prof. dr. F.L.J. (Frank ) Visseren

prof. dr. F.L.J. (Frank ) Visseren

Full Professor
prof. dr. F.L.J. (Frank ) Visseren
  • Internal Medicine

Research Programs

Circulatory Health



Frank Visseren (1965) is Internist, Epidemiologist and Professor in Vascular Medicine at the University Medical Center in Utrecht. He is head of the Department of Vascular Medicine and responsible for patient care, research, and teaching. The Department of Vascular Medicine at the UMC Utrecht consists of Internists, Fellows, Research Nurses and PhD students. His main research interest is in the field of insulin resistance and vascular diseases and consists of basic, translational and epidemiologic research covering etiology, therapy, prognosis and diagnosis. There is a focus on (visceral) adipose tissue and development of atherosclerosis, atherotrombosis and diabetes. An other research focus is on translating the results of large clinical trials to invidivual patients, in collaboration with (inter)national partners. He is (co-)author of over 300 publications and associate editor of 2 scientific journals. The GCP certified research unit of the Department of Vascular Medicine performs state-of-the-art non-invasive vascular imaging tests including FMD, FBF, PWV, fingertip plethysmography, IMT and HRV. There is broad experience with industry-sponsored clinical trials in the field of Vascular Medicine, Cardiology and Diabetology and he also serves as sponsor of multi-national investigator initiated studies. He is the clinical director of the Second Manifestations of ARTerial disease (SMART) cohort at the UMC Utrecht. This is a cohort with over 13,000 patients with vascular diseases and/or type 2 diabetes or severe hypertension or familial hyperlipidemia, growing with 800 patients annually, for etiologic, prognostic, diagnostic and therapeutic research. He was (co-)supervisor of 30 thesis and currently involved in the supervision of 11  PhD students.

The clinical work of the Department of Vascular Medicine is concentrated around patients at high risk for the development of cardiovascular diseases including patients with Familial Hypercholesterolemia, patients with therapy-resistant hypertension and patients with diabetes and vascular disease. He strongly believes in a multidisciplinary, patient-centered approach in the treatment of patients at high risk for the development of (new) vascular diseases.

Teaching covers first year Medical Students to clinical specialty training in Vascular Medicine. He is member of the Concilium Medicinae Internae and chairman of the section Vascular Medicine of the Dutch Internal Medicine Society.

Side Activities

Chairman ESC 2021 Cardiovascular Prevention Guideline Task Force (2019-2021)

Member board Vascular Medicine, Dutch Internal Medicine Association (NIV) (2006- ongoing)

Member National guideline committee Cardio Vascular Risk Management (CVRM) (2016-2019, 2021- ongoing)

Member National guideline committee addendum CVRM for elderly (2015-2019)

Member National guideline committee addendum (Genetic) Dyslipidemia (2015-2019)

Chairman ‘Writing committee Facts & Figures’ (Commissie Cijfers) Dutch Heart Foundation (2009-2020)

Research Output (540)

Physical exercise volume, type, and intensity and risk of all-cause mortality and cardiovascular events in patients with cardiovascular disease:a mediation analysis

Bonekamp Nadia E, May Anne M, Halle Martin, Dorresteijn Jannick A N, van der Meer Manon G, Ruigrok Ynte M, de Borst Gert J, Geleijnse Johanna M, Visseren Frank L J, Koopal Charlotte 13 Jun 2023, In: European heart journal open. 3

Development and Validation of a Lifetime Risk Model for Kidney Failure and Treatment Benefit in Type 2 Diabetes:10-Year and Lifetime Risk Prediction Models

Østergaard Helena Bleken, Read Stephanie H, Sattar Naveed, Franzén Stefan, Halbesma Nynke, Dorresteijn Jannick A N, Westerink Jan, Visseren Frank L J, Wild Sarah H, Eliasson Björn, van der Leeuw Joep Dec 2022, In: Clinical Journal of the American Society of Nephrology. 17 , p. 1783-1791 9 p.

Clinical heterogeneity in monogenic chylomicronaemia

Heidemann Britt E., Bemelmans Remy H.H., Marais A. David, Visseren Frank L.J., Koopal Charlotte 24 Nov 2022, In: BMJ Case Reports. 15 , p. 1-5

Een afwijkend lipidenprofiel

Heidemann Britt E, Prinssen Monique, Marais A D, Visseren Frank L J, Koopal Charlotte 8 Nov 2022, In: Nederlands Tijdschrift voor Geneeskunde. 166

Leisure-time and occupational physical activity and health outcomes in cardiovascular disease

Bonekamp Nadia E, Visseren Frank L J, Ruigrok Ynte, Cramer Maarten J M, de Borst Gert Jan, May Anne M, Koopal Charlotte, 21 Oct 2022, In: Heart (British Cardiac Society). 109 , p. 686-694 9 p.

Smartphone Application-Assisted Home Blood Pressure Monitoring Compared With Office and Ambulatory Blood Pressure Monitoring in Patients With Hypertension:the AMUSE-BP Study

Groenland Eline H., Vendeville Jean Paul A.C., Bemelmans Remy H.H., Monajemi Houshang, Bots Michiel L., Visseren Frank L.J., Spiering Wilko 1 Oct 2022, In: Hypertension. 79 , p. 2373-2382 10 p.

Establishing the relationship between familial dysbetalipoproteinemia and genetic variants in the APOE gene

Heidemann Britt E, Koopal Charlotte, Baass Alexis, Defesche Joep C, Zuurbier Linda, Mulder Monique T, Roeters van Lennep Jeanine E, Riksen Niels P, Boot Christopher, Marais A David, Visseren Frank L J Oct 2022, In: Clinical Genetics. 102 , p. 253-261 9 p.

Personalizing treatment in end-stage kidney disease:deciding between haemodiafiltration and haemodialysis based on individualized treatment effect prediction

van Kruijsdijk Rob C M, Vernooij Robin W M, Bots Michiel L, Peters Sanne A E, Dorresteijn Jannick A N, Visseren Frank L J, Blankestijn Peter J, Debray Thomas P A, Oct 2022, In: Clinical Kidney Journal. 15 , p. 1924-1931 8 p.

The readiness of public primary health care (PUSKESMAS) for cardiovascular services in Makasar city, Indonesia

Arsyad Dian Sidik, Hamsyah Esliana Fitrida, Qalby Nurul, Qanitha Andriany, Westerink Jan, Cramer Maarten J., Visseren Frank L. J., Doevendans Pieter A., Ansariadi Ansariadi 1 Sep 2022, In: BMC Health Services Research. 22

Cardiovascular disease in the elderly:proceedings of the European Society of Cardiology - Cardiovascular Round Table

Lettino Maddalena, Mascherbauer Julia, Nordaby Matias, Ziegler André, Collet Jean Philippe, Derumeaux Geneviève, Hohnloser Stefan H., Leclercq Christophe, O'neill Deirdre E., Visseren Frank, Weidinger Franz, Richard-Lordereau Isabelle 1 Aug 2022, In: European journal of preventive cardiology. 29 , p. 1412-1424 13 p.

All research output

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