dr. L.B. Creemers

Associate Professor
  • Department of Orthopaedics



Dr Creemers studied  Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using  in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.

Side Activities

Chair Science and Research  Committee (Wetenschapscommissie) Division Surgical Specialties UMCU, member International Reviewer panel eCM, member several research organisations (AO, ICRS, OARSI, NVMB, NBTE)

Fellowship and Awards

Co-awardee ‘Mathijsen award’ to R Custers (2011) and KG Auw Yang (2009) by the Dutch Orthopaedic Society for the best PhD thesis

Research Output (139)

Proinflammatory intervertebral disc cell and organ culture models induced by tumor necrosis factor alpha

Du Jie, Pfannkuche Judith-J, Lang Gernot, Häckel Sonja, Creemers Laura B, Alini Mauro, Grad Sibylle, Li Zhen sep 2020, In: JOR spine. 3 , p. 1-12

Drug delivery in intervertebral disc degeneration and osteoarthritis:Selecting the optimal platform for the delivery of disease-modifying agents

Colella Fabio, Garcia João Pedro, Sorbona Marco, Lolli Andrea, Antunes Bernardo, Barré Florian P Y, Oieni Jacopo, Vainieri Maria Letizia, Zerrillo Luana, Capar Serdar, Häckel Sonja, Cai Yunpeng, Creemers Laura B 27 aug 2020, In: Journal of controlled release : official journal of the Controlled Release Society. 328 , p. 985-999 15 p.

"Old Drugs, New Tricks" - Local controlled drug release systems for treatment of degenerative joint disease

Tryfonidou Marianna A, de Vries Geert, Hennink Wim E, Creemers Laura B mei 2020, In: Advanced Drug Delivery Reviews. 160 , p. 170-185 16 p.

Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration

Krouwels Anita, Iljas Juvita D, Kragten Angela H M, Dhert Wouter J A, Öner F Cumhur, Tryfonidou Marianna A, Creemers Laura B 14 apr 2020, In: International journal of molecular sciences. 21

Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model

Rudnik-Jansen Imke, Schrijver Karin, Woike Nina, Tellegen Anna, Versteeg Sabine, Thies Jens, Emans Pieter, Mihov George, Eijkelkamp Niels, Tryfonidou Marianna, Creemers Laura dec 2019, In: Drug delivery. 26 , p. 226-236 11 p.

Hedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification

Bach Frances C, de Rooij Kim M, Riemers Frank M, de Jong Willem A M, Zhang Ying, Creemers Laura B, Chan Danny, Le Maitre Christine, Tryfonidou Marianna A dec 2019, In: JOR spine. 2

Contrast enhanced computed tomography for real-time quantification of glycosaminoglycans in cartilage tissue engineered constructs

Garcia João P, Longoni Alessia, Gawlitta Debby, J W P Rosenberg Antoine, Grinstaff Mark W, Töyräs Juha, Weinans Harrie, Creemers Laura B, Pouran Behdad 30 sep 2019, In: Acta Biomaterialia. 100 , p. 202-212 11 p.

Enhanced sensitivity using maldi imaging coupled with laser postionization (maldi-2) for pharmaceutical research

Barré Florian P.Y., Paine Martin R.L., Flinders Bryn, Trevitt Adam J., Kelly Patrick D., Ait-Belkacem Rima, Garcia João P., Creemers Laura B., Stauber Jonathan, Vreeken Rob J., Cillero-Pastor Berta, Ellis Shane R., Heeren Ron M.A. 20 aug 2019, In: Analytical Chemistry. 91 , p. 10840-10848 9 p.

Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing

Rudnik-Jansen Imke, Tellegen Anna R, Pouran Behdad, Schrijver Karin, Meij Björn P, Emans Pieter J, de Gendt Erin, Thomas Rachel E, Kik Marja J L, de Visser Huub M, Weinans Harrie, Egas Annelies, van Maarseveen Erik, Woike Nina, Mihov George, Thies Jens, Tryfonidou Marianna A, Creemers Laura B 5 aug 2019, In: British Journal of Pharmacology. 176 , p. 4050-4064 15 p.

All research output

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