Neutrophil study

This project has started in the Meyaard/Bont translation research team in 2014. PhD student Ruben Geerdink aims to elucidate the function of the inhibitory immune receptors on neutrophils and probe the potential as therapeutic to prevent neutrophil mediated pathology. Neutrophils are essential innate mediators of antimicrobial defense, but their actions are invariably accompanied by collateral tissue damage. In the lower airways of respiratory syncytial virus (RSV)-induced bronchiolitis patients, neutrophils constitute the majority of cells (>75%), exacerbating pathology.

Despite a large medical need, no effective treatment is currently available to regulate neutrophil activity and reduce collateral tissue damage. The hypothesis is that inhibitory receptors may be functional receptors on tissue lung neutrophils and represents a novel target to prevent neutrophil-mediated lung damage in children suffering RSV bronchiolitis. For this work, Geerdink will use animal models, including relevant mouse models with targeted deletion of inhibitory receptors as well as human data.

Despite a large medical need, no effective treatment is currently available to regulate neutrophil activity and reduce collateral tissue damage. The hypothesis is that inhibitory receptors may be functional receptors on tissue lung neutrophils and represents a novel target to prevent neutrophil-mediated lung damage in children suffering RSV bronchiolitis. For this work, Geerdink will use animal models, including relevant mouse models with targeted deletion of inhibitory receptors as well as human data.

This project has started in the Meyaard/Bont translation research team in 2014. PhD student Ruben Geerdink aims to elucidate the function of the inhibitory immune receptors on neutrophils and probe the potential as therapeutic to prevent neutrophil mediated pathology. Neutrophils are essential innate mediators of antimicrobial defense, but their actions are invariably accompanied by collateral tissue damage. In the lower airways of respiratory syncytial virus (RSV)-induced bronchiolitis patients, neutrophils constitute the majority of cells (>75%), exacerbating pathology.

Despite a large medical need, no effective treatment is currently available to regulate neutrophil activity and reduce collateral tissue damage. The hypothesis is that inhibitory receptors may be functional receptors on tissue lung neutrophils and represents a novel target to prevent neutrophil-mediated lung damage in children suffering RSV bronchiolitis. For this work, Geerdink will use animal models, including relevant mouse models with targeted deletion of inhibitory receptors as well as human data.

Despite a large medical need, no effective treatment is currently available to regulate neutrophil activity and reduce collateral tissue damage. The hypothesis is that inhibitory receptors may be functional receptors on tissue lung neutrophils and represents a novel target to prevent neutrophil-mediated lung damage in children suffering RSV bronchiolitis. For this work, Geerdink will use animal models, including relevant mouse models with targeted deletion of inhibitory receptors as well as human data.

This project has started in the Meyaard/Bont translation research team in 2014. PhD student Ruben Geerdink aims to elucidate the function of the inhibitory immune receptors on neutrophils and probe the potential as therapeutic to prevent neutrophil mediated pathology. Neutrophils are essential innate mediators of antimicrobial defense, but their actions are invariably accompanied by collateral tissue damage. In the lower airways of respiratory syncytial virus (RSV)-induced bronchiolitis patients, neutrophils constitute the majority of cells (>75%), exacerbating pathology.

This project has started in the Meyaard/Bont translation research team in 2014. PhD student Ruben Geerdink aims to elucidate the function of the inhibitory immune receptors on neutrophils and probe the potential as therapeutic to prevent neutrophil mediated pathology. Neutrophils are essential innate mediators of antimicrobial defense, but their actions are invariably accompanied by collateral tissue damage. In the lower airways of respiratory syncytial virus (RSV)-induced bronchiolitis patients, neutrophils constitute the majority of cells (>75%), exacerbating pathology.