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Research nieuws

Research nieuws

Antiplatelet therapy not effective in treating critically ill COVID-19 patients

For patients with COVID-19 who are receiving organ support in an ICU, antiplatelet therapy, either with aspirin or P2Y12 inhibitor (which were found to be equivalent), was ineffective at improving the composite endpoint of death and organ support free days when compared to no antiplatelet therapy.

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Two grants (NWO and ZonMW) for Utrecht researchers

CONTRACT study

Utrecht researchers Magdalena Harakalova, Frank van Steenbeek, Folkert Asselbergs and Jeroen Bakkers have obtained prestigious funding to further build infrastructure on genetic cardiomyopathies (severe diseases of the cardiac muscle).

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Mathematical brain model helpful in epilepsy surgery

Removing as small a brain area as possible to stop epileptic seizures. That is epilepsy surgery.

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Microbiome compositional changes may precede the development of inflammatory bowel disease

The gut microbiome of people at increased risk of developing inflammatory bowel disease (IBD) displays IBD-like signatures. The presence of such IBD-like microbiome signatures might precede the onset of IBD. This was concluded from a study, recently published in Gastroenterology, investigating the intestinal microbiome in IBD-discordant and IBD-concordant twin pairs coordinated by UMC Utrecht in collaboration with the UMC Groningen, Netherlands Twin Register and a consortium of Dutch IBD centers.

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'Live' measurements of cell signals show need for combination therapy in colorectal cancer

oncode research

'Live' metingen van celsignalen tonen noodzaak van combinatietherapie bij dikkedarmkanker

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Biological discovery heralds new medication

2 signaling proteins appear to be able to bind to 1 nerve cell at the same time, causing the cell to "switch off" temporarily

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Treating artery stenosis with sound waves

By aiming high-frequency sound waves at a narrowing – a plaque – in the artery, it is broken down layer by layer. That is the theory behind the Hifu treatment (High Intensity Focused Ultrasound). This method has recently been successfully tested in patients with carotid stenosis in the groin. This non-invasive operation can be an alternative to patients in the long term to surgery or stent placement.

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Dec 1: Rheumatologists compare rheumatoid arthritis drugs in difficult-to-treat patients

Dutch rheumatologists have started a clinical study in patients with difficult-to-treat rheumatoid arthritis (RA). They compare the efficacy of adding either tocilizumab or prednisone in patients who do not benefit sufficiently from treatment with the conventional RA drug methotrexate.

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Outcome of European study: the sooner epilepsy surgery, the better the result

A large-scale European study into the effectiveness of epilepsy surgery, led by the UMC Utrecht and the University Hospitals of Erlangen, convincingly shows its success. One year after surgery, 72% of patients with epilepsy are seizure-free. After two years, that percentage is still 68% and after five years 66%. The results help in deciding whether surgery to treat epilepsy is effective. The findings also support the idea that operating as quickly as possible improves the outcome. This study was published in the Lancet Neurology on August 18.

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Exercise as medicine after a stroke

People sit too much and do not exercise enough. Also after a stroke. This increases the risk of another stroke and premature death. Roderick Wondergem investigated the health risks and developed a coaching program. “Excessive sitting is habitual behavior. To break that habit, confidence in one's own abilities is crucial.”

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