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prof. dr. R.J. (Jeroen) Pasterkamp

Full Professor
prof. dr. R.J. (Jeroen) Pasterkamp
  • Translational Neuroscience

Biography

Biography

Jeroen Pasterkamp obtained his PhD degree at the Netherlands Institute for Brain Research and the Vrije Universiteit in Amsterdam with Joost Verhaagen and Dick Swaab. He carried out postdoctoral research at the Department of Neuroscience of the Johns Hopkins University School of Medicine in Baltimore, USA. In 2005, he joined the Department of Translational Neuroscience of the Brain Center Rudolf Magnus, where he is currently appointed as a professor of translational neuroscience.

His research focuses on understanding 1) the signaling events and molecular mechanisms involved in the formation of neuronal connections during development, and 2) the molecular mechanisms underlying changes in or loss of neuronal connectivity during neurological disease (in particular amyotrophic lateral sclerosis (ALS) and epilepsy). This research concentrates on mouse models and humanized cell models (iPSC) using an integrated approach involving molecular biology, cell biology, neuroanatomy, (in vivo) functional proteomics, imaging, HC screening, and mouse genetics.

His work was published in leading journals such as Cell, Journal of Neuroscience, Nature, Nature Genetics, PNAS and he regularly contributes reviews to Current Opinion, Trends and Nature Reviews journals.

Jeroen Pasterkamp is a recipient of a NARSAD Young Investigator, and a Dan Nathans Young Investigator Award. He is a member of the Scientific Advisory board of the Dutch National Epilepsy Fund (NEF) and the Dutch Society for Developmental Biology. He organizes scientific meetings under the framework of the Royal Netherlands Academy of Arts and Sciences (KNAW), EMBO, and Utrecht Summerschool series.

Research line

Neural circuit development and Translational neuroscience

Most recent key publications

1. Vangoor VR, Reschke CR, Senthilkumar K, van de Haar LL, de Wit M, Giuliani G, Broekhoven MH, Morris G, Engel T, Brennan GP, Conroy RM, van Rijen PC, Gosselaar PH, Schorge S, Schaapveld RQJ, Henshall DC, De Graan PNE, Pasterkamp RJ (2019) Antagonizing increased miR-135a levels at the chronic stage of experimental TLE reduces spontaneous recurrent seizures. J Neurosci 39, 5064-5079.
 
2. Ormel PR, Vieira de Sá R, van Bodegraven EJ, Karst H, Harschnitz O, Sneeboer MAM, Johansen LE, van Dijk RE, Scheefhals N, Berdenis van Berlekom A, Ribes Martínez E, Kling S, MacGillavry HD, van den Berg LH, Kahn RS, Hol EM, de Witte LD, Pasterkamp RJ (2018) Microglia innately develop within cerebral organoids. Nat Commun 9, 4167.
 
3. Jongbloets BC, Lemstra S, Schellino R, Broekhoven MH, Parkash J, Hellemons AJ, Mao T, Giacobini P, van Praag H, De Marchis S, Ramakers GM, Pasterkamp RJ (2017) Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nat Commun 8:14666.
 
4. Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ*, Jones EY* (2016). Structural Basis for Plexin Activation and Regulation. Neuron 91, 548-60. *Shared senior authors.
 
5. Harschnitz O, van den Berg LH, Johansen LE, Jansen MD, Kling S, Vieira de Sá R, Vlam L, van Rheenen W, Karst H, Wierenga CJ, Pasterkamp RJ*, van der Pol WL* (2016). Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model. Ann Neurol 80, 71-88. *Shared senior authors.
 
6. Van Erp S, van den Heuvel DMA, Fujita Y, Robinson R, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers J, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ (2015) Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases. Dev Cell 35, 537-552.

Side Activities

  • None.

Fellowship and Awards

  • VICI, 2015
    ZonMW TOP, 2008
    VIDI, 2006
    HFSP career development award, 2005
    VENI, 2004
    NWO Talent, 2000

Research Output (144)

How the COVID-19 pandemic highlights the necessity of animal research (vol 30, pg R1014, 2020):How the COVID-19 pandemic highlights the necessity of animal research (Current Biology (2020) 30(18) (R1014–R1018), (S0960982220311842), (10.1016/j.cub.2020.08.030))

Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen J.J.P., Blokland Arjan, Boddeke Erik H.W.G.M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C.J.J., van Dam Anne Marie, Deen Peter M.T., van Dijk K. W., Eggen Bart J.L., Elgersma Ype, Erdogan Izel, Englitz Bernhard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes J.A.G., Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A.B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer Jaap, Kersten Sander, Kiliaan Amanda J., Kooij Taco W.A., Kooijman Sander, Koopman Werner J.H., Lesscher Heidi M.B., Meye Frank J., Mul Joram D., Pasterkamp R. Jeroen, van Rheenen Jacco, Vanderschuren Louk J.M.J., Homberg Judith R., 2 nov 2020, In: Current Biology. 30 , p. 4328-4328 1 p.

How the COVID-19 pandemic highlights the necessity of animal research

Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen, Blokland Arjan, Boddeke Erik H.W.G.M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C.J.J., Dam Anne Marie van, Deen Peter M.T., van Dijk K. W., Eggen Bart J.L., Elgersma Ype, Erdogan Izel, Englitz Bernard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes, Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A.B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer J., Kersten Sander, Kiliaan Amanda J., Kooij Taco W.A., Kooijman Sander, Koopman Werner J.H., Lesscher Heidi, Meye Frank J., Mul Joram D., Pasterkamp R. Jeroen, van Rheenen Jacco, Vanderschuren Louk J.M.J., Homberg Judith R., 21 sep 2020, In: Current Biology. 30 , p. R1014-R1018

A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy

Venø Morten T., Reschke Cristina R., Morris Gareth, Connolly Niamh M.C., Su Junyi, Yan Yan, Engel Tobias, Jimenez-Mateos Eva M., Harder Lea M., Pultz Dennis, Haunsberger Stefan J., Pal Ajay, Heller Janosch P., Campbell Aoife, Langa Elena, Brennan Gary P., Conboy Karen, Richardson Amy, Norwood Braxton A., Costard Lara S., Neubert Valentin, Gallo Federico Del, Salvetti Beatrice, Vangoor Vamshidhar R., Sanz-Rodriguez Amaya, Muilu Juha, Fabene Paolo F., Pasterkamp R. Jeroen, Prehn Jochen H.M., Schorge Stephanie, Andersen Jens S., Rosenow Felix, Bauer Sebastian, Kjems Jørgen, Henshall David C. 7 jul 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117 , p. 15977-15988 12 p.

Nolz1 expression is required in dopaminergic axon guidance and striatal innervation

Soleilhavoup Clement, Travaglio Marco, Patrick Kieran, Garção Pedro, Boobalan Elangovan, Adolfs Youri, Spriggs Ruth V., Moles-Garcia Emma, Dhiraj Dalbir, Oosterveen Tony, Ferri Sarah L., Abel Ted, Brodkin Edward S., Pasterkamp R. Jeroen, Brooks Brian P., Panman Lia 19 jun 2020, In: Nature Communications. 11 , p. 1-17

Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development

Brignani Sara, Raj Divya D A, Schmidt Ewoud R E, Düdükcü Özge, Adolfs Youri, De Ruiter Anna A, Rybiczka-Tesulov Mateja, Verhagen Marieke G, van der Meer Christiaan, Broekhoven Mark H, Moreno-Bravo Juan A, Grossouw Laurens M, Dumontier Emilie, Cloutier Jean-François, Chédotal Alain, Pasterkamp R Jeroen 18 jun 2020, In: Neuron. 107 , p. 684-702

Deciphering the Proteome Dynamics during Development of Neurons Derived from Induced Pluripotent Stem Cells

Varderidou-Minasian Suzy, Varderidou-Minasian Suzy, Verheijen Bert M., Schätzle Philipp, Hoogenraad Casper C., Pasterkamp R. Jeroen, Altelaar Maarten, Altelaar Maarten 5 jun 2020, In: Journal of Proteome Research. 19 , p. 2391-2403 13 p.

Structural basis of semaphorin-plexin cis interaction

Rozbesky Daniel, Verhagen Marieke G., Karia Dimple, Nagy Gergely N., Alvarez Luis, Robinson Ross A., Harlos Karl, Padilla-Parra Sergi, Pasterkamp R. Jeroen, Jones Edith Yvonne 1 jan 2020, In: EMBO Journal. 39

ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization

Tazelaar Gijs H P, Boeynaems Steven, De Decker Mathias, van Vugt Joke J F A, Kool Lindy, Goedee H Stephan, McLaughlin Russell L, Sproviero William, Iacoangeli Alfredo, Moisse Matthieu, Jacquemyn Maarten, Daelemans Dirk, Dekker Annelot M, van der Spek Rick A, Westeneng Henk-Jan, Kenna Kevin P, Assialioui Abdelilah, Da Silva Nica, Povedano Mónica, Pardina Jesus S Mora, Hardiman Orla, Salachas François, Millecamps Stéphanie, Vourc'h Patrick, Corcia Philippe, Couratier Philippe, Morrison Karen E, Shaw Pamela J, Shaw Christopher E, Pasterkamp R Jeroen, Landers John E, Van Den Bosch Ludo, Robberecht Wim, Al-Chalabi Ammar, van den Berg Leonard H, Van Damme Philip, Veldink Jan H, van Es Michael A, 2020, In: Brain communications. 2 , p. 1-13

LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky Nikolaus, Almouzni Geneviève, Gorski Stanislaw A., Aerts Stein, Amit Ido, Bertero Michela G., Bock Christoph, Bredenoord Annelien L., Cavalli Giacomo, Chiocca Susanna, Clevers Hans, De Strooper Bart, Eggert Angelika, Ellenberg Jan, Fernández Xosé M., Figlerowicz Marek, Gasser Susan M., Hubner Norbert, Kjems Jørgen, Knoblich Jürgen A., Krabbe Grietje, Lichter Peter, Linnarsson Sten, Marine Jean Christophe, Marioni John, Marti-Renom Marc A., Netea Mihai G., Nickel Dörthe, Nollmann Marcelo, Novak Halina R., Parkinson Helen, Piccolo Stefano, Pinheiro Inês, Pombo Ana, Popp Christian, Reik Wolf, Roman-Roman Sergio, Rosenstiel Philip, Schultze Joachim L., Stegle Oliver, Tanay Amos, Testa Giuseppe, Thanos Dimitris, Theis Fabian J., Torres-Padilla Maria Elena, van Oudenaarden Alexander, Bruining Hilgo, Jongsma Karin R., Pasterkamp R. Jeroen, van Oudenaarden Alexander, 2020, In: Nature. 587 , p. 377-386 10 p.

TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells

Wu Bin, Blot François Gc, Wong Aaron Benson, Osório Catarina, Adolfs Youri, Pasterkamp R. Jeroen, Hartmann Jana, Becker Esther Be, Boele Henk Jan, De Zeeuw Chris I., Schonewille Martijn 1 sep 2019, In: eLife. 8

All research output