxicity by smart analyses

- Increasing quality of life by incorporating MR-guided treatment (MR-Linac)

- U-color prospective cohort, for all lung cancer patients that receive radiotherapy


Cardiac Ablative SBRT:

- In the lead of a consortium of 30 European hospitals we develop strategies to treat Ventricular Tachycardia in the framework (Principal Investigator, EU H2020 grant).



- Szabolcs David PhD (brain tumors, imaging)
- Jacqueline Pomp MD PhD, radiation oncologist, (lung cancer and deep learning)
- Peter van Rossum MD PhD MSc, resident radiation oncologist (MRI-linac, epidemiology, lung cancer)


PhD students:

- Steven Nagtegaal MD (brain tumors, cognitive changes)
- Wouter van Amsterdam MD (deep learning, lung cancer)
- Eva van Grinsven MSc (neuro-psychology, brain tumors)
- Arthur van der Boog BS (brain tumors, clinical trials)
- Belle van Duin MD (melanoma, imaging, pathology)
- Fia Cialdella MD (brain metastases, neuro-oncology)


Residents radiation oncology performing research:

- Joyce Lodeweges MD (lung cancer)
- Max Peters MD PhD MSc (epidemiology, lung cancer)
- Pim Damen MD (immunotherapies)
- Janneke van der Stap NP (lung cancer)


Students (medical, biomedical, informatics):

- Selena Huisman (brain tumor imaging)
- Victor Wasser (brain tumor imaging)
- Salah Gasle (brain tumor imaging)
- Michelle Sierts (MR-Linac for brain tumors)
- Karlijn Smitt (brain tumors)
- Mathijs Tomassen (lung cancer)
- Lucie Egberink (lung cancer)
- Myra van Laar (lung cancer)

Former group members (medical, biomedical, informatics):

- Sjors Witteveen (lung cancer)
- Hajo Boersma (psychiatric disorders and radiotherapy)
- Hugo van Joolingen (lung cancer)
- Anne van der Tuin (MR-Linac for lung cancer)
- Eva Swinkels (lung cancer)
- Marnix Rading MD (lung cancer)
- Laura Merckel MD PhD (MRI-linac lung cancer)
- Bas Arends (deep learning for spine tumor treatment)
- Jasper Hennecken (spinal imaging)
- Céline Bogers (lung cancer)
- Eliza van Wulfften Palthe (brain metastases)
- Anouk Steennis (brain tumors)
- Ali Ghannam (brain metastases cohort)
- Emma Nessen (brain metastases)
- Marc Pijper (lung cancer)
- Cathalijne Post (brain tumors)
- Robin Schuijlenburg (brain tumors)
- Merel Kraak (lung cancer)
- Suzanne Vellinga (lung cancer)
- Netanja Harlianto (lung cancer)
- Yannic Hanekamp (Covid treatment)
- Sjors Wagemakers (pain meassurement)
- Max van Essen (brain tumors)
- Chris Hammerstein (survival analyses)




Full list of publications on PubMed: click here (automatic list is incomplete)

Research Output (87)

Morphological changes after cranial fractionated photon radiotherapy: Localized loss of white matter and grey matter volume with increasing dose

Nagtegaal S. H. J., David S., van Grinsven E. E., van Zandvoort M. J. E., Seravalli E., Snijders J., Philippens M. E. P., Verhoeff J. J. C. nov 2021, 31

The Influence of Severe Radiation-Induced Lymphopenia on Overall Survival in Solid Tumors:A Systematic Review and Meta-Analysis

Damen Pim J.J., Kroese Tiuri E., van Hillegersberg Richard, Schuit Ewoud, Peters Max, Verhoeff Joost J.C., Lin Steven H., van Rossum Peter S.N. 28 jul 2021, In: International Journal of Radiation Oncology Biology Physics. 111 , p. 936-948 13 p.

Visual Outcomes after Endoscopic Endonasal Transsphenoidal Resection of Pituitary Adenomas:Our Institutional Experience

Van Essen Max J., Muskens Ivo S., Lamba Nayan, Belunek Stephan F.J., Van Der Boog Arthur T.J., Amelink G. Johan, Gosselaar Peter H., Van Doormaal Tristan P.C., Stades Aline M.E., Verhoeff Joost J.C., Van Genderen Maria M., Eenhorst Christine A.E., Broekman Marike L.D. 1 jul 2021, In: Journal of Neurological Surgery, Part B: Skull Base. 82 , p. E79-E87

Ultra-central lung tumors:safety and efficacy of protracted stereotactic body radiotherapy

Lodeweges Joyce E, van Rossum Peter S N, Bartels Marcia M T J, van Lindert Anne S R, Pomp Jacqueline, Peters Max, Verhoeff Joost J C 30 jun 2021, In: Acta Oncologica. 60 , p. 1061-1068 8 p.

Simultaneous multi-slice accelerated 4D-MRI for radiotherapy guidance

Keijnemans Katrinus, Borman Pim T S, van Lier Astrid L H M W, Verhoeff Joost J C, Raaymakers Bas W, Fast Martin F 7 apr 2021, In: Physics in medicine and biology. 66

A Dutch phase III randomized multicenter trial:whole brain radiotherapy versus stereotactic radiotherapy for 4-10 brain metastases

Hartgerink Dianne, Bruynzeel Anna, Eekers Danielle, Swinnen Ans, Hurkmans Coen, Wiggenraad Ruud, Swaak-Kragten Annemarie, Dieleman Edith, van der Toorn Peter-Paul, Oei Bing, van Veelen Lieneke, Verhoeff Joost, Lagerwaard Frank, de Ruysscher Dirk, Lambin Philippe, Zindler Jaap 20 mrt 2021, In: Neuro-oncology advances. 3 9 p.

Initial Clinical Experience of MR-Guided Radiotherapy for Non-Small Cell Lung Cancer

Crockett Cathryn B, Samson Pamela, Chuter Robert, Dubec Michael, Faivre-Finn Corinne, Green Olga L, Hackett Sara L, McDonald Fiona, Robinson Clifford, Shiarli Anna-Maria, Straza Michael W, Verhoeff Joost J C, Werner-Wasik Maria, Vlacich Gregory, Cobben David 10 mrt 2021, In: Frontiers in oncology. 11 , p. 617681

Prophylactic cranial irradiation in patients with small cell lung cancer in The Netherlands:A population-based study

Tomassen Mathijs L, Aarts Mieke J, Peters Max, van Lindert Anne, De Ruysscher Dirk K M, Verhoeff Joost J C, van Rossum Peter S N mrt 2021, In: Clinical and translational radiation oncology. 27 , p. 157-163 7 p.

Combining radiotherapy and focused ultrasound for pain palliation of cancer induced bone pain; a stage I/IIa study according to the IDEAL framework

Bartels Marcia M T J, Verpalen Inez M, Ferrer Cyril J, Slotman Derk J, Phernambucq Erik C J, Verhoeff Joost J C, Eppinga Wietse S C, Braat Manon N G J A, van den Hoed Rolf D, van 't Veer-Ten Kate Miranda, de Boer Erwin, Naber Harry R, Nijholt Ingrid M, Bartels Lambertus W, Bos Clemens, Moonen Chrit T W, Boomsma Martijn F, Verkooijen Helena M mrt 2021, In: Clinical and translational radiation oncology. 27 , p. 57-63 7 p.

Impact of the COVID-19 pandemic on quality of life and emotional wellbeing in patients with bone metastases treated with radiotherapy:a prospective cohort study

Bartels M M T J, Gal R, van der Velden J M, Verhoeff J J C, Verlaan J J, Verkooijen H M 25 feb 2021, In: Clinical & Experimental Metastasis. 38 , p. 209-217 9 p.

All research output

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