p120-catenin as Tumour Suppressor p120-catenin as Tumour Suppressor
p120 is a breast tumor suppressor. Our research has shown that dual somatic inactivation of p120 and p53 in the mouse mammary gland leads to high grade and invasive metaplastic carcinoma. While the common denominator of either E-cadherin or p120 inactivation is loss of cell-cell adhesion and metastasis, the phenotypic outcome when ablating p120 is dissimilar.
Also, the downstream biochemistry and consequences for the cytoskeleton is different in p120 knockout versus E-cadherin knockout mice. We are trying to understand the biochemical and cellular consequences of p120 loss in breast cancer, which affects 30% of all breast cancer patients.
Loss of p120 leads to metaplastic triple negative breast cancer (TNBC) with an inflammatory micro environment. Shown are p120 positive IDC and p120 negative TNBC. Note the massive influx of CD68 positive macrophages.