dr. J.J.C. (Joost) Verhoeff

dr. J.J.C. (Joost) Verhoeff

Associate Professor - medical
dr. J.J.C. (Joost) Verhoeff
  • Department of Radiotherapy

Research Programs

Strategic Program Cancer



View my YouTube research presentation (in Dutch):

MRI-geleide radiotherapie in Utrecht: Harder, Better, Faster, Stronger


My lab's mission is to redefine Standard Radiotherapy

As radiation oncologists, we want to treat cancer patients with high precision radiotherapy. The UMC Utrecht has the right team and right machinery for this (3x MRI-linac, 10x CT-linac). My lab's goal is to design the best cancer treatment for each patient. Some patients want to live as long as possible regardless of treatment side effects, others want quality of life. To find balance is key.

The UMC Utrecht department of Radiation Oncology is a terrific place to do clinical research, as it is even the birthplace of the MRI-linac. Next, the Radiation Oncology department harbours 2 1.5T MRI systems, a 3.0T MRI, a 7.0T MRI and a MRI/PET scanner.

Joost Verhoeff subspecialized in treatment of brain tumors, lung cancer and cardiac SBRT. About half of his time he spends on research as associate professor.


Brain tumors:

- Increasing quality of life by compact but extremely precise focused radiation treatment

- Increasing overall survival by combining better treatment modalities

- Principal Investigator of ZonMW funded GOLD trial (dutch info), 30x2Gy+TMZ versus 6x6Gy+TMZ for primary GBM (responsible researcher drs. Arthur van der Boog)

- Principal Investigator of KWF funded RISinG trial (dutch info), 10x3.5Gy versus 4x7.5Gy for recurrent GBM (responsible researcher drs. Arthur van der Boog)


Brain metastases:

- Finding best treatments for each specific patient: personalized medicine.

- Increasing quality of life by incorporating MR-guided treatment post operative (MRI-linac)

- Coimbra brain metastasis prospective cohort (website) (responsible researcher drs. Fia Cialdella)


Lung cancer:

- Better predicting patient survival and toxicity by smart analyses

- Increasing quality of life by incorporating MR-guided treatment (MR-Linac)

- U-color prospective cohort, for all lung cancer patients that receive radiotherapy


Cardiac Ablative SBRT:

- In the lead of a consortium of 30 European hospitals we develop strategies to treat Ventricular Tachycardia in the framework (Principal Investigator, EU H2020 grant).



- Szabolcs David PhD (brain tumors, imaging)
- Jacqueline Pomp MD PhD, radiation oncologist, (lung cancer and deep learning)
- Peter van Rossum MD PhD MSc, resident radiation oncologist (MRI-linac, epidemiology, lung cancer)


PhD students:

- Steven Nagtegaal MD (brain tumors, cognitive changes)
- Wouter van Amsterdam MD (deep learning, lung cancer)
- Eva van Grinsven MSc (neuro-psychology, brain tumors)
- Arthur van der Boog BS (brain tumors, clinical trials)
- Belle van Duin MD (melanoma, imaging, pathology)
- Fia Cialdella MD (brain metastases, neuro-oncology)


Residents radiation oncology performing research:

- Joyce Lodeweges MD (lung cancer)
- Max Peters MD PhD MSc (epidemiology, lung cancer)
- Pim Damen MD (immunotherapies)
- Janneke van der Stap NP (lung cancer)


Students (medical, biomedical, informatics):

- Selena Huisman (brain tumor imaging)
- Victor Wasser (brain tumor imaging)
- Salah Gasle (brain tumor imaging)
- Michelle Sierts (MR-Linac for brain tumors)
- Karlijn Smitt (brain tumors)
- Mathijs Tomassen (lung cancer)
- Lucie Egberink (lung cancer)
- Myra van Laar (lung cancer)

Former group members (medical, biomedical, informatics):

- Sjors Witteveen (lung cancer)
- Hajo Boersma (psychiatric disorders and radiotherapy)
- Hugo van Joolingen (lung cancer)
- Anne van der Tuin (MR-Linac for lung cancer)
- Eva Swinkels (lung cancer)
- Marnix Rading MD (lung cancer)
- Laura Merckel MD PhD (MRI-linac lung cancer)
- Bas Arends (deep learning for spine tumor treatment)
- Jasper Hennecken (spinal imaging)
- Céline Bogers (lung cancer)
- Eliza van Wulfften Palthe (brain metastases)
- Anouk Steennis (brain tumors)
- Ali Ghannam (brain metastases cohort)
- Emma Nessen (brain metastases)
- Marc Pijper (lung cancer)
- Cathalijne Post (brain tumors)
- Robin Schuijlenburg (brain tumors)
- Merel Kraak (lung cancer)
- Suzanne Vellinga (lung cancer)
- Netanja Harlianto (lung cancer)
- Yannic Hanekamp (Covid treatment)
- Sjors Wagemakers (pain meassurement)
- Max van Essen (brain tumors)
- Chris Hammerstein (survival analyses)




Full list of publications on PubMed: click here (automatic list is incomplete)

Research Output (100)

Added Value of Cognition in the Prediction of Survival in Low and High Grade Glioma

van Kessel Emma, Schuit Ewoud, Huenges Wajer Irene M C, Ruis Carla, De Vos Filip Y F L, Verhoeff Joost J C, Seute Tatjana, van Zandvoort Martine J E, Robe Pierre A, Snijders Tom J 18 nov 2021, In: Frontiers in Neurology. 12 , p. 1-11

Spatial Glioma Distribution and Development of Post-Radiation Injury:The Left Temporal Region

van der Boog A. T.J., David S., Steennis A. M.M., Dankbaar J. W., Snijders T., Robe P., Verhoeff J. 1 nov 2021, In: International journal of radiation oncology, biology, physics. 111 , p. e603

Morphological changes after cranial fractionated photon radiotherapy: Localized loss of white matter and grey matter volume with increasing dose

Nagtegaal S. H. J., David S., van Grinsven E. E., van Zandvoort M. J. E., Seravalli E., Snijders J., Philippens M. E. P., Verhoeff J. J. C. nov 2021, In: Clinical and translational radiation oncology. 31 , p. 14-20 7 p.

Meta-analysis on the influence of radiation-induced lymphopenia on overall survival in solid tumors.

Damen P., Kroese T., van Hillegersberg R., Schuit E., Peters M., Verhoeff J., Lin S., van Rossum P. aug 2021, In: Radiotherapy and Oncology. 161 , p. S1241-S1242

Cardiac-Synchronized T1 mapping on the Unity MR-linac to guide STereotactic Arrhythmia Radioablation

Mandija S., Akdag O., van Lier A., Borman P., Schakel T., Alberts E., van der Heide O., Hassink R., Alings M., Verhoeff J., Mohamed Hoesein F., Fast M. aug 2021, In: Radiotherapy and Oncology. 161 , p. S408-S409

Adjuvant treatment following irradical resection of stage I-III NSCLC: a population-based study

Rasing M., Peters M., Aarts M., Herder G., van Lindert A., Schramel F., van der Meer F., Verhoeff J., van Rossum P. aug 2021, In: Radiotherapy and Oncology. 161 , p. S117-S118

Automatic PTV margin determination for midposition-based lung SBRT planning on the Unity MR-linac

Ligtenberg H., Hackett S., Merckel L. G., Snoeren L., Kontaxis C., Zachiu C., Bol G., Verhoeff J. J., Fast M. F. aug 2021, In: Radiotherapy and Oncology. 161 , p. S697-S698

Feasibility of stereotactic body radiotherapy of (ultra)central lung tumors using an 1.5 T MR-linac

Merckel L., Hackett S., van Lier A., van den Dobbelsteen M., Rasing M., Snoeren L., van Es C., Fast M., van Rossum P., Verhoeff J. aug 2021, In: Radiotherapy and Oncology. 161 , p. S963-S964

First VMAT delivery with MLC-tracking for single and multi fraction lung SBRT on a Unity MR-linac

Uijtewaal P., Borman P., Woodhead P., Kontaxis C., Hackett S., Verhoeff J., Raaymakers B., Fast M. aug 2021, In: Radiotherapy and Oncology. 161 , p. S479-S480

The delta index: a novel metric to assess dose accumulation uncertainty in MR-guided radiotherapy

van den Dobbelsteen M., Hackett S., Verhoeff J., Merckel L., van Es C., Snoeren L., Kontaxis C., Fast M. aug 2021, In: Radiotherapy and Oncology. 161 , p. S700-S702

All research output

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