Cardiac Implantable Electronical Devices in Advanced Heart Failure
Cardiac Implantable Electronical Devices in Advanced Heart Failure
Research Topics uitklapper, klik om te openen
Thee research in this theme is focused on the treatment of heart failure with cardiac implantable electronic devices (CIED). It can be divided in the following three topics:
1. Prevention of ventricular tachyarrhythmias
In collaboration with the Department of Medical Physiology we elaborate the mechanism of arrhythmias in the remodeled heart and develop new techniques which were implemented into implantable cardioverter / defibrillators to predict and prevent ventricular arrhythmias in heart failure patients.
2. Imaging guided pacemaker implantation
We want to improve cardiac resynchronization therapy (CRT) by enhanced patient selection and MRI targeting left ventricular lead placement in collaboration with the cardiac imaging group
3. Remote patient monitoring.
In an international multicenter randomized trial (Remote CIED) we showed the usefulness of remote patient monitoring of heart failure patients with implantable cardioverter/defibrillator (ICD). The future plan is to combine remote patient monitoring with self-care management of heart failure patients with an ICD
Key Publications uitklapper, klik om te openen
- Versteeg H; Timmermans I; Widdershoven J; Kimman GJ; Prevot S; Rauwolf T; Scholten MF; Zitron E; Mabo P; Denollet J; Pedersen SS; Meine M. Effect of remote monitoring on patient-reported outcomes in European heart failure patients with an implantable cardioverter-defibrillator: primary results of the REMOTE-CIED randomized trial. Europace 2019;21(9):1360-1368.
- van Everdingen WM; Zweerink A; Salden OAE; Cramer MJ; Doevendans PA; Engels EB; van Rossum AC; Prinzen FW; Vernooy K; Allaart CP; Meine M. Pressure-Volume Loop Analysis of Multipoint Pacing With a Quadripolar Left Ventricular Lead in Cardiac Resynchronization Therapy. JACC: Clinical Electrophysiology. 2018;4(7):881-889.
- Salden OAE, van Stipdonk AMW, den Ruijter HM, Cramer MJ, Kloosterman M, Rienstra M, Maass AH, Prinzen FP, Vernooy K, Meine M. Heart size corrected electrical dyssynchrony and its impact on sex-specific response to cardiac resynchronization therapy. Circulation A&E. 2021;14(1):76-85. https://doi.org/10.1161/CIRCEP.120.008452.
- Salden OAE; van den Broek HT; van Everdingen WM; Mohamed Hoesein FAA; Velthuis BK; Doevendans PA; Cramer MJ; Tuinenburg AE; Leufkens P; van Slochteren FJ; Meine M. Multimodality imaging for real-time image-guided left ventricular lead placement during cardiac resynchronization therapy implantations. International Journal of Cardiovascular Imaging. 2019; 35(7):1327-1337.
- Wijers SC; Sprenkeler DJ; Bossu A; Dunnink A; Beekman JDM; Varkevisser R; Hernández AA; Meine M; Vos MA. Beat-to-beat variations in activation-recovery interval derived from the right ventricular electrogram can monitor arrhythmic risk under anesthetic and awake conditions in the canine chronic atrioventricular block model. Heart Rhythm. 2018;15(3):442-448
People Involved uitklapper, klik om te openen
Contact uitklapper, klik om te openen
Mathias Meine, m.meine@umcutrecht.nl