N. Charlotte Onland-Moret
My research focusses on sex-differences in disease risk, with a special focus on reproductive risk factors in the etiology of disease. Early and late menarche, polycystic ovary symdrome, pregnancy related complications, parity, early age at menopause all increase the risk of cardiometabolic diseases in observational studies. However, the mechanisms explaining this female risk profile and whether this profile is indeed female-specific, or whether we can only measure it better in women, is largely unknown. Using –omics data, ranging from genomics to proteomics, I try to understand these mechanisms. Using both Mendelian randomization studies, the exposome approach and the meet-in-the-middle approach, I try to unravel these mechanisms on the one hand, and also search for the drivers that can affect these risk factors. Hopefully, this will lead to better prevention and treatment of cardiometabolic diseases in women.
Contact:
Email: n.c.onland@umcutrecht.nl;
Phone: 088-7569610
Keywords
sex-differences, reproductive risk factors, seks-steroids, female, Mendelian Randomization, -omics, epidemiology
Research topic
Sex-differences in disease risk
Type of research
- Fundamental datascience
- Clinical research
Collaborations
I collaborate with many scientist that participate in EPIC (the European Investigation into Cancer and Nutrition), mostly in Imperial College Londen, Cambridge, Oxford, IARC Lyon.