prof. dr. F.L.J. (Frank ) Visseren

Full Professor

  • Internal Medicine

prof. dr. F.L.J. (Frank ) Visseren

Research Programs


Frank Visseren (1965) is Internist, Epidemiologist and Professor in Vascular Medicine at the University Medical Center in Utrecht. He is head of the Department of Vascular Medicine and responsible for patient care, research, and teaching. The Department of Vascular Medicine at the UMC Utrecht consists of Internists, Fellows, Research Nurses and PhD students. His main research interest is in the field of insulin resistance and vascular diseases and consists of basic, translational and epidemiologic research covering etiology, therapy, prognosis and diagnosis. There is a focus on (visceral) adipose tissue and development of atherosclerosis, atherotrombosis and diabetes. An other research focus is on translating the results of large clinical trials to invidivual patients, in collaboration with (inter)national partners. He is (co-)author of over 300 publications and associate editor of 2 scientific journals. The GCP certified research unit of the Department of Vascular Medicine performs state-of-the-art non-invasive vascular imaging tests including FMD, FBF, PWV, fingertip plethysmography, IMT and HRV. There is broad experience with industry-sponsored clinical trials in the field of Vascular Medicine, Cardiology and Diabetology and he also serves as sponsor of multi-national investigator initiated studies. He is the clinical director of the Second Manifestations of ARTerial disease (SMART) cohort at the UMC Utrecht. This is a cohort with over 13,000 patients with vascular diseases and/or type 2 diabetes or severe hypertension or familial hyperlipidemia, growing with 800 patients annually, for etiologic, prognostic, diagnostic and therapeutic research. He was (co-)supervisor of 30 thesis and currently involved in the supervision of 11  PhD students.

The clinical work of the Department of Vascular Medicine is concentrated around patients at high risk for the development of cardiovascular diseases including patients with Familial Hypercholesterolemia, patients with therapy-resistant hypertension and patients with diabetes and vascular disease. He strongly believes in a multidisciplinary, patient-centered approach in the treatment of patients at high risk for the development of (new) vascular diseases.

Teaching covers first year Medical Students to clinical specialty training in Vascular Medicine. He is member of the Concilium Medicinae Internae and chairman of the section Vascular Medicine of the Dutch Internal Medicine Society.

Side Activities

  • Chairman ESC 2021 Cardiovascular Prevention Guideline Task Force (2019)

    Member board Vascular Medicine, Dutch Internal Medicine Association (NIV) (2006)

    Member National guideline committee Cardio Vascular Risk Management (CVRM) (2016)

    Member National guideline committee addendum CVRM for elderly (2015)

    Member National guideline committee addendum (Genetic) Dyslipidemia (2015)

    Chairman ‘Writing committee Facts & Figures’ (Commissie Cijfers) Dutch Heart Foundation (2009)

Research Output (470)

The relation between healthy lifestyle changes and decrease in systemic inflammation in patients with stable cardiovascular disease

van ’t Klooster C. C., van der Graaf Y., Ridker P. M., Westerink J., Hjortnaes J., Sluijs I., Asselbergs F. W., Bots M. L., Kappelle L. J., Visseren F. L.J., mei 2020, In: Atherosclerosis. 301 , p. 37-43 7 p.

Prediction of individualized lifetime benefit from cholesterol lowering, blood pressure lowering, antithrombotic therapy, and smoking cessation in apparently healthy people

Jaspers Nicole E.M., Blaha Michael J., Matsushita Kunihiro, Van Der Schouw Yvonne T., Wareham Nicholas J., Khaw Kay Tee, Geisel Marie H., Lehmann Nils, Erbel Raimund, Jöckel Karl Heinz, Van Der Graaf Yolanda, Verschuren W. M.Monique, Boer Jolanda M.A., Nambi Vijay, Visseren Frank L.J., Dorresteijn Jannick A.N. 14 mrt 2020, In: European heart journal. 41 , p. 1190-1199 10 p.

Corrigendum to “2019 ESC/EAS Guidelines for the management of dyslipidaemias:lipid modification to reduce cardiovascular risk” (Atherosclerosis (2019) 290 (140–205), (S0021915019314595), (10.1016/j.atherosclerosis.2019.08.014))

Mach Francois, Baigent Colin, Catapano Alberico L., Koskinas Konstantinos C., Casula Manuela, Badimon Lina, Chapman M. John, De Backer Guy G., Delgado Victoria, Ference Brian A., Graham Ian M., Halliday Alison, Landmesser Ulf, Mihaylova Borislava, Pedersen Terje R., Riccardi Gabriele, Richter Dimitrios J., Sabatine Marc S., Taskinen Marja Riitta, Tokgozoglu Lale, Wiklund Olov, Nibouche Djamaleddine, Zelveian Parounak H., Siostrzonek Peter, Najafov Ruslan, van de Borne Philippe, Pojskic Belma, Postadzhiyan Arman, Kypris Lambros, Špinar Jindřich, Larsen Mogens Lytken, Eldin Hesham Salah, Viigimaa Margus, Strandberg Timo E., Ferrieres Jean, Agladze Rusudan, Laufs Ulrich, Rallidis Loukianos, Bajnok Laszlo, Gudjonsson Thorbjorn, Maher Vincent, Henkin Yaakov, Gulizia Michele Massimo, Mussagaliyeva Aisulu, Bajraktari Gani, Kerimkulova Alina, Latkovskis Gustavs, Hamoui Omar, Visseren Frank, Grobbee Diederick, , , 1 feb 2020, In: Atherosclerosis. 294 , p. 80-82 3 p.

Mortality after hospital admission for heart failure:improvement over time, equally strong in women as in men

Buddeke J, Valstar G B, van Dis I, Visseren F L J, Rutten F H, den Ruijter H M, Vaartjes I, Bots M L, 10 jan 2020, In: BMC Public Health. 20 10 p.

Apparent therapy-resistant hypertension as risk factor for the development of type 2 diabetes mellitus

Holtrop Joris, Spiering Wilko, Nathoe Hendrik M, De Borst Gert J, Kappelle Laurens J, De Valk Harold W, Visseren Frank L J, Westerink Jan, jan 2020, In: Journal of Hypertension. 38 , p. 45-51 7 p.

Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis:The SMART-MR Study

Zwartbol M. H. T., Geerlings M. I., Ghaznawi R., Hendrikse J., van der Kolk A. G., Asselbergs F. W., Nathoe H. M., de Borst G. J., Bots M. L., Emmelot M. H., de Jong P. A., Leiner T., Lely A. T., van der Kaaij N. P., Kappelle L. J., Ruigrok Y. M., Verhaar M. C., Visseren F. L. J., Westerink J., 5 dec 2019, In: American Journal of Neuroradiology. 40 , p. 2016-2022 7 p.

Treatment of hypercholesterolaemia in older adults calls for a patient-centred approach

Kleipool Emma E.F., Dorresteijn Johannes A.N., Smulders Yvo M., Visseren Frank L.J., Peters Mike J.L., Muller Majon 28 nov 2019, In: Heart. 106 , p. 261-266 6 p.

Normal-range thyroid-stimulating hormone levels and cardiovascular events and mortality in type 2 diabetes

de Vries Tamar I., de Valk Harold W., van der Graaf Yolanda, de Borst Gert J., Cramer Maarten J.M., Jaap Kappelle L., Visseren Frank L.J., Westerink Jan 16 okt 2019, In: Diabetes Research and Clinical Practice. 157

Heterogeneity of treatment effects from an intensive lifestyle weight loss intervention on cardiovascular events in patients with type 2 diabetes:Data from the look AHEAD trial

De Vries Tamar I., Dorresteijn Jannick A.N., Van Der Graaf Yolanda, Visseren Frank L.J., Westerink Jan 1 okt 2019, In: Diabetes Care. 42 , p. 1988-1994 7 p.

All Research Output (470)