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UNRAVEL – multi-species cardiac research platform

UNRAVEL – multi-species cardiac research platform

UNRAVEL platform has started in 2013 by collecting clinical and genetic information and biobanking blood and cardiac tissue from human cardiomyopathy patients and their family members treated at Department of Cardiology and Department of Medical Genetics, UMC Utrecht: https://www.unravelrdp.nl/. In 2021 also similar collection of clinical, genetic data and blood and cardiac tissue from veterinary patients (companion animals: cats and dogs) treated at the Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University was added. This platform allows an unprecedented resource for translational medicine.

Key Publications uitklapper, klik om te openen

Unfolded Protein Response as a Compensatory Mechanism and Potential Therapeutic Target in PLN R14del Cardiomyopathy. Feyen DAM, Perea-Gil I, Maas RGC, Harakalova M, Gavidia AA, Arthur Ataam J, Wu TH, Vink A, Pei J, Vadgama N, Suurmeijer AJ, Te Rijdt WP, Vu M, Amatya PL, Prado M, Zhang Y, Dunkenberger L, Sluijter JPG, Sallam K, Asselbergs FW, Mercola M, Karakikes I. Circulation. 2021 Aug 3;144(5):382-392. doi: 10.1161/CIRCULATIONAHA.120.049844. Epub 2021 Apr 30.PMID: 33928785

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations. Pei J, Schuldt M, Nagyova E, Gu Z, El Bouhaddani S, Yiangou L, Jansen M, Calis JJA, Dorsch LM, Blok CS, van den Dungen NAM, Lansu N, Boukens BJ, Efimov IR, Michels M, Verhaar MC, de Weger R, Vink A, van Steenbeek FG, Baas AF, Davis RP, Uh HW, Kuster DWD, Cheng C, Mokry M, van der Velden J, Asselbergs FW, Harakalova M. Clin Epigenetics. 2021 Mar 23;13(1):61. doi: 10.1186/s13148-021-01043-3.PMID: 33757590 

Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23. Garnier S, Harakalova M, Weiss S, Mokry M, Regitz-Zagrosek V, Hengstenberg C, Cappola TP, Isnard R, Arbustini E, Cook SA, van Setten J, Calis JJA, Hakonarson H, Morley MP, Stark K, Prasad SK, Li J, O'Regan DP, Grasso M, Müller-Nurasyid M, Meitinger T, Empana JP, Strauch K, Waldenberger M, Marguiles KB, Seidman CE, Kararigas G, Meder B, Haas J, Boutouyrie P, Lacolley P, Jouven X, Erdmann J, Blankenberg S, Wichter T, Ruppert V, Tavazzi L, Dubourg O, Roizes G, Dorent R, de Groote P, Fauchier L, Trochu JN, Aupetit JF, Bilinska ZT, Germain M, Völker U, Hemerich D, Raji I, Bacq-Daian D, Proust C, Remior P, Gomez-Bueno M, Lehnert K, Maas R, Olaso R, Saripella GV, Felix SB, McGinn S, Duboscq-Bidot L, van Mil A, Besse C, Fontaine V, Blanché H, Ader F, Keating B, Curjol A, Boland A, Komajda M, Cambien F, Deleuze JF, Dörr M, Asselbergs FW, Villard E, Trégouët DA, Charron P. Eur Heart J. 2021 May 21;42(20):2000-2011. doi: 10.1093/eurheartj/ehab030.PMID: 33677556

H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts. Pei J, Harakalova M, Treibel TA, Lumbers RT, Boukens BJ, Efimov IR, van Dinter JT, González A, López B, El Azzouzi H, van den Dungen N, van Dijk CGM, Krebber MM, den Ruijter HM, Pasterkamp G, Duncker DJ, Nieuwenhuis EES, de Weger R, Huibers MM, Vink A, Moore JH, Moon JC, Verhaar MC, Kararigas G, Mokry M, Asselbergs FW, Cheng C. Clin Epigenetics. 2020 Jul 14;12(1):106. doi: 10.1186/s13148-020-00895-5.PMID: 32664951 

UNRAVEL: big data analytics research data platform to improve care of patients with cardiomyopathies using routine electronic health records and standardised biobanking. Sammani A, Jansen M, Linschoten M, Bagheri A, de Jonge N, Kirkels H, van Laake LW, Vink A, van Tintelen JP, Dooijes D, Te Riele ASJM, Harakalova M, Baas AF, Asselbergs FW. Neth Heart J. 2019 Sep;27(9):426-434. doi: 10.1007/s12471-019-1288-4. PMID: 31134468

People Involved uitklapper, klik om te openen

Human cohort

Folkert Asselbergs, Magdalena Harakalova, Peter van Tintelen, Arjan Sammani, Annette Baas, Linda van Laake, Michal Mokry, Joost Sluijter, Alain van Mil, Anneline ter Riele, Pieter Doevendans, Dennis Dooijes, Arco Tesce, Marish Oerlemans, Hanneke Linde, Natascha Hazendonk, Angela Schoemaker, Doraya Haarmans, Irene van de Ploeg, Aryan Vink, Jiayi Pei, Renee Maas, Talitha Spanjersberg, Karen Gaar-Humphreys, Christian Snijders Blok, Jessica van Setten, Jan Willem Buikema, Mark Jansen, Marijke Linschoten, Lieke Numan, Mimount Bourfis, Machteld Boonstra, Karim Taha, Feddo Kirkels, Ayoub Bagheri, 

Veterinary cohort

Frank van Steenbeek, Hille Fieten, Viktor Szatmari, Guy Grinwis, Marja Kik, Giorgia Santarelli, Alma Hulsman, Hans Kooistra

Contact uitklapper, klik om te openen

Magdalena Harakalova, Frank van Steenbeek, Folkert Asselbergs

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