prof. dr. N.C. (Nicolette) Notermans
prof. dr. N.C. (Nicolette) Notermans
- Neurology & Neurosurgery
Research Programs
Biography
Biography
Biography
Nicolette Notermans obtained her PhD degree on the clinical features and pathogenesis of Chronic Idiopathic Axonal Polyneuropathy (CIAP) and Polyneuropathy associated with Monoclonal Gammopathy of undetermined significance (MGUS) in Utrecht (1994). After her PhD she obtained several grants (NWO, Prinses Beatrix foundation) to study the etiology of CIAP, polyneuropathy associated with MGUS and other immune-mediated neuropathies. She has initiated several studies of large, national cohorts of patients with CIAP and MGUS, in close collaboration with haematologists throughout the country.
She is a member of the word-wide task force of vasculitic neuropathy and MGUS neuropathy. As president of the Dutch neuromuscular research organization (ISNO), she organized the 7th annual conference of the World Muscle Society in 2002, in Rotterdam. Since 2010, she is the director of the successful neuromuscular diseases residency program which attracts many residents from other teaching hospitals.
Research line
Polyneuropathy
Key publications
1: Warendorf JK, Vrancken AFJE, van Eijk RPA, Visser NA, van den Berg LH, Notermans NC. Statins do not increase risk of polyneuropathy: a case-control study and literature review. Neurology. 2019 Apr 30;92(18):e2136-e2144
2. Vos JM, Notermans NC, D'Sa S, Lunn MP, van der Pol WL, Kraan W, Reilly MM, Chalker J, Gupta R, Kersten MJ, Pals ST, Minnema MC. High prevalence of the MYD88 L265P mutation in IgM anti-MAG paraprotein-associated peripheral neuropathy. J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):1007-1009
3. Pruppers MHJ, Merkies ISJ, Lunn MPT, Notermans NC; IMAGiNe Study Group. 230th ENMC International Workshop: Improving future assessment and research in IgM anti-MAG peripheral neuropathy: a consensus collaborative effort, Naarden, The Netherlands, 24-26 February 2017. Neuromuscul Disord. 2017 Nov;27(11):1065-1072
4: Visser NA, Vrancken AF, van der Schouw YT, van den Berg LH, Notermans NC. Chronic idiopathic axonal polyneuropathy is associated with the metabolic syndrome. Diabetes Care. 2013 36(4):817-22.
5: Niermeijer JM, Fischer K, Eurelings M, Franssen H, Wokke JH, Notermans NC. Prognosis of polyneuropathy due to IgM monoclonal gammopathy: a prospective cohort study. Neurology. 2010 2;74(5):406-12.
6: Niermeijer JM, Eurelings M, van der Linden MW, Lokhorst HM, Franssen H, Fischer K, Teunissen LL, van den Berg LH, Schobben F, Wokke JH, Notermans NC. Intermittent cyclophosphamide with prednisone versus placebo for polyneuropathy with IgM monoclonal gammopathy. Neurol. 2007 3;69(1):50-9.
7: Franssen H, Notermans NC. Length dependence in polyneuropathy associated with IgM gammopathy. Ann Neurol. 2006;59(2):365-71
Fellowship & awards
1: ENMC Grant, starten Europees samenwerkingsverband MGUS (2016)
2: Guillain-Barré Peripheral Nerve Society Grant: IgM Anti-MAG peripheral Neuropathy (Imagine study). From proper assessment to trial needs (2015)
3: Prinses Beatrix Foundation grant (2009-2014): Unraveling CIAP pathogenesis
4: NWO-AGIKO grant (2002-2007): Analysis chromosomal aberrations and risk factors MGUS
5: ZonMw Netwerk grant (2001)
6: ZonMw Health care efficiency research grant (1999-2002)
7: NWO- AGIKO grant (1996-2001): CIAP, the role of ischemia in pathogenesis
Education
Basic Teaching Qualification (2016)
Side Activities
2016-2020 chair, Reeders Stichting (unsalaried)
The Reeders Foundation was established in 1984 for the purpose of granting financial support to institutions for public benefit. At first the focus was on financial support for research into Multiple Sclerosis. Over the years, as the funds of the foundation increased, others areas of interest were added. The Reeders Foundation has contributed to many organisations active at home and abroad.
2019- member of Supervisory Board, Valuas zorggroep (salaried)
https://valuaszorggroep.nl
Valuas is a family business founded in 2011. In the Valuas care homes care is provided in a homely, small scale environment with high quality attention and service. The organisation and its employees respond flexibly to the wishes of the client. Care is not only provided on the basis of medical needs, but special emphasis is put in improving the client's welfare.
supervisory board Valuas zorggroep
Fellowship and Awards
1: Prinses Beatrix Foundation grant (2009-2014): Unraveling CIAP pathogenesis
2: NWO-AGIKO grant (2002-2007): Analysis chromosomal aberrations and risk factors MGUS
3: ZonMw Netwerk grant (2001)
4: ZonMw Health care efficiency research grant (1999-2002)
5: NWO- AGIKO grant (1996-2001): CIAP, the role of ischemia in pathogenesis
Research Output (134)
van de Mortel Max, D'Sa Shirley, Vrancken Alexander, Notermans Nicolette C, Vos Josephine, Minnema M Dec 2022, In: Hemato. 3 , p. 663-688
Amaador Karima, Wieske Luuk, Koel-Simmelink Marleen J A, Kamp A, Jongerius Ilse, de Heer Koen, Teunissen Charlotte E, Minnema Monique C, Notermans Nicolette C, Eftimov Filip, Kersten Marie José, Vos Josephine M I 14 Feb 2022, In: Journal of Neurology. 269 , p. 3700-3705 6 p.
Warendorf Janna K, van Doormaal Perry T C, Vrancken Alexander F J E, Verhoeven-Duif Nanda M, van Eijk Ruben P A, van den Berg Leonard H, Notermans Nicolette C 12 Oct 2021, In: Nutritional neuroscience. 25 , p. 2536-2546 11 p.
Kuitwaard K., Brusse E., Jacobs B. C., Vrancken A. F.J.E., Eftimov F., Notermans N. C., van der Kooi A. J., Fokkink W. J.R., Nieboer D., Lingsma H. F., Merkies I. S.J., van Doorn P. A. Jan 2021, In: European Journal of Neurology. 28 , p. 286-296 11 p.
van Oeijen Karlijn, Teunissen Laurien L., van Leeuwen Christel, van Opstal Marleen, José van der Putten Marie, Notermans Nicolette C., van Meeteren Nico L.U., Schröder Carin D. Nov 2020, In: Archives of Physical Medicine and Rehabilitation. 101 , p. 1946-1952 7 p.
Mul Karlien, Schouten Meyke I, van der Looij Erica, Dooijes Dennis, Hennekam Frederic A M, Notermans Nicolette C, Praamstra Peter, van Gaalen Judith, Kamsteeg Erik-Jan, Verbeek Nienke E, van de Warrenburg Bart P C 12 Sep 2020, In: Parkinsonism & Related Disorders. 80 , p. 98-101 4 p.
Kopsky David J, Vrancken Alexander F J E, Keppel Hesselink Jan M, van Eijk Ruben P A, Notermans Nicolette C 2020, In: Journal of Pain Research. 13 , p. 877-882 6 p.
Goedee H. Stephan, Notermans Nicolette C., Visser Leo H., van Asseldonk Jan Thies H., Franssen Hessel, Vrancken Alexander F.J.E., Nikolakopoulos Stavros, van den Berg Leonard H., van der Pol W. Ludo Sep 2019, In: Muscle and Nerve. 60 , p. 263-270 8 p.
Hanewinckel Rens, van Oijen Marieke, Taams Noor E, Merkies Ingemar S J, Notermans Nicolette C, Vrancken Alexander F J E, Ikram M Arfan, van Doorn Pieter A Sep 2019, In: Journal of the Peripheral Nervous System. 24 , p. 235-241 7 p.
Stork Abraham C J, Rijkers Ger T, Vlam Lotte, Cats Elisabeth A, de Jong Ben A W, Fritsch-Stork Ruth D E, Veldink Jan H, van den Berg Leonard H, Notermans Nicolette C, van der Pol W-Ludo 7 Mar 2019, In: Muscle & Nerve. 59 , p. 694-698 5 p.