Prof. dr. D.J. de Wildt

Wetenschappelijk onderzoek

Expertise Cardiovasculaire Farmacologie.
De aandachtsvelden hierbij zijn (geweest):

• Centrale cholinerge regulatie van de bloeddruk
• Cardiovasculaire bijwerkingen van kinkhoestvaccin.
• Cardiovasculaire intoxicaties (thioridazine, :-blokkers, fluoride).
• Ontwikkeling atherosclerose modellen voor de screening van atherogeneen anti-atherogene stoffen.
• Septische shock: modellen en therapie.
• Ontwikkeling cerebrale ischemie modellen in de rat en therapeutische interventies.
• Cardiovasculaire werking melanotropinen.
• Cardiovasculaire oorzaken en therapie van diabetische neuropathie.

Publicaties

• Middle cerebral artery occlusion in Wistar and Fischer-344 rats; functional and morphological assessment of the model. J. CerebralBlood Flow and metabolism 16(2):296-3021996

• Dynamics of cerebral tissue injury and perfusion after temporary hypoxia-ischemia in the rat: evidence for region-specific sensitivity and delayed response Stroke 29(3): 695-704 1998

• ACE inhibitor induced angioedema. Drug Safety 1998;18(3):171-188

• Melanocortins and cardiovascular regulation. European J.Pharmacol.360(1):1-14 1998

• Relevance of the C-terminal Arg-Phe sequence in gamma(2)-melanocyte-stimulating hormone for inducing cardiovascular effetcs inconscious rats Brit. J. of Pharmacol. 131(7): 1468-74 2000

• Pertussis toxin-induced histamine sensitisation: an aspecific phenomenon independent from nitric oxide European J. Pharmacol.493(1-30)139-50 2004
• In vivo cardiovascular reactivity and baroreflex activity in diabetic rats. Cardiovascular Research 38(3) 763-71 1998.