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prof. dr. K.P.J. (Kees) Braun

prof. dr. K.P.J. (Kees) Braun

Full Professor
prof. dr. K.P.J. (Kees) Braun
  • Neurologen

Research Programs

Brain

Biography

Biography

Kees Braun obtained his Medical Degree at Utrecht University in January 1992. He specialized in Neurology (registered in 2000) and Paediatric Neurology (registered in 2002) in the UMC Utrecht. In 2000 he obtained his PhD degree on a thesis entitled “Magnetic Resonance Spectroscopy in Hydrocephalus. He was appointed as staff neurologist in 2000 and paediatric neurologist in 2002. Since 2011 he is head of Paediatric Neurology/Neurosurgery.  In May 2012 he was appointed as a full professor of Paediatric Neurology.

His clinical and scientific areas of expertise are: refractory paediatric epilepsy, epilepsy surgery,  imaging in epilepsy, and childhood arteriopathic stroke, in particular moyamoya treatment.

He coordinates epilepsy research in the  UMCU Brain center. The epilepsy research projects he is personally involved in  focus on the effects of focal epilepsy on the brain in animal models and patients (structural and functional integrity and network analysis); seizure- and cognitive outcome after paediatric epilepsy surgery; postoperative antiepileptic drug withdrawal; ESES treatment; stress and epilepsy; and epileptic focus detection in surgical candidates.

Kees Braun currently is president of the Dutch Society of Paediatric Neurology and of the organizing committee of the 2016 world congress of child neurology (ICNC) in Amsterdam. He is member of the European Task Force for Epilepsy Surgery in Children (U-Task), the European Network for Epilepsy Research (ENER), and work-package leader of the EU-funded E-PILEPSY project.

Research line

Refractory epilepsy

Most recent key publications

1: Boshuisen K, Arzimanoglou A, Cross JH, Uiterwaal CS, Polster T, van Nieuwenhuizen O, Braun KP; for the TimeToStop study Group. Timing of antiepileptic drug withdrawal and long-term seizure outcome after paediatric epilepsy surgery (TimeToStop): a retrospective observational study. Lancet Neurol 2012:11:784-791
2: Van Campen JS, Jansen FE, Pet MA, Otte WM, Hillegers MH, Joels M, Braun KP. Relation between stress-precipitated seizures and the stress response in childhood epilepsy. Brain 2015;138:2234-2248
3: Lamberink HJ, Boshuisen K, van Rijen PC, Gosselaar PH, Braun KP. Changing profiles of pediatric epilepsy surgery candidates over time: a nationwide single-center experience from 1990 to 2011. Epilepsia 215;56:717-725
4: Boshuisen K, van Schooneveld MM, Uiterwaal CS, Cross JH, Harrison S, Polster T, Daehn M, Djimjadi S, Yalnizoglu D, Turanli G, Sassen R, Hoppe C, Kuczaty S, Barba C, Kahane P, Schubert-Bast S, Reuner G, Bast T, Strobl K, Mayer H, de Saint-Martin A, Seegmuller C, Laurent A, Arzimanoglou A, Braun KP, for the TimeToStop cognitive outcome study group. Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery. Ann Neurol 2015;78:104-114
5: Braun KPJ, Bulder MMM, Chabrier S, Kirkham FJ, Uiterwaal CSP, Tardieu M, Sebire G. Longitudinal vascular imaging in 79 children with ischemic stroke and unilateral intracranial arteriopathy. Brain 2009;132:544-557

Side Activities

As mentioned in the Biography.

Fellowship and Awards

1: Recipient of the first “Patrick Hanlo Award”, March 17 2009
2: Personal investment grant for epilepsy research by the Dutch National Epilepsy Fund
3: Recipient of the “Gerlach Cerfontaine Fellowship” of the Catharijne Foundation, UMCU, 1998-2000, for the PhD project “Magnetic Resonance Spectroscopy in Hydrocephalus”
4: Recipient of several research grants from e.g. the Dutch Epilepsy Fund, Johanna Children’s Fund, and Wilhelmina Research Fund.

Research Output (244)

The epileptogenic zone in children with tuberous sclerosis complex is characterized by prominent features of focal cortical dysplasia

Hulshof Hanna M., Benova Barbora, Krsek Pavel, Kyncl Martin, Lequin Maarten H., Belohlavkova Anezka, Jezdik Petr, Braun Kees P.J., Jansen Floor E. dec 2021, In: Epilepsia Open. 6 , p. 663-671 9 p.

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse, van Huffelen Alexander, van Klink Nicole, Benders Manon, de Vries Linda, Leijten Frans, Jansen Floor E., Braun Kees, Zijlmans Maeike nov 2021, In: Epilepsia. 62 , p. 114-115

CRISPRa-Mediated Upregulation of scn1laa during Early Development Causes Epileptiform Activity and dCas9-Associated Toxicity

Weuring Wout J., Dilevska Ivana, Hoekman Jos, Van De Vondervoort Joep, Koetsier Martijn, Van 'T Slot Ruben H., Braun Kees P.J., Koeleman Bobby P.C. aug 2021, In: CRISPR Journal. 4 , p. 575-582 8 p.

Shared genetic basis between genetic generalized epilepsy and background electroencephalographic oscillations

Stevelink Remi, Luykx Jurjen J., Lin Bochao D., Leu Costin, Lal Dennis, Smith Alexander W., Schijven Dick, Carpay Johannes A., Rademaker Koen, Rodrigues Baldez Roiza A., Devinsky Orrin, Braun Kees P.J., Jansen Floor E., Smit Dirk J.A., Koeleman Bobby P.C., , jul 2021, In: Epilepsia. 62 , p. 1518-1527 10 p.

Fetal Brain Magnetic Resonance Imaging Findings Predict Neurodevelopment in Children with Tuberous Sclerosis Complex

Hulshof Hanna M, Slot Emma M H, Lequin Maarten, Breuillard Delphine, Boddaert Nathalie, Jozwiak Sergiusz, Kotulska Katarzyna, Riney Kate, Feucht Martha, Samueli Sharon, Scholl Theresa, Krsek Pavel, Benova Barbora, Braun Kees P J, Jansen Floor E, Nabbout Rima, jun 2021, In: The Journal of Pediatrics. 233 , p. 156-162.e2

Prognostic factors for relapse and outcome in pediatric acute transverse myelitis

Helfferich Jelte, Bruijstens Arlette L., Wong Yu Yi M., Danielle van Pelt E., Boon Maartje, Neuteboom Rinze F., Bakker D. P., Braun K. P.J., van Dijk K. G.J., Eikelenboom M. J., Engelen M., Brandsma R., Haaxma C. A., Niermeijer J. M.F., Niks E. H., Peeters E. A.J., Peeters-Scholte C. M.P.C.D., Portier R. P., de Rijk-van Andel J. F., Samijn J. P.A., Schippers H. M., Sie L. T.L., Snoeck I. N., Vermeulen R. J., Verrips A., Visscher F., Willemsen M. A.A.P., Catsman-Berrevoets C. E. mei 2021, In: Brain and Development. 43 , p. 626-636 11 p.

High-frequency oscillations recorded with surface EEG in neonates with seizures

Noorlag Lotte, van 't Klooster Maryse A, van Huffelen Alexander C, van Klink Nicole E C, Benders Manon J N L, de Vries Linda S, Leijten Frans S S, Jansen Floor E, Braun Kees P J, Zijlmans Maeike 16 apr 2021, In: Clinical Neurophysiology. 132 , p. 1452-1461 10 p.

Alcohol and Brain Development in Adolescents and Young Adults:A Systematic Review of the Literature and Advisory Report of the Health Council of the Netherlands

de Goede Janette, van der Mark-Reeuwijk Kerstin G, Braun Kees P, le Cessie Saskia, Durston Sarah, Engels Rutger C M E, Goudriaan Anna E, Moons Karel G M, Vollebergh Wilma A M, de Vries Taco J, Wiers Reinout W, Oosterlaan Jaap 2 feb 2021, In: Advances in nutrition (Bethesda, Md.). 12 , p. 1379-1410 32 p.

Contralateral improvement of cerebrovascular reactivity and TIA frequency after unilateral revascularization surgery in moyamoya vasculopathy

Deckers Pieter T., van Hoek Wytse, Kronenburg Annick, Yaqub Maqsood, Siero Jeroen C.W., Bhogal Alex A., van Berckel Bart N.M., van der Zwan Albert, Braun Kees P.J. jan 2021, In: NeuroImage: Clinical. 30

Can we use intraoperative high-frequency oscillations to guide tumor-related epilepsy surgery?

van Klink Nicole E C, Zweiphenning Willemiek J E M, Ferrier Cyrille H, Gosselaar Peter H, Miller Kai J, Aronica Eleonora, Braun Kees P J, Zijlmans Maeike 2021, In: Epilepsia. 62 , p. 997-1004 8 p.

All research output

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