Jeanine Prompers
Jeanine Prompers
The mission of my research is to develop and apply advanced Magnetic Resonance Spectroscopy (MRS) and Magnetic Resonance Imaging (MRI) methods for better understanding of disease mechanisms and to provide handles for improving disease diagnostics and therapy. I focus on the study of derangements in metabolism and mitochondrial function in metabolic disorders, in particular the metabolic syndrome and its complications, such as type 2 diabetes, fatty liver disease and cardiovascular disease. I combine pre-clinical studies in small animal models of human disease with translational research in patients. For the latter, I am involved in the development of world’s first dedicated whole-body 7 Tesla MR scanner for metabolic imaging (META-scan) in humans. This creates unique opportunities for new metabolic imaging applications, such as 31P MRS imaging of cardiac energy status and deuterium (2H) metabolic imaging of glucose metabolism in the liver (see pictures). In addition, I apply ultra-high field MRI (22.3 T, uNMR-NL facility) to study very small model systems, such as organoids and zebrafish. I am also setting up a research line in the field of Image Based Regenerative Medicine. The goal is to develop innovative MRI methods to non-invasively monitor the success of cardiac regenerative therapies.
Contact
Email: j.j.prompers@umcutrecht.nl
Phone: 088-7556674
Keywords research
Metabolic imaging, magnetic resonance spectroscopy, magnetic resonance imaging, diabetes, fatty liver disease, heart failure, mitochondrial function, cardiac energetics, lipid metabolism, carbohydrate metabolism
Research topic
Metabolic imaging
Type of research
Pre-clinical and clinical
Collaborations / partnerships
National:
- UMC Utrecht
- UMC Groningen
- Maastricht UMC
- Eindhoven UT
- Amsterdam UMC
- Maxima MC
- Leiden UMC
- Radboud UMC
- Utrecht University
- Hubrecht Institute
International:
- Mount Sinai School of Medicine, USA
- University of Oxford, UK
- University of Liverpool, UK
- Yale University School of Medicine, USA
- Yale University School of Medicine, USA
- University Hospital of Münster, Germany
- European Institute for Mol. Imaging, Germany
Links Public Private Partners:
- Philips Healthcare
- WaveTronica
- AR Benelux