dr. G.J.M. (Maeike) Zijlmans

dr. G.J.M. (Maeike) Zijlmans

Associate Professor
dr. G.J.M. (Maeike) Zijlmans
  • Neurology & Neurosurgery



Maeike Zijlmans is a neurologist and principle investigator at the UMC Utrecht Brain Center and Stichting Epilepsie Instellingen Nederland (SEIN). She finished her PhD with honors in May 2011 (prof van Huffelen, Utrecht, and prof Gotman, Montreal). Her thesis is about new presurgical techniques to characterize the focus of epilepsy. These techniques included EEG-fMRI, magnetoencephalography (MEG), special EEG electrodes and 3 T MRI. She stayed at the Montreal Neurological Institute for one year where she studied the use of high frequency oscillations (HFOs) in depth EEG in presurgical epilepsy patients.  She applied the acquired knowledge at the UMC Utrecht to record HFOs with corticography during surgery. This work ultimately led to the conduct of a prospective randomized controlled trial 'the HFO trial' comparing the use of HFOs to spikes as electrical biomarkers for epileptic tissue during epilepsy surgery. Results are expected to be published in 2022. Another part of the thesis concerned quality of life and coping style in epilepsy.  In 2013 she started her work as clinical researcher. She is now leading the 'epilab' which focusses on advanced technologies to recognize epileptic brain tissue. Her research group consists of a post-doctoral fellow, 7 PhD students (+3 finished) and several master students. She obtained an ERC starting grant in 2019 for the project 'the Core and Effects of Epilepsy'. The group studies how to delineate epileptic brain tissue from healthy cortex with optimal signal recording and analysis in a large dataset of retrospectively gathered highly sampled intra-operative electrocorticography and by prospectively recording high denisity electrocorticography. The group is trying to improve the clinical yield of the HFO-signal using different signal analytic methods, like high frequent network analysis and machine learning. Her ultimate goal is to find a way to direct the neurosurgeon directly to the epileptogenic tissue. Also, the clinical yield is studied to predict cognitive outcome and to compare HFOs to other disease markers like in tumours. Part of the research group works on related issues like the non-invasive identification of HFOs with EEG and MEG, and finding alterative biomarkers with metabolic MRI. Allied research focuses on stress-related epilepsy, psychogenic non-epileptic seizures and effect of surgery on patient well being.

Research line

Advance diagnostics for epilepsy surgery

Most recent key publications

1: Zijlmans M, Zweiphenning WJEM, van Klink NEC. Changing concepts in presurgical assessment for epilepsy surgery. Nat Rev Neurol 2019;15:594-606.

2: van 't Klooster MA, van Klink NEC, Zweiphenning WJEM, Leijten FSS, Zelmann R, Ferrier CH, van Rijen PC, Otte WM, Braun KPJ, Huiskamp GJM, Zijlmans M. Tailoring epilepsy surgery with fast ripples in the intraoperative electrocorticogram. Ann Neurol. 2017 May;81(5):664-676

3: Zijlmans M, Jiruska P, Zelmann R, Leijten FS, Jefferys JG, Gotman J. High-frequency oscillations as a new biomarker in epilepsy. Ann Neurol. 2012 Feb;71(2):169-78.

4: Zijlmans M, Jacobs J, Zelmann R, Dubeau F, Gotman J. High-frequency oscillations mirror disease activity in patients with epilepsy. Neurology. 2009

5: Zijlmans M, Huiskamp G, Hersevoort M, Seppenwoolde JH, van Huffelen AC, Leijten FS. EEG-fMRI in the preoperative work-up for epilepsy surgery. Brain. 2007 Sep;130(Pt 9):2343-53.

Fellowship and Awards

1: ERC starting grant 803880

2: ZonMW veni personal grant

3: BCRM young talent grant and prize

4: Dutch Epilepsy Foundation research grant (2011, 2015)

5: Hersenstichting Prize for scientific work

6: Amsterdam Neurologists Prize for clinical research

7: Dutch Epilepsy Foundation Reseach prize

Research Output (96)

Nasopharyngeal electrodes for recording mesiotemporal spikes:Post-covid revival?

Zijlmans Maeike, van der Salm Sandra M A, Van't Klooster Maryse 28 apr 2021, In: Clinical Neurophysiology. 132 , p. 1718-1720 3 p.

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse A, van Huffelen Alexander C, van Klink Nicole E C, Benders Manon J N L, de Vries Linda S, Leijten Frans S S, Jansen Floor E, Braun Kees P J, Zijlmans Maeike 16 apr 2021, In: Clinical Neurophysiology. 132 , p. 1452-1461 10 p.

Are HFOs in the Intra-operative ECoG Related to Hippocampal Sclerosis, Volume and IQ?

Agudelo Valencia Paula, van Klink Nicole E C, van 't Klooster Maryse A, Zweiphenning Willemiek J E M, Swampillai Banu, van Eijsden Pieter, Gebbink Tineke, van Zandvoort Martine J E, Zijlmans Maeike, 24 mrt 2021, In: Frontiers in Neurology. 12 10 p.

Can we use intraoperative high-frequency oscillations to guide tumor-related epilepsy surgery?

van Klink Nicole E C, Zweiphenning Willemiek J E M, Ferrier Cyrille H, Gosselaar Peter H, Miller Kai J, Aronica Eleonora, Braun Kees P J, Zijlmans Maeike 2021, In: Epilepsia. 62 , p. 997-1004 8 p.

High frequency oscillations associate with neuroinflammation in low-grade epilepsy associated tumors

Sun Dongqing, van Klink Nicole E.C., Bongaarts Anika, Zweiphenning Willemiek E.J.M., van 't Klooster Maryse A., Gebbink Tineke A., Snijders Tom J., van Eijsden Pieter, Robe Pierre A.J.T., Aronica Eleonora, Zijlmans Maeike 2021, In: Clinical Neurophysiology.

HFO to Measure Seizure Propensity and Improve Prognostication in Patients With Epilepsy

Jacobs Julia, Zijlmans Maeike 22 okt 2020, In: Epilepsy Currents. 20 , p. 338-347 10 p.

Validation of virtual resection on intraoperative interictal data acquired during epilepsy surgery

Demuru Matteo, Zweiphenning Willemiek, van Blooijs Dorien, Van Eijsden Pieter, Leijten Frans, Zijlmans Maeike, Kalitzin Stiliyan 21 okt 2020, In: Journal of Neural Engineering. 17 , p. 1-10

The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery:from group-level to patient-level analysis

Demuru Matteo, Kalitzin Stiliyan, Zweiphenning Willemiek, van Blooijs Dorien, van’t Klooster Maryse, Van Eijsden Pieter, Leijten Frans, Zijlmans Maeike, Braun Kees, Ferrier Cyrille, Gebbink Tineke, Gosselaar Peter, Huiskamp Geertjan, van Klink Nicole, Ophorst Janine, van Rijen Peter, van der Salm Sandra, Winter Anouk Velders de, 4 sep 2020, In: Scientific Reports. 10

High frequency oscillations relate to cognitive improvement after epilepsy surgery in children

Sun Dongqing, van 't Klooster Maryse A., van Schooneveld Monique M.J., Zweiphenning Willemiek J.E.M., van Klink Nicole E.C., Ferrier Cyrille H., Gosselaar Peter H., Braun Kees P.J., Zijlmans Maeike 1 mei 2020, In: Clinical Neurophysiology. 131 , p. 1134-1141 8 p.

The resolution revolution:Comparing spikes and high frequency oscillations in high-density and standard intra-operative electrocorticography of the same patient

Zweiphenning Willemiek J E M, van Diessen Eric, Aarnoutse Erik J, Leijten Frans S S, van Rijen Peter C, Braun Kees P J, Zijlmans Maeike 2 mrt 2020, In: Clinical Neurophysiology. 131 , p. 1040-1043 4 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical maakt gebruik van cookies

Deze website maakt gebruik van cookies Deze website toont video’s van o.a. YouTube. Dergelijke partijen plaatsen cookies (third party cookies). Als u deze cookies niet wilt kunt u dat hier aangeven. Wij plaatsen zelf ook cookies om onze site te verbeteren.

Lees meer over het cookiebeleid

Akkoord Nee, liever niet