dr. H.G. (Henny) Otten

dr. H.G. (Henny) Otten

Associate Professor
dr. H.G. (Henny) Otten
  • Central Diagnostic Laboratory

Research Programs

Infection & Immunity



Henny Otten is a Medical Immunologist and an associate professor research with a primary research interest focused on humoral immunity including associated effector mechanisms. He studied medical biology at the University of Amsterdam and obtained his PhD at the Department of Rheumatology of the University Hospital Leiden. In 1992 he started as post-doc at the department of Immunohematology at the University Hospital Utrecht developing molecular HLA-typing and performing research in the field of bone marrow and organ transplantation. Between  1997-2012 he was co-director of the HLA laboratory in the UMCU, between 1997-2000 interim head of the bone-marrow transplantation laboratory, and since 2010 he is head of the laboratory for Immunoserology. He is leader of the national PROCARE 2.0 consortium which studies the impact of humoral allo- and auto-immunity in ~10.000 kidney transplants; a study subsidized by Dutch Kidney Foundation. Together with funding from multiple commercial partners, studies are performed on the effector functions of antibodies in relation to complement. He holds certificates as Medical Immunologist,  European Specialist in Histocompatibility & Immunogenetics, Transplantation Immunologist, and Immunologist. In close collaboration with clinicians, Henny Otten has (co-)authored >140 peer-reviewed papers with translational objectives.

Side Activities

Member of the Dutch Transplantation Society

Member of the society of Medical Immunology

Member of the Dutch Society of Immunology

Co-editor Frontiers of Immunology on resarch topic non-HLA antibodies


Research Output (163)

The number of donor HLA-derived T cell epitopes available for indirect antigen presentation determines the risk for vascular rejection after kidney transplantation

Betjes Michiel G.H., Peereboom Emma T.M., Otten Henny G., Spierings Eric 30 Aug 2022, In: Frontiers in Immunology. 13

Editorial:A hill of needs: Non-HLA antibodies and transplantation

Otten H. G., Dieudé Mélanie, Hickey Michelle J. 22 Aug 2022, In: Frontiers in Immunology. 13

Microarray analysis of autoantibodies can identify future Systemic Lupus Erythematosus patients

Brunekreef Tammo E, Reteig Leon C, Limper Maarten, Haitjema Saskia, Dias Jorge, Mathsson-Alm Linda, van Laar Jacob M, Otten Henny G Jun 2022, In: Human Immunology. 83 , p. 509-514 6 p.

Adult mouse and human organoids derived from thyroid follicular cells and modeling of Graves’ hyperthyroidism

van der Vaart Jelte, Bosmans Lynn, Sijbesma Stijn F, Knoops Kèvin, van de Wetering Willine J, Otten Henny G, Begthel Harry, Borel Rinkes Inne H M, Korving Jeroen, Lentjes Eef G W M, Lopez-Iglesias Carmen, Peters Peter J, van Santen Hanneke M, Vriens Menno R, Clevers Hans 21 Dec 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118 , p. 1-11

T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Peereboom Emma T M, Matern Benedict M, Tomosugi Toshihide, Niemann Matthias, Drylewicz Julia, Joosten Irma, Allebes Wil A, van der Meer Arnold, Hilbrands Luuk B, Baas Marije C, van Reekum Franka E, Verhaar Marianne C, Kamburova Elena G, Seelen Marc A J, Sanders Jan Stephan, Hepkema Bouke G, Lambeck Annechien J, Bungener Laura B, Roozendaal Caroline, Tilanus Marcel G J, Voorter Christien E, Wieten Lotte, van Duijnhoven Elly M, Gelens Mariëlle A C J, Christiaans Maarten H L, van Ittersum Frans J, Nurmohamed Azam, Lardy Neubury M, Swelsen Wendy, van der Pant Karlijn A, van der Weerd Neelke C, Ten Berge Ineke J M, Bemelman Fréderike J, de Vries Aiko P J, de Fijter Johan W, Betjes Michiel G H, Roelen Dave L, Claas Frans H, Otten Henny G, Heidt Sebastiaan, van Zuilen Arjan D, Kobayashi Takaaki, Geneugelijk Kirsten, Spierings Eric 18 Nov 2021, In: Frontiers in Immunology. 12 , p. 1-13

Measurement of IgE to hazelnut allergen components cannot replace hazelnut challenge in Dutch adults

Lyons Sarah A, Welsing Paco M J, Hakobyan Mariam, Kansen Hannah M, Knol Edward F, Otten Henny G, van Ree Ronald, Knulst André C, Le Thuy-My 16 Nov 2021, In: Allergy. 77 , p. 1559-1569 11 p.

Microarray testing in patients with systemic lupus erythematosus identifies a high prevalence of CpG DNA-binding antibodies

Brunekreef Tammo, Limper Maarten, Melchers Rowena, Mathsson-Alm Linda, Dias Jorge, Hoefer Imo, Haitjema Saskia, van Laar Jacob M, Otten Henny Oct 2021, In: Lupus science & medicine. 8

A Comprehensive Overview of the Clinical Relevance and Treatment Options for Antibody-mediated Rejection Associated With Non-HLA Antibodies

Kardol-Hoefnagel Tineke, Otten Henny G. 1 Jul 2021, In: Transplantation. 105 , p. 1459-1470 12 p.

Systemic and local evidence for complement involvement in chronic spontaneous urticaria

Alizadeh Aghdam Mehran, van den Elzen Mignon, van Os-Medendorp Harmieke, van Dijk Marijke R, Knol Edward F, Knulst André C, Röckmann Heike, Otten Henny G Jul 2021, In: Clinical and Translational Allergy. 11 , p. 1-8

Distinction between peanut allergy and tolerance by characterization of B-cell receptor repertoires

Ehlers Anna, den Hartog Jager CF, Knulst André C., Otten Henny G. 10 May 2021, In: Allergy: European Journal of Allergy and Clinical Immunology. 76 , p. 2753-2764 12 p.

All research output

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