prof. dr. N.M. (Nico M.) Wulffraat

prof. dr. N.M. (Nico M.) Wulffraat

Full Professor
prof. dr. N.M. (Nico M.) Wulffraat
  • Cluster B
  • Rheumatology Research 1
  • Immunology



Nico Wulffraat is professor of pediatric Rheumatology at the department of pediatrics, University Medical Center, Utrecht, The Netherlands. He obtained his MD and PhD (1987) at the Free University Hospital Amsterdam. He trained as a paediatrician from 1988 untill 1993 in Utrecht. He was fellow pediatric immunology and rheumatology from 1993 to 1995 in the WKZ. Since 1995 he worked as a consultant in pediatric immunology-rheumatology. Since 2010 he is the head of this subunit. From 1997-2004 he was also coordinator of the pediatric allogeneic and autologous stem cell transplantations for immune deficiencies, metabolic disorders and autoimmune diseases. He is PI of several investigator initiated trials of immunisations in children with rheumatic diseases including MMR, HPV and Men C, prevention of MTX side effects, and application of Mesenchymal Stem cells in refractory GvHD and JIA. He is coordinator of a FP7 consortium for pharmacovigilance of biologics used in JIA (PHARMACHILD). Also he leads the EHHC project SHARE that aims at documenting standards of care and treatment recommendations for pediatric rheumatic diseases throughout Europe.

Since 2008 he became supervisor of the postgraduate clinical fellowship pediatric rheumatology and since 2009 head of pediatric immunology and rheumatology. In 2014, he was appointed as head of pediatric Rheumatology, Immunology, hematology and infectious diseases.

He has co-authored 220 Pubmed cited papers in international journals on pediatric rheumatology and immunology and 12 chapters in books.

Side Activities


Gezondheidsraad advies CVS

ZonMW commissie programma translationeel onderzoek en adulte stamcellen, adviesgroep medische producten (2009-2016)

Evaluatie beoordeling NFU expertise centra

Council PRES (2004-2010)

Council PRINTO National representative for NL (2001-2014)

ERN RITA HCP Member Representative (2017) and since 2019 ERN RITA coordinator

Reviewer for all major rheumatology Journals, Blood, Lancet, NEJM


Member of EBMT working party for autoimmune diseases (Chair R Saccardi, Florence Italy)

Member of the ZONWM programme committee Translational Adult Stem cell research

Member of the European Medicines Agency (EMA) expert group for pediatric rheumatology

Member of the ZONMW programme committee Priority medicines for children

Member of the advisory council Ter Meulen Fonds

Member of the Drug Safety Monitoring board of the adalumimab trial for uveitis (NHS, England)

Member of the board for the Dutch pediatric rheumatology society, for education and research (2001-2010)

Member of the board for Utrecht pediatric postgraduate courses (1999-2010)

Member of the Scientific Advisory Council of the Dutch League for Rheumatology (Nationaal Reumafonds, 2006-2009)

Member of the Utrecht study group for the development of the electronic patient file into clinical paractise (2005-2009)

Member of the EBMT working party for inborn errors and immunodeficiencies (1996-2008)

Fellowship and Awards

FP7 Grant Pharmachild


Div. ZON MW Grants



AbbVie (bijdrage Reuma2Go)

Roche (bijdrage Reuma2Go)

ERN coordinator RITA

ZonMW grant Chronic Fatique QFS and JIA

Research Output (594)

Burden of comorbid conditions in children and young people with juvenile idiopathic arthritis:a collaborative analysis of 3 JIA registries

Kearsley-Fleet Lianne, Klotsche Jens, van Straalen Joeri W, Costello Wendy, D'Angelo Gianfranco, Giancane Gabriella, Horneff Gerd, Klein Ariane, Láday Matilda, Lunt Mark, de Roock Sytze, Ruperto Nicolino, Schoemaker Casper, Vijatov-Djuric Gordana, Vojinovic Jelena, Vougiouka Olga, Wulffraat Nico M, Hyrich Kimme L, Minden Kirsten, Swart Joost F, 6 okt 2021, In: Rheumatology (Oxford, England).

Increased incidence of inflammatory bowel disease on etanercept in juvenile idiopathic arthritis regardless of concomitant methotrexate use

van Straalen Joeri W, Krol Roline M, Giancane Gabriella, Panaviene Violeta, Ailioaie Laura Marinela, Doležalová Pavla, Cattalini Marco, Susic Gordana, Sztajnbok Flavio, Maritsi Despoina, Constantin Tamas, Sawhney Sujata, Rygg Marite, Oliveira Sheila Knupp, Nordal Ellen Berit, Saad-Magalhaes Claudia, Rubio-Perez Nadina, Jelusic Marija, de Roock Sytze, Wulffraat Nico M, Ruperto Nicolino, Swart Joost F, 11 sep 2021, In: Rheumatology (Oxford, England).

Mandibular range of motion in children with juvenile idiopathic arthritis with and without clinically established temporomandibular joint involvement and in healthy children: a cross-sectional study

de Sonnaville Willemijn F C, Speksnijder Caroline M, Zuithoff Nicolaas P A, Verkouteren Daan R C, Wulffraat Nico W, Steenks Michel H, Rosenberg Antoine J W P 3 jul 2021, In: Pediatric Rheumatology. 19

Maximum bite force in children with juvenile idiopathic arthritis with and without clinical established temporomandibular joint involvement and in healthy children: a cross-sectional study

de Sonnaville Willemijn, Speksnijder Caroline, Zuithoff NPA, Verkouteren Daan, Wulffraat Nico M., Steenks MH, Rosenberg AJWP jul 2021, In: Journal of Oral Rehabilitation. 48 , p. 774-784 11 p.

Monitoring patients with juvenile idiopathic arthritis using health-related quality of life

Doeleman Martijn J.H., de Roock Sytze, Buijsse Nathan, Klein Mark, Bonsel Gouke J., Seyfert-Margolis Vicki, Swart Joost F., Wulffraat Nico M. 22 mrt 2021, In: Pediatric Rheumatology. 19 , p. 40

Costs of medication use among patients with juvenile idiopathic arthritis in the Dutch healthcare system

Kip Michelle M A, de Roock Sytze, Currie Gillian, Marshall Deborah A, Grazziotin Luiza R, Twilt Marinka, Yeung Rae S M, Benseler Susanne M, Schreijer Maud A, Vastert Sebastiaan J, Wulffraat Nico, van Royen-Kerkhof Annet, Swart Joost F, IJzerman Maarten J 28 dec 2020, In: Expert Review of Pharmacoeconomics and Outcomes Research. 21 , p. 975-984 10 p.

Tapering Canakinumab Monotherapy in Patients With Systemic Juvenile Idiopathic Arthritis in Clinical Remission: Results From a Phase IIIb/IV Open-Label, Randomized Study:Results From a Phase IIIb/IV Open-Label, Randomized Study

Quartier Pierre, Alexeeva Ekaterina, Tamàs Constantin, Chasnyk Vyacheslav, Wulffraat Nico, Palmblad Karin, Wouters Carine, Brunner Hermine, Marzan Katherine, Schneider Rayfel, Horneff Gerd, Martini Alberto, Anton Jordi, Wei Xiaoling, Slade Alan, Ruperto Nicolino, Abrams Ken, 11 dec 2020, In: Arthritis & Rheumatology. 73 , p. 336-346 11 p.

A clinical prediction model for estimating the risk of developing uveitis in patients with juvenile idiopathic arthritis

Van Straalen Joeri W., Giancane Gabriella, Amazrhar Yasmine, Tzaribachev Nikolay, Lazar Calin, Uziel Yosef, Telcharova-Mihaylovska Albena, Len Claudio A., Miniaci Angela, Boteanu Alina L., Filocamo Giovanni, Mastri Mariel V., Arkachaisri Thaschawee, Magnolia Maria G., Hoppenreijs Esther, De Roock Sytze, Wulffraat Nico M., Ruperto Nicolino, Swart Joost F. 4 dec 2020, In: Rheumatology (Oxford, England). 60 , p. 2896-2905 10 p.

Safety and immunogenicity of the quadrivalent human papillomavirus vaccine in patients with juvenile dermatomyositis:a real-world multicentre study

Grein Ingrid Herta Rotstein, Pinto Natalia Balera Ferreira, Groot Noortje, Martins Camila Bertini, Lobo Aline, Aikawa Nadia Emi, Barbosa Cassia, Terreri Maria Teresa, da Fraga Aline Coelho Moreira, de Oliveira Sheila Knupp Feitosa, Sztajnbok Flavio, Paim Marques Luciana B, Islabão Aline Garcia, Appenzeller Simone, Bica Blanca, de Oliveira Sato Juliana, Magalhães Claudia Saad, Ferriani Virgínia, Pasmans Hella, Schepp Rutger, van der Klis Fiona, de Roock Sytze, Wulffraat Nico, Pileggi Gecilmara Salviato 11 nov 2020, In: Pediatric rheumatology online journal. 18 , p. 1-12

Consensus-based recommendations for the management of juvenile systemic sclerosis

Foeldvari Ivan, Culpo Roberta, Sperotto Francesca, Anton Jordi, Avcin Tadej, Baildam Eileen, Boros Christina, Chaitow Jeffrey, Constantin Tamas, Kasapcopur Ozgur, Knupp Feitosa de Oliveira Sheila, Pilkington Clarissa, Toplak Natasa, van Royen Annet, Saad Magalhaes Claudia, Vastert Sebastiaan J, Wulffraat Nico, Zulian Francesco 4 nov 2020, In: Rheumatology (Oxford, England). 60 , p. 1651-1658 8 p.

All research output

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