prof. dr. F.L.J. (Frank ) Visseren

Full Professor
prof. dr. F.L.J. (Frank ) Visseren
  • Internal Medicine

Research Programs

Circulatory Health



Frank Visseren (1965) is Internist, Epidemiologist and Professor in Vascular Medicine at the University Medical Center in Utrecht. He is head of the Department of Vascular Medicine and responsible for patient care, research, and teaching. The Department of Vascular Medicine at the UMC Utrecht consists of Internists, Fellows, Research Nurses and PhD students. His main research interest is in the field of insulin resistance and vascular diseases and consists of basic, translational and epidemiologic research covering etiology, therapy, prognosis and diagnosis. There is a focus on (visceral) adipose tissue and development of atherosclerosis, atherotrombosis and diabetes. An other research focus is on translating the results of large clinical trials to invidivual patients, in collaboration with (inter)national partners. He is (co-)author of over 300 publications and associate editor of 2 scientific journals. The GCP certified research unit of the Department of Vascular Medicine performs state-of-the-art non-invasive vascular imaging tests including FMD, FBF, PWV, fingertip plethysmography, IMT and HRV. There is broad experience with industry-sponsored clinical trials in the field of Vascular Medicine, Cardiology and Diabetology and he also serves as sponsor of multi-national investigator initiated studies. He is the clinical director of the Second Manifestations of ARTerial disease (SMART) cohort at the UMC Utrecht. This is a cohort with over 13,000 patients with vascular diseases and/or type 2 diabetes or severe hypertension or familial hyperlipidemia, growing with 800 patients annually, for etiologic, prognostic, diagnostic and therapeutic research. He was (co-)supervisor of 30 thesis and currently involved in the supervision of 11  PhD students.

The clinical work of the Department of Vascular Medicine is concentrated around patients at high risk for the development of cardiovascular diseases including patients with Familial Hypercholesterolemia, patients with therapy-resistant hypertension and patients with diabetes and vascular disease. He strongly believes in a multidisciplinary, patient-centered approach in the treatment of patients at high risk for the development of (new) vascular diseases.

Teaching covers first year Medical Students to clinical specialty training in Vascular Medicine. He is member of the Concilium Medicinae Internae and chairman of the section Vascular Medicine of the Dutch Internal Medicine Society.

Side Activities

Chairman ESC 2021 Cardiovascular Prevention Guideline Task Force (2019)

Member board Vascular Medicine, Dutch Internal Medicine Association (NIV) (2006)

Member National guideline committee Cardio Vascular Risk Management (CVRM) (2016)

Member National guideline committee addendum CVRM for elderly (2015)

Member National guideline committee addendum (Genetic) Dyslipidemia (2015)

Chairman ‘Writing committee Facts & Figures’ (Commissie Cijfers) Dutch Heart Foundation (2009)

Research Output (477)

Applicability of Blood Pressure-Lowering Drug Trials to Real-World Patients With Cardiovascular Disease

Bonekamp Nadia E, Spiering Wilko, Nathoe Hendrik M, Kappelle L Jaap, de Borst Gert J, Visseren Frank L J, Westerink Jan, 2021, In: Hypertension (Dallas, Tex. : 1979). 77 , p. 357-366 10 p.

Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk:Meta-Analysis of 119 Clinical Trials Involving 100,667 Patients

Willeit Peter, Tschiderer Lena, Allara Elias, Reuber Kathrin, Seekircher Lisa, Gao Lu, Liao Ximing, Lonn Eva, Gerstein Hertzel C, Yusuf Salim, Brouwers Frank P, Asselbergs Folkert W, van Gilst Wiek, Anderssen Sigmund A, Grobbee Diederick E, Kastelein John J P, Visseren Frank L J, Ntaios George, Hatzitolios Apostolos I, Savopoulos Christos, Nieuwkerk Pythia T, Stroes Erik, Walters Matthew, Higgins Peter, Dawson Jesse, Gresele Paolo, Guglielmini Giuseppe, Migliacci Rino, Ezhov Marat, Safarova Maya, Balakhonova Tatyana, Sato Eiichi, Amaha Mayuko, Nakamura Tsukasa, Kapellas Kostas, Jamieson Lisa M, Skilton Michael, Blumenthal James A, Hinderliter Alan, Sherwood Andrew, Smith Patrick J, van Agtmael Michiel A, Reiss Peter, van Vonderen Marit G A, Kiechl Stefan, Klingenschmid Gerhard, Sitzer Matthias, Stehouwer Coen D A, Blankestijn Peter J, Bots Michiel L, 17 jun 2020, In: Circulation. 142 , p. 621-642 22 p.

The relation between healthy lifestyle changes and decrease in systemic inflammation in patients with stable cardiovascular disease

van ’t Klooster C. C., van der Graaf Y., Ridker P. M., Westerink J., Hjortnaes J., Sluijs I., Asselbergs F. W., Bots M. L., Kappelle L. J., Visseren F. L.J., mei 2020, In: Atherosclerosis. 301 , p. 37-43 7 p.

Development of a clinical decision tool to reduce diagnostic testing for primary aldosteronism in patients with difficult-to-control hypertension

van Kleef Monique E A M, Visseren Frank L J, Westerink Jan, Bots Michiel L, Blankestijn Peter J, van der Graaf Yolanda, Spiering Wilko 29 apr 2020, In: BMC Endocrine Disorders. 20 , p. 56

Multifocal cardiovascular calcification in patients with established cardiovascular disease; prevalence, risk factors, and relation with recurrent cardiovascular disease

van 't Klooster Cilie C., Nathoe Hendrik M., Hjortnaes J., Bots Michiel L., Isgum Ivana, Lessmann Nikolas, van der Graaf Yolanda, Leiner Tim, Visseren Frank L.J., 1 apr 2020, In: IJC Heart and Vasculature. 27

Prediction of individualized lifetime benefit from cholesterol lowering, blood pressure lowering, antithrombotic therapy, and smoking cessation in apparently healthy people

Jaspers Nicole E.M., Blaha Michael J., Matsushita Kunihiro, Van Der Schouw Yvonne T., Wareham Nicholas J., Khaw Kay Tee, Geisel Marie H., Lehmann Nils, Erbel Raimund, Jöckel Karl Heinz, Van Der Graaf Yolanda, Verschuren W. M.Monique, Boer Jolanda M.A., Nambi Vijay, Visseren Frank L.J., Dorresteijn Jannick A.N. 14 mrt 2020, In: European heart journal. 41 , p. 1190-1199 10 p.

Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

Meeuwsen John A L, de Vries Judith, Zoet Gerbrand A, Franx Arie, Fauser Bart C J M, Maas Angela H E M, Velthuis Birgitta K, Appelman Yolande E, Visseren Frank L, Pasterkamp Gerard, Hoefer Imo E, van Rijn Bas B, den Ruijter Hester M, de Jager Saskia C A 18 feb 2020, In: Cells. 9

Corrigendum to “2019 ESC/EAS Guidelines for the management of dyslipidaemias:lipid modification to reduce cardiovascular risk” (Atherosclerosis (2019) 290 (140–205), (S0021915019314595), (10.1016/j.atherosclerosis.2019.08.014))

Mach Francois, Baigent Colin, Catapano Alberico L., Koskinas Konstantinos C., Casula Manuela, Badimon Lina, Chapman M. John, De Backer Guy G., Delgado Victoria, Ference Brian A., Graham Ian M., Halliday Alison, Landmesser Ulf, Mihaylova Borislava, Pedersen Terje R., Riccardi Gabriele, Richter Dimitrios J., Sabatine Marc S., Taskinen Marja Riitta, Tokgozoglu Lale, Wiklund Olov, Nibouche Djamaleddine, Zelveian Parounak H., Siostrzonek Peter, Najafov Ruslan, van de Borne Philippe, Pojskic Belma, Postadzhiyan Arman, Kypris Lambros, Špinar Jindřich, Larsen Mogens Lytken, Eldin Hesham Salah, Viigimaa Margus, Strandberg Timo E., Ferrieres Jean, Agladze Rusudan, Laufs Ulrich, Rallidis Loukianos, Bajnok Laszlo, Gudjonsson Thorbjorn, Maher Vincent, Henkin Yaakov, Gulizia Michele Massimo, Mussagaliyeva Aisulu, Bajraktari Gani, Kerimkulova Alina, Latkovskis Gustavs, Hamoui Omar, Visseren Frank, Grobbee Diederick, , , 1 feb 2020, In: Atherosclerosis. 294 , p. 80-82 3 p.

Mortality after hospital admission for heart failure:improvement over time, equally strong in women as in men

Buddeke J, Valstar G B, van Dis I, Visseren F L J, Rutten F H, den Ruijter H M, Vaartjes I, Bots M L, 10 jan 2020, In: BMC Public Health. 20 10 p.

All research output

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