dr. R.M. (Roelie) Wösten-van Asperen

Assistant Professor - medical

  • IC patient care

dr. R.M. (Roelie) Wösten-van Asperen

Research Programs


Roelie Wösten-van Asperen is a pediatric-intensivist at the PICU of the Wilhelmina Children’s Hospital in Utrecht. She started her fellowship in pediatric intensive care in 2002. After finalization of her fellowship, she has been a consultant pediatric intensivist in the Emma Children’s Hospital/Academic Medical Center, Amsterdam. In 2011, she defended her thesis ‘The role of the renin-angiotensin system in acute lung injury’ at the University of Amsterdam.

After almost 15 years (in January 2016), she moved from the PICU of the Emma Children’s Hospital to the PICU of the Wilhelmina Children’s Hospital in Utrecht. Together with Prof. Marry van den Heuvel of the Princess Máxima Center for Pediatric Oncology, she started a research group on pediatric cancer patients at the PICU.

She is currently chair of the PICU Oncology Kids in Europe Research group (POKER), a research consortium comprising of 20 PICU’s which are adhered to large pediatric oncological centers in nine different countries (Austria, Belgium, Denmark, Germany, France, Italy, Poland, Spain, Switzerland, the Netherlands, and the UK). Our mission is to improve our understanding and our ability to appropriately treat these patients, thereby improving outcomes of children with cancer who are admitted to the PICU. 



1988-1993 Medical Biology, Groningen University, Groningen, The Netherlands Degree: MSc (cum laude)

1991-1995 Medicine, Groningen University, Groningen, The Netherlands. Degree: MSc (cum laude)

1995-1997 Medical Degree Groningen University, Groningen, The Netherlands. Degree: MD (cum laude)

1997-2002 Training in pediatrics, University of Leiden (1997-1999) and University of Groningen (2000-2002), The Netherlands

2002-2006 Fellowship pediatric intensive care medicine, Emma Children’s Hospital/Academic Medical Center, Amsterdam, The Netherlands

2005-2011 PhD ‘The role of the renin angiotensin system in acute lung injury’, University of Amsterdam, Amsterdam, The Netherlands



Pediatric cancer patients at the PICU: identifying prognostic factors influencing PICU admission and outcome of pediatric cancer patients.


Side Activities

  • Chair of POKER (PICU Oncology Kids in Europe Research group) research consortium of ESPNIC (European Society of Paediatric & Neonatol Intensive Care).

    Member of European Society of Paediatric & Neonatol Intensive Care


Fellowship and Awards

  • Funding as Co-PI:

    2012 Academic Medical Center Graduate School Scholarship: Impact of age on the pulmonary renin-angiotensin system in acute respiratory distress syndrome (Euro 205K)

    2017 Research grant supported by KiKa: Identifying the critically ill pediatric cancer patient. (Euro 590K)

Research Output (27)

Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response

Schouten Laura R A, Bos Lieuwe D J, Serpa Neto A, van Vught Lonneke A, Wiewel Maryse A, Hoogendijk Arie J, Bonten Marc J M, Cremer Olaf L, Horn Janneke, van der Poll Tom, Schultz Marcus J, Wösten-van Asperen Roelie M, 29 okt 2019, In: Intensive Care Medicine Experimental. 7 10 p.

Short-term effect of surgery for non-idiopathic scoliosis on pulmonary function

Veldhoen Esther, De Vries Anneloes, Tersmette Joyce, Verweij-Van den Oudenrijn Laura, Hulzebos Erik, Wosten-Van Asperen Roelie, Van der Ent Kors 28 sep 2019, In: European Respiratory Journal. 54

Epidemiology and Outcome of Critically Ill Pediatric Cancer and Hematopoietic Stem Cell Transplant Patients Requiring Continuous Renal Replacement Therapy:A Retrospective Nationwide Cohort Study

Raymakers-Janssen Paulien A M A, Lilien Marc R, Tibboel Dick, Kneyber Martin C J, Dijkstra Sandra, van Woensel Job B M, Lemson Joris, Cransberg Karlien, van den Heuvel-Eibrink Marry M, Wösten-van Asperen Roelie M, 27 aug 2019, In: Critical Care Medicine. 47 , p. e893-e901

PICU mortality of children with cancer admitted to pediatric intensive care unit a systematic review and meta-analysis

Wösten-van Asperen Roelie M, van Gestel Josephus P J, van Grotel Martine, Tschiedel Eva, Dohna-Schwake Christian, Valla Frédéric V, Willems Jef, Angaard Nielsen Jeppe S, Krause Martin F, Potratz Jenny, van den Heuvel-Eibrink Marry M, Brierley Joe, 3 aug 2019, In: Critical Reviews in Oncology/Hematology. 142 , p. 153-163 11 p.

Age-dependent differences in pulmonary host responses in ARDS:a prospective observational cohort study

Schouten Laura R., van Kaam Anton H., Kohse Franziska, Veltkamp Floor, Bos Lieuwe D., de Beer Friso M., van Hooijdonk Roosmarijn T., Horn Janneke, Straat Marleen, Witteveen Esther, Glas Gerie J., Wieske Luuk, van Vught Lonneke A., Wiewel Maryse A., Ingelse Sarah A., Cortjens Bart, van Woensel Job B., Bos Albert P., Walther Thomas, Schultz Marcus J., Wösten-van Asperen Roelie M., de Beer Friso M., Bos Lieuwe D., Glas Gerie J., Horn Janneke, Hoogendijk Arie J., van Hooijdonk Roosmarijn T., Huson Mischa A., van der Poll Tom, Scicluna Brendon, Schouten Laura R., Schultz Marcus J., Straat Marleen, van Vught Lonneke A., Wieske Luuk, Wiewel Maryse A., Witteveen Esther, Bonten Marc J., Cremer Olaf L., Frencken Jos F., van de Groep Kirsten, Klein Klouwenberg Peter M., Koster-Brouwer Maria E., Ong David S., Verboom Diana M., 14 mei 2019, In: Annals of Intensive Care. 9 , p. 55

Brain microstructural development in neonates with critical congenital heart disease:An atlas-based diffusion tensor imaging study

Claessens Nathalie H. P., Breur Johannes M. P. J., Groenendaal Floris, Wosten-van Asperen Roelie M., Stegeman Raymond, Haas Felix, Dudink Jeroen, de Vries Linda S., Jansen Nicolaas J. G., Benders Manon J. N. L. 7 jan 2019, In: Neuroimage: Clinical [E]. 21 , p. 101672

Research priorities in pediatric onco-critical care:an international Delphi consensus study

Soeteman Marijn, Potratz Jenny, Nielsen Jeppe S.Angaard, Willems Jef, Valla Frédéric V., Brierley Joe, Wösten-van Asperen Roelie M., van Grotel Martine, Tschiedel Eva, Dohna-Schwake Christian, Krause Martin F., van Gestel Josephus P.J., Marquis Patrick, Aziz Omer, van den Heuvel-Eibrink Marry M., 2019, In: Intensive Care Medicine. 45 , p. 1681-1683 3 p.

Citrate versus heparin anticoagulation in continuous renal replacement therapy in small children

Raymakers-Janssen Paulien A M, Lilien Marc, van Kessel Ingrid A., Veldhoen Esther S., Wösten-van Asperen Roelie M., van Gestel Josephus P.J. 1 okt 2017, In: Pediatric Nephrology. 32 , p. 1971-1978 8 p.

Factors Associated with Mortality in Low-Risk Pediatric Critical Care Patients in the Netherlands

Verlaat Carin W., Visser Idse H., Wubben Nina, Hazelzet Jan A., Lemson Joris, van Waardenburg Dick A, Van Der Heide Douwe, Van Dam Nicolette A., Jansen Nicolaas J., Van Heerde Mark, van der Starre Cynthia, Van Asperen Roelie, Kneyber Martin, van Woensel Job B M, Van Den Boogaard Mark, van der Hoeven Johannes G. 1 apr 2017, In: Pediatric Critical Care Medicine. 18 , p. e155-e161

Generalizability Concern of Alveolar Dead Space Fraction of Yehya et al

Koomen Erik, Wösten-van Asperen Roelie M feb 2017, In: Pediatric Critical Care Medicine. 18 , p. 204 1 p.

All Research Output (27)