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prof. dr. J. Hendrikse

prof. dr. J. Hendrikse

Full Professor
prof. dr. J. Hendrikse

Research Programs

Brain

Biography

Biography

The overall aim of prof. Hendrikse’s research is to understand the cause of ischemic stroke with a focus on the three P’s: Pipes (vessel and vessel walls), Perfusion (CBF and reserve capacity) and Parenchyma (brain tissue and tissue changes/infarcts). After his PhD in 2004 he has created a new research field with technical development and clinical applications of MR methods of cerebral perfusion (so called arterial spin labeling MRI) and intracranial vessel wall imaging. His original MR research is recognized by the international research field with European grants (FP7, Biocog; WP leader) and personal national excellence grants (ERC-StG, VIDI, VENI, Heart association, Technical Research Council), chairmanship of international (ISMRM) perfusion study group, steering committee member of Carotid Stenosis Triallists Collaboration (CSTC), invited lectures, reviews, white papers and book chapters. 22 of his publications are within international collaborations (including Johns Hopkins University and Vanderbilt University, USA). He has over 30 publications within the field of 7T MRI brain imaging method developments. In the radiology and neurovascular research arena ‘RADIOLOGY and ‘STROKE’ are leading journals: he has over 30 publications in these journals. He is the first radiologist awarded with a VIDI grant and an ERC-StG. The focus of his research group is to understand the relation between the ‘3Ps’: pipes (arterial vasculature), perfusion and parenchyma (brain tissue damage) by using innovative imaging methods. Early 2017 he was appointed Chairman of Radiology and Nuclear Medicine UMC Utrecht.

 

Research line

Brain MRI: Pipes, Perfusion, Parenchyma

Most recent key publications

1: Dieleman N, Van der Kolk AG. Hendrikse J. MR intracranial vessel wall imaging: current prospects and future directions. Circulation. 2014 Jul 8;130(2):192-201
2: De Vis JB, Petersen ET, Bhogal A, Hartkamp NS, Klijn CJ, Kappelle LJ, Hendrikse J. Calibrated MRI to evaluate cerebral hemodynamics in patients with an internal carotid artery occlusion. J Cereb Blood Flow Metab. 2015 Jun;35(6):1015-23
3: Van der Kolk AG, Zwanenburg JJ, Brundel M, Biessels GJ, Visser F, Luijten PR, Hendrikse J. Distribution and natural course of intracranial vessel wall lesions in patients with ischemic stroke or TIA at 7.0 Tesla MRI. Eur Radiol. 2015 Jun;25(6):1692-700
4: De Rotte AA, Truijman MT, van Dijk AC, Liem MI, Schreuder FH, van der Kolk AG, de Kruijk JR, Daemen MJ, van der Steen AF, de Borst GJ, Luijten PR, Nederkoorn PJ, Kooi ME, van der Lugt A, Hendrikse J. Plaque components in symptomatic moderately stenosed carotid arteries related to cerebral infarcts: the plaque at RISK study. Stroke. 2015 Feb;46(2):568-71
5: Hendrikse J, Van der Grond J, Lu H, Van Zijl PCM, Golay X. Flow territory mapping of the cerebral arteries with MRI. Stroke. 2004;35:882-887

Side Activities

ZonMW Veni-subsidiereviewer 2018, 2019, 2020, 2021, 2022

ASNR congres 2022: panel discussion

 

Fellowship and Awards

1: ERC-StG
2: VENI and VIDI
3: FP7-WP-Leader
4: Dutch Heart Association
5: STW/Technical Research Council

Research Output (335)

Carotid Plaque Characteristics Predict Recurrent Ischemic Stroke and TIA:The PARISK (Plaque At RISK) Study

van Dam-Nolen Dianne H K, Truijman Martine T B, van der Kolk Anja G, Liem Madieke I, Schreuder Floris H B M, Boersma Eric, Daemen Mat J A P, Mess Werner H, van Oostenbrugge Robert J, van der Steen Antonius F W, Bos Daniel, Koudstaal Peter J, Nederkoorn Paul J, Hendrikse Jeroen, van der Lugt Aad, Kooi M Eline, Oct 2022, In: JACC. Cardiovascular imaging. 15 , p. 1715-1726 12 p.

Association between plaque vulnerability and neutrophil extracellular traps (NETs) levels:The Plaque At RISK study

de Vries Judith J, Autar Anouchska S A, van Dam-Nolen Dianne H K, Donkel Samantha J, Kassem Mohamed, van der Kolk Anja G, van Velzen Twan J, Kooi M Eline, Hendrikse Jeroen, Nederkoorn Paul J, Bos Daniel, van der Lugt Aad, de Maat Moniek P M, van Beusekom Heleen M M Jun 2022, In: PLoS ONE. 17 , p. 1-14

Microinfarcts in the Deep Gray Matter on 7T MRI:Risk Factors, MRI Correlates, and Relation to Cognitive Functioning-The SMART-MR Study

Ghaznawi R, Zwartbol M H T, de Bresser J, Kuijf H J, Vincken K L, Rissanen I, Geerlings M I, Hendrikse J, 26 May 2022, In: AJNR. American journal of neuroradiology. 43 , p. 829-836 8 p.

Conventional MRI Criteria to Differentiate Progressive Disease from Treatment-Induced Effects in High-Grade (WHO Grade 3-4) Gliomas

Flies Christina M, van Leuken Karlijn H, Voorde Marlies Ten, Verhoeff Joost J C, De Vos Filip Y F, Seute Tatjana, Robe Pierre A, Witkamp Theodoor D, Hendrikse Jeroen, Dankbaar Jan Willem, Snijders Tom J 18 Apr 2022, In: Neurology. 99 , p. e77-e88

Automatic quantification of perivascular spaces in T2-weighted images at 7 T MRI

Verbeek-Spijkerman Jolanda, Zwanenburg J. J.M., Bouvy W. H., Geerlings M. I., Biessels G. J., Hendrikse J., Luijten P. R., Kuijf H. J. 13 Apr 2022, In: Cerebral Circulation - Cognition and Behavior. 3 , p. 1-9

Sex Differences in Plaque Composition and Morphology Among Symptomatic Patients With Mild-to-Moderate Carotid Artery Stenosis

van Dam-Nolen Dianne H K, van Egmond Nina C M, Dilba Kristine, Nies Kelly, van der Kolk Anja G, Liem Madieke I, Kooi M Eline, Hendrikse Jeroen, Nederkoorn Paul J, Koudstaal Peter J, van der Lugt Aad, Bos Daniel Feb 2022, In: Stroke. 53 , p. 370-378 9 p.

Proximal Region of Carotid Atherosclerotic Plaque Shows More Intraplaque Hemorrhage:The Plaque at Risk Study

Crombag G A J C, Aizaz M, Schreuder F H B M, Benali F, van Dam-Nolen D H K, Liem M I, Lucci C, van der Steen A F, Daemen M J A P, Mess W H, van der Lugt A, Nederkoorn P J, Hendrikse J, Hofman P A M, van Oostenbrugge R J, Wildberger J E, Kooi M E Feb 2022, In: AJNR. American journal of neuroradiology. 43 , p. 265-271 7 p.

MRI of the intraspinal nerve roots in patients with chronic inflammatory neuropathies:abnormalities correlate with clinical phenotypes

van Rosmalen Marieke H.J., Froeling Martijn, Mandija Stefano, Hendrikse Jeroen, van der Pol W. Ludo, Stephan Goedee H. 2022, In: Journal of Neurology. 269 , p. 3159-3166 8 p.

Perforating artery flow velocity and pulsatility in patients with carotid occlusive disease. A 7 tesla MRI study

Onkenhout L. P., Arts Tine, Ferro D., Oudeman E. A., van Osch M. J.P., Zwanenburg J. J.M., Hendrikse J., Kappelle L. J., Biessels G. J., 2022, In: Cerebral Circulation - Cognition and Behavior. 3 , p. 1-7

An anomaly detection approach to identify chronic brain infarcts on MRI

van Hespen Kees M, Zwanenburg Jaco J M, Dankbaar Jan W, Geerlings Mirjam I, Hendrikse Jeroen, Kuijf Hugo J Dec 2021, In: Scientific Reports. 11

All research output

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