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Group van Loosdregt-Vastert
Group van Loosdregt-Vastert

About

Together Jorg van Loosdregt (fundamental scientists) and Bas Vastert (pediatric rheumatologist/scientist) lead the pediatric rheumatology translational research group in the University Medical Center Utrecht (The Netherlands). Our mission is to increase our understanding of the molecular mechanisms underlying Juvenile Idiopathic Arthritis (JIA), and translating these findings into novel therapeutics. JIA is a disease that affects 1/1000 children and can lead to impaired severe loss of quality of life. Our group combines both fundamental and clinically orientated research projects. We believe that bringing these fields of research, and researchers, together facilitates translational research allowing for more efficient transition of experimental findings to the clinic.

Research programs

Infection and Immunity
Child Health

 

Research interests

Epigenetics and transcriptomics in JIA
Identification of therapeutic targets for JIA treatment
Clinical trials to improve JIA treatment and care

Contacts

Jorg van Loosdregt

Email

Bas Vastert

Email

Related websites

Group members

Group leaders: Bas Vastert and Jorg van Loosdregt

Postdoc

Dr. Jorg Calis (affiliated researcher)

Research technicians

Rianne Scholman
Yesper Smits

Clinician-Scientist

Arjen Leek

 

PhD students

Lucas Picavet
Lotte Nijhuis
Ellen van Vroonhoven
Anouk Verwoerd

Students

Sietske Gadella
Janneke Hulsen
Koen Heuvelmans
 

Join our group

PhD positions available

Key Publications

  1. Ter Haar, N. M., et al. (2019). "Treatment to Target Using Recombinant Interleukin-1 Receptor Antagonist as First-Line Monotherapy in New-Onset Systemic Juvenile Idiopathic Arthritis: Results From a Five-Year Follow-Up Study." Arthritis Rheumatol 71(7): 1163-1173. View
  2. Ter Haar, N. M., et al. (2018). "Reversal of Sepsis-Like Features of Neutrophils by Interleukin-1 Blockade in Patients With Systemic-Onset Juvenile Idiopathic Arthritis." Arthritis Rheumatol 70(6): 943-956. View
  3. Peeters, J. G., et al. (2015). "Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression." Cell Rep 12(12): 1986-1996. View
  4. van Loosdregt, J., et al. (2013). "Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity." Immunity 39(2): 259-271. View
  5. van Loosdregt, J., et al. (2013). "Canonical Wnt signaling negatively modulates regulatory T cell function." Immunity 39(2): 298-310. View

PhD theses

Autoinflammation: from monogenic to complex diseases




Nienke ter Haar
2018

Collaborations

Our research acitivities are closely linked to the department of Pediatric Rheumatology and Immunology in the Wilhelmina Children’s Hospital, University Medical Center Utrecht.
 
Within the Center of Translational Immunoloy, we closely collaborate with the group of Femke van Wijk. Together we supervise 1 PhD student in a PhD trajectory on residential T cells in Synovial fluid in JIA.
 
We collaborate with multiple groups in the Netherlands and abroad

 

Grants

   



                    

  

  

  

  


 

Prizes

 

Pediatric Rheumatology European Association - Young Investigator Meeting

Nienke ter Haar Best Basic Presentation (2015, 2018)

Dutch Pediatric Society (NVK) - Young Investigator Prize

Nienke ter Haar 3rd prize (2018)

Pediatric Rheumatology European Association

Lotte Nijhuis Kourir award 2018 for relevant research to patients (2018)

 

In the media

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12 Oct 2018: Het Klokhuis - Jeugdreuma

22 Aug 2016: ReumaNederlands - Jeugdreuma