dr. ir. J.J.M. (Jaco J.M.) Zwanenburg

dr. ir. J.J.M. (Jaco J.M.) Zwanenburg

Associate Professor
dr. ir. J.J.M. (Jaco J.M.) Zwanenburg



Jaco Zwanenburg studied Applied Physics at the Delft University of Technology (1995 - 2001). He concluded his study with a research project in MRI at Philips Medical Systems, Best. In this project he developed a patented method to use sensitivity encoding from multiple receive coils to reduce artifacts in the reconstructed image caused by the field inhomogeneity and gradient non-linearity of the MR system.

From 2001 until 2005, he did his PhD research at the VU University Medical Center, Amsterdam, with a project on MRI and myocardial tagging to study the dyssynchrony in the mechanical contraction of the human heart.

His current research focus is on designing and implementing new MRI techniques at ultra-high field strength (7T), to stimulate further understanding of cerebrovascular diseases. Exploiting the rich sources of endogenous MRI contrast, he developed imaging techniques for angiography, venography, brain anatomy, and microscopic brain lesions resulting from small vessel disease, including microbleeds and microinfarcts. Furthermore, he has developed imaging strategies for imaging post mortem specimens at high resolution, to bridge the gap between histology and in-vivo imaging in patients.

Side Activities


Fellowship and Awards

ERC starting grant "Towards understanding cerebral small vessel disease: Innovative, MRI-based, functional markers to discover the terra incognita between large vessels and macroscopic brain lesions (SmallVesselMRI)" (2013, ERC grant agreement n°337333).

Vici grant: "Seismology of the brain - A new approach for probing the brain’s microvasculature and tissue properties" (2021)

Research Output (147)

Theory for a non-invasive diagnostic biomarker for craniospinal diseases

Karimi Fariba, Neufeld Esra, Fallahi Arya, Boraschi Andrea, Zwanenburg Jaco J M, Spiegelberg Andreas, Kurtcuoglu Vartan, Kuster Niels 8 Dec 2022, In: NeuroImage: Clinical. 37 , p. 1-16

Cerebral hemodynamics during atrial fibrillation:Computational fluid dynamics analysis of lenticulostriate arteries using 7 T high-resolution magnetic resonance imaging

Scarsoglio S., Saglietto A., Tripoli F., Zwanenburg J. J.M., Biessels G. J., De Ferrari G. M., Anselmino M., Ridolfi L. Dec 2022, In: Physics of Fluids. 34

CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI

van den Brink Hilde, Kopczak Anna, Arts Tine, Onkenhout Laurien, Siero Jeroen C W, Zwanenburg Jaco J M, Hein Sandra, Hübner Mathias, Gesierich Benno, Duering Marco, Stringer Michael S, Hendrikse Jeroen, Wardlaw Joanna M, Joutel Anne, Dichgans Martin, Biessels Geert Jan, 12 Oct 2022, In: Annals of Neurology. 93 , p. 29-39 11 p.

Intracranial atherosclerosis in pseudoxanthoma elasticum:A case-control study

Lucci Carlo, van den Beukel Tim C, Bartstra Jonas W, Zwanenburg Jaco, van der Kolk Anja, Takx Richard, Hendrikse Jeroen, Geerlings Mirjam I, Bos Daniel, Spiering Wilko, de Jong Pim A 15 Apr 2022, In: Atherosclerosis. 350 , p. 19-24 6 p.

Automatic quantification of perivascular spaces in T2-weighted images at 7 T MRI

Verbeek-Spijkerman Jolanda, Zwanenburg J. J.M., Bouvy W. H., Geerlings M. I., Biessels G. J., Hendrikse J., Luijten P. R., Kuijf H. J. 13 Apr 2022, In: Cerebral Circulation - Cognition and Behavior. 3 , p. 1-9

Pulsatility Index in the Basal Ganglia Arteries Increases with Age in Elderly with and without Cerebral Small Vessel Disease

Perosa V, Arts T, Assmann A, Mattern H, Speck O, Oltmer J, Heinze H-J, Düzel E, Schreiber S, Zwanenburg J J M 24 Mar 2022, In: AJNR. American journal of neuroradiology. 43 , p. 540-546 7 p.

Dynamic brain ADC variations over the cardiac cycle and their relation to tissue strain assessed with DENSE at high-field MRI

Sloots Jacob-Jan, Froeling Martijn, Biessels Geert Jan, Zwanenburg Jaco J M 2022, In: Magnetic Resonance in Medicine. 88 , p. 266-279 14 p.

Does the Internal Carotid Artery Attenuate Blood-Flow Pulsatility in Small Vessel Disease?:A 7 T 4D-Flow MRI Study

van Tuijl Rick J, Ruigrok Ynte M, Geurts Lennart J, van der Schaaf Irene C, Biessels Geert Jan, Rinkel Gabriël J E, Velthuis Birgitta K, Zwanenburg Jaco J M 2022, In: Journal of Magnetic Resonance Imaging. 56 , p. 527-535 9 p.

Perforating artery flow velocity and pulsatility in patients with carotid occlusive disease. A 7 tesla MRI study

Onkenhout L. P., Arts Tine, Ferro D., Oudeman E. A., van Osch M. J.P., Zwanenburg J. J.M., Hendrikse J., Kappelle L. J., Biessels G. J., 2022, In: Cerebral Circulation - Cognition and Behavior. 3 , p. 1-7

All research output

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