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prof. dr. K.P.J. (Kees) Braun

prof. dr. K.P.J. (Kees) Braun

Full Professor
prof. dr. K.P.J. (Kees) Braun
  • Neurologen

Research Programs

Brain

Biography

Biography

Kees Braun obtained his Medical Degree at Utrecht University in January 1992. He specialized in Neurology (registered in 2000) and Paediatric Neurology (registered in 2002) in the UMC Utrecht. In 2000 he obtained his PhD degree on a thesis entitled “Magnetic Resonance Spectroscopy in Hydrocephalus. He was appointed as staff neurologist in 2000 and paediatric neurologist in 2002. Since 2011 he is head of Paediatric Neurology/Neurosurgery.  In May 2012 he was appointed as a full professor of Paediatric Neurology.

His clinical and scientific areas of expertise are: refractory paediatric epilepsy, epilepsy surgery,  imaging in epilepsy, and childhood arteriopathic stroke, in particular moyamoya treatment.

He coordinates epilepsy research in the  UMCU Brain center. The epilepsy research projects he is personally involved in  focus on the effects of focal epilepsy on the brain in animal models and patients (structural and functional integrity and network analysis); seizure- and cognitive outcome after paediatric epilepsy surgery; postoperative antiepileptic drug withdrawal; ESES treatment; stress and epilepsy; and epileptic focus detection in surgical candidates.

Kees Braun currently is president of the Dutch Society of Paediatric Neurology and of the organizing committee of the 2016 world congress of child neurology (ICNC) in Amsterdam. He is member of the European Task Force for Epilepsy Surgery in Children (U-Task), the European Network for Epilepsy Research (ENER), and work-package leader of the EU-funded E-PILEPSY project.

Research line

Refractory epilepsy

Most recent key publications

1: Boshuisen K, Arzimanoglou A, Cross JH, Uiterwaal CS, Polster T, van Nieuwenhuizen O, Braun KP; for the TimeToStop study Group. Timing of antiepileptic drug withdrawal and long-term seizure outcome after paediatric epilepsy surgery (TimeToStop): a retrospective observational study. Lancet Neurol 2012:11:784-791
2: Van Campen JS, Jansen FE, Pet MA, Otte WM, Hillegers MH, Joels M, Braun KP. Relation between stress-precipitated seizures and the stress response in childhood epilepsy. Brain 2015;138:2234-2248
3: Lamberink HJ, Boshuisen K, van Rijen PC, Gosselaar PH, Braun KP. Changing profiles of pediatric epilepsy surgery candidates over time: a nationwide single-center experience from 1990 to 2011. Epilepsia 215;56:717-725
4: Boshuisen K, van Schooneveld MM, Uiterwaal CS, Cross JH, Harrison S, Polster T, Daehn M, Djimjadi S, Yalnizoglu D, Turanli G, Sassen R, Hoppe C, Kuczaty S, Barba C, Kahane P, Schubert-Bast S, Reuner G, Bast T, Strobl K, Mayer H, de Saint-Martin A, Seegmuller C, Laurent A, Arzimanoglou A, Braun KP, for the TimeToStop cognitive outcome study group. Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery. Ann Neurol 2015;78:104-114
5: Braun KPJ, Bulder MMM, Chabrier S, Kirkham FJ, Uiterwaal CSP, Tardieu M, Sebire G. Longitudinal vascular imaging in 79 children with ischemic stroke and unilateral intracranial arteriopathy. Brain 2009;132:544-557

Side Activities

As mentioned in the Biography.

Fellowship and Awards

1: Recipient of the first “Patrick Hanlo Award”, March 17 2009
2: Personal investment grant for epilepsy research by the Dutch National Epilepsy Fund
3: Recipient of the “Gerlach Cerfontaine Fellowship” of the Catharijne Foundation, UMCU, 1998-2000, for the PhD project “Magnetic Resonance Spectroscopy in Hydrocephalus”
4: Recipient of several research grants from e.g. the Dutch Epilepsy Fund, Johanna Children’s Fund, and Wilhelmina Research Fund.

Research Output (262)

Cumulative effects of antiseizure medication on intelligence in children with focal epilepsy

Stevering Carmen H., Lamberink Herm J., Woodfield Julie, van Schooneveld Monique, Otte Willem M., Chin Richard F.M., Bastin Mark E., Geleijns Karin, Braun Kees P.J. 1 Oct 2022, In: Epileptic disorders : international epilepsy journal with videotape. 24 , p. 877-888 12 p.

Incidence of and predictors for antiseizure medication gaps in Medicare beneficiaries with epilepsy:a retrospective cohort study

Terman Samuel W., Niznik Joshua D., Slinger Geertruida, Otte Willem M., Braun Kees P.J., Aubert Carole E., Kerr Wesley T., Boyd Cynthia M., Burke James F. 1 Sep 2022, In: BMC Neurology. 22 , p. 1-14

Tailored epilepsy surgery with high frequency oscillations versus spikes in intra-operative electrocorticography: Results of the RCT HFO trial

Klooster M. Van ' T., Zweiphenning W., Van Klink N., Leijten F., Ferrier C., Gebbink T., Huiskamp G., Van Zandvoort M., Van Schooneveld M., Bourez M., Goemans S., Straumann S., Van Rijen P., Gosselaar P., Van Eijsden P., Otte W., Van Diessen E., Braun K., Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 19-20

Neurostimulation in people with drug-resistant epilepsy:Systematic review and meta-analysis from the ILAE Surgical Therapies Commission

Touma Lahoud, Dansereau Bénédicte, Chan Alvin Y., Jetté Nathalie, Kwon Churl Su, Braun Kees P.J., Friedman Daniel, Jehi Lara, Rolston John D., Vadera Sumeet, Wong-Kisiel Lily C., Englot Dario J., Keezer Mark R. Jun 2022, In: Epilepsia. 63 , p. 1314-1329 16 p.

Reappraisal of the Medical Research Council Antiepileptic Drug Withdrawal Study:contamination-adjusted and dose-response re-analysis

Terman Samuel W, Wang Chang, Wang Lu, Braun Kees Pj, Otte Willem M, Slinger Geertruida, Kerr Wesley T, Lossius Morten I, Bonnett Laura, Burke James F, Marson Anthony 1 May 2022, In: Epilepsia. 63 , p. 1724-1735 12 p.

Diagnostic value of MRI in the presurgical evaluation of patients with epilepsy:influence of field strength and sequence selection: a systematic review and meta-analysis from the E-PILEPSY Consortium

Rados Matea, Mouthaan Brian, Barsi Peter, Carmichael David, Heckemann Rolf A., Kelemen Anna, Kobulashvili Teia, Kuchukhidze Giorgi, Marusic Petr, Minkin Krasimir, Tisdall Martin, Trinka Eugen, Veersema Tim, Vos Sjoerd B., Wagner Jan, Braun Kees, van Eijsden Pieter, Apr 2022, In: Epileptic Disorders. 24 , p. 323-342 20 p.

Genetic and Functional Differences between Duplicated Zebrafish Genes for Human SCN1A

Weuring Wout J., Hoekman Jos W., Braun Kees P.J., Koeleman Bobby P.C. 1 Feb 2022, In: Cells. 11 , p. 1-8

Association of Early MRI Characteristics With Subsequent Epilepsy and Neurodevelopmental Outcomes in Children With Tuberous Sclerosis Complex

Hulshof Hanna M, Kuijf Hugo J, Kotulska Katarzyna, Curatolo Paolo, Weschke Bernhard, Riney Kate, Krsek Pavel, Feucht Martha, Nabbout Rima, Lagae Lieven, Jansen Anna, Otte Wim M, Lequin Maarten H, Sijko Kamil, Benvenuto Arianna, Hertzberg Christoph, Benova Barbora, Scholl Theresa, De Ridder Jessie, Aronica EleonoraM A, Kwiatkowski David J, Jozwiak Sergiusz, Jurkiewicz Elzbieta, Braun Kees, Jansen Floor E, 31 Jan 2022, In: Neurology. 98 , p. e1216-e1225

High-frequency oscillations in scalp EEG:A systematic review of methodological choices and clinical findings

Noorlag Lotte, van Klink Nicole E.C., Kobayashi Katsuhiro, Gotman Jean, Braun Kees P.J., Zijlmans Maeike 20 Jan 2022, In: Clinical Neurophysiology. 137 , p. 46-58 13 p.

Development and Validation of Prediction Models for Developmental and Intellectual Outcome Following Pediatric Epilepsy Surgery

Cloppenborg Thomas, van Schooneveld Monique, Hagemann Anne, Hopf Johanna Lena, Kalbhenn Thilo, Otte Willem M., Polster Tilman, Bien Christian G., Braun Kees P.J. 18 Jan 2022, In: Neurology. 98 , p. e225-e235

All research output

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