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prof. dr. P.A.F.M. (Pieter A.) Doevendans Full Professor

  • Department of Cardiology

P.A.F.M. Doevendans

Contact

Research Programs

Biography

Pieter A. Doevendans became a cardiologist in Maastricht (trained by H. Wellens) after his medical training at the Leiden University. In 1993-1994 he had the opportunity to work with Ken Chien at the University of California San Diego, where the work on embryonic stem cells started. The work was completed in Maastricht and provided the basis for a thesis on the function of the promoter of the atrial Myosin Light Chain gene. Upon return in The Netherlands he worked with Christine Mummery and Hans Clevers on both human Embryonic as well as human Cardiac stem cells. In the meantime he remained active as an interventional cardiologist initially in Maastricht, but from 2002 on in Utrecht at the UMC Utrecht. Here he was appointed full professor in Translational Cardiology in 2004 and head of the department in 2005. The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. He was funded by various national and international foundations. Thus far (2017) he published more than 700 peer reviewed papers and 11 books

Side Activities

  •                                    

    • Member of the Scientific Board, Netherlands Heart Institute                                                                                         
    • Chairman Steering committee Heart and Vascular Center                                                                             

Fellowship and Awards

  •  

    Honors

    • Fellow of the European Society of Cardiology, 2000
    • Honorary Professor Yantai Yuhuangding Hospital, China, 2007
    • Visiting Professor Harvard University, USA, 2007-2009
    • Romanian Academy of Medical Sciences (Honorary Foreign Fellow), 2009
    • Visiting Professor Rose Weiss Lahey Hospital & Medical Center, USA, 2014

     

    Research grants obtained 

    • NATO Collaborative Research Grant. 1996-1997. Travel grant for collaboration with Robert S. Kass, University of Columbia, New York USA. "Expression of min K channels in heart".
    • The Netherlands Heart Foundation: 1997-1999. "The characterization of the regulatory sequence of the atrial myosin light chain 2 gene".

    • NIH: "The role of the min K gene". Grant with R.S. Kass.

    • The Netherlands Heart Foundation: “Hypertrophic cardiomyopathy: early non-invasive identification of altered myocardial mechanics and coronary flow” (nr. 99.203) with A.C. van Rossum, VU Amsterdam.

    • The Netherlands Heart Foundation: “Characterization of the effects of estrogen on cardiac function under pathophysiologic conditions” (nr. 99.114)

    • The Netherlands Heart Foundation: “Elucidation of pathogenic genetic pathways in the hypertrophic and failing heart by micro-array-technology” (nr. 99.122) with H. Smeets, University Maastricht.

    • Jan Dekkerstichting en dr. Ludgardine Bouwmanstichting: “Adenovirale gentherapie voor boezemfibrilleren” (nr. 99-04)

    • The Netherlands Heart Foundation: “Inhibition of myocardial hypertrophy and dilatation by viral mediated blockade of intracellular signaling pathways” (nr. 2000.160)

    • ICIN: Molecular genetic basis of cardiovascular disease (2000)

    • ICIN: Human genetics and cardiovascular developement (2000)

    • NHS: Dekker program: Vanessa van Empel (2001-2004)

    • STW: Stem cell based cardiomyocyte differentiation and classification in 3 D cultures (2003)

    • BSIK: Weefsel op maat (2003)

    • Bekales Research Grant – Cardiology 2004, candidature.

    • Bekales Research Grant (2005)

    • NHS: Translational medicine: stem cell applications (2006)

    • ICIN: Stem cells from patients with genetic cardiac disease (2007)

    • BMM: SMARTCARE: cardiac repair with microtissues (2008)

    • NIRM: Stem cells as disease models (2009)

    • ZonMw: TAS (Translationeel Adult Stamcelonderzoek) Cardiomyocyte progenitor cells for clinical application in cardiac repair (2011-2015)
      Phase A1 preclinical PL €300.000 (total project  €2.0M)

    • CVON: HUSTCARE: HUman STem cells for CArdiac Repair (2012-2017)
      (Total project 0,5M)

    • CAS-NW Program: Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathie (Total project 450K)

    • Leducq (Total project 6 M€) (2018)

    • RegMed: Cardiovascular Moonshot (4 M€) (2018)

Research Output (681)

Randomised comparison of a balloon-expandable and self-expandable valve with quantitative assessment of aortic regurgitation using magnetic resonance imaging

Kooistra N H M, Abawi M, Voskuil M, Urgel K, Samim M, Nijhoff F, Nathoe H M, Doevendans P A F M, Chamuleau S A J, Leenders G E H, Leiner T, Abrahams A C, van der Worp H B, Agostoni P, Stella P R 3 apr 2020, In: Netherlands Heart Journal. 28 , p. 253-265 13 p.

Cardiovascular adverse events in patients with non-Hodgkin lymphoma treated with first-line cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP with rituximab (R-CHOP):a systematic review and meta-analysis

Linschoten Marijke, Kamphuis Janine A M, van Rhenen Anna, Bosman Laurens P, Cramer Maarten J, Doevendans Pieter A, Teske Arco J, Asselbergs Folkert W 2 mrt 2020, In: Lancet haematology. 7 , p. e295-e308 14 p.

Feasibility and potential benefit of pre-procedural CMR imaging in patients with ischaemic cardiomyopathy undergoing cardiac resynchronisation therapy

Gathier W. A., Salden O. A.E., van Ginkel D. J., van Everdingen W. M., Mohamed Hoesein F. A.A., Cramer M. J.M., Doevendans P. A., Meine M., Chamuleau S. A.J., van Slochteren F. J. 1 feb 2020, In: Netherlands Heart Journal. 28 , p. 89-95 7 p.

High intensity interval training after cardiac resynchronization therapy:An explorative randomized controlled trial

Spee Ruud F., Niemeijer Victor M., Schoots Thijs, Tuinenburg Anton, Houthuizen Patrick, Wijn Pieter F., Doevendans Pieter A., Kemps Hareld M. 15 jan 2020, In: International Journal of Cardiology. 299 , p. 169-174 6 p.

Cancer Therapy-Related Cardiac Dysfunction of Nonanthracycline Chemotherapeutics. What Is the Evidence?

Kamphuis Janine, Linschoten Marijke, Cramer Maarten J, Gort Eelke, van Rhenen Anna, Asselbergs Folkert, Doevendans PA, Teske Arco 1 dec 2019, In: JACC. Cardio Oncology. 1 , p. 280-290 10 p.

Are there gender disparities in symptom presentation or triage of patients with chest discomfort at primary care out-of-hours services?:An observational study

van der Meer Manon G, Appelman Yolande, Rutten Karlijn H G, van der Graaf Yolanda, Nathoe Hendrik M, Doevendans Pieter A, Smit Michelle, Verheij Emmy, Botermans Anne, Rutten Frans H 19 nov 2019, In: BMJ Open. 9

Impact of baseline cigarette smoking status on clinical outcome after transcatheter aortic valve replacement

Abawi Masieh, van Gils Lennart, Agostoni Pierfrancesco, van Mieghem Nicolas M., Kooistra Nynke H. M., van Dongen Charlotte S., van Jaarsveld Romy C., de Jaegere Peter P. T., Doevendans Pieter A. F. M., Stella Pieter R. 15 nov 2019, In: Catheterization and Cardiovascular Interventions. 94 , p. 795-805 11 p.

Survival analysis of patients with rheumatic MS after PBMV compared with MVS in a low-to-middle-income country

Ambari A. M., Setianto B., Santoso A., Dwiputra B., Radi B., Alkatiri A. A., Adji A. B., Susilowati E., Tulrahmi F., Cramer M. J.M., Doevendans P. A. nov 2019, In: Netherlands Heart Journal. 27 , p. 559-564 6 p.

Coronary microvascular function in athletes with abnormal exercise test results

van de Sande D. A.J.P., Barneveld P. C., Hoogsteen J., Doevendans P. A., Kemps H. M.C. 25 okt 2019, In: Netherlands Heart Journal. 27 , p. 621-628 8 p.

Evaluation of Disease Progression in Arrhythmogenic Cardiomyopathy:The Change of Echocardiographic Deformation Characteristics Over Time

Taha Karim, Mast Thomas P, Cramer Maarten J, van der Heijden Jeroen F, Asselbergs Folkert W, Doevendans Pieter A, Teske Arco J 11 okt 2019, In: JACC. Cardiovascular imaging. 13 , p. 631-634 4 p.

All Research Output (681)
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