prof. dr. R.J. (Jeroen) Pasterkamp

prof. dr. R.J. (Jeroen) Pasterkamp

Full Professor
prof. dr. R.J. (Jeroen) Pasterkamp
  • Translational Neuroscience



Jeroen Pasterkamp obtained his PhD degree at the Netherlands Institute for Neuroscience and the Vrije Universiteit in Amsterdam with Joost Verhaagen and Dick Swaab. He carried out postdoctoral research at the Department of Neuroscience of the Johns Hopkins University School of Medicine in Baltimore, USA. In 2005, he joined the Department of Translational Neuroscience of the UMC Utrecht, where he is currently appointed as a professor of translational neuroscience. He is chair of the UMC Utrecht Brain Center and head of the Department of Translational Neuroscience.

His research focuses on understanding 1) the signaling events and molecular mechanisms involved in the formation of neuronal connections during development, and 2) the molecular mechanisms underlying changes in or loss of neuronal connectivity during neurological disease (in particular amyotrophic lateral sclerosis (ALS)). This research concentrates on mouse models and humanized cell models (iPSC, organoids, microfluidics) using an integrated approach involving molecular biology, cell biology, neuroanatomy, (in vivo) functional proteomics, imaging, HC screening, and mouse genetics.

His work was published in leading journals such as Cell, Developmental Cell, Neuron, Nature, Nature Communications, and he regularly contributes reviews to Current Opinion, Trends and Nature Reviews journals.

Jeroen Pasterkamp is a recipient of a NARSAD Young Investigator, Dan Nathans Young Investigator Award, and HFSP Career Development Award. He received VENI, VIDI and VICI grants, and is co-leading the NWO Gravitation program BRAINSCAPES. He is a member of the Scientific Advisory board of the Prinses Beatrix Spierfonds and a board member of the Dutch Parkinson Scientists. He organizes scientific meetings under the framework of EMBO and Utrecht Summerschool series.

Research line

Neural circuit development and Translational neuroscience

Most recent key publications

1. Robinson RA, Griffiths SC, van de Haar LL, Malinauskas T, van Battum EY, Zelina P, Schwab RA, Karia D, Malnauskaite L, Brignani S, van den Munkhof M, Düdükcü Ö, de Ruiter AA, van den Heuvel DMA, Bishop B, Elegheert J, Aricescu AR, Pasterkamp RJ*, Siebold C* (2021) Simultaneous binding of guidance cues NET1 and RGM blocks extracellular NEO1 signaling (2021) Cell 184:2103-2120. *Shared senior authors.

2. Brignani S, Raj DDA, Schmidt ERE, Düdükcü Ö, Adolfs Y, De Ruiter AA, Rybiczka-Tesulov M, Verhagen MG, van der Meer C, Broekhoven MH, Moreno-Bravo JA, Grossouw LM, Dumontier E, Cloutier JF, Chédotal A, Pasterkamp RJ (2020). Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. Neuron 107, 684-702.

3. Ormel PR, Vieira de Sá R, van Bodegraven EJ, Karst H, Harschnitz O, Sneeboer MAM, Johansen LE, van Dijk RE, Scheefhals N, Berdenis van Berlekom A, Ribes Martínez E, Kling S, MacGillavry HD, van den Berg LH, Kahn RS, Hol EM, de Witte LD, Pasterkamp RJ (2018) Microglia innately develop within cerebral organoids. Nat Commun 9, 4167.
4. Jongbloets BC, Lemstra S, Schellino R, Broekhoven MH, Parkash J, Hellemons AJ, Mao T, Giacobini P, van Praag H, De Marchis S, Ramakers GM, Pasterkamp RJ (2017) Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nat Commun 8:14666.
5. Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ*, Jones EY* (2016). Structural Basis for Plexin Activation and Regulation. Neuron 91, 548-60. *Shared senior authors.
6. Van Erp S, van den Heuvel DMA, Fujita Y, Robinson R, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers J, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ (2015) Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases. Dev Cell 35, 537-552.

7. Schmidt ER, Brignani S, Adolfs Y, Lemstra S, Demmers J, Vidaki M, Donahoo AL, Lilleväli K, Vasar E, Richards LJ, Karagogeos D, Kolk SM, Pasterkamp RJ (2014). Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula. Neuron 83, 372-387.

Side Activities

  • Member General board, Dutch Parkinson Scientists

  • Member, F1000Prime, section Neurodevelopment

  • Member Scientific Advisory Board, Prinses Beatrix Spierfonds (PBS)


Fellowship and Awards

NWO Gravitation grant BRAINSCAPES, 2019

VICI, 2015

ZonMW TOP, 2008

VIDI, 2006

HFSP career development award, 2005

VENI, 2004

NWO Talent, 2000

Research Output (179)

Purkinje cell microzones mediate distinct kinematics of a single movement

Blot François G.C., White Joshua J., van Hattem Amy, Scotti Licia, Balaji Vaishnavi, Adolfs Youri, Pasterkamp R. Jeroen, De Zeeuw Chris I., Schonewille Martijn 19 Jul 2023, In: Nature Communications. 14

In vitro modeling of the neurobiological effects of glucocorticoids:A review

Bassil Katherine, Krontira Anthi C., Leroy Thomas, Escoto Alana I.H., Snijders Clara, Pernia Cameron D., Pasterkamp R. Jeroen, de Nijs Laurence, van den Hove Daniel, Kenis Gunter, Boks Marco P., Vadodaria Krishna, Daskalakis Nikolaos P., Binder Elisabeth B., Rutten Bart P.F. Mar 2023, In: Neurobiology of stress. 23 20 p.

Development, wiring and function of dopamine neuron subtypes

Garritsen Oxana, van Battum Eljo Y., Grossouw Laurens M., Pasterkamp R. Jeroen 2023, In: Nature Reviews Neuroscience. 24 , p. 134-152 19 p.

A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development

Seeler Sabine, Andersen Maria Schertz, Sztanka-Toth Tamas, Rybiczka-Tešulov Mateja, van den Munkhof Marleen H., Chang Chi Chih, Maimaitili Muyesier, Venø Morten Trillingsgaard, Hansen Thomas Birkballe, Pasterkamp R. Jeroen, Rybak-Wolf Agnieszka, Denham Mark, Rajewsky Nikolaus, Kristensen Lasse Sommer, Kjems Jørgen 2023, In: Molecular Neurobiology. 60 , p. 3239-3260 22 p.

Editorial:Mental health: cell models to mechanisms

Harwood Adrian J., Petrakis Spyros, Oktay Yavuz, Pasterkamp R. Jeroen 2023, In: Frontiers in Cell and Developmental Biology. 11

UNC13A in amyotrophic lateral sclerosis:From genetic association to therapeutic target

Willemse Sean W., Harley Peter, Van Eijk Ruben P.A., Demaegd Koen C., Zelina Pavol, Pasterkamp R. Jeroen, Van Damme Philip, Ingre Caroline, Van Rheenen Wouter, Veldink Jan H., Kiernan Matthew C., Al-Chalabi Ammar, Van Den Berg Leonard H., Fratta Pietro, Van Es Michael A. 2023, In: Journal of Neurology, Neurosurgery and Psychiatry. 94 , p. 649-656 8 p.

Molecular signatures and cellular diversity during mouse habenula development

van de Haar Lieke L., Riga Danai, Boer Juliska E., Garritsen Oxana, Adolfs Youri, Sieburgh Thomas E., van Dijk Roland E., Watanabe Kyoko, van Kronenburg Nicky C.H., Broekhoven Mark H., Posthuma Danielle, Meye Frank J., Basak Onur, Pasterkamp R. Jeroen 5 Jul 2022, In: Cell Reports. 40 , p. 1-32

Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model

Berdenis van Berlekom Amber, Kübler Raphael, Hoogeboom Jeske W, Vonk Daniëlle, Sluijs Jacqueline A, Pasterkamp R Jeroen, Middeldorp Jinte, Kraneveld Aletta D, Garssen Johan, Kahn René S, Hol Elly M, de Witte Lot D, Boks Marco P 2 May 2022, In: Nutrients. 14 , p. 1-19

Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome

Siqueira Edilene, Obiols-Guardia Aida, Jorge-Torres Olga C., Oliveira-Mateos Cristina, Soler Marta, Ramesh-Kumar Deepthi, Setién Fernando, van Rossum Daniëlle, Pascual-Alonso Ainhoa, Xiol Clara, Ivan Cristina, Shimizu Masayoshi, Armstrong Judith, Calin George A., Pasterkamp R. Jeroen, Esteller Manel, Guil Sonia 8 Mar 2022, In: Molecular Therapy - Nucleic Acids. 27 , p. 621-644 24 p.

All research output

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