prof. dr. A. Algra

prof. dr. A. Algra

Professor Emeritus
prof. dr. A. Algra
  • Julius Center, dept. Epidemiology & Health Economics



Ale Algra trained in physics at Utrecht University and obtained a BSc in 1975. He continued training at the Medical School of the Erasmus University Rotterdam (MD 1981). In the meantime he worked at the Thoraxcenter on the computer analysis of 24-hour ECGs; originally on technical aspects of ECG-analysis. Later he studied predictors for sudden death from 24-hour ECG, resulting in his doctorate thesis in 1990. In 1984-85 he trained at Harvard School of Public Health (MSc Epidemiology). From 1990 on he works at University Medical Center Utrecht, half-time in the department of Neurology, and half-time in the Julius Center. In 1999-2000 he spent a sabbatical as Visiting Professor at the University of Western Ontario, London, Ontario, Canada, with the research group of Barnett and Hachinski. As of 2005 he works one day per week as professor of clinical epidemiology in the department of Clinical Epidemiology of the Leiden University Medical Center. October 1st, 2015 he was appointed professor of Clinical Epidemiology of Cerebrovascular Diseases at University Utrecht.

Interests and Focus

My main field of research is cerebrovascular disease. I have been involved as principal (co-)investigator in several multicenter secondary prevention trials with antithrombotic treatments, both in patients with cerebral ischaemia and patients after infrainguinal bypass surgery. Within the Julius Center I am one of the principal investigators of the ongoing SMART (Second Manifestations in ARTerial Disease) study, in which currently over 10,000 patients with vascular disease are enrolled. One of my current interests is the difference in coagulation propensity between young patients with ischaemic stroke and myocardial infarction.

Research line and group


Most recent key publications

1: Vlak MHM, Algra A, Brandenburg R, Rinkel GJE. Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol 2011;10:626-36.
2: van Beijnum J, van der Worp HB, Buis DR, Al-Shahi Salman R, Kappelle LJ, Rinkel GJE, Berkelbach van der Sprenkel JW, Vandertop WP, Algra A, Klijn CJM. Treatment of brain arteriovenous malformations. A systematic review and meta-analysis. JAMA 2011;306:2011-9.
3: Greving JP, Schonewille WJ, Wijman CAC, Michel P, Kappelle LJ, Algra A, on behalf of the BASICS Study Group. Predicting outcome after acute basilar artery occlusion based on admission characteristics. Neurology 2012;78:1058-63.
4: Dorhout Mees SM, Algra A, Vandertop WP, van Kooten F, Kuijsten HAJM, Boiten J, van Oostenbrugge RJ, Al-Shahi Salman R, Lavados P, Rinkel GJE, van den Bergh WM, on behalf of the MASH-2 Study Group. Magnesium for aneurysmal aubarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet 2012;379:44-9
5: Stenting versus medical treatment in patients with symptomatic vertebral artery stenosis: a randomised open-label phase 2 trial Compter A, van der Worp HB, Schonewille WJ, Vos JA, Boiten J, Nederkoorn PJ, Uyttenboogaart M, Lo RT, Algra A, Kappelle LJ, for the VAST InvestigatorsLancet Neurol, 2015;14:606-14

Side Activities

Member Scientific Advisory Committee of the ESO Conference.
Member Data Monitoring Committee TO-ACT trial (J. Stam, principal investigator).
Member editorial board Stroke.
Independent chairman Carotid Stenting Trialists’ Collaboration: pooled analysis of individual patient data from RCTs on stenting versus endarterectomy for symptomatic carotid stenosis.
Member Scientific Advisory Board Center for Stroke Research, Charité, Berlin, Germany.
Editor Cochrane Stroke Group (P. Sandercock, editor-in-chief).


Fellowship and Awards

1: Netherlands Heart Foundation: educational grant MSc HSPH

Research Output (808)

Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH):prospective, individual participant data meta-analysis of randomised trials

Al-Shahi Salman Rustam, Stephen Jacqueline, Tierney Jayne F., Lewis Steff C., Newby David E., Parry-Jones Adrian R., White Philip M., Connolly Stuart J., Benavente Oscar R., Dowlatshahi Dar, Cordonnier Charlotte, Viscoli Catherine M., Sheth Kevin N., Kamel Hooman, Veltkamp Roland, Larsen Kristin T., Hofmeijer Jeannette, Kerkhoff Henk, Schreuder Floris H.B.M., Shoamanesh Ashkan, Klijn Catharina J.M., van der Worp H. Bart, Klug Didier, Casolla Barbara, Puy Laurent, Coffee Morgane, Kuchcinski Grégory, Labreuche Julien, van Nieuwenhuizen Koen M., Algra Ale, van Gelder Isabelle C., Kappelle L. Jaap, Rinkel Gabriel J.E., Schutgens Roger E.G., Khatri Pooja, Conwit Robin, Falcone Guido, Elm Jordan, Anderson Craig S., Song Lili, Pandian Jeyaraj, Hart Robert G., Sharma Mukul, Aref Hany, Tarhuni Wadea, Fabregas Joan Marti, Diener Hans Christoph, Endres Matthias, Lemmens Robin, Kwon Sun U., Dec 2023, In: The Lancet Neurology. 22 , p. 1140-1149 10 p.

Circle of Willis variation and outcome after intra-arterial treatment

Rozeman Anouk, Hund Hajo, Boiten Jelis, Vos Jan Albert, Schonewille Wouter, Wermer Marieke, Lycklama A Nijeholt Geert, Algra Ale 20 Sep 2022, In: BMJ Neurology Open. 4

Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease:An Individual-Level Meta-Analysis

Schillemans Tessa, Tragante Vinicius, Maitusong Buamina, Gigante Bruna, Cresci Sharon, Laguzzi Federica, Vikström Max, Richards Mark, Pilbrow Anna, Cameron Vicky, Foco Luisa, Doughty Robert N, Kuukasjärvi Pekka, Allayee Hooman, Hartiala Jaana A, Tang W H Wilson, Lyytikäinen Leo-Pekka, Nikus Kjell, Laurikka Jari O, Srinivasan Sundararajan, Mordi Ify R, Trompet Stella, Kraaijeveld Adriaan, van Setten Jessica, Gijsberts Crystel M, Maitland-van der Zee Anke H, Saely Christoph H, Gong Yan, Johnson Julie A, Cooper-DeHoff Rhonda M, Pepine Carl J, Casu Gavino, Leiherer Andreas, Drexel Heinz, Horne Benjamin D, van der Laan Sander W, Marziliano Nicola, Hazen Stanley L, Sinisalo Juha, Kähönen Mika, Lehtimäki Terho, Lang Chim C, Burkhardt Ralph, Scholz Markus, Jukema J Wouter, Eriksson Niclas, Åkerblom Axel, James Stefan, Held Claes, Hagström Emil, Spertus John A, Algra Ale, de Faire Ulf, Åkesson Agneta, Asselbergs Folkert W, Patel Riyaz S, Leander Karin 23 Jun 2022, In: Frontiers in Physiology. 13

Is Blood Pressure Lowering in the Very Elderly With Previous Stroke Associated With a Higher Risk of Adverse Events?

Tharmaratnam Damien, Karayiannis Christopher C, Collyer Taya A, Arima Hisatomi, McClure Leslie A, Chalmers John, Anderson Craig S, Benavente Oscar R, White Carole L, Algra Ale, Moran Chris, Phan Thanh G, Wang Wei C, Srikanth Velandai, 16 Dec 2021, In: Journal of the American Heart Association. 10

Statistical reanalysis of vascular event outcomes in primary and secondary vascular prevention trials

Woodhouse Lisa J, Montgomery Alan A, Mant Jonathan, Davis Barry R, Algra Ale, Mas Jean-Louis, Staessen Jan A, Thijs Lutgarde, Tonkin Andrew, Kirby Adrienne, Pocock Stuart J, Chalmers John, Hankey Graeme J, Spence J David, Sandercock Peter, Diener Hans-Christoph, Uchiyama Shinichiro, Sprigg Nikola, Bath Philip M Dec 2021, In: BMC Medical Research Methodology. 21

Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF):a randomised, open-label, phase 2 trial

Schreuder Floris H B M, van Nieuwenhuizen Koen M, Hofmeijer Jeannette, Vermeer Sarah E, Kerkhoff Henk, Zock Elles, Luijckx Gert-Jan, Messchendorp Gert P, van Tuijl Julia, Bienfait H Paul, Booij Suzanne J, van den Wijngaard Ido R, Remmers Michel J M, Schreuder Antonia H C M L, Dippel Diederik W, Staals Julie, Brouwers Paul J A M, Wermer Marieke J H, Coutinho Jonathan M, Kwa Vincent I H, van Gelder Isabelle C, Schutgens Roger E G, Zweedijk Berber, Algra Ale, van Dalen Jan Willem, Jaap Kappelle L, Rinkel Gabriel J E, van der Worp H Bart, Klijn Catharina J M, Nov 2021, In: The Lancet. Neurology. 20 , p. 907-916 10 p.

Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death:an individual participant-level data meta-analysis

Rahimi Kazem, Bidel Zeinab, Nazarzadeh Milad, Copland Emma, Canoy Dexter, Wamil Malgorzata, Majert Jeannette, McManus Richard, Adler Amanda, Agodoa Larry, Algra Ale, Asselbergs Folkert W., Beckett Nigel S., Berge Eivind, Black Henry, Boersma Eric, Brouwers Frank P.J., Brown Morris, Brugts Jasper J., Bulpitt Christopher J., Byington Robert P., Cushman William C., Cutler Jeffrey, Devereaux Richard B., Dwyer Jamie P., Estacio Ray, Fagard Robert, Fox Kim, Fukui Tsuguya, Gupta Ajay K., Holman Rury R., Imai Yutaka, Ishii Masao, Julius Stevo, Kanno Yoshihiko, Kjeldsen Sverre E., Kostis John, Kuramoto Kizuku, Lanke Jan, Lewis Edmund, Lewis Julia B., Lievre Michel, Lindholm Lars H., Lueders Stephan, MacMahon Stephen, Mancia Giuseppe, Matsuzaki Masunori, Mehlum Maria H., Nissen Steven, Ogawa Hiroshi, 18 Sep 2021, In: The Lancet. 398 , p. 1053-1064 12 p.

Trial of endovascular treatment of Basilar-Artery occlusion

Puetz Volker, Algra Ale, Schonewille Wouter J 2 Sep 2021, In: The New England journal of medicine. 385 , p. 958-958 1 p.

Author Response:Location-Specific Risk Factors for Intracerebral Hemorrhage: Systematic Review and Meta-Analysis

Jolink Wilmar M T, Wiegertjes Kim, Rinkel Gabriël J E, Algra Ale, de Leeuw Frank-Erik, Klijn Catharina J M 25 May 2021, In: Neurology. 96 , p. 1011-1011 1 p.

Endovascular Therapy for Stroke Due to Basilar-Artery Occlusion

Langezaal Lucianne C M, van der Hoeven Erik J R J, Mont'Alverne Francisco J A, de Carvalho João J F, Lima Fabrício O, Dippel Diederik W J, van der Lugt Aad, Lo Rob T H, Boiten Jelis, Lycklama À Nijeholt Geert J, Staals Julie, van Zwam Wim H, Nederkoorn Paul J, Majoie Charles B L M, Gerber Johannes C, Mazighi Mikael, Piotin Michel, Zini Andrea, Vallone Stefano, Hofmeijer Jeannette, Martins Sheila O, Nolte Christian H, Szabo Kristina, Dias Francisco A, Abud Daniel G, Wermer Marieke J H, Remmers Michel J M, Schneider Hauke, Rueckert Christina M, de Laat Karlijn F, Yoo Albert J, van Doormaal Pieter-Jan, van Es Adriaan C G M, Emmer Bart J, Michel Patrik, Puetz Volker, Audebert Heinrich J, Pontes-Neto Octavio M, Vos Jan-Albert, Kappelle L Jaap, Algra Ale, Schonewille Wouter J, 20 May 2021, In: The New England journal of medicine. 384 , p. 1910-1920 11 p.

All research output

Thank you for your review!

Has this information helped you?

Please tell us why, so that we can improve our website.

Working at UMC Utrecht





Practical uses cookies

This website uses cookies This website displays videos from, among others, YouTube. Such parties place cookies (third-party cookies). If you do not want these cookies, you can indicate that here. We also place cookies ourselves to improve our site.

Read more about the cookie policy

Agree No, rather not