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Busulfan_English
Busulfan_English
Bepaling
Busulfan
| Synonyms: | Busilvex, Myleran |
|---|---|
| Sampling tube | EDTA/2 mL (without gel!) |
| Volume: | Minimal: 0,5 ml plasma |
| Administation and Sampling: | Click below to download the full Dosing, Administrating and Sampling protocol of Busulfan at the UMC Utrecht. Busulfan English |
| Verzendcondities: | Send the plasma samples on dry ice via overnight delivery to the UMC Utrecht pharmacology lab (see Address) |
| Storage conditions: | Plasma; -20 °C |
| Method: | LC-MS/MS |
| Frequency: | On request |
| Form: | Please fill out our digital form. Click here |
| Address: | Please copy this exact Dutch text: UMC Utrecht CDL lokatie G.03.330 Materiaal t.a.v. Laboratorium Apotheek Heidelberglaan 100 3584 CX Utrecht Nederland |
| Contacts: | Kim van der Elst, Clinical Pharmacist |
| References: | [1] Bartelink IH, Bredius RG, Belitser SV, Suttorp MM, Bierings M, Knibbe CA, et al. Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematologic stem cell transplantation. Biol Blood Marrow Transplant 2009 Feb;15(2):231-41. [2] Andersson BS, de LM, Thall PF, Wang X, Couriel D, Korbling M, et al. Once daily i.v. busulfan and fludarabine (i.v. Bu-Flu) compares favorably with i.v. busulfan and cyclophosphamide (i.v. BuCy2) as pretransplant conditioning therapy in AML/MDS. Biol Blood Marrow Transplant 2008 Jun;14(6):672-84. [3] Geddes M, Kangarloo SB, Naveed F, Quinlan D, Chaudhry MA, Stewart D, et al. High busulfan exposure is associated with worse outcomes in a daily i.v. busulfan and fludarabine allogeneic transplant regimen. Biol Blood Marrow Transplant 2008 Feb;14(2):220-8. [4] Bartelink I.H., Flinsenberg TWH, Versluys C.A., Lindemans C.A., Bierings M., Boelens J.J. Busulfan + Fludarabine: an effective and low toxic conditioning regimen prior to HSCT in children with either malignant or non-malignant diseases. Biology of Blood and Marrow Transplantation 17. 2-19-2011. Ref Type: Abstract [5] I.H. Bartelink, J.J. Boelens, R.G.M. Bredius, A.C.G. Egberts, C. Wang, M.B. Bierings, P.J. Shaw, C.E. Nath, G. Hempel, J. Zwaveling, M. Danhof, C.A.J. Knibbe Body weight-dependent pharmacokinetics of busulfan in pediatric hematopoietic stem cell transplantation patients: towards individualized dosing, Clin Pharmacokinet. 2012 May 1;51(5):331-45. |
| Last check: | 25/08/2022 |
| Quality system: | ISO 15189 (M219), KF.TDM.02 |