prof. dr. N.M. (Nico M.) Wulffraat
Full Professor
- Cluster B
- Rheumatology Research 1
- Immunology
Contact
Biography
Nico Wulffraat is professor of pediatric Rheumatology at the department of pediatrics, University Medical Center, Utrecht, The Netherlands. He obtained his MD and PhD (1987) at the Free University Hospital Amsterdam. He trained as a paediatrician from 1988 untill 1993 in Utrecht. He was fellow pediatric immunology and rheumatology from 1993 to 1995 in the WKZ. Since 1995 he worked as a consultant in pediatric immunology-rheumatology. Since 2010 he is the head of this subunit. From 1997-2004 he was also coordinator of the pediatric allogeneic and autologous stem cell transplantations for immune deficiencies, metabolic disorders and autoimmune diseases. He is PI of several investigator initiated trials of immunisations in children with rheumatic diseases including MMR, HPV and Men C, prevention of MTX side effects, and application of Mesenchymal Stem cells in refractory GvHD and JIA. He is coordinator of a FP7 consortium for pharmacovigilance of biologics used in JIA (PHARMACHILD). Also he leads the EHHC project SHARE that aims at documenting standards of care and treatment recommendations for pediatric rheumatic diseases throughout Europe.
Since 2008 he became supervisor of the postgraduate clinical fellowship pediatric rheumatology and since 2009 head of pediatric immunology and rheumatology. In 2014, he was appointed as head of pediatric Rheumatology, Immunology, hematology and infectious diseases.
He has co-authored 220 Pubmed cited papers in international journals on pediatric rheumatology and immunology and 12 chapters in books.
Side Activities
Coördinator ERN/RITA 2019 - heden
Commissie lid ZONMW Translationeel Adult Stamcelresearch
Commissielid ZONMW call Priority Medicins Children, thans Goed gebruik Geneesmiddelen
Editor Werkboek Kinderreumatologie
Werkgroep uveitis richtlijn (Orde medisch specialisten, 2014-2015)
Lid Drug safety Monitoring Board Sycamore trial (RCT for adalimumab in JIA associated uveitis).
Lid bestuur Pediatric Rheumatology European Society (PRES, treasurer, 2012-)
Lid bestuur Pediatric Rheumatology International Trials organization (Printo, 2012-)
Editorial board Pediatric Rheumatology Online Journal
Reviewer for all major rheumatology Journals, Blood, Lancet, NEJM
Organiser (PRES representative) and faculty of basic& advanced educational courses in pediatric Rheumatology (India, Turkey, Brasilia)
Fellowship and Awards
FP7 Grant Pharmachild
AEMC Grant SHARE
Div. ZON MW Grants
UCAN CANDU
Foreum
AbbVie (bijdrage Reuma2Go)
Roche (bijdrage Reuma2Go)
ERN coordinator RITA
ZonMW grant Chronic Fatique QFS and JIA
Research Output (504)
European consensus-based recommendations for the diagnosis and treatment of rare paediatric vasculitides - the SHARE initiative (vol 58, pg 656, 2019):European consensus-based recommendations for the diagnosis and treatment of rare paediatric vasculitides - The SHARE initiative (Rheumatology (2019)58 (656-671) DOI: 10.1093/rheumatology/key322)
De Graeff Nienke, Groot Noortje, Brogan Paul, Ozen Seza, Avcin Tadej, Bader-Meunier Brigitte, Dolezalova Pavla, Feldman Brian M., Kone-Paut Isabelle, Lahdenne Pekka, Marks Stephen D., McCann Liza, Pilkington Clarissa, Ravelli Angelo, Van Royen Annet, Uziel Yosef, Vastert Bas, Wulffraat Nico, Kamphuis Sylvia, Beresford Michael W. 1 apr 2020, In: Rheumatology (United Kingdom). 59 , p. 919 1 p.
Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases:updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE)
Sharrack Basil, Saccardi Riccardo, Alexander Tobias, Badoglio Manuela, Burman Joachim, Farge Dominique, Greco Raffaella, Jessop Helen, Kazmi Majid, Kirgizov Kirill, Labopin Myriam, Mancardi Gianluigi, Martin Roland, Moore John, Muraro Paolo, Rovira Montserrat, Sormani Maria Pia, Snowden John A., Snowden John, Saccardi Riccardo, McGrath Eoin, Bambi Franco, Sanchez-Guijo Fermín, Worel Nina, Snowden John, Alexander Tobias, Badolglio Manuela, Abinun Mario, Arnold Renate, Brierley Charlotte, Castilla-Llorente Cristina, Cooper Nichola, Daikeler Thomas, del Papa Nicoletta, Farge Dominique, Finke Jurgen, Greco Raffaella, Hagglund Hans, Henes Joerg, Hiepe Falk, Jessop Helen, Kiely David, Labopin Myriam, Kazmi Majid, Kirgizov Kirill, Mancardi Gianluigi, Marjanovic Zora, Martin Roland, Martin Thierry, Wulffraat Nico, feb 2020, In: Bone Marrow Transplantation. 55 , p. 283-306
International Consortium for Health Outcome Measurement Set of Outcomes That Matter to People Living With Inflammatory Arthritis:Consensus From an International Working Group
Oude Voshaar Martijn A H, Das Gupta Zofia, Bijlsma Johannes W J, Boonen Annelies, Chau Jeffrey, Courvoisier Delphine S, Curtis Jeffrey R, Ellis Benjamin, Ernestam Sofia, Gossec Laure, Hale Christine, Hornjeff Jennifer, Leung Katy Y Y, Lidar Merav, Mease Phillip, Michaud Kaleb, Mody Girish M, Ndosi Mwidimi, Opava Christina H, Pinheiro Geraldo R C, Salt Matthew, Soriano Enrique R, Taylor William J, Voshaar Maria J H, Weel Angelique E A M, de Wit Maarten, Wulffraat Nico, van de Laar Mart A F J, Vonkeman Harald E dec 2019, In: Arthritis care and research. 71 , p. 1556-1565 10 p.
Fatigue in Children Post-Cancer Treatment and Other Long-Term Diseases
Nap-Van der Vlist M., Dalmeijer G., Grootenhuis M., van der Ent C., van den Heuvel-Eibrink M., Wulffraat N., Swart J., van Litsenburg R., van de Putte E., Nijhof S. dec 2019, In: Pediatric Blood & Cancer. 66 , p. S150-S151
2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases
Furer Victoria, Rondaan Christien, Heijstek Marloes W., Agmon-Levin Nancy, Van Assen Sander, Bijl Marc, Breedveld Ferry C., D'Amelio Raffaele, Dougados Maxime, Kapetanovic Meliha Crnkic, Van Laar Jacob M., De Thurah A., Landewé Robert B.M., Molto Anna, Mueller-Ladner Ulf, Schreiber Karen, Smolar Leo, Walker Jim, Warnatz Klaus, Wulffraat Nico M., Elkayam Ori okt 2019, In: Annals of the Rheumatic Diseases. 79 , p. 39-52 14 p.
Multimodal assessment and phenomapping of early atherosclerosis in children with chronic disease
Ververs F. A., Eikendal A. L. M., Westenberg J. J. M., Van der Geest R. J., Nuboer R., Wulffraat N. M., Van der Ent C. K., Leiner T., Grotenhuis H. B., Schipper H. S. okt 2019, In: European heart journal. 40 , p. 2066-2066
Incidence and prevalence of vaccine preventable infections in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD):A systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD
Furer Victoria, Rondaan Christien, Heijstek Marloes, Van Assen Sander, Bijl Marc, Agmon-Levin Nancy, Breedveld Ferdinand C., D'Amelio Raffaele, Dougados Maxime, Kapetanovic Meliha Crnkic, Van Laar Jacob M., Ladefoged De Thurah Annette, Landewé Robert, Molto Anna, Müller-Ladner Ulf, Schreiber Karen, Smolar Leo, Walker Jim, Warnatz Klaus, Wulffraat Nico M., Elkayam Ori 1 sep 2019, In: RMD Open. 5
Efficacy, immunogenicity and safety of vaccination in adult patients with autoimmune inflammatory rheumatic diseases:A systematic literature review for the 2019 update of EULAR recommendations
Rondaan Christien, Furer Victoria, Heijstek Marloes W., Agmon-Levin Nancy, Bijl Marc, Breedveld Ferdinand C., D'Amelio Raffaele, Dougados Maxime, Kapetanovic Meliha C., Van Laar Jacob M., De Thurah Annette Ladefoged, Landewé Robert, Molto Anna, Müller-Ladner Ulf, Schreiber Karen, Smolar Leo, Walker Jim, Warnatz Klaus, Wulffraat Nico M., Van Assen Sander, Elkayam Ori 1 sep 2019, In: RMD Open. 5
Consensus-based recommendations for the management of juvenile localised scleroderma
Zulian Francesco, Culpo Roberta, Sperotto Francesca, Anton Jordi, Avcin Tadej, Baildam Eileen M., Boros Christina, Chaitow Jeffrey, Constantin Tamàs, Kasapcopur Ozgur, Knupp Feitosa De Oliveira Sheila, Pilkington Clarissa A., Russo Ricardo, Toplak Natasa, Van Royen Annet, Saad Magalhães Claudia, Vastert Sebastiaan J., Wulffraat Nico M., Foeldvari Ivan 1 aug 2019, In: Annals of the Rheumatic Diseases. 78 , p. 1019-1024 6 p.
The European network for care of children with paediatric rheumatic diseases:Care across borders
Dolezalova Pavla, Anton Jordi, Avcin Tadej, Beresford Michael W., Brogan Paul A., Constantin Tamas, Egert Yona, Foeldvari Ivan, Foster Helen E., Hentgen Veronique, Kone-Paut Isabelle, Kuemmerle-Deschner Jasmine B., Lahdenne Pekka, Magnusson Bo, Martini Alberto, McCann Liza, Minden Kirsten, Ozen Seza, Schoemaker Casper, Quartier Pierre, Ravelli Angelo, Rumba-Rozenfelde Ingrida, Ruperto Nicola, Vastert Sebastian, Wouters Carine, Zulian Francesco, Wulffraat Nico M., Beresford Michael W., Huemer Christian, Joos Rik, Mihaylova Dimitrina, Harjacek Miroslav, Mina Elpida, Nielsen Susan, Foell Dirk, Vougiouka Olga, Orbán Ilona, Uziel Yosef, Ruperto Nicolino, Wulffraat Nico M., Flato Berit, Smolewska Elzbieta, Melo-Gomes Jose Antonio, Lazar Calin, Susic Gordana, Dallos Tomas, De Inocencio Jaime, Berntson Lillemor, Hofer Michael, Boyko Yaryna 1 jul 2019, In: Rheumatology (United Kingdom). 58 , p. 1188-1195 8 p.