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prof. dr. R. (Rene) Bernards

prof. dr. R. (Rene) Bernards

Full Professor

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Research Output (41)

A price to pay for tumor regression

Bernards Rene Jul 2015, In: Cell Research. 25 , p. 763-4 2 p.

PIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer

Majewski Ian J, Nuciforo Paolo, Mittempergher Lorenza, Bosma Astrid J, Eidtmann Holger, Holmes Eileen, Sotiriou Christos, Fumagalli Debora, Jimenez Jose, Aura Claudia, Prudkin Ludmila, Díaz-Delgado Maria Carmen, de la Peña Lorena, Loi Sherene, Ellis Catherine, Schultz Nikolaus, de Azambuja Evandro, Harbeck Nadia, Piccart-Gebhart Martine, Bernards René, Baselga José 20 Apr 2015, In: Journal of Clinical Oncology. 33 , p. 1334-1339 6 p.

SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer

Papadakis Andreas I, Sun Chong, Knijnenburg Theo A, Xue Yibo, Grernrum Wipawadee, Hölzel Michael, Nijkamp Wouter, Wessels Lodewyk F A, Beijersbergen Roderick L, Bernards Rene, Huang Sidong Apr 2015, In: Cell Research. 25 , p. 445-458 14 p.

A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity

Bajpe P K, Prahallad A, Horlings H, Nagtegaal I, Beijersbergen R, Bernards R 22 Jan 2015, In: Oncogene. 34 , p. 531-6 6 p.

Hurdles on the road to personalized medicine

Tursz Thomas, Bernards Rene 2015, In: Molecular Oncology. 9 , p. 935-9 5 p.

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation

Groenendijk Floris H, Mellema Wouter W, van der Burg Eline, Schut Eva, Hauptmann Michael, Horlings Hugo M, Willems Stefan M, van den Heuvel Michel M, Jonkers Jos, Smit Egbert F, Bernards René 2015, In: International Journal of Cancer. 136 , p. 1434-1444 11 p.

BRCA1-like signature in triple negative breast cancer:Molecular and clinical characterization reveals subgroups with therapeutic potential

Severson Tesa M, Peeters Justine, Majewski Ian, Michaut Magali, Bosma Astrid, Schouten Philip C, Chin Suet-Feung, Pereira Bernard, Goldgraben Mae A, Bismeijer Tycho, Kluin Roelof J C, Muris Jettie J F, Jirström Karin, Kerkhoven Ron M, Wessels Lodewyk, Caldas Carlos, Bernards René, Simon Iris M, Linn S.C. 2015, In: Molecular Oncology. 9 , p. 1528-38 11 p.

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma.

Sun C., Wang L., Huang S., Heynen GJJE, Prahallad A.C, Robert C., Haanen J., Blank C., Wesseling J., Willems S.M., Zecchin D., Hobor S., Bajpe P.K., Lieftink C., Mateus C., Vagner S., Grernrum W., Hofland I., Schlicker A., Wessels L.F.A., Beijersbergen R.L., Bardelli A., Di Nicolantonio F., Eggermont A.M.M., Bernards R. 2014, In: Nature. 508 , p. 118-122 5 p.

Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing.

Majewski I.J., Mittempergher L., Davidson N.M., Bosma A., Willems S.M., Horlings H.M., de Rink I., Greger L., Hooijer G.K.J., Peters D., Nederlof P.M., Hofland I., de Jong J., Wesseling J., Kluin R.J.C., Brugman W., Kerkhoven R., Nieboer F., Roepman P., Broeks A., Muley T.R., Jassem J., Niklinski J., van Zandwijk N., Brazma A., Oshlack A., van den Heuvel M., Bernards R. 2013, In: Journal of Pathology. 230 , p. 270-276 7 p.

TGF-β: an emerging player in drug resistance.

Brunen D., Willems S.M., Kellner U, Midgley R., Simon I., Bernards R. 2013, In: Cell Cycle. 15 , p. 2960-2968 9 p.

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