Extracellular Vesicle-Based Therapeutics
Extracellular Vesicle-Based Therapeutics
Our main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer.
Key Publications uitklapper, klik om te openen
Functional siRNA Delivery by Extracellular Vesicle-Liposome Hybrid Nanoparticles. Evers MJW, van de Wakker SI, de Groot EM, de Jong OG, Gitz-François JJJ, Seinen CS, Sluijter JPG, Schiffelers RM, Vader P. Adv Healthc Mater. 2021 Aug 11:e2101202.
Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles. Murphy DE, de Jong OG, Evers MJW, Nurazizah M, Schiffelers RM, Vader P. Nano Lett. 2021 Feb 24;21(4):1888-1895.
A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA. de Jong OG, Murphy DE, Mäger I, Willms E, Garcia-Guerra A, Gitz-Francois JJ, Lefferts J, Gupta D, Steenbeek SC, van Rheenen J, El Andaloussi S, Schiffelers RM, Wood MJA, Vader P. Nat Commun. 2020 Feb
People Involved uitklapper, klik om te openen
Postdocs
Dr. Maria Laura Tognoli, Dr. Sander Kooijmans, Dr. Tom Driedonks
PhD Students
Omnia Elsharkasy, Willemijn de Voogt, Diego Aguilar Rodriguez, Luuk van de Schepop
Technicians
Jerney Gitz, Cor Seinen
Contact uitklapper, klik om te openen
Dr. Pieter Vader, pvader@umcutrecht.nl