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prof. dr. R.J. (Jeroen) Pasterkamp

prof. dr. R.J. (Jeroen) Pasterkamp

Full Professor
prof. dr. R.J. (Jeroen) Pasterkamp
  • Translational Neuroscience

Biography

Biography

Jeroen Pasterkamp obtained his PhD degree at the Netherlands Institute for Neuroscience and the Vrije Universiteit in Amsterdam with Joost Verhaagen and Dick Swaab. He carried out postdoctoral research at the Department of Neuroscience of the Johns Hopkins University School of Medicine in Baltimore, USA. In 2005, he joined the Department of Translational Neuroscience of the UMC Utrecht, where he is currently appointed as a professor of translational neuroscience. He is chair of the UMC Utrecht Brain Center and head of the Department of Translational Neuroscience.

His research focuses on understanding 1) the signaling events and molecular mechanisms involved in the formation of neuronal connections during development, and 2) the molecular mechanisms underlying changes in or loss of neuronal connectivity during neurological disease (in particular amyotrophic lateral sclerosis (ALS)). This research concentrates on mouse models and humanized cell models (iPSC, organoids, microfluidics) using an integrated approach involving molecular biology, cell biology, neuroanatomy, (in vivo) functional proteomics, imaging, HC screening, and mouse genetics.

His work was published in leading journals such as Cell, Developmental Cell, Neuron, Nature, Nature Communications, and he regularly contributes reviews to Current Opinion, Trends and Nature Reviews journals.

Jeroen Pasterkamp is a recipient of a NARSAD Young Investigator, Dan Nathans Young Investigator Award, and HFSP Career Development Award. He received VENI, VIDI and VICI grants, and is co-leading the NWO Gravitation program BRAINSCAPES. He is a member of the Scientific Advisory board of the Prinses Beatrix Spierfonds and a board member of the Dutch Parkinson Scientists. He organizes scientific meetings under the framework of EMBO and Utrecht Summerschool series.

Research line

Neural circuit development and Translational neuroscience

Most recent key publications

1. Robinson RA, Griffiths SC, van de Haar LL, Malinauskas T, van Battum EY, Zelina P, Schwab RA, Karia D, Malnauskaite L, Brignani S, van den Munkhof M, Düdükcü Ö, de Ruiter AA, van den Heuvel DMA, Bishop B, Elegheert J, Aricescu AR, Pasterkamp RJ*, Siebold C* (2021) Simultaneous binding of guidance cues NET1 and RGM blocks extracellular NEO1 signaling (2021) Cell 184:2103-2120. *Shared senior authors.

2. Brignani S, Raj DDA, Schmidt ERE, Düdükcü Ö, Adolfs Y, De Ruiter AA, Rybiczka-Tesulov M, Verhagen MG, van der Meer C, Broekhoven MH, Moreno-Bravo JA, Grossouw LM, Dumontier E, Cloutier JF, Chédotal A, Pasterkamp RJ (2020). Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. Neuron 107, 684-702.


3. Ormel PR, Vieira de Sá R, van Bodegraven EJ, Karst H, Harschnitz O, Sneeboer MAM, Johansen LE, van Dijk RE, Scheefhals N, Berdenis van Berlekom A, Ribes Martínez E, Kling S, MacGillavry HD, van den Berg LH, Kahn RS, Hol EM, de Witte LD, Pasterkamp RJ (2018) Microglia innately develop within cerebral organoids. Nat Commun 9, 4167.
 
4. Jongbloets BC, Lemstra S, Schellino R, Broekhoven MH, Parkash J, Hellemons AJ, Mao T, Giacobini P, van Praag H, De Marchis S, Ramakers GM, Pasterkamp RJ (2017) Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nat Commun 8:14666.
 
5. Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ*, Jones EY* (2016). Structural Basis for Plexin Activation and Regulation. Neuron 91, 548-60. *Shared senior authors.
 
6. Van Erp S, van den Heuvel DMA, Fujita Y, Robinson R, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers J, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ (2015) Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases. Dev Cell 35, 537-552.

7. Schmidt ER, Brignani S, Adolfs Y, Lemstra S, Demmers J, Vidaki M, Donahoo AL, Lilleväli K, Vasar E, Richards LJ, Karagogeos D, Kolk SM, Pasterkamp RJ (2014). Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula. Neuron 83, 372-387.

Side Activities

  • Member General board, Dutch Parkinson Scientists

  • Member, F1000Prime, section Neurodevelopment

  • Member Scientific Advisory Board, Prinses Beatrix Spierfonds (PBS)

  • Member Scientific Advisory Board, Swiss Regen Therapeutics GmbH

Fellowship and Awards

NWO Gravitation grant BRAINSCAPES, 2019

VICI, 2015

ZonMW TOP, 2008

VIDI, 2006

HFSP career development award, 2005

VENI, 2004

NWO Talent, 2000

Research Output (166)

Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome

Siqueira Edilene, Obiols-Guardia Aida, Jorge-Torres Olga C., Oliveira-Mateos Cristina, Soler Marta, Ramesh-Kumar Deepthi, Setién Fernando, van Rossum Daniëlle, Pascual-Alonso Ainhoa, Xiol Clara, Ivan Cristina, Shimizu Masayoshi, Armstrong Judith, Calin George A., Pasterkamp R. Jeroen, Esteller Manel, Guil Sonia 8 Mar 2022, In: Molecular Therapy - Nucleic Acids. 27 , p. 621-644 24 p.

Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology

Gomes-Duarte Andreia, Venø Morten T., de Wit Marina, Senthilkumar Ketharini, Broekhoven Mark H., van den Herik Joëlle, Heeres Fleur R., van Rossum Daniëlle, Rybiczka-Tesulov Mateja, Legnini Ivano, van Rijen Peter C., van Eijsden Pieter, Gosselaar Peter H., Rajewsky Nikolaus, Kjems Jørgen, Vangoor Vamshidhar R., Pasterkamp R. Jeroen 3 Mar 2022, In: Frontiers in Molecular Neuroscience. 15

Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns

Tomris Ilhan, Bouwman Kim M., Adolfs Youri, Noack Danny, van der Woude Roosmarijn, Kerster Gius, Herfst Sander, Sanders Rogier W., van Gils Marit J., Boons Geert Jan, Haagmans Bart L., Pasterkamp R. Jeroen, Rockx Barry, de Vries Robert P. Mar 2022, In: PLoS Pathogens. 18 , p. 1-23

Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors

Donega Vanessa, van der Geest Astrid T., Sluijs Jacqueline A., van Dijk Roland E., Wang Chi Chiu, Basak Onur, Pasterkamp R. Jeroen, Hol Elly M. 24 Feb 2022, In: Nature Communications. 13 , p. 1-12

Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

Hop Paul J, Zwamborn Ramona A J, Hannon Eilis, Shireby Gemma L, Nabais Marta F, Walker Emma M, van Rheenen Wouter, van Vugt Joke J F A, Dekker Annelot M, Westeneng Henk-Jan, Tazelaar Gijs H P, van Eijk Kristel R, Moisse Matthieu, Baird Denis, Al Khleifat Ahmad, Iacoangeli Alfredo, Ticozzi Nicola, Ratti Antonia, Cooper-Knock Jonathan, Morrison Karen E, Shaw Pamela J, Basak A Nazli, Chiò Adriano, Calvo Andrea, Moglia Cristina, Canosa Antonio, Brunetti Maura, Grassano Maurizio, Gotkine Marc, Lerner Yossef, Zabari Michal, Vourc'h Patrick, Corcia Philippe, Couratier Philippe, Mora Pardina Jesus S, Salas Teresa, Dion Patrick, Ross Jay P, Henderson Robert D, van Es Michael A, Pasterkamp R Jeroen, McLaughlin Russell L, Kenna Kevin P, van den Berg Leonard H, Veldink Jan H, Veldink Jan H, van den Berg Leonard H, Deelen Patrick, Deelen Patrick, Veldink Jan H, 23 Feb 2022, In: Science translational medicine. 14 , p. 1-15

The mouse brain after foot shock in four dimensions:Temporal dynamics at a single-cell resolution

Bonapersona Valeria, Schuler Heike, Damsteegt Ruth, Adolfs Youri, Pasterkamp R. Jeroen, van den Heuvel Martijn P., Joëls Marian, Sarabdjitsingh R. Angela 22 Feb 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119 , p. 1-9

Author Correction:Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology (Nature Genetics, (2021), 53, 12, (1636-1648), 10.1038/s41588-021-00973-1)

van Rheenen Wouter, van der Spek Rick A A, Bakker Mark K, van Vugt Joke J F A, Hop Paul J, Zwamborn Ramona A J, de Klein Niek, Westra Harm-Jan, Bakker Olivier B, Deelen Patrick, Shireby Gemma, Hannon Eilis, Moisse Matthieu, Baird Denis, Restuadi Restuadi, Dolzhenko Egor, Dekker Annelot M, Gawor Klara, Westeneng Henk-Jan, Tazelaar Gijs H P, van Eijk Kristel R, Kooyman Maarten, Byrne Ross P, Doherty Mark, Heverin Mark, Al Khleifat Ahmad, Iacoangeli Alfredo, Shatunov Aleksey, Ticozzi Nicola, Cooper-Knock Johnathan, Smith Bradley N, Gromicho Marta, Chandran Siddharthan, Pal Suvankar, Morrison Karen E, Shaw Pamela J, Hardy John, Orrell Richard W, Sendtner Michael, Meyer Thomas, Başak Nazli, van der Kooi Anneke J, Ratti Antonia, Ophoff Roel A, van Es Michael A, Pasterkamp R Jeroen, McLaughlin Russell L, Kenna Kevin P, van den Berg Leonard H, Veldink Jan H, 2022, In: Nature Genetics. 54 , p. 361-361

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

van Rheenen Wouter, van der Spek Rick A A, Bakker Mark K, van Vugt Joke J F A, Hop Paul J, Zwamborn Ramona A J, de Klein Niek, Westra Harm-Jan, Bakker Olivier B, Deelen Patrick, Shireby Gemma, Hannon Eilis, Moisse Matthieu, Baird Denis, Restuadi Restuadi, Dolzhenko Egor, Dekker Annelot M, Gawor Klara, Westeneng Henk-Jan, Tazelaar Gijs H P, van Eijk Kristel R, Kooyman Maarten, Byrne Ross P, Doherty Mark, Heverin Mark, Al Khleifat Ahmad, Iacoangeli Alfredo, Shatunov Aleksey, Ticozzi Nicola, Cooper-Knock Johnathan, Smith Bradley N, Gromicho Marta, Chandran Siddharthan, Pal Suvankar, Morrison Karen E, Shaw Pamela J, Hardy John, Orrell Richard W, Sendtner Michael, Meyer Thomas, Başak Nazli, van der Kooi Anneke J, Ratti Antonia, Ophoff Roel A, van Es Michael A, Pasterkamp R Jeroen, McLaughlin Russell L, Kenna Kevin P, van den Berg Leonard H, Veldink Jan H, Dec 2021, In: Nature Genetics. 53 , p. 1636-1648 13 p.

Protocol for tissue clearing and 3D analysis of dopamine neurons in the developing mouse midbrain

Adolfs Youri, Raj Divya D.A., Brignani Sara, Pasterkamp R. Jeroen 17 Sep 2021, In: STAR protocols. 2 33 p.

Dorsal root ganglia macrophages maintain osteoarthritis pain

Raoof Ramin, Gil Christian Martin, Lafeber Floris P.J.G., De Visser Huub, Prado Judith, Versteeg Sabine, Pascha Mirte N., Heinemans Anne L.P., Adolfs Youri, Pasterkamp Jeroen, Wood John N., Mastbergen Simon C., Eijkelkamp Niels 16 Aug 2021, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 41 , p. 8249-8261 13 p.

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