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dr. L.B. Creemers Associate Professor

  • ORT Research


Research Programs


Dr Creemers studied  Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using  in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.

Side Activities

  • Chair Science and Research  Committee (Wetenschapscommissie) Division Surgical Specialties UMCU, member International Reviewer panel eCM, member several research organisations (AO, ICRS, OARSI, NVMB, NBTE)

Fellowship and Awards

  • Co-awardee ‘Mathijsen award’ to R Custers (2011) and KG Auw Yang (2009) by the Dutch Orthopaedic Society for the best PhD thesis

Research Output (108)

Hedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification

Bach Frances C, de Rooij Kim M, Riemers Frank M, de Jong Willem A M, Zhang Ying, Creemers Laura B, Chan Danny, Le Maitre Christine, Tryfonidou Marianna A dec 2019, In: JOR spine. 2

Contrast enhanced computed tomography for real-time quantification of glycosaminoglycans in cartilage tissue engineered constructs

Garcia João P, Longoni Alessia, Gawlitta Debby, J W P Rosenberg Antoine, Grinstaff Mark W, Töyräs Juha, Weinans Harrie, Creemers Laura B, Pouran Behdad 30 sep 2019, In: Acta Biomaterialia. 100 , p. 202-212 11 p.

Enhanced sensitivity using maldi imaging coupled with laser postionization (maldi-2) for pharmaceutical research

Barré Florian P.Y., Paine Martin R.L., Flinders Bryn, Trevitt Adam J., Kelly Patrick D., Ait-Belkacem Rima, Garcia João P., Creemers Laura B., Stauber Jonathan, Vreeken Rob J., Cillero-Pastor Berta, Ellis Shane R., Heeren Ron M.A. 20 aug 2019, In: Analytical Chemistry. 91 , p. 10840-10848 9 p.

Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing

Rudnik-Jansen Imke, Tellegen Anna R, Pouran Behdad, Schrijver Karin, Meij Björn P, Emans Pieter J, de Gendt Erin, Thomas Rachel E, Kik Marja J L, de Visser Huub M, Weinans Harrie, Egas Annelies, van Maarseveen Erik, Woike Nina, Mihov George, Thies Jens, Tryfonidou Marianna A, Creemers Laura B 5 aug 2019, In: British Journal of Pharmacology. 176 , p. 4050-4064 15 p.

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia João Pedro, Stein Jeroen, Cai Yunpeng, Riemers Frank, Wexselblatt Ezequiel, Wengel Jesper, Tryfonidou Marianna, Yayon Avner, Howard Kenneth A, Creemers Laura B 28 jan 2019, In: Journal of Controlled Release. 294 , p. 247-258 12 p.

Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis

Tellegen A. R., Rudnik-Jansen I., Pouran B., de Visser H. M., Weinans H. H., Thomas R. E., Kik M. J. L., Grinwis G. C. M., Thies J. C., Woike N., Mihov G., Emans P. J., Meij B. P., Creemers L. B., Tryfonidou M. A. nov 2018, In: Drug delivery. 25 , p. 1438-1447 10 p.

Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model

Tellegen A. R., Rudnik-Jansen I., Beukers M., Miranda-Bedate A., Bach F. C., de Jong W., Woike N., Mihov G., Thies J. C., Meij B. P., Creemers L. B., Tryfonidou M. A. 12 aug 2018, In: Journal of Controlled Release. 286 , p. 439-450 12 p.

Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix:From bench towards bedside

Bach Frances C., Tellegen Anna R., Beukers Martijn, Miranda-Bedate Alberto, Teunissen Michelle, de Jong Willem A.M., de Vries Stefan A.H., Creemers Laura B., Benz Karin, Meij Björn P., Ito Keita, Tryfonidou Marianna A. 29 mei 2018, In: Oncotarget. 9 , p. 26507-26526 20 p.

Intradiscal application of a PCLA–PEG–PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines:What's in it for humans?

Tellegen Anna R., Willems Nicole, Beukers Martijn, Grinwis Guy C.M., Plomp Saskia G.M., Bos Clemens, van Dijk Maarten, de Leeuw Mike, Creemers Laura B., Tryfonidou Marianna A., Meij Björn P. 1 mrt 2018, In: Journal of Tissue Engineering and Regenerative Medicine. 12 , p. 642-652 11 p.

Safety of intradiscal delivery of triamcinolone acetonide by a poly(esteramide) microsphere platform in a large animal model of intervertebral disc degeneration

Rudnik-Jansen Imke, Tellegen Anna, Beukers Martijn, Öner Fetullah, Woike Nina, Mihov George, Thies Jens, Meij Björn, Tryfonidou Marianna, Creemers Laura 1 jan 2018, In: Spine Journal. 19 , p. 905-919 15 p.

All Research Output (108)
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