dr. ir. J.J.M. (Jaco J.M.) Zwanenburg

Associate Professor
dr. ir. J.J.M. (Jaco J.M.) Zwanenburg



Jaco Zwanenburg studied Applied Physics at the Delft University of Technology (1995 - 2001). He concluded his study with a research project in MRI at Philips Medical Systems, Best. In this project he developed a patented method to use sensitivity encoding from multiple receive coils to reduce artifacts in the reconstructed image caused by the field inhomogeneity and gradient non-linearity of the MR system.

From 2001 until 2005, he did his PhD research at the VU University Medical Center, Amsterdam, with a project on MRI and myocardial tagging to study the dyssynchrony in the mechanical contraction of the human heart.

His current research focus is on designing and implementing new MRI techniques at ultra-high field strength (7T), to stimulate further understanding of cerebrovascular diseases. Exploiting the rich sources of endogenous MRI contrast, he developed imaging techniques for angiography, venography, brain anatomy, and microscopic brain lesions resulting from small vessel disease, including microbleeds and microinfarcts. Furthermore, he has developed imaging strategies for imaging post mortem specimens at high resolution, to bridge the gap between histology and in-vivo imaging in patients.

Side Activities


Fellowship and Awards

ERC starting grant 'Towards understanding cerebral small vessel disease: Innovative, MRI-based, functional markers to discover the terra incognita between large vessels and macroscopic brain lesions (SmallVesselMRI)' (2013, ERC grant agreement n°337333).

Research Output (126)

Subvoxel vessel wall thickness measurements of the intracranial arteries using a convolutional neural network

van Hespen Kees M, Zwanenburg Jaco J M, Hendrikse Jeroen, Kuijf Hugo J jan 2021, In: Medical Image Analysis. 67 , p. 1-10

Velocity Pulsatility and Arterial Distensibility Along the Internal Carotid Artery

van Tuijl Rick J., Ruigrok Ynte M., Velthuis Birgitta K., van der Schaaf Irene C., Rinkel Gabriël J.E., Zwanenburg Jaco J.M. 18 aug 2020, In: Journal of the American Heart Association. 9 , p. e016883 11 p.

Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI

Sloots Jacob-Jan, Biessels Geert Jan, Zwanenburg Jaco J M 15 apr 2020, In: NeuroImage. 210 11 p.

Inter-patient variations in flow boundary conditions at middle cerebral artery from 7T PC-MRI and influence on Computational Fluid Dynamics of intracranial aneurysms

Rajabzadeh-Oghaz Hamidreza, van Ooij Pim, Veeturi Sricharan S., Tutino Vincent M., Zwanenburg Jaco JM, Meng Hui 15 apr 2020, In: Computers in Biology and Medicine. 120 , p. 103759 9 p.

Microbleeds colocalize with enlarged juxtacortical perivascular spaces in amnestic mild cognitive impairment and early Alzheimer's disease:A 7 Tesla MRI study

Bouvy Willem H, van Veluw Susanne J, Kuijf Hugo J, Zwanenburg Jaco Jm, Kappelle Jaap L, Luijten Peter R, Koek Huiberdina L, Geerlings Mirjam I, Biessels Geert J, 1 apr 2020, In: Journal of Cerebral Blood Flow and Metabolism. 40 , p. 739-746 8 p.

Validating faster DENSE measurements of cardiac-induced brain tissue expansion as a potential tool for investigating cerebral microvascular pulsations

Adams Ayodeji L., Viergever Max A., Luijten Peter R., Zwanenburg Jaco J.M. 1 mrt 2020, In: NeuroImage. 208 10 p.

European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

Düzel Emrah, Acosta-Cabronero Julio, Berron David, Biessels Geert Jan, Björkman-Burtscher Isabella, Bottlaender Michel, Bowtell Richard, Buchem Mark V, Cardenas-Blanco Arturo, Boumezbeur Fawzi, Chan Dennis, Clare Stuart, Costagli Mauro, de Rochefort Ludovic, Fillmer Ariane, Gowland Penny, Hansson Oskar, Hendrikse Jeroen, Kraff Oliver, Ladd Mark E, Ronen Itamar, Petersen Esben, Rowe James B, Siebner Hartwig, Stoecker Tony, Straub Sina, Tosetti Michela, Uludag Kamil, Vignaud Alexandre, Zwanenburg Jaco, Speck Oliver dec 2019, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 11 , p. 538-549 12 p.

Intracranial Vessel Wall Magnetic Resonance Imaging Does Not Allow for Accurate and Precise Wall Thickness Measurements:An Ex Vivo Study

van Hespen Kees M., Zwanenburg Jaco J.M., Harteveld Anita A., Luijten Peter R., Hendrikse Jeroen, Kuijf Hugo J. 1 okt 2019, In: Stroke. 50 , p. e283-e284

Subvoxel vessel wall thickness measurements from vessel wall MR images

van Hespen KM, Zwanenburg JJM, Hendrikse J, Kuijf HJ 1 jan 2019,

High resolution 7T and 9.4T-MRI of human cerebral arterial casts enables accurate estimations of the cerebrovascular morphometry

Helthuis Jasper H.G., van der Zwan Albert, van Doormaal Tristan P.C., Bleys Ronald L.A.W., Harteveld Anita A., van der Toorn Annette, Brozici Mariana, Hendrikse Jeroen, Zwanenburg Jaco J.M. 1 dec 2018, In: Scientific Reports. 8

All research output

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