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prof. dr. N.C. (Nicolette) Notermans

Full Professor

  • Neurology & Neurosurgery

prof. dr. N.C. (Nicolette) Notermans

Research Programs

Biography

Biography

Nicolette Notermans obtained her PhD degree on the clinical features and pathogenesis of Chronic Idiopathic Axonal Polyneuropathy (CIAP) and Polyneuropathy associated with Monoclonal Gammopathy of undetermined significance (MGUS) in Utrecht (1994). After her PhD she obtained several  grants (NWO, Prinses Beatrix foundation) to study the etiology of CIAP, polyneuropathy associated with MGUS and other immune-mediated neuropathies. She has initiated several studies of large, national cohorts of patients with CIAP and MGUS, in close collaboration with haematologists throughout the country.

She is a member of the word-wide task force of vasculitic  neuropathy and MGUS neuropathy. As president of the Dutch neuromuscular research organization (ISNO), she organized the 7th annual conference of the World Muscle Society in 2002, in Rotterdam. Since 2010, she is the director of the successful neuromuscular diseases residency program which attracts many residents from other teaching hospitals. 

 

Research line

Polyneuropathy

 

Key publications

1: Warendorf JK, Vrancken AFJE, van Eijk RPA, Visser NA, van den Berg LH, Notermans NC. Statins do not increase risk of polyneuropathy: a case-control study and literature review. Neurology. 2019 Apr 30;92(18):e2136-e2144

2. Vos JM, Notermans NC, D'Sa S, Lunn MP, van der Pol WL, Kraan W, Reilly MM, Chalker J, Gupta R, Kersten MJ, Pals ST, Minnema MC. High prevalence of the MYD88 L265P mutation in IgM anti-MAG paraprotein-associated peripheral neuropathy. J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):1007-1009

3. Pruppers MHJ, Merkies ISJ, Lunn MPT, Notermans NC; IMAGiNe Study Group. 230th ENMC International Workshop: Improving future assessment and research in IgM anti-MAG peripheral neuropathy: a consensus collaborative effort, Naarden, The Netherlands, 24-26 February 2017. Neuromuscul Disord. 2017 Nov;27(11):1065-1072

4: Visser NA, Vrancken AF, van der Schouw YT, van den Berg LH, Notermans NC. Chronic idiopathic axonal polyneuropathy is associated with the metabolic syndrome. Diabetes Care. 2013 36(4):817-22.

5: Niermeijer JM, Fischer K, Eurelings M, Franssen H, Wokke JH, Notermans NC. Prognosis of polyneuropathy due to IgM monoclonal gammopathy: a prospective cohort study. Neurology. 2010 2;74(5):406-12.

6: Niermeijer JM, Eurelings M, van der Linden MW, Lokhorst HM, Franssen H, Fischer K, Teunissen LL, van den Berg LH, Schobben F, Wokke JH, Notermans NC. Intermittent cyclophosphamide with prednisone versus placebo for polyneuropathy with IgM monoclonal gammopathy. Neurol. 2007 3;69(1):50-9.

7: Franssen H, Notermans NC. Length dependence in polyneuropathy associated with IgM gammopathy. Ann Neurol. 2006;59(2):365-71

 

 Fellowship & awards

1: ENMC Grant, starten Europees samenwerkingsverband MGUS (2016)

2: Guillain-Barré Peripheral Nerve Society Grant: IgM Anti-MAG peripheral Neuropathy (Imagine study). From proper assessment to trial needs (2015)

3: Prinses Beatrix Foundation grant (2009-2014): Unraveling CIAP pathogenesis

4: NWO-AGIKO grant (2002-2007): Analysis chromosomal aberrations and risk factors MGUS

5: ZonMw Netwerk grant (2001)

6: ZonMw Health care efficiency research grant (1999-2002)

7: NWO- AGIKO grant (1996-2001): CIAP, the role of ischemia in pathogenesis

 

 Education

Basic Teaching Qualification (2016)

Side Activities

  • 2016- chair, Reeders Stichting (unsalaried)

     The Reeders Foundation was established in 1984 for the purpose of granting financial support to institutions for public benefit. At first the focus was on financial support for research into Multiple Sclerosis. Over the years, as the funds of the foundation increased, others areas of interest were added. The Reeders Foundation has contributed to many organisations active at home and abroad.

     

    2019- member of Supervisory Board, Valuas zorggroep (salaried) 

    https://valuaszorggroep.nl

    Valuas is a family business founded in 2011. In the Valuas care homes care is provided in a homely, small scale environment with high quality attention and service. The organisation and its employees respond flexibly to the wishes of the client. Care is not only provided on the basis of medical needs, but special emphasis is put in improving the client's welfare.

Fellowship and Awards

  • 1: Prinses Beatrix Foundation grant (2009-2014): Unraveling CIAP pathogenesis
    2: NWO-AGIKO grant (2002-2007): Analysis chromosomal aberrations and risk factors MGUS
    3: ZonMw Netwerk grant (2001)
    4: ZonMw Health care efficiency research grant (1999-2002)
    5: NWO- AGIKO grant (1996-2001): CIAP, the role of ischemia in pathogenesis

Research Output (123)

Diagnostic value of symptoms in chronic polyneuropathy:The Erasmus Polyneuropathy Symptom Score

Hanewinckel Rens, van Oijen Marieke, Taams Noor E, Merkies Ingemar S J, Notermans Nicolette C, Vrancken Alexander F J E, Ikram M Arfan, van Doorn Pieter A sep 2019, In: Journal of the Peripheral Nervous System. 24 , p. 235-241 7 p.

Neuropathy associated with immunoglobulin M monoclonal gammopathy:A combined sonographic and nerve conduction study

Goedee H. Stephan, Notermans Nicolette C., Visser Leo H., van Asseldonk Jan Thies H., Franssen Hessel, Vrancken Alexander F.J.E., Nikolakopoulos Stavros, van den Berg Leonard H., van der Pol W. Ludo sep 2019, In: Muscle and Nerve. 60 , p. 263-270 8 p.

Serum cytokine patterns in immunoglobulin m monoclonal gammopathy-associated polyneuropathy

Stork Abraham C J, Rijkers Ger T, Vlam Lotte, Cats Elisabeth A, de Jong Ben A W, Fritsch-Stork Ruth D E, Veldink Jan H, van den Berg Leonard H, Notermans Nicolette C, van der Pol W-Ludo 7 mrt 2019, In: Muscle & Nerve. 59 , p. 694-698 5 p.

Efficacy and safety of IVIG in CIDP:Combined data of the PRIMA and PATH studies

Merkies Ingemar S J, van Schaik Ivo N, Léger Jean-Marc, Bril Vera, van Geloven Nan, Hartung Hans-Peter, Lewis Richard A, Sobue Gen, Lawo John-Philip, Durn Billie L, Cornblath David R, De Bleecker Jan L, Sommer Claudia, Robberecht Wim, Saarela Mika, Kamienowski Jerzy, Stelmasiak Zbigniew, Tackenberg Björn, Mielke Orell, , Notermans Nicolette C mrt 2019, In: Journal of the Peripheral Nervous System. 24 , p. 48-55 8 p.

Restabilization treatment after intravenous immunoglobulin withdrawal in chronic inflammatory demyelinating polyneuropathy:Results from the pre-randomization phase of the Polyneuropathy And Treatment with Hizentra study

Mielke Orell, Bril Vera, Cornblath David R, Lawo John-Philip, van Geloven Nan, Hartung Hans-Peter, Lewis Richard A, Merkies Ingemar S J, Sobue Gen, Durn Billie, Shebl Amgad, van Schaik Ivo N, , Notermans Nicolette C mrt 2019, In: Journal of the Peripheral Nervous System. 24 , p. 72-79 8 p.

Statins do not increase risk of polyneuropathy:A case-control study and literature review

Warendorf Janna K, Vrancken Alexander F J E, van Eijk Ruben P A, Visser Nora A, van den Berg Leonard H, Notermans Nicolette C 8 feb 2019, In: Neurology. 92 , p. e2136-e2144

Clinical relevance of serum antibodies to GD1b in immune-mediated neuropathies

Taams Noor E, Notermans Nicolette C, Fokkink Willem-Jan R, Tio-Gillen Anne P, Huizinga Ruth, Schreurs Marco W J, Jacobs Bart C dec 2018, In: Journal of the Peripheral Nervous System. 23 , p. 227-234 8 p.

High prevalence of the MYD88 L265P mutation in IgM anti-MAG paraprotein-associated peripheral neuropathy

Vos Josephine Mathilde, Notermans Nicolette C., D'Sa Shirley, Lunn Michael P., Van Der Pol W. Ludo, Kraan Willem, Reilly Mary M., Chalker Jane, Gupta Rajeev, Kersten Marie José, Pals Steven T., Minnema Monique C. 1 sep 2018, In: Journal of Neurology, Neurosurgery and Psychiatry. 89 , p. 1007-1009 3 p.

Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH):a randomised, double-blind, placebo-controlled, phase 3 trial

van Schaik Ivo N, Bril Vera, van Geloven Nan, Hartung Hans-Peter, Lewis Richard A, Sobue Gen, Lawo John-Philip, Praus Michaela, Mielke Orell, Durn Billie L, Cornblath David R, Merkies Ingemar S J, , Notermans Nicolette C, Visser Nora A. 1 jan 2018, In: Lancet Neurology. 17 , p. 35-46 12 p.

Quality of life in inflammatory neuropathies:the IN-QoL

Draak Thomas H P, Faber Catharina G, Merkies Ingemar S J, , Notermans Nicolette C 2018, In: Journal of Neurology, Neurosurgery and Psychiatry. 89 , p. 256-262 7 p.

All Research Output (123)