prof. dr. F.P.J.G. (Floris) Lafeber

Full Professor

  • Rheumatology & Clinical Immunology

prof. dr. F.P.J.G. (Floris) Lafeber


Floris Lafeber (1961) is professor of ‘Experimental Rheumatology’ at the UMC Utrecht. He studied Biology at the University of Nijmegen (NL; graduated Nov 1984) and did his PhD at this University in collaboration with the Univerity of Leiden (NL), with a visit of three months at the department of Physiology, Univ. of Ottawa (Canada) (graduated April 1988).  He is scientifically active in the field of ‘Regenerative Medicine’ and ‘Immunology’.

Currently, his main research interest is in 1) Implementation of joint distraction in the treatment of knee osteoarthritis; 2) The potential of IL4-10 synerkine in control of cartilage damage, inflammation, and pain in osteoarthritis (and haemophilic arthropathy); 3) The prediction of progression and response to treatment in osteoarthritis, rheumatoid arthritis, and haemophilic arthropathy.

Floris Lafeber is (co-)author of over 300 peer-reviewed papers (H-index 48), of which more than half in the top 10% of the field. He co-supervised 30 PhD students with several additionally scheduled. He has several patent (provisional) in the fields described above, and gained over his career for more than 15 million Euros research funding from the Dutch Arthritis Association, government, and industry. At present he is manager of research and head of research laboratory of the department of Rheumatology & Clinical Immunology, UMCU (3 days/week)

Side Activities

  • Manager Research of the Division of Internal Medicine & Dermatology (2018 - present) 1 day/week

    Member of the steering committee of APPROACH within IMI (2015-2021)

    Member of: OsteoArthritis Research Society International (OARSI); Orthopaedic Research Society (ORS); and International Cartilage Repair Society (ICRS) (present)

    Member of the Advisory Board Biobanking (2019-present)

    Consultant: SynerkinePharma BV

    Reviewer for several international journals and funding agencies


Research Output (401)

Comparison of the Heel Enthesitis MRI Scoring System (HEMRIS) with clinical enthesitis and local metabolic activity on PET-CT

Kleinrensink Nienke J, Foppen Wouter, Ten Katen Iris, van der Veen Pieternella H, de Klerk Bo, Diepstraten Suzanne C E, Radstake Timothy R D J, Lafeber Floris P J G, de Jong Pim A, Leijten Emmerik F A nov 2020, In: RMD Open. 6

Gene Expression Signatures of Synovial Fluid Multipotent Stromal Cells in Advanced Knee Osteoarthritis and Following Knee Joint Distraction

Sanjurjo-Rodriguez Clara, Altaie Ala, Mastbergen Simon, Baboolal Thomas, Welting Tim, Lafeber Floris, Pandit Hemant, McGonagle Dennis, Jones Elena 14 okt 2020, In: Frontiers in bioengineering and biotechnology. 8

Validation of a Prognostic Multivariable Prediction Model for Insufficient Clinical Response to Methotrexate in Early Rheumatoid Arthritis and Its Clinical Application in Evidencio

Gosselt Helen R, Verhoeven Maxime M A, de Rotte Maurits C F J, Pluijm Saskia M F, Muller Ittai B, Jansen Gerrit, Tekstra Janneke, Bulatović-Ćalasan Maja, Heil Sandra G, Lafeber Floris P J G, Hazes Johanna M W, de Jonge Robert 14 sep 2020, In: Rheumatology and therapy. 7 , p. 837-850 14 p.

The multi-biomarker disease activity test for assessing response to treatment strategies using methotrexate with or without prednisone in the CAMERA-II trial

Jurgens M. S., Safy-Khan M., De Hair M. J.H., Bijlsma J. W.J., Welsing P. M.J., Tekstra J., Lafeber F. P.J.G., Sasso E. H., Jacobs J. W.G. 9 sep 2020, In: Arthritis Research and Therapy. 22

Effectiveness and safety over 3 years after the 2-year U-Act-Early trial of the strategies initiating tocilizumab and/or methotrexate

Verhoeven Maxime M.A., Tekstra Janneke, Welsing Paco M.J., Pethö-Schramm Attila, Borm Michelle E.A., Bruyn George A.W., Bos Reinhard, Griep Ed N., Klaasen Ruth, van Laar Jacob M., Lafeber Floris P.J.G., Bijlsma Johannes W.J., de Hair Marjolein J.H., Jacobs Johannes W.G. 1 sep 2020, In: Rheumatology (Oxford, England). 59 , p. 2325-2333 9 p.

Cohort profile:The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers

van Helvoort Eefje M., van Spil Willem E., Jansen Mylène P., Welsing Paco M.J., Kloppenburg Margreet, Loef Marieke, Blanco Francisco J., Haugen Ida K., Berenbaum Francis, Bacardit Jaume, Ladel Christoph H., Loughlin John, Bay-Jensen Anne C., Mobasheri Ali, Larkin Jonathan, Boere Janneke, Weinans Harrie H., Lalande Agnes, Marijnissen Anne C.A., Lafeber Floris P.J.G. 28 jul 2020, In: BMJ Open. 10 10 p.

Multi-classifier prediction of knee osteoarthritis progression from incomplete imbalanced longitudinal data

Widera Paweł, Welsing Paco M.J., Ladel Christoph, Loughlin John, Lafeber Floris P.F.J., Petit Dop Florence, Larkin Jonathan, Weinans Harrie, Mobasheri Ali, Bacardit Jaume 21 mei 2020, In: Scientific Reports. 10 15 p.

Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain

van Helvoort Eefje M, Eijkelkamp Niels, Lafeber Floris P J G, Mastbergen Simon C 4 mei 2020, In: Rheumatology (Oxford, England). 59 , p. 3452-3457 6 p.

Difficulté de prédire la réponse clinique au méthotrexate chez les patients atteints de polyarthrite rhumatoïde:revue systématique de la littérature

Roodenrijs Nadia M.T., van der Goes Marlies C., Welsing Paco M.J., Tekstra Janneke, van Laar Jacob M., Lafeber Floris P.J.G., Bijlsma Johannes W.J., Jacobs Johannes W.G. mei 2020, In: Revue du Rhumatisme (Edition Francaise). 87 , p. 169-180 12 p.

The molecular profile of synovial fluid changes upon joint distraction and is associated with clinical response in knee osteoarthritis

Watt F. E., Hamid B., Garriga C., Judge A., Hrusecka R., Custers R. J.H., Jansen M. P., Lafeber F. P., Mastbergen S. C., Vincent T. L. mrt 2020, In: Osteoarthritis and Cartilage. 28 , p. 324-333 10 p.

All Research Output (401)