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dr. ir. J.J.M. (Jaco J.M.) Zwanenburg Associate Professor

  • 7T Group

J.J.M. Zwanenburg


Research Programs


Jaco Zwanenburg studied Applied Physics at the Delft University of Technology (1995 - 2001). He concluded his study with a research project in MRI at Philips Medical Systems, Best. In this project he developed a patented method to use sensitivity encoding from multiple receive coils to reduce artifacts in the reconstructed image caused by the field inhomogeneity and gradient non-linearity of the MR system.

From 2001 until 2005, he did his PhD research at the VU University Medical Center, Amsterdam, with a project on MRI and myocardial tagging to study the dyssynchrony in the mechanical contraction of the human heart.

His current research focus is on designing and implementing new MRI techniques at ultra-high field strength (7T), to stimulate further understanding of cerebrovascular diseases. Exploiting the rich sources of endogenous MRI contrast, he developed imaging techniques for angiography, venography, brain anatomy, and microscopic brain lesions resulting from small vessel disease, including microbleeds and microinfarcts. Furthermore, he has developed imaging strategies for imaging post mortem specimens at high resolution, to bridge the gap between histology and in-vivo imaging in patients.

Side Activities

  • None

Fellowship and Awards

  • ERC starting grant 'Towards understanding cerebral small vessel disease: Innovative, MRI-based, functional markers to discover the terra incognita between large vessels and macroscopic brain lesions (SmallVesselMRI)' (2013, ERC grant agreement n°337333).

Research Output (122)

Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI

Sloots Jacob-Jan, Biessels Geert Jan, Zwanenburg Jaco J M 15 apr 2020, In: NeuroImage. 210 11 p.

Validating faster DENSE measurements of cardiac-induced brain tissue expansion as a potential tool for investigating cerebral microvascular pulsations

Adams Ayodeji L., Viergever Max A., Luijten Peter R., Zwanenburg Jaco J.M. 1 mrt 2020, In: NeuroImage. 208 10 p.

European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

Düzel Emrah, Acosta-Cabronero Julio, Berron David, Biessels Geert Jan, Björkman-Burtscher Isabella, Bottlaender Michel, Bowtell Richard, Buchem Mark V, Cardenas-Blanco Arturo, Boumezbeur Fawzi, Chan Dennis, Clare Stuart, Costagli Mauro, de Rochefort Ludovic, Fillmer Ariane, Gowland Penny, Hansson Oskar, Hendrikse Jeroen, Kraff Oliver, Ladd Mark E, Ronen Itamar, Petersen Esben, Rowe James B, Siebner Hartwig, Stoecker Tony, Straub Sina, Tosetti Michela, Uludag Kamil, Vignaud Alexandre, Zwanenburg Jaco, Speck Oliver dec 2019, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11 , p. 538-549 12 p.

Intracranial Vessel Wall Magnetic Resonance Imaging Does Not Allow for Accurate and Precise Wall Thickness Measurements:An Ex Vivo Study

van Hespen Kees M., Zwanenburg Jaco J.M., Harteveld Anita A., Luijten Peter R., Hendrikse Jeroen, Kuijf Hugo J. 1 okt 2019, In: Stroke. 50 , p. e283-e284

Subvoxel vessel wall thickness measurements from vessel wall MR images

van Hespen KM, Zwanenburg JJM, Hendrikse J, Kuijf HJ 1 jan 2019,

High resolution 7T and 9.4T-MRI of human cerebral arterial casts enables accurate estimations of the cerebrovascular morphometry

Helthuis Jasper H.G., van der Zwan Albert, van Doormaal Tristan P.C., Bleys Ronald L.A.W., Harteveld Anita A., van der Toorn Annette, Brozici Mariana, Hendrikse Jeroen, Zwanenburg Jaco J.M. 1 dec 2018, In: Scientific Reports. 8

White matter hyperintensity shape and location feature analysis on brain MRI; Proof of principle study in patients with diabetes

De Bresser Jeroen, Kuijf Hugo J., Zaanen Karlijn, Viergever Max A., Hendrikse Jeroen, Biessels Geert Jan, Van Den Berg E., Bouvy W., Brundel M., Heringa S., Kappelle L. J., Leemans A., Luijten P. R., Mali W. P.T.M., Rutten G. E.H.M., Vincken K. L., Zwanenburg J., 1 dec 2018, In: Scientific Reports. 8

Detailed view on slow sinusoidal, hemodynamic oscillations on the human brain cortex by Fourier transforming oxy/deoxy hyperspectral images

Noordmans H. J., van Blooijs D., Siero J. C.W., Zwanenburg J. J.M., Klaessens J. H.G.M., Ramsey N. F. sep 2018, In: Human Brain Mapping. 39 , p. 3558-3573

Ex vivo vessel wall thickness measurements of the human circle of Willis using 7T MRI

Harteveld Anita A., Denswil Nerissa P., Van Hecke Wim, Kuijf Hugo J., Vink Aryan, Spliet Wim G.M., Daemen Mat J., Luijten Peter R., Zwanenburg Jaco J.M., Hendrikse Jeroen, van der Kolk Anja G. 1 jun 2018, In: Atherosclerosis. 273 , p. 106-114 9 p.

Comparison of 3T Intracranial Vessel Wall MRI Sequences

Lindenholz A, Harteveld A A, Zwanenburg J J M, Siero J C W, Hendrikse J jun 2018, In: American Journal of Neuroradiology. 39 , p. 1112-1120

All Research Output (122)
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