prof.dr. J.C. (Jan) Grutters

prof.dr. J.C. (Jan) Grutters

Full Professor
prof.dr. J.C. (Jan) Grutters
  • Department of Pulmonary Diseases

Research Programs

Infection & Immunity



Jan C. Grutters (1966) studied Medicine at the University of Nijmegen, and was trained in Respiratory Medicine at St. Antonius Hospital Nieuwegein and University Medical Center (UMC) Utrecht, the Netherlands. In 2001 he was awarded an ERS Research Fellowship at Imperial College and Royal Brompton Hospital London, resulting in his Thesis: ‘Genetic polymorphisms and phenotypes in sarcoidosis’. Since 2002 he works as a pulmonologist at St. Antonius Hospital, where he is head of the Interstitial Lung Diseases (ILD) Center of Excellence. He is also a member of the Lung Transplant Team at UMC Utrecht. From 2009 to 2011 he was head of training Pulmonology & Tuberculosis at St. Antonius Hospital. Additionally, he has been a Professor of ILD at University Utrecht since 2010, with his research focusing on genetics, biomarkers and novel therapies for progressive lung fibrosis, sarcoidosis, and various auto-immune, exposure-related and ultra-rare ILD. Throughout his career Prof. Grutters has supervised over 25 PhD students, authored and co-authored more than 300 scientific articles, and is regularly invited as speaker or chairman at international medical and scientific conferences. Lastly, he is a member of the editorial board of Sarcoidosis Vasculitis and Diffuse Lung Diseases, and President Elect of the World Association of Sarcoidosis and Other Granulomatous Disorders.

Side Activities

president elect World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG)
chairman Prof. Dr. Jaap Swierenga Stichting
member Sectie ILD (SIL) NVALT
member wetenschappelijke adviesraad (WAR) St Antonius  Onderzoeksfonds
member wetenschappelijke adviescommissie (WAC) Longfonds
member Horizonscan geneesmiddelen ZiN
member commissie dure geneesmiddelen NVALT
member medische adviesraad
member medische adviesraad Longfibrose patientenvereniging
member medische adviesraad Nationale Vereniging Sjogrenpatienten
medisch adviseur stichting LAM-Nederland
member Editorial Board of the journal SVDLD
member forum CPMS ERN-LUNG
member Nederlands asbestosis panel IAS 
member Adjudication Committee Pliant (Pliant)
member Steering Committee Sphinx trial (Actelion)


Research Output (333)

Methotrexate Polyglutamate Concentrations as a Possible Predictive Marker for Effectiveness of Methotrexate Therapy in Patients with Sarcoidosis:A Pilot Study

Janssen Bonás Montse, Sundaresan Janani, Keijsers Ruth G.M., Struys Eduard A., Peters Bas J.M., Kahlmann Vivienne, Wijsenbeek Marlies S., de Rotte Maurits C.F.J., Grutters Jan C., Veltkamp Marcel Dec 2023, In: Lung. 201 , p. 617-624 8 p.

Fully Automatic, Semiautomatic, and Manual Corneal Nerve Fiber Analysis in Patients With Sarcoidosis

Raasing Lisette R M, Vogels Oscar J M, Datema Mirjam, Tannemaat Martijn R, Veltkamp Marcel, Grutters Jan C Dec 2023, In: Translational vision science & technology. 12

New Insights via RNA Profiling of Formalin-Fixed Paraffin-Embedded Lung Tissue of Pulmonary Fibrosis Patients

Klay Dymph, Kazemier Karin M, van der Vis Joanne J, Smits Hidde M, Grutters Jan C, van Moorsel Coline H M Dec 2023, In: International Journal of Molecular Sciences. 24

Establishing a Diagnosis of Pulmonary Sarcoidosis

Grutters Jan C 2 Nov 2023, In: Journal of Clinical medicine. 12

No effect of danazol treatment in patients with advanced idiopathic pulmonary fibrosis

Hoffman Thijs W, van Moorsel Coline H M, van der Vis Joanne J, Biesma Douwe H, Grutters Jan C Sep 2023, In: ERJ Open Research. 9

Thermal threshold testing:call for a balance between the number of measurements and abnormalities in the diagnosis of sarcoidosis-associated small fiber neuropathy

Raasing Lisette R M, Veltkamp Marcel, Datema Mirjam, Grutters Jan C, Vogels Oscar J M Sep 2023, In: Pain reports. 8

Simultaneous Assessment of mTORC1, JAK/STAT, and NLRP3 Inflammasome Activation Pathways in Patients with Sarcoidosis

Kraaijvanger Raisa, Ambarus Carmen A., Damen Jan, van der Vis Joanne J., Kazemier Karin M., Grutters Jan C., van Moorsel Coline H.M., Veltkamp Marcel Aug 2023, In: International Journal of Molecular Sciences. 24

Outcomes in pulmonary sarcoidosis:results of a newly implemented prednisone protocol

Kampstra Nynke, Van der Wees Philip J, Van Beek Frouke T, Biesma Douwe H, Grutters Jan C, Van der Nat Paul B 28 Mar 2023, In: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases. 40

Potential limitations of activity tracking devices in monitoring effects of treatment for sarcoidosis

Klein Rebecca, Judson Marc, Barkes Briana, Maier Lisa, Zeigler Joyce, Culver Daniel, Sweiss Nadera, Chen Edward, Hamzeh Nabeel, Grutters Jan, Valeyre Dominique, Singh Noopur, Spitzer Ginger, Shivas Tricha, Baughman Robert 28 Mar 2023, In: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases. 40

Latent class analysis-based subgroups and response to corticosteroids in hospitalised community-acquired pneumonia patients:a validation study

Wittermans Esther, van der Zee Philip A, Qi Hongchao, Grutters Jan C, Voorn G Paul, Bos Willem Jan W, van de Garde Ewoudt M W, Endeman Henrik Mar 2023, In: ERJ Open Research. 9

All research output

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