dr. M.P.M. Boks

dr. M.P.M. Boks

Associate Professor - medical
dr. M.P.M. Boks
  • Psychiatry

Research Programs




Genetic, epigenetic and epidemiological studies of Gene- Environment interplay

The main theme of my research is how our genetic background shapes the influence of the environmental risk for bipolar disorder and schizophrenia. 

 The idea that psychiatric disorders develop as a result of the interaction between genes and environment is generally supported. However methodological challenges of such studies have limited large scale genome wide efforts. Therefore studies that focus on the interaction between environmental risk and genetic background remain timely and necessary.

 However such genetic studies do not take into account  a more subtle but highly relevant molecular mechanisms of interactions between environment and genes that recently is identified as a key mechanism of adaptation. These mechanisms, referred to as epigenetics, are extensive and complex and to date not fully understood. Central to our understanding is that epigenetic mechanisms influences transcription of DNA by modifying access to the DNA sequences. What makes this line of research extra interesting is the potential for pharmaceutical manipulation.

To focus these studies we have chosen cannabis and trauma as a main environmental exposure. 

Specialties: Psychiatry, epigenetics, genetics, bio-informatics


Fellowship and Awards

1:  NARSAD Young Investigator Award 2010
2: Semel Institute of Neuroscience, 2009 Phenomics Travel Award

Research Output (263)

Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders

Boltz Toni, Schwarz Tommer, Bot Merel, Hou Kangcheng, Caggiano Christa, Lapinska Sandra, Duan Chenda, Boks Marco P., Kahn Rene S., Zaitlen Noah, Pasaniuc Bogdan, Ophoff Roel 1 Feb 2024, In: American Journal of Human Genetics. 111 , p. 323-337 15 p.

Potential causal association between gut microbiome and posttraumatic stress disorder

He Qiang et al. 31 Jan 2024, In: Translational Psychiatry. 14

GWAS Meta-Analysis of Suicide Attempt:Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors

Docherty Anna R, Mullins Niamh, Ashley-Koch Allison E, Qin Xuejun, Coleman Jonathan R I, Shabalin Andrey, Kang JooEun, Murnyak Balasz, Wendt Frank, Adams Mark, Campos Adrian I, DiBlasi Emily, Fullerton Janice M, Kranzler Henry R, Bakian Amanda V, Monson Eric T, Rentería Miguel E, Walss-Bass Consuelo, Andreassen Ole A, Behera Chittaranjan, Bulik Cynthia M, Edenberg Howard J, Kessler Ronald C, Mann J John, Nurnberger John I, Pistis Giorgio, Streit Fabian, Ursano Robert J, Polimanti Renato, Dennis Michelle, Garrett Melanie, Hair Lauren, Harvey Philip, Hauser Elizabeth R, Hauser Michael A, Huffman Jennifer, Jacobson Daniel, Madduri Ravi, McMahon Benjamin, Oslin David W, Trafton Jodie, Awasthi Swapnil, Berrettini Wade H, Bohus Martin, Chang Xiao, Chen Hsi-Chung, Boks Marco P, Cahn Wiepke, Kahn René S, Ophoff Roel A, 1 Oct 2023, In: American Journal of Psychiatry. 180 , p. 723-738 16 p.

An international research agenda for clozapine-resistant schizophrenia

Luykx Jurjen J, Gonzalez-Diaz Jairo M, Guu Ta-Wei, van der Horst Marte Z, van Dellen Edwin, Boks Marco P, Guloksuz Sinan, DeLisi Lynn E, Sommer Iris E, Cummins Russel, Shiers David, Lee Jimmy, Every-Palmer Susanna, Mhalla Ahmed, Chadly Zohra, Chan Sherry K W, Cotes Robert O, Takahashi Shun, Benros Michael E, Wagner Elias, Correll Christoph U, Hasan Alkomiet, Siskind Dan, Endres Dominique, MacCabe James, Tiihonen Jari 14 Jun 2023, In: The lancet. Psychiatry. 10 , p. 644-652 9 p.

Cell type deconvolution of bulk blood RNA-Seq to reveal biological insights of neuropsychiatric disorders

Boltz Toni, Schwarz Tommer, Bot Merel, Hou Kangcheng, Caggiano Christa, Lapinska Sandra, Duan Chenda, Boks Marco P, Kahn Rene S, Zaitlen Noah, Pasaniuc Bogdan, Ophoff Roel 25 May 2023,

Changes in perfusion, and structure of hippocampal subfields related to cognitive impairment after ECT:A pilot study using ultra high field MRI

Van der A Julia, De Jager Jesca E., van Dellen Edwin, Mandl René C.W., Somers Metten, Boks Marco P.M., Sommer Iris E.C., Nuninga Jasper O. 15 Mar 2023, In: Journal of Affective Disorders. 325 , p. 321-328 8 p.

In vitro modeling of the neurobiological effects of glucocorticoids:A review

Bassil Katherine, Krontira Anthi C., Leroy Thomas, Escoto Alana I.H., Snijders Clara, Pernia Cameron D., Pasterkamp R. Jeroen, de Nijs Laurence, van den Hove Daniel, Kenis Gunter, Boks Marco P., Vadodaria Krishna, Daskalakis Nikolaos P., Binder Elisabeth B., Rutten Bart P.F. Mar 2023, In: Neurobiology of stress. 23 20 p.

Negative parenting, epigenetic age, and psychological problems:prospective associations from adolescence to young adulthood

Mastrotheodoros Stefanos, Boks Marco P., Rousseau Céline, Meeus Wim, Branje Susan 2023, In: Journal of Child Psychology and Psychiatry and Allied Disciplines. 64 , p. 1446-1461 16 p.

The Cutting Edge of Epigenetic Clocks:In Search of Mechanisms Linking Aging and Mental Health

Harvanek Zachary M., Boks Marco P., Vinkers Christiaan H., Higgins-Chen Albert T. 2023, In: Biological Psychiatry. 94 , p. 694-705 12 p.

All research output

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