dr. L.B. Creemers

dr. L.B. Creemers

Associate Professor
  • Department of Orthopaedics



Dr Creemers studied  Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using  in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.

Side Activities

Chair Science and Research  Committee (Wetenschapscommissie) Division Surgical Specialties UMCU, member International Reviewer panel eCM, member several research organisations (AO, ICRS, OARSI, NVMB, NBTE)

Fellowship and Awards

Co-awardee ‘Mathijsen award’ to R Custers (2011) and KG Auw Yang (2009) by the Dutch Orthopaedic Society for the best PhD thesis

Research Output (147)

The Added Value of the "Co" in Co-Culture Systems in Research on Osteoarthritis Pathology and Treatment Development

Muenzebrock Katrin Agnes, Kersten Valerie, Alblas Jacqueline, Creemers Laura B 3 Mar 2022, In: Frontiers in bioengineering and biotechnology. 10 , p. 1-17

Prospective evaluation of local sustained release of celecoxib in dogs with low back pain

Wiersema Tijn, Tellegen Anna R., Beukers Martijn, van Stralen Marijn, Wouters Erik, van de Vooren Mandy, Woike Nina, Mihov George, Thies Jens C., Creemers Laura B., Tryfonidou Marianna A., Meij Björn P. Aug 2021, In: Pharmaceutics. 13 , p. 1-17

Nanoghosts:Mesenchymal Stem cells derived nanoparticles as a unique approach for cartilage regeneration

D'Atri D., Zerrillo L., Garcia J., Oieni J., Lupu-Haber Y., Schomann T., Chan A., Cruz L. J., Creemers L. B., Machluf Marcelle 17 May 2021, In: Journal of controlled release : official journal of the Controlled Release Society. 337 , p. 472-481 10 p.

The role of altered glycosylation in human nucleus pulposus cells in inflammation and degeneration

Joyce K, Mohd Isa I L, Krouwels A, Creemers L, Devitt A, Pandit A 28 Mar 2021, In: European Cells & Materials. 41 , p. 401-420 20 p.

Intra-Articular Slow-Release Triamcinolone Acetonide from Polyesteramide Microspheres as a Treatment for Osteoarthritis

Tellegen Anna, Beukers Martijn, Rudnik-Jansen Imke, van Klaveren Nicolien, How Kan Loi, Woike Nina, Mihov George, Thies Jens, Teske Erik, Creemers Laura, Tryfonidou Marianna, Meij Björn 11 Mar 2021, In: Pharmaceutics. 13 18 p.

Association between oncostatin m expression and inflammatory phenotype in experimental arthritis models and osteoarthritis patients

Garcia Joao Pedro, Utomo Lizette, Rudnik-Jansen Imke, Du Jie, Zuithoff Nicolaas P.A., Krouwels Anita, van Osch Gerjo J.V.M., Creemers Laura B. Mar 2021, In: Cells. 10 , p. 1-14 14 p.

The function of CD146 in human annulus fibrosus cells and mechanism of the regulation by TGF-β

Du Jie, Guo Wei, Häckel Sonja, Hoppe Sven, Garcia João P., Alini Mauro, Tryfonidou Marianna A., Creemers Laura B., Grad Sibylle, Li Zhen 2021, In: Journal of Orthopaedic Research. 40 , p. 1661-1671 11 p.

Comparison of annulus fibrosus cell collagen remodeling rates in a microtissue system

Tromp Isabel N, Foolen Jasper, van Doeselaar Marina, Zhang Ying, Chan Danny, Kruyt Moyo C, Creemers Laura B, Castelein Rene M, Ito Keita 1 Dec 2020, In: Journal of Orthopaedic Research. 39 , p. 1955-1964 10 p.

Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha

Du Jie, Pfannkuche Judith-J, Lang Gernot, Häckel Sonja, Creemers Laura B, Alini Mauro, Grad Sibylle, Li Zhen Sep 2020, In: JOR spine. 3 , p. 1-12

All research output

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