dr. L.B. Creemers

Associate Professor

  • Department of Orthopaedics


Dr Creemers studied  Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using  in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.

Side Activities

  • Chair Science and Research  Committee (Wetenschapscommissie) Division Surgical Specialties UMCU, member International Reviewer panel eCM, member several research organisations (AO, ICRS, OARSI, NVMB, NBTE)

Fellowship and Awards

  • Co-awardee ‘Mathijsen award’ to R Custers (2011) and KG Auw Yang (2009) by the Dutch Orthopaedic Society for the best PhD thesis

Research Output (130)

Hedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification

Bach Frances C, de Rooij Kim M, Riemers Frank M, de Jong Willem A M, Zhang Ying, Creemers Laura B, Chan Danny, Le Maitre Christine, Tryfonidou Marianna A dec 2019, In: JOR spine. 2

Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model

Rudnik-Jansen Imke, Schrijver Karin, Woike Nina, Tellegen Anna, Versteeg Sabine, Thies Jens, Emans Pieter, Mihov George, Eijkelkamp Niels, Tryfonidou Marianna, Creemers Laura dec 2019, In: Drug delivery. 26 , p. 226-236 11 p.

Contrast enhanced computed tomography for real-time quantification of glycosaminoglycans in cartilage tissue engineered constructs

Garcia João P, Longoni Alessia, Gawlitta Debby, J W P Rosenberg Antoine, Grinstaff Mark W, Töyräs Juha, Weinans Harrie, Creemers Laura B, Pouran Behdad 30 sep 2019, In: Acta Biomaterialia. 100 , p. 202-212 11 p.

Enhanced sensitivity using maldi imaging coupled with laser postionization (maldi-2) for pharmaceutical research

Barré Florian P.Y., Paine Martin R.L., Flinders Bryn, Trevitt Adam J., Kelly Patrick D., Ait-Belkacem Rima, Garcia João P., Creemers Laura B., Stauber Jonathan, Vreeken Rob J., Cillero-Pastor Berta, Ellis Shane R., Heeren Ron M.A. 20 aug 2019, In: Analytical Chemistry. 91 , p. 10840-10848 9 p.

Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing

Rudnik-Jansen Imke, Tellegen Anna R, Pouran Behdad, Schrijver Karin, Meij Björn P, Emans Pieter J, de Gendt Erin, Thomas Rachel E, Kik Marja J L, de Visser Huub M, Weinans Harrie, Egas Annelies, van Maarseveen Erik, Woike Nina, Mihov George, Thies Jens, Tryfonidou Marianna A, Creemers Laura B 5 aug 2019, In: British Journal of Pharmacology. 176 , p. 4050-4064 15 p.

Dog as a Model for Osteoarthritis:The FGF4 Retrogene Insertion May Matter

Tellegen Anna R, Dessing Aileen J, Houben Kaat, Riemers Frank M, Creemers Laura B, Mastbergen Simon C, Meij Björn P, Miranda-Bedate Alberto, Tryfonidou Marianna A 2 aug 2019, In: Journal of Orthopaedic Research. 37 , p. 2550-2560 11 p.

Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems

Rudnik-Jansen Imke, Woike Nina, de Jong Suzanne, Versteeg Sabine, Kik Marja, Emans Pieter, Mihov George, Thies Jens, Eijkelkamp Niels, Tryfonidou Marianna, Creemers Laura 6 feb 2019, In: Pharmaceutics. 11

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia João Pedro, Stein Jeroen, Cai Yunpeng, Riemers Frank, Wexselblatt Ezequiel, Wengel Jesper, Tryfonidou Marianna, Yayon Avner, Howard Kenneth A, Creemers Laura B 28 jan 2019, In: Journal of Controlled Release. 294 , p. 247-258 12 p.

PTH decreases in vitro human cartilage regeneration without affecting hypertrophic differentiation

Rutgers Marijn, Bach Frances, Vonk Luciënne, Akrum Vanessa, van Boxtel Antonette, Dhert Wouter, Creemers Laura 2019, In: PLoS ONE. 14

Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis

Tellegen A. R., Rudnik-Jansen I., Pouran B., de Visser H. M., Weinans H. H., Thomas R. E., Kik M. J. L., Grinwis G. C. M., Thies J. C., Woike N., Mihov G., Emans P. J., Meij B. P., Creemers L. B., Tryfonidou M. A. nov 2018, In: Drug delivery. 25 , p. 1438-1447 10 p.

All Research Output (130)