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Immune Evasion - Group van Strijp
Immune Evasion - Group van Strijp

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Identification of (novel) bacterial proteins and functional characterization of their potential as immune evasion molecule. In the first place these molecules explain why pathogenic bacteria are able to survive and replicate in the human body. Next, they lead researchers directly to key immunological functions. Also they are leads for anti-inflammatory therapy in our Drugs form Bugs program, using structured peptides as mimics. Finally they represent essential virulence factors and therefore prime targets for vaccine strategies and antibody therapy.

Research program

Infection and Immunity

Research interests

Innate immunity
Phagocytes
Bacterial infections
Host-pathogen interaction
Immune-evasion

Contact

Yvonne Hagenaar

Email

Related website

Group members

Postdocs

Dr. András Spaan
Dr. Beatrix Förster-Schäfer
Dr. Carla de Haas
Dr. Daphne Stapels
Dr. Kirsten Koymans
Dr. Kok van Kessel

Research technicians

Adinda Bisschop
Anneroos Velthuizen
Piet Aerts

PhD students

Leonardo Cecotto
Rita Cruz

Manager

Erik Heezius

Secretary

Yvonne Hagenaar

Join our group

Check for availability for bachelor and master level research internships with Kok van kesselor Bart Bardoel  

Key publications

  1. Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings MP, Lina G, Vandenesch F, Van Strijp JAG, Jan Lebbink R, Haas PA, Henry T, Spaan AN. “Human CD45 is an F-component-specific receptor for the staphylococcal toxin Panton-Valentine leukocidin“. Nat Microbiol. 2018 June; 3:708–717 (Pubmed: 29736038) View
  2. de Jong NWM, Ramyar KX, Guerra FE, Nijland R, Fevre C, Voyich JM, McCarthy AJ, Garcia BL, van Kessel KPM, van Strijp JAG, Geisbrecht BV, Haas PA. “Immune evasion by a staphylococcal inhibitor of myeloperoxidase”. Proc Natl Acad Sci USA. 2017 Aug 14. pii: 201707032 (Pubmed: 28808028) View
  3. Koymans KJ, Feitsma LJ, Brondijk TH, Aerts PC, Lukkien E, Lössl P, van Kessel KP, de Haas CJ, van Strijp JA, Huizinga EG. “Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3)”. Proc Natl Acad Sci USA. 2015 Sep 1;112(35):11018-23 (Pubmed: 26283364) View
  4. Vrieling M, Koymans KJ, Heesterbeek DA, Aerts PC, Rutten VP, de Haas CJ, van Kessel KP, Koets AP, Nijland R, van Strijp JA. “Bovine Staphylococcus aureus Secretes the Leukocidin LukMF’ To Kill Migrating Neutrophils through CCR1”. MBio. 2015 Jun 4;6(3):e00335 (Pubmed: 26045537) View
  5. Surewaard BG, Nijland R, Spaan AN, Kruijtzer JA, de Haas CJ, van Strijp JA. “Inactivation of staphylococcal phenol soluble modulins by serum lipoprotein particles”. PLoS Pathog. 2012;8(3):e1002606. (Pubmed: 22457627) View

PhD theses

The art of Phospholipase A2-IIA: New insights into the host-pathogen battle

Vincent P. van Hensbergen
2019