prof. dr. A.C. (André) Knulst

prof. dr. A.C. (André) Knulst

Full Professor
prof. dr. A.C. (André) Knulst
  • Dermatology and Allergology

Research Programs

Infection & Immunity



Prof. dr. André C. Knulst is dermatologist and immunologist at the Department of Dermatology/Allergology of the UMC Utrecht. He heads the outpatient department of Allergology and  has a longstanding experience in diagnosis and treatment of patients with allergies, urticaria and angio-edema, with a particular interest in food allergy, urticaria and angio-edema. The Dept. of Dermatology/Allergology is a centre of expertise for eczema, food allergy and urticaria/angio-edema. Prof. Knulst is involved in the training of dermatologists, otolaryngologists, pediatric allergists, and clinical immunologists/internist-allergologists.

He also heads the allergy research. Within the UMC Utrecht there is a close collaboration with the department of Children’s Pulmonology and Allergology and the Center of Translational Immunology of the UMC Utrecht. His research focus is on patient profiling and improvement of food allergy diagnosis a.o. using component resolved diagnostics. He participated in many multicenter studies a.o. the EU sponsored SAFE, CREATE and Europrevall projects. Another research area of particular interest is the development of novel therapeutic options for food allergy. He was involved in the VIPES study on the efficacy and safety of epicutaneously administered peanut and the FAST study on the efficacy of subcutaneous immunotherapy using a hypoallergenic cod fish parvalbumin.


Side Activities

Member guideline committee immunotherapy

2018 → 2021

Giving lectures on epicutaneous immunotherapy for food allergy at company sponsored symposia by DBV


Member programme committee Hub Future Food Utrecht

2016 → …
Member DSMB ART study Friesland Campina

Health council advice food allergy


member ILSI Europe expert group ‘Prioritisation of allergenic foods with respect to public health relevance’

2015 → 2019

chair guideline chronic urticaria


vice chair guideline food provocations


international advisory board chronic urticaria Novartis

2012 → …

Advisory board immunotherapy ALK-ABELLO

2012 → …

Giving lectures on allergic diseases for general practitioners, otolaryngologists (in training), pediatricians (in training), immunologist-allergologists (in training), dermatologists (in training), also on the European and international level


Research Output (309)

Precautionary allergen labeling:Current communication problems and potential for future improvements

Linders Yvette F.M., Lentz Leo R., Blom W. Marty, Michelsen-Huisman Anouska, Strikwerda Jelle, van Dijk Liselotte M., Knulst André C., Houben Geert F., van Os-Medendorp Harmieke, Holleman Bregje C. May 2023, In: Food Control. 147 , p. 1-10 10 p.

EAACI Molecular Allergology User's Guide 2.0

Dramburg Stephanie et al. Mar 2023, In: Pediatric Allergy and Immunology. 34

A European-Japanese study on peach allergy:IgE to Pru p 7 associates with severity

Kallen E. J.J., Revers A., Fernández-Rivas M., Asero R., Ballmer-Weber B., Barreales L., Belohlavkova S., de Blay F., Clausen M., Dubakiene R., Ebisawa M., Fernández-Perez C., Fritsche P., Fukutomi Y., Gislason D., Hoffmann-Sommergruber K., Jedrzejczak-Czechowicz M., Knulst A. C., Kowalski M. L., Kralimarkova T., Lidholm J., Metzler C., Mills E. N.C., Papadopoulos N. G., Popov T. A., Purohit A., Reig I., Seneviratne S. L., Sinaniotis A., Takei M., Versteeg S. A., Vassilopoulou A. E., Vieths S., Welsing P. M.J., Zwinderman A. H., Le T. M., Van Ree R. 2023, In: Allergy: European Journal of Allergy and Clinical Immunology. 78 , p. 2497-2509 13 p.

Co-sensitization between legumes is frequently seen, but variable and not always clinically relevant

Smits Mark, Verhoeckx Kitty, Knulst André, Welsing Paco, de Jong Aard, Gaspari Marco, Ehlers Anna, Verhoeff Paulien, Houben Geert, Le Thuy My 2023, In: Frontiers in allergy. 4

Accidental allergic reactions to food in adolescents and adults:An overview of the factors involved and implications for prevention

Versluis Astrid, Le Thuy-My, Houben Geert F, Knulst André C, Van Os-Medendorp Harmieke 2023, In: Frontiers in allergy. 4

Dupilumab has a profound effect on specific-IgE levels of several food allergens in atopic dermatitis patients

Spekhorst Lotte S, van der Rijst Lisa P, de Graaf Marlies, van Megen Maxime, Zuithoff Nicolaas P A, Knulst André C, de Bruin-Weller Marjolein S, Le Thuy-My 24 Nov 2022, In: Allergy. 78 , p. 875-878 4 p.

Managing food allergy:GA<sup>2</sup>LEN guideline 2022

Muraro Antonella, de Silva Debra, Halken Susanne, Worm Margitta, Khaleva Ekaterina, Arasi Stefania, Dunn-Galvin Audrey, Nwaru Bright I., De Jong Nicolette W., Rodríguez Del Río Pablo, Turner Paul J., Smith Pete, Begin Philippe, Angier Elizabeth, Arshad Hasan, Ballmer-Weber Barbara, Beyer Kirsten, Bindslev-Jensen Carsten, Cianferoni Antonella, Demoulin Céline, Deschildre Antoine, Ebisawa Motohiro, Fernandez-Rivas Maria Montserrat, Fiocchi Alessandro, Flokstra-de Blok Bertine, Gerdts Jennifer, Gradman Josefine, Grimshaw Kate, Jones Carla, Lau Susanne, Loh Richard, Alvaro Lozano Montserrat, Makela Mika, Marchisotto Mary Jane, Meyer Rosan, Mills Clare, Nilsson Caroline, Nowak-Wegrzyn Anna, Nurmatov Ulugbek, Pajno Giovanni, Podestà Marcia, Poulsen Lars K., Sampson Hugh A., Sanchez Angel, Schnadt Sabine, Szajewska Hania, Van Ree Ronald, Venter Carina, Vlieg-Boerstra Berber, Knulst André C., Sep 2022, In: World Allergy Organization Journal. 15

Recombinant human C1 esterase inhibitor as prophylactic treatment in idiopathic non-histaminergic angioedema

Alizadeh Aghdam Mehran, Hofman Zonne L.M., Meertens Michelle, Lebens Ans, Hack C. Erik, Knulst André C., Maas Coen, Röckmann Heike 15 Jul 2022, In: Allergy: European Journal of Allergy and Clinical Immunology. 77 , p. 3673-3676 4 p.

Systemic glucocorticoid use and the occurrence of flares in psoriatic arthritis and psoriasis:a systematic review

Vincken Nanette L A, Balak Deepak M W, Knulst André C, Welsing Paco M J, van Laar Jacob M 14 Mar 2022, In: Rheumatology (Oxford, England). 61 , p. 4232-4244 13 p.

Low dietary adherence after a positive food challenge in food allergic adults

Versluis Astrid, Le Thuy My, Erp Francine C.van, Blankestijn Mark A., Houben Geert F., Knulst André C., Os- Medendorp Harmieke van Feb 2022, In: Clinical and Translational Allergy. 12 , p. 1-9

All research output

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