dr. J.J.C. (Joost) Verhoeff

Associate Professor - medical

  • Radiotherapy (research)
  • Department of Radiotherapy

dr. J.J.C. (Joost) Verhoeff

Research Programs


My lab's mission is to redefine Standard Radiotherapy

As radiation oncologists, we treat cancer patients with high precision radiotherapy. The UMC Utrecht has the right caring team and right machinery for this (2x MRI-linac, 10x CT-linac). My lab's goal is providing the best cancer treatment for each patient. Some patients want to live as long as possible regardless of treatment side effects, others want quality of life. To find balance is key.

The UMC Utrecht department of radiation oncology is a terrific place to do clinical research, as it is even the birthplace of the MRI-linac. Next, the Radiation Oncology department harbours 2 1.5T MRI systems, a 3.0T MRI and soon a 7.0T MRI and a PET-MRI.

Joost subspecialized in treatment of brain tumors and lung cancer. About half of his time he spends on research as associate professor.


Brain tumors:


- Increasing quality of life by shorter but better focused radiation treatment

- Increasing overall survival by combining better treatment modalities


Brain metastases:

- Finding best treatments for each specific patient: personalized medicine.

- Increasing quality of life by incorporating MR-guided treatment post operative (MRI-linac)

- Coimbra brain metastasis prospective cohort


Lung cancer:

- Better predicting patient survival and toxicity by deep learning

- Increasing quality of life by incorporating MR-guided treatment (MR-Linac)

- U-color prospective cohort


Cardiac Ablative SBRT:

- In collaboration with 30 other European hospitals we develop strategies to treat Ventricular Tachycardia in the framework.



- Szabolcs David PhD (brain tumors)

- Jacqueline Pomp MD PhD (lung cancer and deep learning)


PhD students:

- Steven Nagtegaal MD (brain tumors)

- Wouter van Amsterdam MD (deep learning, lung cancer)

- Eva van Grinsven MSc (brain tumors)

- Arthur van der Boog BS (brain tumors)

- Belle van Duin MD (melanoma)


Residents radiation oncology performing research:Marnix Rasing MD (lung cancer)

- Laura Merckel MD PhD (MRI-linac lung cancer)
- Joyce Lodeweges MD (lung cancer)
- Max Peters MD PhD (epidemiology, lung cancer)
- Peter van Rossum MD PhD (MRI-linac, epidemiology, lung cancer)
- Pim Damen MD (immunotherapies)
- Janneke van der Stap MANP (lung cancer)


Students (medical, biomedical, informatics):

- Alexander van Hulsbergen BS (brain tumors)
- Daniel Versnel (brain tumors)
- Myra van Laar (lung cancer)
- Sjors Witteveen (lung cancer)
- Marc Pijper (lung cancer)
- Bas Arends (deep learning for spine tumor treatment)
- Anouk Steennis (brain metastases)
- Hajo Boersma (psychiatric disorders and radiotherapy)
- Eliza van Wulfften Palthe (brain metastases)


Full list of publications on PubMed: click here (automatic list is incomplete)

Research Output (58)

Age, pathology and CA-125 are prognostic factors for survival in patients with brain metastases from gynaecological tumours

Nagtegaal S H J, Hulsbergen A F C, van Dorst E B L, Kavouridis V K, Jessurun C A C, Broekman M L D, Smith T R, Verhoeff J J C sep 2020, In: Clinical and translational radiation oncology. 24 , p. 11-15 5 p.

Impact of the COVID-19 crisis on imaging in oncological trials

Deroose Christophe M, Lecouvet Frédéric E, Collette Laurence, Oprea-Lager Daniela E, Kunz Wolfgang G, Bidaut Luc, Verhoeff Joost J C, Caramella Caroline, Lopci Egesta, Tombal Bertrand, de Geus-Oei Lioe-Fee, Fournier Laure, Smits Marion, deSouza Nandita M 1 aug 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47 , p. 2054-2058 5 p.

Effect of radiation therapy on cerebral cortical thickness in glioma patients:Treatment-induced thinning of the healthy cortex

Nagtegaal Steven H J, David Szabolcs, Snijders Tom J, Philippens Marielle E P, Leemans Alexander, Verhoeff Joost J C 10 jul 2020, In: Neuro-oncology advances. 2 8 p.

A single neural network for cone-beam computed tomography-based radiotherapy of head-and-neck, lung and breast cancer

Maspero Matteo, Houweling Antonetta C., Savenije Mark H.F., van Heijst Tristan C.F., Verhoeff Joost J.C., Kotte Alexis N.T.J., van den Berg Cornelis A.T. apr 2020, In: Physics and Imaging in Radiation Oncology. 14 , p. 24-31 8 p.

Impact of body fat distribution and sarcopenia on the overall survival in patients with spinal metastases receiving radiotherapy treatment:a prospective cohort study

Pielkenrood B J, van Urk P R, van der Velden J M, Kasperts N, Verhoeff J J C, Bol G H, Verkooijen H M, Verlaan J J mrt 2020, In: Acta Oncologica. 59 , p. 291-297 7 p.

Subtype switching in breast cancer brain metastases:a multicenter analysis

Hulsbergen Alexander F C, Claes An, Kavouridis Vasileios K, Ansaripour Ali, Nogarede Claudine, Hughes Melissa E, Smith Timothy R, Brastianos Priscilla K, Verhoeff Joost J C, Lin Nancy U, Broekman Marike L D 23 jan 2020, In: Neuro-Oncology. 22 , p. 1173-1181 9 p.

Eliminating biasing signals in lung cancer images for prognosis predictions with deep learning

van Amsterdam W. A. C., Verhoeff J. J. C., de Jong P. A., Leiner T., Eijkemans M. J. C. 10 dec 2019, In: NPJ DIGITAL MEDICINE. 2 , p. 122

Preoperative Prediction of Incomplete Resection in Non-Small Cell Lung Cancer: An Externally Validated Clinical Nomogram

Rasing M., Peters M., Moreno A., Hofman E., Herder J., Welvaart P., Schramel Franz M N H, Lodeweges J., Lin Steven H, Verhoeff J., Van Rossum P. okt 2019, In: Journal of Thoracic Oncology. 14 , p. S623-S623

Significance of Programmed Death Receptor Ligand One Expression in Brain Metastases of Non-Small Cell Lung Carcinoma

Hulsbergen A., Mammi M., Nagtegaal S., Verhoeff J., Smith T., Phillips J. 1 sep 2019, In: International Journal of Radiation Oncology Biology Physics. 105 , p. E78-E78

A Multi-Institutional Estimation of Interobserver Variability in Glioblastoma Delineation in the EORTC-1709-BTG /CCTG CE.8 Trial

Kaidar-Person O., Saez J., Andratschke N., de Abrunhosa Branquinho A. N., Clementel E., Corning C., Hurkmans C., Monti A. F., Roth P., Verhoeff J., Dhermain F. 1 sep 2019, In: International Journal of Radiation Oncology Biology Physics. 105 , p. E617-E618

All Research Output (58)