prof. dr. F.P.J.G. (Floris) Lafeber

prof. dr. F.P.J.G. (Floris) Lafeber

Full Professor
prof. dr. F.P.J.G. (Floris) Lafeber
  • Rheumatology & Clinical Immunology



Floris Lafeber (1961) is professor of ‘Experimental Rheumatology’ at the UMC Utrecht. He studied Biology at the University of Nijmegen (NL; graduated Nov 1984) and did his PhD at this University in collaboration with the Univerity of Leiden (NL), with a visit of three months at the department of Physiology, Univ. of Ottawa (Canada) (graduated April 1988).  He is scientifically active in the field of ‘Regenerative Medicine’ and ‘Immunology’.

Currently, his main research interest is in 1) Implementation of joint distraction in the treatment of knee osteoarthritis; 2) The potential of IL4-10 synerkine in control of cartilage damage, inflammation, and pain in osteoarthritis (and haemophilic arthropathy); 3) The prediction of progression and response to treatment in osteoarthritis, rheumatoid arthritis, and haemophilic arthropathy.

Floris Lafeber is (co-)author of over 300 peer-reviewed papers (H-index 48), of which more than half in the top 10% of the field. He co-supervised 30 PhD students with several additionally scheduled. He has several patent (provisional) in the fields described above, and gained over his career for more than 15 million Euros research funding from the Dutch Arthritis Association, government, and industry. At present he is manager of research and head of research laboratory of the department of Rheumatology & Clinical Immunology, UMCU (3 days/week)

Side Activities

Manager Research of the Division of Internal Medicine & Dermatology (2018 - present) 1 day/week

Member of the steering committee of APPROACH within IMI (2015-2021)

Member of: OsteoArthritis Research Society International (OARSI); Orthopaedic Research Society (ORS); and International Cartilage Repair Society (ICRS) (present)

Member of the Advisory Board Biobanking (2019-present)

Consultant: SynerkinePharma BV

Reviewer for several international journals and funding agencies


Research Output (452)

Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain

Gil Christian Martín, Raoof Ramin, Versteeg Sabine, Willemen Hanneke L D M, Lafeber Floris P J G, Mastbergen Simon C, Eijkelkamp Niels 7 Dec 2023, In: Brain, Behavior, and Immunity. 116 , p. 203-215 13 p.

Development and validation of a machine learning-supported strategy of patient selection for osteoarthritis clinical trials:the IMI-APPROACH study

Widera Paweł, Welsing Paco M.J., Danso Samuel O., Peelen Sjaak, Kloppenburg Margreet, Loef Marieke, Marijnissen Anne C., van Helvoort Eefje M., Blanco Francisco J., Magalhães Joana, Berenbaum Francis, Haugen Ida K., Bay-Jensen Anne Christine, Mobasheri Ali, Ladel Christoph, Loughlin John, Lafeber Floris P.J.G., Lalande Agnès, Larkin Jonathan, Weinans Harrie, Bacardit Jaume Dec 2023, In: Osteoarthritis and Cartilage Open. 5

CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in Primary Sjögren’s Syndrome and Are Enriched in PD-1/ICOS-Expressing Effector T Cells

Hinrichs Anneline C., Kruize Aike A., Lafeber Floris P.J.G., Leavis Helen L., van Roon Joel A.G. Aug 2023, In: International Journal of Molecular Sciences. 24

Identifying multivariate disease trajectories and potential phenotypes of early knee osteoarthritis in the CHECK cohort

Altamirano Sara, Jansen Mylène P., Oberski Daniel L., Eijkemans Marinus J.C., Mastbergen Simon C., Lafeber Floris P.J.G., van Spil Willem E., Welsing Paco M.J. 14 Jul 2023, In: PLoS ONE. 18 13 p.

Machine-learning predicted and actual 2-year structural progression in the IMI-APPROACH cohort

Jansen Mylène P., Wirth Wolfgang, Bacardit Jaume, van Helvoort Eefje M., Marijnissen Anne C.A., Kloppenburg Margreet, Blanco Francisco J., Haugen Ida K., Berenbaum Francis, Ladel Cristoph H., Loef Marieke, Lafeber Floris P.J.G., Welsing Paco M., Mastbergen Simon C., Roemer Frank W. 1 May 2023, In: Quantitative Imaging in Medicine and Surgery. 13 , p. 3298-3306 9 p.

Structural changes after ankle joint distraction in haemophilic arthropathy:an explorative study investigating biochemical markers and 3D joint space width

van Bergen Eline D P, Mastbergen Simon C, Lafeber Floris P J G, Bay-Jensen Anne-Christine, Madsen Sofie F, Port Helena, Foppen Wouter, Schutgens Roger E G, Jansen Mylène P, van Vulpen Lize F D May 2023, In: Haemophilia. 29 , p. 874-882 9 p.

Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort:Association of bone mineral density with radiographic disease severity, meniscal coverage and meniscal extrusion

Heiss Rafael, Laredo Jean-Denis, Wirth Wolfgang, Jansen Mylène P, Marijnissen Anne C A, Lafeber Floris, Lalande Agnes, Weinans Harrie H, Blanco Francisco J, Berenbaum Francis, Kloppenburg Margreet, Haugen Ida K, Engelke Klaus, Roemer Frank W 7 Jan 2023, In: Bone. 168 10 p.

The catabolic-to-anabolic shift seen in the canine osteoarthritic cartilage treated with knee joint distraction occurs after the distraction period

Teunissen M., Meij B. P., Snel L., Coeleveld K., Popov-Celeketic J., Ludwig I. S., Broere F., Lafeber F. P.J.G., Tryfonidou M. A., Mastbergen S. C. Jan 2023, In: Journal of Orthopaedic Translation. 38 , p. 44-55 12 p.

Subclinical synovial proliferation in patients with severe haemophilia A:The value of ultrasound screening and biochemical markers

van Bergen Eline D.P., van Leeuwen Flora H.P., Foppen Wouter, Timmer Merel A., Schutgens Roger E.G., Mastbergen Simon C., Lafeber Floris P.J.G., de Jong Pim A., Fischer Kathelijn, van Vulpen Lize F.D. 2023, In: Haemophilia. 29 , p. 1580-1588 9 p.

Exploring the differences between radiographic joint space width and MRI cartilage thickness changes using data from the IMI-APPROACH cohort

Jansen Mylène P., Roemer Frank W., Marijnissen Anne Karien C.A., Kloppenburg Margreet, Blanco Francisco J., Haugen Ida K., Berenbaum Francis, Lafeber Floris P.J.G., Welsing Paco M.J., Mastbergen Simon C., Wirth Wolfgang 2023, In: Skeletal Radiology. 52 , p. 1339-1348 10 p.

All research output

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