Infection and Immunity nieuws
Sep 9: Anti-apoptotic proteins potential therapeutic target for multiple myeloma
Inhibition of MCL-1, an anti-apoptotic protein, is a promising therapeutic strategy in the treatment of multiple myeloma. Moreover, amplification of locus 1q21 may have diagnostic potential as a marker to predict MCL-1 inhibitor sensitivity in patients with multiple myeloma. These were the main conclusions drawn by Anne Slomp who defended her PhD research on September 9 in Utrecht.
Read moreSep 2: Study into the use of the BCG vaccine against the effects of COVID-19 in frail elderly
In the Netherlands, a large-scale study will start this week in 22 hospitals, including all university medical centers and the Santeon hospitals, investigating whether the vaccine against tuberculosis (the BCG vaccine) offers protection against the consequences of an infection with the coronavirus in frail elderly people. The Ministry of Health, Welfare and Sport considers this research of significant importance and has therefore asked ZonMw to include it as an urgent project in the research program for COVID-19. The study is coordinated by UMC Utrecht.
Read moreSep 2: Corticosteroids Improve Survival in Critically Ill COVID-19 Patients
In a tremendous demonstration of global collaboration, clinician-scientists have pooled data from 121 hospitals in eight countries to find that inexpensive, widely available steroids improve the odds that very sick COVID-19 patients will survive the illness. The findings were made through the “Randomized Embedded Multifactorial Adaptive Platform-Community Acquired Pneumonia” (REMAP-CAP) trial and are reported today in JAMA as part of a four-article package. The WHO is updating its COVID-19 treatment guidance as a result.
Read moreAug 30: UMC Utrecht starts Phase 2a study with COVID-19 vaccine
UMC Utrecht is one of three study centers in the Netherlands where as of September 2 onwards 135 participants can participate in a Phase 2a study with the Janssen Vaccines candidate vaccine against COVID-19.
Read moreAug 27: Two-day provocation test for peanut allergy is often unnecessary
Proper diagnosis of peanut allergy in children currently takes a two-day provocation test. PhD research by Hannah Kansen at UMC Utrecht shows that for some children a blood test is sufficient, for others a blood test and a one-day provocation test are sufficient. This is a considerably lower burden for the children and their parents and is a lot cheaper. These results will lead to an adjustment of the national guideline.
Read moreAug 6: Research on corona in secondary schools
Many people in small spaces, ventilation that is not optimal ... Secondary schools can pose a risk for the spread of COVID-19. UMC Utrecht will conduct research into this together with TU Delft, Erasmus MC and IRAS.
Read moreJul 31: International study with BCG vaccine against COVID-19 among health care workers also starting in the Netherlands
A large international investigation into the possible protective effect of the BCG vaccine against COVID-19 has now also started in the Netherlands. The Dutch part of the study, in which 2,000 healthcare employees can participate, is coordinated by UMC Utrecht and Radboudumc.
Read moreJul 22: Self-imposed measures and governmental interventions may halt spread of COVID-19
A modelling study performed at UMC Utrecht indicates that self-imposed prevention measures (handwashing, wearing face masks, social distancing) as well as governmental interventions (e.g. closure of restaurants and bars, cancellation of mass events) may significantly contribute to tackling the spread of COVID-19. Increasing disease awareness among the general public is essential for controlling the ongoing pandemic and preventing a 2nd wave of infections.
Read moreJul 2: Platelets involved in coagulation ánd host defence
Platelets are not only involved in blood coagulation and the development of thrombosis. Researchers from Utrecht University, UMC Utrecht and Erasmus MC have now discovered that they also play a role in our immune system: they appear to be indispensable in protecting our respiratory system against pathogens. "In patients with flu, the platelets absorb virus particles from the lungs, after which they return to the bloodstream”, says lead researcher Erhard van der Vries. This insight is also important for research into coagulation and acute cardiovascular problems in corona patients, such as strokes and blood clots in the pulmonary vessels.
Read moreJun 30: The accelerated search for a COVID-19 drug
In previous virus outbreaks, the search for effective medication often only started when the epidemic was over. Partly thanks to the REMAP-CAP research, this is now earlier possible. How far-sightedness after the Mexican flu in 2009 made it possible to start testing medicines for COVID-19 shortly after the outbreak. "If things go well, we will learn how to treat patients during the pandemic."
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