dr. L.B. Creemers
- Department of Orthopaedics
Research Programs
Biography
Biography
Dr Creemers studied Biomedical Sciences in Leiden and has worked in several research areas, including spermatogenic stem cells, (periodontal) ligament, tendon and bone. Since 2005 her focus is on cartilage and intervertebral disc research with a special interest in biomaterials-based local delivery approaches for regeneration and treatment of inflammation. Delivery includes small molecules, proteins, peptides and nucleic acids, research approaches involve biological effects, pharmacokinetics and imaging,using in vitro and in vivo models, the latter in close collaboration with the dept of Companion Animals at the Fac Veterinary Medicine. She is author on over 90 peer-reviewed publications and has in the past years been involved in several projects on local delivery, including BMM IdiDAS (9.2 M€; PI) targeting disc degeneration, BMM-OAcontrol on osteoarthritis and LSH –ArIADNE (1.2 M€;PI), where local delivery of anti-inflammatory mediators in osteoarthritis and intervertebral disc degeneration is further being taken towards clinical translation. In addition she is involved in H2020 ITN-TargetCaRe on targeted delivery in intervertebral disc and cartilage regeneration.
Side Activities
Chair Science and Research Committee (Wetenschapscommissie) Division Surgical Specialties UMCU, member International Reviewer panel eCM, member several research organisations (AO, ICRS, OARSI, NVMB, NBTE)
Fellowship and Awards
Co-awardee ‘Mathijsen award’ to R Custers (2011) and KG Auw Yang (2009) by the Dutch Orthopaedic Society for the best PhD thesis
Research Output (142)
Zerrillo L, Garcia J, Oieni J, Schomann T, Cruz L J, Creemers L B, Machluf Marcelle 17 mei 2021, In: Journal of controlled release : official journal of the Controlled Release Society.
Joyce K, Mohd Isa I L, Krouwels A, Creemers L, Devitt A, Pandit A 28 mrt 2021, In: European Cells & Materials. 41 , p. 401-420 20 p.
Tellegen Anna, Beukers Martijn, Rudnik-Jansen Imke, van Klaveren Nicolien, How Kan Loi, Woike Nina, Mihov George, Thies Jens, Teske Erik, Creemers Laura, Tryfonidou Marianna, Meij Björn 11 mrt 2021, In: Pharmaceutics. 13 18 p.
Korpershoek J V, Vonk L A, Kester E C, Creemers L B, de Windt T S, Kip M M A, Saris D B F, Custers R J H 9 okt 2020, In: Trials. 21 , p. 1-11
Du Jie, Pfannkuche Judith-J, Lang Gernot, Häckel Sonja, Creemers Laura B, Alini Mauro, Grad Sibylle, Li Zhen sep 2020, In: JOR spine. 3 , p. 1-12
Colella Fabio, Garcia João Pedro, Sorbona Marco, Lolli Andrea, Antunes Bernardo, Barré Florian P Y, Oieni Jacopo, Vainieri Maria Letizia, Zerrillo Luana, Capar Serdar, Häckel Sonja, Cai Yunpeng, Creemers Laura B 27 aug 2020, In: Journal of controlled release : official journal of the Controlled Release Society. 328 , p. 985-999 15 p.
Tryfonidou Marianna A, de Vries Geert, Hennink Wim E, Creemers Laura B mei 2020, In: Advanced Drug Delivery Reviews. 160 , p. 170-185 16 p.
Krouwels Anita, Iljas Juvita D, Kragten Angela H M, Dhert Wouter J A, Öner F Cumhur, Tryfonidou Marianna A, Creemers Laura B 14 apr 2020, In: International journal of molecular sciences. 21
Rudnik-Jansen Imke, Schrijver Karin, Woike Nina, Tellegen Anna, Versteeg Sabine, Thies Jens, Emans Pieter, Mihov George, Eijkelkamp Niels, Tryfonidou Marianna, Creemers Laura dec 2019, In: Drug delivery. 26 , p. 226-236 11 p.
Bach Frances C, de Rooij Kim M, Riemers Frank M, de Jong Willem A M, Zhang Ying, Creemers Laura B, Chan Danny, Le Maitre Christine, Tryfonidou Marianna A dec 2019, In: JOR spine. 2