prof. dr. J. Hendrikse

Full Professor
prof. dr. J. Hendrikse
  • Researchgr. Neuroradiologie

Research Programs




The overall aim of prof. Hendrikse’s research is to understand the cause of ischemic stroke with a focus on the three P’s: Pipes (vessel and vessel walls), Perfusion (CBF and reserve capacity) and Parenchyma (brain tissue and tissue changes/infarcts). After his PhD in 2004 he has created a new research field with technical development and clinical applications of MR methods of cerebral perfusion (so called arterial spin labeling MRI) and intracranial vessel wall imaging. His original MR research is recognized by the international research field with European grants (FP7, Biocog; WP leader) and personal national excellence grants (ERC-StG, VIDI, VENI, Heart association, Technical Research Council), chairmanship of international (ISMRM) perfusion study group, steering committee member of Carotid Stenosis Triallists Collaboration (CSTC), invited lectures, reviews, white papers and book chapters. 22 of his publications are within international collaborations (including Johns Hopkins University and Vanderbilt University, USA). He has over 30 publications within the field of 7T MRI brain imaging method developments. In the radiology and neurovascular research arena ‘RADIOLOGY and ‘STROKE’ are leading journals: he has over 30 publications in these journals. He is the first radiologist awarded with a VIDI grant and an ERC-StG. The focus of his research group is to understand the relation between the ‘3Ps’: pipes (arterial vasculature), perfusion and parenchyma (brain tissue damage) by using innovative imaging methods. Early 2017 he was appointed Chairman of Radiology and Nuclear Medicine UMC Utrecht.


Research line

Brain MRI: Pipes, Perfusion, Parenchyma

Most recent key publications

1: Dieleman N, Van der Kolk AG. Hendrikse J. MR intracranial vessel wall imaging: current prospects and future directions. Circulation. 2014 Jul 8;130(2):192-201
2: De Vis JB, Petersen ET, Bhogal A, Hartkamp NS, Klijn CJ, Kappelle LJ, Hendrikse J. Calibrated MRI to evaluate cerebral hemodynamics in patients with an internal carotid artery occlusion. J Cereb Blood Flow Metab. 2015 Jun;35(6):1015-23
3: Van der Kolk AG, Zwanenburg JJ, Brundel M, Biessels GJ, Visser F, Luijten PR, Hendrikse J. Distribution and natural course of intracranial vessel wall lesions in patients with ischemic stroke or TIA at 7.0 Tesla MRI. Eur Radiol. 2015 Jun;25(6):1692-700
4: De Rotte AA, Truijman MT, van Dijk AC, Liem MI, Schreuder FH, van der Kolk AG, de Kruijk JR, Daemen MJ, van der Steen AF, de Borst GJ, Luijten PR, Nederkoorn PJ, Kooi ME, van der Lugt A, Hendrikse J. Plaque components in symptomatic moderately stenosed carotid arteries related to cerebral infarcts: the plaque at RISK study. Stroke. 2015 Feb;46(2):568-71
5: Hendrikse J, Van der Grond J, Lu H, Van Zijl PCM, Golay X. Flow territory mapping of the cerebral arteries with MRI. Stroke. 2004;35:882-887

Side Activities

ZonMW Veni-subsidiereviewer 2018, 2019 en 2020 


Fellowship and Awards

1: ERC-StG
2: VENI and VIDI
3: FP7-WP-Leader
4: Dutch Heart Association
5: STW/Technical Research Council

Research Output (303)

Preoperative MRI brain phenotypes are related to postoperative delirium in older individuals

Kant Ilse M J, Slooter Arjen J C, Jaarsma-Coes Myriam, van Montfort Simone J T, Witkamp Theo D, Pasma Wietze, Hendrikse Jeroen, de Bresser Jeroen, mei 2021, In: Neurobiology of Aging. 101 , p. 247-255 9 p.

Subvoxel vessel wall thickness measurements of the intracranial arteries using a convolutional neural network

van Hespen Kees M, Zwanenburg Jaco J M, Hendrikse Jeroen, Kuijf Hugo J jan 2021, In: Medical Image Analysis. 67 , p. 1-10

Absence of Consistent Sex Differences in Outcomes From Symptomatic Carotid Endarterectomy and Stenting Randomized Trials

Howard Virginia J, Algra Ale, Howard George, Bonati Leo H, de Borst Gert J, Bulbulia Richard, Calvet David, Eckstein Hans-Henning, Fraedrich Gustav, Greving Jacoba P, Halliday Alison, Hendrikse Jeroen, Jansen Olav, Brown Martin M, Mas Jean-Louis, Ringleb Peter A, Brott Thomas G, jan 2021, In: Stroke. 52 , p. 416-423 8 p.

Quantification of disease progression in spinal muscular atrophy with muscle MRI-a pilot study

Otto Louise A M, Froeling Martijn, van Eijk Ruben P A, Asselman Fay-Lynn, Wadman Renske, Cuppen Inge, Hendrikse Jeroen, van der Pol W-Ludo 2021, In: NMR in Biomedicine. 34 , p. e4473

Exploring label dynamics of velocity-selective arterial spin labeling in the kidney

Bones Isabell K, Franklin Suzanne L, Harteveld Anita A, van Osch Matthias J P, Schmid Sophie, Hendrikse Jeroen, Moonen Chrit, van Stralen Marijn, Bos Clemens 2021, In: Magnetic Resonance in Medicine. 86 , p. 131-142 12 p.

Distribution of Cerebral Blood Flow:The Role of Superselective Arterial Spin Labeling MRI

Hendrikse Jeroen dec 2020, In: Radiology. 297 , p. 638-639 2 p.

Preoperative brain MRI features and occurrence of postoperative delirium

Kant Ilse M J, van Montfort Simone J T, Mutsaerts Henri J M M, Witkamp Theo D, Buijsrogge Marc, Spies Claudia, Hendrikse Jeroen, Slooter Arjen J C, de Bresser Jeroen 16 nov 2020, In: Journal of Psychosomatic Research. 140 , p. 1-6

Quantitative MRI of skeletal muscle in a cross-sectional cohort of patients with spinal muscular atrophy types 2 and 3

Otto Louise A M, van der Pol W-Ludo, Schlaffke Lara, Wijngaarde Camiel A, Stam Marloes, Wadman Renske I, Cuppen Inge, van Eijk Ruben P A, Asselman Fay-Lynn, Bartels Bart, van der Woude Danny, Hendrikse Jeroen, Froeling Martijn 1 okt 2020, In: NMR in Biomedicine. 33 , p. 1-13

Influence of labeling parameters and respiratory motion on velocity-selective arterial spin labeling for renal perfusion imaging

Bones Isabell K., Franklin Suzanne L., Harteveld Anita A., van Osch Matthias J.P., Hendrikse Jeroen, Moonen Chrit, van Stralen Marijn, Bos Clemens 1 okt 2020, In: Magnetic Resonance in Medicine. 84 , p. 1919-1932 14 p.

ExploreASL:An image processing pipeline for multi-center ASL perfusion MRI studies

Mutsaerts Henk J M M, Petr Jan, Groot Paul, Vandemaele Pieter, Ingala Silvia, Robertson Andrew D, Václavů Lena, Groote Inge, Kuijf Hugo, Zelaya Fernando, O'Daly Owen, Hilal Saima, Wink Alle Meije, Kant Ilse, Caan Matthan W A, Morgan Catherine, de Bresser Jeroen, Lysvik Elisabeth, Schrantee Anouk, Bjørnebekk Astrid, Clement Patricia, Shirzadi Zahra, Kuijer Joost P A, Wottschel Viktor, Anazodo Udunna C, Pajkrt Dasja, Richard Edo, Bokkers Reinoud P H, Reneman Liesbeth, Masellis Mario, Günther Matthias, MacIntosh Bradley J, Achten Eric, Chappell Michael A, van Osch Matthias J P, Golay Xavier, Thomas David L, De Vita Enrico, Bjørnerud Atle, Nederveen Aart, Hendrikse Jeroen, Asllani Iris, Barkhof Frederik 1 okt 2020, In: NeuroImage. 219 17 p.

All research output

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