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Research nieuws

Research nieuws

Oct 5: Improved patient profiling and prediction of response to immune-modulating treatment in atopic dermatitis

Clinical and translational research by Daphne Bakker and colleagues at UMC Utrecht has provided new leads for improved patient profiling and a better prediction of response to treatment with dupilumab, a biologic immune-modulating drug for the treatment of moderate-to-severe atopic dermatitis. On September 28, 2021 Daphne Bakker received her PhD cum laude at Utrecht University.

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Rotavirus vaccination of children with medical risk factors does not offer sufficient protection

Vaccination of children with medical risk factors against acute gastroenteritis due to rotavirus infection does not appear to offer sufficient protection.

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Healthcare data offer more knowledge on male-female differences in cardiovascular disease

Men and women may react differently to medication for cardiovascular disease.

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Gene Tbx5 essential for getting the heart in correct shape during embryonic development

Researchers from the group of Jeroen Bakkers, in collaboration with Leiden University and the Amsterdam UMC, provide a detailed description of cardiac looping during zebrafish embryonic development.

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Antiplatelet therapy not effective in treating critically ill COVID-19 patients

For patients with COVID-19 who are receiving organ support in an ICU, antiplatelet therapy, either with aspirin or P2Y12 inhibitor (which were found to be equivalent), was ineffective at improving the composite endpoint of death and organ support free days when compared to no antiplatelet therapy.

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Two grants (NWO and ZonMW) for Utrecht researchers

CONTRACT study

Utrecht researchers Magdalena Harakalova, Frank van Steenbeek, Folkert Asselbergs and Jeroen Bakkers have obtained prestigious funding to further build infrastructure on genetic cardiomyopathies (severe diseases of the cardiac muscle).

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Mathematical brain model helpful in epilepsy surgery

Removing as small a brain area as possible to stop epileptic seizures. That is epilepsy surgery.

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Microbiome compositional changes may precede the development of inflammatory bowel disease

The gut microbiome of people at increased risk of developing inflammatory bowel disease (IBD) displays IBD-like signatures. The presence of such IBD-like microbiome signatures might precede the onset of IBD. This was concluded from a study, recently published in Gastroenterology, investigating the intestinal microbiome in IBD-discordant and IBD-concordant twin pairs coordinated by UMC Utrecht in collaboration with the UMC Groningen, Netherlands Twin Register and a consortium of Dutch IBD centers.

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'Live' measurements of cell signals show need for combination therapy in colorectal cancer

oncode research

'Live' metingen van celsignalen tonen noodzaak van combinatietherapie bij dikkedarmkanker

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Biological discovery heralds new medication

2 signaling proteins appear to be able to bind to 1 nerve cell at the same time, causing the cell to "switch off" temporarily

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