Newsletter I&I nieuws
Jun 10: Pathophysiology of systemic sclerosis further elucidated
In his PhD research, Andrea Ottria explored the augmented production of CXCL4 and its role in aberrant fibrogenesis in patients with Systemic sclerosis (SSc). Moreover, the metabolic status of fat biology in pathophysiology of SSc was further inquired. Ottria found several mechanisms thought to be responsible for reduction of pro-inflammatory cytokine production in patients with SSc.
Read moreJun 8: Marie Curie grant for Jonas Kuiper
Translational investigator Jonas Kuiper (CTI and department of Ophthalmology) recently received a prestigious Marie Curie grant, sponsored by the European Commission.
Read moreMay 28: Quantification of therapeutic antibodies and endogenous proteins
Use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) equipment in combination with adequate sample preparation allows for measurement of therapeutic as well as endogenous proteins with high accuracy and specificity. This was the main conclusion of Mohsin El Amrani (Department of Clinical Pharmacy) in his thesis on basis of which he received his PhD on May 28 in Utrecht.
Read moreMay 19: Keeping antibiotic resistance at bay
The human body is colonized with millions of bacteria, which are usually innocent. These bacteria can also cause infections, prompting antibiotic treatment. Bacteria can become resistant to certain types of antibiotics. An important tool to monitor and control antibiotic resistance is surveillance, according to Denise van Hout (Julius Center) who investigated for her PhD project several aspects of hospital surveillance of antimicrobial resistance.
Read moreMay 13: Viral evasion of the MHC class I antigen presentation pathway
Herpesviruses use a broad set of immune modulating mechanisms to escape the immune system, causing lifelong infections with these viruses. Human herpesviruses are associated with a wide variety of diseases. In this ‘digital I&I PhD defense’, Patrique Praest (Department of Medical Microbiology) presented newly identified interactions between viral evasins and host proteins and tried to understand how these evasins influence essential processes in the host.
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