dr. A. (Aryan) Vink

dr. A. (Aryan) Vink

Assistant Professor - medical
dr. A. (Aryan) Vink
  • Department of Pathology

Research Programs

Circulatory Health



After his medical training at the Free University in Amsterdam, Aryan Vink studied inflammation in atherosclerosis at the Laboratory for Experimental Cardiology of the UMC Utrecht which led to a thesis. Fascinated by the pathophysiology and microscopic world behind diseases he decided to become a pathologist and finished his residency in 2007. Currently he is a staff pathologist with special interest in Cardiovascular, Pulmonary and Autopsy pathology.

At the Pathology Department of UMC Utrecht we have one of the largest and best documented cardiac tissue biobanks of the world. Based on this cardiac tissue biobank the research of Aryan Vink focuses on the phenotype – genotype correlation in cardiomyopathies. In addition he works in close collaboration with researchers from the Hubrecht Laboratory to validate findings of basic myocardial research in human tissue from the biobank. Finally he is the consulting pathologist for the Athero-Express biobank.

On the topic of his other specialization, Pulmonary Pathology, he is involved in the continuous process of implementation of new diagnostic tests in lung cancer pathology to come to optimal personalized state-of-the-art treatment of lung cancer patients in the UMC Utrecht.


Research Output (194)

A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity

Lu Dongchao, Chatterjee Shambhabi, Xiao Ke, Riedel Isabelle, Huang Cheng-Kai, Costa Alessia, Cushman Sarah, Neufeldt Dimyana, Rode Laura, Schmidt Arne, Juchem Malte, Leonardy Julia, Büchler Gwen, Blume Jonas, Gern Olivia-Luise, Kalinke Ulrich, Wen Tan Wilson Lek, Foo Roger, Vink Aryan, van Laake Linda W, van der Meer Peter, Bär Christian, Thum Thomas 7 Nov 2022, In: European heart journal. 43 , p. 4496-4511 16 p.

Spatial multi-omic map of human myocardial infarction

Kuppe Christoph, Ramirez Flores Ricardo O, Li Zhijian, Hayat Sikander, Levinson Rebecca T, Liao Xian, Hannani Monica T, Tanevski Jovan, Wünnemann Florian, Nagai James S, Halder Maurice, Schumacher David, Menzel Sylvia, Schäfer Gideon, Hoeft Konrad, Cheng Mingbo, Ziegler Susanne, Zhang Xiaoting, Peisker Fabian, Kaesler Nadine, Saritas Turgay, Xu Yaoxian, Kassner Astrid, Gummert Jan, Morshuis Michiel, Amrute Junedh, Veltrop Rogier J A, Boor Peter, Klingel Karin, Van Laake Linda W, Vink Aryan, Hoogenboezem Remco M, Bindels Eric M J, Schurgers Leon, Sattler Susanne, Schapiro Denis, Schneider Rebekka K, Lavine Kory, Milting Hendrik, Costa Ivan G, Saez-Rodriguez Julio, Kramann Rafael 25 Aug 2022, In: Nature. 608 , p. 766–777 12 p.

Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model

Gaar-Humphreys Karen R, Spanjersberg Talitha C F, Santarelli Giorgia, Grinwis Guy C M, Szatmári Viktor, Roelen Bernard A J, Vink Aryan, van Tintelen J Peter, Asselbergs Folkert W, Fieten Hille, Harakalova Magdalena, van Steenbeek Frank G 1 Jul 2022, In: Animals : an open access journal from MDPI. 12 , p. 1-18

Computational modeling identifies the cellular electromechanical effects of disrupted intracellular calcium handling in arrhythmogenic cardiomyopathy patients

Lyon Aurore, van Ham WB, van der Voorn Stephanie, Heijman Jordi, Kirkels Feddo, Vink Aryan, te Riele Anneline S.J.M., Lumens Joost, van Veen TAB 19 May 2022, In: Europace. 24

Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy

Wehrens Martijn, de Leeuw Anne E., Wright-Clark Maya, Eding Joep E.C., Boogerd Cornelis J., Molenaar Bas, van der Kraak Petra H., Kuster Diederik W.D., van der Velden Jolanda, Michels Michelle, Vink Aryan, van Rooij Eva 10 May 2022, In: Cell Reports. 39 , p. 1-22

Radiography and Computed Tomography Detection of Intimal and Medial Calcifications in Leg Arteries in Comparison to Histology

Vos Annelotte, Vink Aryan, Kockelkoren Remko, Takx Richard A P, Celeng Csilla, Mali Willem P T M, Isgum Ivana, Bleys Ronald L A W, de Jong Pim A May 2022, In: Journal of Personalized Medicine. 12 , p. 1-7

Characteristics and time course of acute and chronic myocardial lesion formation after electroporation ablation in the porcine model

Neven Kars, van Driel Vincent J.H.M., Vink Aryan, du Pré Bastiaan C., van Wessel Harry, Füting Anna, Doevendans Pieter A., Wittkampf Fred H.M., van Es René Mar 2022, In: Journal of Cardiovascular Electrophysiology. 33 , p. 360-367 8 p.

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations

Pei J, Schuldt M, Nagyova E, Gu Z, El Bouhaddani S, Yiangou L, Jansen M, Calis J J A, Dorsch L M, Blok C Snijders, van den Dungen N A M, Lansu N, Boukens B J, Efimov I R, Michels M, Verhaar M C, de Weger R, Vink A, van Steenbeek F G, Baas A F, Davis R P, Uh H W, Kuster D W D, Cheng C, Mokry M, van der Velden J, Asselbergs F W, Harakalova M Dec 2021, In: Clinical Epigenetics. 13 , p. 1-20

Ventricular TLR4 Levels Abrogate TLR2-Mediated Adverse Cardiac Remodeling upon Pressure Overload in Mice

Kessler Elise L., Wang Jiong Wei, Kok Bart, Brans Maike A., Nederlof Angelique, van Stuijvenberg Leonie, Huang Chenyuan, Vink Aryan, Arslan Fatih, Efimov Igor R., Lam Carolyn S.P., Vos Marc A., de Kleijn Dominique P.V., Fontes Magda S.C., van Veen Toon A.B. 1 Nov 2021, In: International journal of molecular sciences. 22 , p. 1-13

Can automatic image analysis replace the pathologist in cardiac allograft rejection diagnosis?

Veta Mitko, van Diest Paul J, Vink Aryan 21 Jun 2021, In: European heart journal. 42 , p. 2370-2372 3 p.

All research output

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