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prof. dr. R.A.H. (Roger) Adan Full Professor

  • Translational Neuroscience

Contact

Research Programs

Biography

Roger Adan was trained as a molecular neurobiologist and received his PhD in 1992 on the regulation of vasopressin and oxytocin gene expression. Since 2002 he is full professor in molecular pharmacology. Via his work on melanocortin receptors he became an expert in molecular and neural pathways underlying feeding behavior, obesity and eating disorders. His lab has a strong multidisciplinary character. A variety of strategies (pharmacogenetics, viral vector technology, in vivo electrophysiology, optogenetics and automated behavioral and physiological analysis) is used to unravel mechanism underlying behavior.  The main focus is on feeding, since this is a natural behavior ideally suited to dissect neural circuits that underlie decision making, anxiety, anhedonia, impulsivity and reward seeking.

Personal fellowships and awards

1: NWO-VIDI grant (016.036.322): Role of neuropeptides in disorders of energy balance
2: ZOnMW-TOP grant (40-00812-98-14093): Shining light on loss of control over substance and food intake
3: co-applicant of 4 granted FP7 programs (Nudge-IT, NeuroFast, Full4Health and I.Family)
4: Recipient of the Rudolf Magnus Research Prize 2003
5: Recipient of the Organon prize for pharmacology 2004

Research line

Neural circuits of feeding and related behaviors

Side Activities

  • Visiting professor University of Gothenburg, Sweden.

  • Scientific advisor/professor at Rintveld-Altrecht, Zeist

  • Expert European Autority for Foof safety in Parma, Italy.

Fellowship and Awards

  • 1: NWO-VIDI grant (016.036.322): Role of neuropeptides in disorders of energy balance
    2: TI pharma grant T5-210 Rapid in vivo CNS drug target validation and therapeutic potential by RNA-interference PI (and co-applicant on 2 other TI pharma grants)
    3:co-applicant of 3 granted FP7 programs (NeuroFast, Full4Health and I.Family)
    4: Recipient of the Rudolf Magnus Research Prize 2003
    5: Recipient of the Organon prize for pharmacology 2004

Research Output (230)

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Lee Phil H., Anttila Verneri, Won Hyejung, Feng Yen-Chen A., Rosenthal Jacob, Zhu Zhaozhong, Tucker-Drob Elliot M., Nivard Michel G., Grotzinger Andrew D., Posthuma Danielle, Wang Meg M-J, Yu Dongmei, Stahl Eli A., Walters Ray-mond K., Anney Richard J. L., Duncan Laramie E., Ge Tian, Adolfsson Rolf, Banaschewski Tobias, Belangero Sintia, Cook Edwin H., Coppola Giovanni, Derks Eske M., Hoekstra Pieter J., Kaprio Jaakko, Keski-Rahkonen Anna, Kirov George, Kranzler Henry R., Luykx Jurjen J., Rohde Luis A., Zai Clement C., Agerbo Esben, Arranz M. J., Asherson Philip, Baekvad-Hansen Marie, Baldursson Gisli, Bellgrove Mark, Belliveau Richard A., Jr., Buitelaar Jan, Burton Christie L., Bybjerg-Grauholm Jonas, Casas Miguel, Cerrato Felecia, Chambert Kimberly, Churchhouse Claire, Gormand Bru, Ophoff Roel A., Adan Roger A. H., Kas Martien J. H., van Os Jim, 12 dec 2019, In: Cell. 179 , p. 1469-1482.e11

Limbic control over the homeostatic need for sodium

Verharen Jeroen P H, Roelofs Theresia J M, Menting-Henry Shanice, Luijendijk Mieneke C M, Vanderschuren Louk J M J, Adan Roger A H 1 dec 2019, In: Scientific Reports. 9

Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making

Verharen Jeroen P.H., Adan Roger A.H., Vanderschuren Louk J.M.J. 1 dec 2019, In: Neuropsychopharmacology. 44 , p. 2195-2204 10 p.

Nutritional psychiatry:Towards improving mental health by what you eat

Adan Roger A.H., van der Beek Eline M., Buitelaar Jan K., Cryan John F., Hebebrand Johannes, Higgs Suzanne, Schellekens Harriet, Dickson Suzanne L. 1 dec 2019, In: European Neuropsychopharmacology. 29 , p. 1321-1332 12 p.

Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice

van Meer Floor, van der Laan Laura N, Eiben Gabriele, Lissner Lauren, Wolters Maike, Rach Stefan, Herrmann Manfred, Erhard Peter, Molnar Denes, Orsi Gergely, Viergever Max A, Adan Roger A H, Smeets Paul A M, 1 nov 2019, In: NeuroImage. 201

Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders:A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches

Yao Shuyang, Kuja-Halkola Ralf, Martin Joanna, Lu Yi, Lichtenstein Paul, Hübel Christopher, Almqvist Catarina, Magnusson Patrik K., Bulik Cynthia M., Larsson Henrik, Norring Claes, Birgegård Andreas, Norring Claes, Birgegård Andreas, Almqvist Catarina, Larsson Henrik, Martin Joanna, Hübel Christopher, Yilmaz Zeynep, Watson Hunna, Baker Jessica, Thornton Laura M., Bulik Cynthia M., Bulik Cynthia M., Adan Roger, Ando Tetsuya, Baker Jessica, Bergen Andrew, Berrettini Wade, Birgegård Andreas, Boni Claudette, Boraska Perica Vesna, Brandt Harry, Burghardt Roland, Cassina Matteo, Cesta Carolyn, Clementi Maurizio, Coleman Joni, Cone Roger, Courtet Philippe, Crawford Steven, Crow Scott, Crowley James, Danner Unna, Davis Oliver, de Zwaan Martina, Finan Chris, Kas Martien, Koeleman Bobby, Ophoff Roel, 15 okt 2019, In: Biological Psychiatry. 86 , p. 577-586 10 p.

Assessing causal links between metabolic traits, inflammation and schizophrenia:a univariable and multivariable, bidirectional Mendelian-randomization study

Lin Bochao D., Alkema Anne, Peters Triinu, Zinkstok Janneke, Libuda Lars, Hebebrand Johannes, Antel Jochen, Hinney Anke, Cahn Wiepke, Adan Roger, Luykx Jurjen J. 31 aug 2019, In: International Journal of Epidemiology. 48 , p. 1505-1514 10 p.

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Watson Hunna J, Yilmaz Zeynep, Thornton Laura M, Hübel Christopher, Coleman Jonathan R I, Gaspar Héléna A, Bryois Julien, Hinney Anke, Leppä Virpi M, Mattheisen Manuel, Medland Sarah E, Ripke Stephan, Yao Shuyang, Giusti-Rodríguez Paola, Hanscombe Ken B, Purves Kirstin L, Adan Roger A H, Alfredsson Lars, Ando Tetsuya, Andreassen Ole A, Baker Jessica H, Berrettini Wade H, Boehm Ilka, Boni Claudette, Perica Vesna Boraska, Buehren Katharina, Burghardt Roland, Cassina Matteo, Cichon Sven, Clementi Maurizio, Cone Roger D, Courtet Philippe, Crow Scott, Crowley James J, Danner Unna N, Davis Oliver S P, de Zwaan Martina, Dedoussis George, Degortes Daniela, DeSocio Janiece E, Dick Danielle M, Dikeos Dimitris, Dina Christian, Dmitrzak-Weglarz Monika, Docampo Elisa, Duncan Laramie E, Egberts Karin, Kas Martien J H, Lin Bochao Danae, Ophoff Roel A, Luykx Jurjen , 15 jul 2019, In: Nature Genetics. 51 , p. 1207-1214 8 p.

Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa

Walton E., Hibar D., Yilmaz Z., Jahanshad N., Cheung J., Batury V. -L., Seitz J., Bulik C. M., Thompson P. M., Ehrlich Stefan, Hibar Derrek P., Stein Jason L., Renteria Miguel E., Arias-Vasquez Alejandro, Desrivieres Sylvane, Jahanshad Neda, Toro Roberto, Wittfeld Katharina, Abramovic Lucija, Andersson Micael, Aribisala Benjamin S., Armstrong Nicola J., Bernard Manon, Bohlken Marc M., Boks Marco P., Bralten Janita, Brown Andrew A., Chakravarty M. Mallar, Chen Qiang, Ching Christopher R. K., Cuellar-Partida Gabriel, Den Braber Anouk, Giddaluru Sudheer, Goldman Aaron L., Grimm Oliver, Guadalupe Tulio, Hass Johanna, Woldehawariat Girma, Klein Marieke, van Eijk Kristel R., Cahn Wiepke, Kahn Rene S., van Haren Neeltje E. M., Brouwer Rachel M., Pol Hilleke E. Hulshoff, Ophoff Roel, Adan Roger, Kas Martien, Koeleman Bobby, Ophoff Roel, 1 jul 2019, In: Molecular Neurobiology. 56 , p. 5146-5156 11 p.

Corticolimbic mechanisms of behavioral inhibition under threat of punishment

Verharen Jeroen P H, van den Heuvel Mauri, Luijendijk Mieneke, Vanderschuren Louk J M J, Adan Roger A H 22 mrt 2019, In: Journal of Neuroscience. 39 , p. 4353-4364 12 p.

All Research Output (230)
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