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prof. dr. R.J. (Jeroen) Pasterkamp

prof. dr. R.J. (Jeroen) Pasterkamp

Full Professor
prof. dr. R.J. (Jeroen) Pasterkamp
  • Translational Neuroscience

Biography

Biography

Jeroen Pasterkamp obtained his PhD degree at the Netherlands Institute for Brain Research and the Vrije Universiteit in Amsterdam with Joost Verhaagen and Dick Swaab. He carried out postdoctoral research at the Department of Neuroscience of the Johns Hopkins University School of Medicine in Baltimore, USA. In 2005, he joined the Department of Translational Neuroscience of the Brain Center Rudolf Magnus, where he is currently appointed as a professor of translational neuroscience.

His research focuses on understanding 1) the signaling events and molecular mechanisms involved in the formation of neuronal connections during development, and 2) the molecular mechanisms underlying changes in or loss of neuronal connectivity during neurological disease (in particular amyotrophic lateral sclerosis (ALS) and epilepsy). This research concentrates on mouse models and humanized cell models (iPSC) using an integrated approach involving molecular biology, cell biology, neuroanatomy, (in vivo) functional proteomics, imaging, HC screening, and mouse genetics.

His work was published in leading journals such as Cell, Journal of Neuroscience, Nature, Nature Genetics, PNAS and he regularly contributes reviews to Current Opinion, Trends and Nature Reviews journals.

Jeroen Pasterkamp is a recipient of a NARSAD Young Investigator, and a Dan Nathans Young Investigator Award. He is a member of the Scientific Advisory board of the Dutch National Epilepsy Fund (NEF) and the Dutch Society for Developmental Biology. He organizes scientific meetings under the framework of the Royal Netherlands Academy of Arts and Sciences (KNAW), EMBO, and Utrecht Summerschool series.

Research line

Neural circuit development and Translational neuroscience

Most recent key publications

1. Vangoor VR, Reschke CR, Senthilkumar K, van de Haar LL, de Wit M, Giuliani G, Broekhoven MH, Morris G, Engel T, Brennan GP, Conroy RM, van Rijen PC, Gosselaar PH, Schorge S, Schaapveld RQJ, Henshall DC, De Graan PNE, Pasterkamp RJ (2019) Antagonizing increased miR-135a levels at the chronic stage of experimental TLE reduces spontaneous recurrent seizures. J Neurosci 39, 5064-5079.
 
2. Ormel PR, Vieira de Sá R, van Bodegraven EJ, Karst H, Harschnitz O, Sneeboer MAM, Johansen LE, van Dijk RE, Scheefhals N, Berdenis van Berlekom A, Ribes Martínez E, Kling S, MacGillavry HD, van den Berg LH, Kahn RS, Hol EM, de Witte LD, Pasterkamp RJ (2018) Microglia innately develop within cerebral organoids. Nat Commun 9, 4167.
 
3. Jongbloets BC, Lemstra S, Schellino R, Broekhoven MH, Parkash J, Hellemons AJ, Mao T, Giacobini P, van Praag H, De Marchis S, Ramakers GM, Pasterkamp RJ (2017) Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nat Commun 8:14666.
 
4. Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ*, Jones EY* (2016). Structural Basis for Plexin Activation and Regulation. Neuron 91, 548-60. *Shared senior authors.
 
5. Harschnitz O, van den Berg LH, Johansen LE, Jansen MD, Kling S, Vieira de Sá R, Vlam L, van Rheenen W, Karst H, Wierenga CJ, Pasterkamp RJ*, van der Pol WL* (2016). Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model. Ann Neurol 80, 71-88. *Shared senior authors.
 
6. Van Erp S, van den Heuvel DMA, Fujita Y, Robinson R, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers J, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ (2015) Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases. Dev Cell 35, 537-552.

Side Activities

  • Member General board, Dutch Parkinson Scientists

  • Member, F1000Prime, section Neurodevelopment

  • Member Scientific Advisory Board, Prinses Beatrix Spierfonds (PBS)

  • Member Scientific Advisory Board, Swiss Regen Therapeutics GmbH

Fellowship and Awards

VICI, 2015
ZonMW TOP, 2008
VIDI, 2006
HFSP career development award, 2005
VENI, 2004
NWO Talent, 2000

Research Output (156)

Protocol for tissue clearing and 3D analysis of dopamine neurons in the developing mouse midbrain

Adolfs Youri, Raj Divya D.A., Brignani Sara, Pasterkamp R. Jeroen 17 sep 2021, In: STAR protocols. 2 33 p.

Recent advances in inter-cellular interactions during neural circuit assembly

Klein Rüdiger, Pasterkamp Ronald Jeroen aug 2021, In: Current Opinion in Neurobiology. 69 , p. 25-32 8 p.

Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling

Robinson Ross A., Griffiths Samuel C., van de Haar Lieke L., Malinauskas Tomas, van Battum Eljo Y., Zelina Pavol, Schwab Rebekka A., Karia Dimple, Malinauskaite Lina, Brignani Sara, van den Munkhof Marleen H., Düdükcü Özge, De Ruiter Anna A., Van den Heuvel Dianne M.A., Bishop Benjamin, Elegheert Jonathan, Aricescu A. Radu, Pasterkamp R. Jeroen, Siebold Christian 15 apr 2021, In: Cell. 184 , p. 2103-2120.e31 12 p.

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky Nikolaus, Almouzni Geneviève, Gorski Stanislaw A., Aerts Stein, Amit Ido, Bertero Michela G., Bock Christoph, Bredenoord Annelien L., Cavalli Giacomo, Chiocca Susanna, Clevers Hans, De Strooper Bart, Eggert Angelika, Ellenberg Jan, Fernández Xosé M., Figlerowicz Marek, Gasser Susan M., Hubner Norbert, Kjems Jørgen, Knoblich Jürgen A., Krabbe Grietje, Lichter Peter, Linnarsson Sten, Marine Jean Christophe, Marioni John C., Marti-Renom Marc A., Netea Mihai G., Nickel Dörthe, Nollmann Marcelo, Novak Halina R., Parkinson Helen, Piccolo Stefano, Pinheiro Inês, Pombo Ana, Popp Christian, Reik Wolf, Roman-Roman Sergio, Rosenstiel Philip, Schultze Joachim L., Stegle Oliver, Tanay Amos, Testa Giuseppe, Thanos Dimitris, Theis Fabian J., Torres-Padilla Maria Elena, van Oudenaarden Alexander, Bruining Hilgo, Jongsma Karin R., Pasterkamp R. Jeroen, van Oudenaarden Alexander, 1 apr 2021, In: Nature. 592 , p. E8

Enrichment of Circular RNA Expression Deregulation at the Transition to Recurrent Spontaneous Seizures in Experimental Temporal Lobe Epilepsy

Gomes-Duarte Andreia, Bauer Sebastian, Venø Morten T., Norwood Braxton A., Henshall David C., Kjems Jørgen, Rosenow Felix, Vangoor Vamshidhar R., Pasterkamp R. Jeroen 28 jan 2021, In: Frontiers in Genetics. 12

A directional 3D neurite outgrowth model for studying motor axon biology and disease

Spijkers Xandor M., Pasteuning-Vuhman Svetlana, Dorleijn Jennifa C., Vulto Paul, Wevers Nienke R., Pasterkamp R. Jeroen 22 jan 2021, In: Scientific Reports. 11 15 p.

Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy

Reschke Cristina R., Silva Luiz F.A., Vangoor Vamshidhar R., Rosso Massimo, David Bastian, Cavanagh Brenton L., Connolly Niamh M.C., Brennan Gary P., Sanz-Rodriguez Amaya, Mooney Catherine, Batool Aasia, Greene Chris, Brennan Marian, Conroy Ronan M., Rüber Theodor, Prehn Jochen H.M., Campbell Matthew, Pasterkamp R. Jeroen, Henshall David C. 2021, In: Molecular Therapy. 29 , p. 2041-2052 12 p.

Neuromuscular junction-on-a-chip:ALS disease modeling and read-out development in microfluidic devices

de Jongh Rianne, Spijkers Xandor M., Pasteuning-Vuhman Svetlana, Vulto Paul, Pasterkamp R. Jeroen 2021, In: Journal of Neurochemistry. 157 , p. 393-412 20 p.

Pharmacological validation of TDO as a target for Parkinson’s disease

Perez-Pardo Paula, Grobben Yvonne, Willemsen-Seegers Nicole, Hartog Mitch, Tutone Michaela, Muller Michelle, Adolfs Youri, Pasterkamp Ronald Jeroen, Vu-Pham Diep, van Doornmalen Antoon M., van Cauter Freek, de Wit Joeri, Gerard Sterrenburg Jan, Uitdehaag Joost C.M., de Man Jos, Buijsman Rogier C., Zaman Guido J.R., Kraneveld Aletta D. 2021, In: FEBS Journal. 288 , p. 4311-4331 21 p.

How the COVID-19 pandemic highlights the necessity of animal research (vol 30, pg R1014, 2020):How the COVID-19 pandemic highlights the necessity of animal research (Current Biology (2020) 30(18) (R1014–R1018), (S0960982220311842), (10.1016/j.cub.2020.08.030))

Genzel Lisa, Adan Roger, Berns Anton, van den Beucken Jeroen J.J.P., Blokland Arjan, Boddeke Erik H.W.G.M., Bogers Willy M., Bontrop Ronald, Bulthuis R., Bousema Teun, Clevers Hans, Coenen Tineke C.J.J., van Dam Anne Marie, Deen Peter M.T., van Dijk K. W., Eggen Bart J.L., Elgersma Ype, Erdogan Izel, Englitz Bernhard, Fentener van Vlissingen J. Martje, la Fleur Susanne, Fouchier Ron, Fitzsimons Carlos P., Frieling Wilbert, Haagmans Bart, Heesters Balthasar A., Henckens Marloes J.A.G., Herfst Sander, Hol Elly, van den Hove Daniel, de Jonge Marien I., Jonkers Jos, Joosten Leo A.B., Kalsbeek Andries, Kamermans Maarten, Kampinga Harm H., Kas Martien J., Keijer Jaap, Kersten Sander, Kiliaan Amanda J., Kooij Taco W.A., Kooijman Sander, Koopman Werner J.H., Lesscher Heidi M.B., Meye Frank J., Mul Joram D., Pasterkamp R. Jeroen, van Rheenen Jacco, Vanderschuren Louk J.M.J., Homberg Judith R., 2 nov 2020, In: Current Biology. 30 , p. 4328-4328 1 p.

All research output

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