Ophthalmo-Immunology group - Group de Boer-Kuiper


Our mission is to improve the understanding of the mechanisms that lead to human ocular inflammatory disease by investigation of the immune system, locally and systemically. We combine clinical phenotyping and systems immunology to develop tools that allow patient stratification to improve clinical care for patients with inflammatory eye disease. 

Group members

Group leaders

prof. dr. J.H. de Boer

Full Professor

dr. J.J.W. Kuiper

Associate Professor

Research technician

Sanne Hiddingh

Senior researchers

Dr. Rachel Kallman

Dr. Viera Kalinina Ayuso

Dr. Annette Ossewaarde-van Norel

Dr . Robert Wisse

Pro. Dr. Saskia Imhof

PhD students

Kamil Laban

Roos Wennink

Wouter Venema

Anna Brouwer

Evianne de Groot

Lude Moekotte

Carlyn Kouwenberg

Join our group

PhD position

Immunology of age related macula degeneration

Key publications

  1. Verhagen FH, Hiddingh S, Rijken R, Pandit A, Leijten E, Olde Nordkamp M, Ten Dam-van Loon NH, Nierkens S, Imhof SM, de Boer JH, Radstake TRDJ, Kuiper JJW. High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis.Front Immunol. 2018 Oct 31;9:2519. View
  2. Haasnoot AJW, Schilham MW, Kamphuis S, Hissink Muller PCE, Heiligenhaus A, Foell D, Minden K, Ophoff RA, Radstake TRDJ, Den Hollander AI, Reinards THCM, Hiddingh S, Schalij-Delfos NE, Hoppenreijs EPAH, van Rossum MAJ, Wouters C, Saurenmann RK, van den Berg JM, Wulffraat NM; ICON-JIA Study Group, Ten Cate R, de Boer JH, Pulit SL, Kuiper JJW. Identification of an Amino Acid Motif in HLA-DRβ1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2018 Jul;70(7):1155-1165. View
  3. Kuiper JJW, Setten JV, Devall M, Cretu-Stancu M, Hiddingh S, Ophoff RA, Missotten TOAR, Velthoven MV, Den Hollander AI, Hoyng CB, James E, Reeves E, Cordero-Coma M, Fonollosa A, Adán A, Martín J, Koeleman BPC, Boer JH, Pulit SL, Márquez A, Radstake TRDJ. Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis. Hum Mol Genet. 2018 Dec 15;27(24):4333-4343. View
  4. Hettinga YM, van Genderen MM, Wieringa W, Ossewaarde-van Norel J, de Boer JH. Retinal Dystrophy in 6 Young Patients Who Presented with Intermediate Uveitis. Ophthalmology. 2016 Sep;123(9):2043-6. View
  5. Haasnoot AM, Kuiper JJ, Hiddingh S, Schellekens PA, de Jager W, Imhof SM, Radstake TR, de Boer JH. Ocular Fluid Analysis in Children Reveals Interleukin-29/Interferon-λ1 as a Biomarker for Juvenile Idiopathic Arthritis-Associated Uveitis. Arthritis Rheumatol. 2016 Jul;68(7):1769-79. View


Kinderimmunology WKZ

Bartimeus, Zeist

Prof. Dr. M.M. van Genderen, UMCU/Bartimeus

E-NED European Network for ERAP biology in Health and Disease

Participation in COST network application COMET


> See all grants 


N.W.O. ZonMW Veni Program

Most innovative research, International Ocular inflammation Society, Lausanne 2016

(Young Investigator) Bayer Ophthalmology Research Award 2015/ 2017 /2018

Education & Courses

Eilanddagen uveitis, back to basic and beyond Uveitis course (Slovenia)

11-13 June 2020, Uveitis Eillanddagen. Schiermonnikoog 2020
14-16 May 2020, Portoroz

Research program

  Infection and Immunity


Joke de Boer

Jonas Kuiper


Research interests

  • Non-infectious uveitis
  • Pediatric uveitis (e.g. JIA-associated uveitis)
  • Systems Immunology of eye inflammation
  • ERAP and MHC-I-opathy associated uveitis
  • Orbital inflammation
  • Corneal inflammatory Eye diseases
  • Immunology of genetic retinal dystrophy
  • Immunology of age related macula degeneration
  • Infectious eye diseases