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prof. dr. J.G.J. (Jan) van de Winkel

prof. dr. J.G.J. (Jan) van de Winkel

Full Professor

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Research Output (250)

Fc receptors: role in biology and antibody therapy.

van de Winkel J.G.J. 2010, In: Immunology Letters. 128 , p. 4-5 2 p.

High throughput screening for antibody induced complement-dependent cytotoxicity in early antibody discovery using homogeneous macroconfocal fluorescence imaging

Gerritsen A.F, Bosch M, de Weers M., van de Winkel J.G.J., Parren P.W.H.I. 2010, In: Journal of Immunological Methods. 352 , p. 140-146 7 p.

Daratumumab, a novel therapeutic human CD38 monoclonal antibody, effectively induces killing of multiple myeloma and other hematological tumors

de Weers M., Bakker J.M., Vink T., Jacobs D.C.H., Oomen L.A., Bleeker W.K., van de Winkel J.G.J., Parren P.W.H.I., Tai Y-T, Anderson K.C., Peipp M., Valerius T., Slootstra J.W., Lokhorst H.M. 2010, p. 24-24 1 p.

Human IgG2 antibodies against epidermal growth factor receptor effectively trigger antibody-dependent cellular cytotoxicity but, in contrast to IgG1, only by cells of myeloid lineage.

Schneider-Merck T., Lammerts van Bueren J.J., Berger S., Rossen K., van Berkel P.H.C., Derer S., Beyer T., Lohse S., Bleeker W.K., Peipp M., Parren P.W.H.I., van de Winkel J.G.J., Valerius T., Dechant M. 2010, In: Journal of Immunology. 184 , p. 512-520 9 p.

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

Labrijn A.F., Ortiz Buijsse A., van den Bremer E.T.J., Verwilligen A.Y.W., Bleeker W.K., Thorpe S.J., Killestein J., Polman C.H., Aalberse R.C., Schuurman J., van de Winkel J.G.J., Parren P.W.H.I. 2009, In: Nature Biotechnology. 27 , p. 767-771 5 p.

N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

van Berkel P.H.C., Gerritsen J., Perdok G., Valbjørn J., Vink T., van de Winkel J.G.J., Parren P.W.H.I. 2009, In: Biotechnology Progress. 25 , p. 244-251 8 p.

Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX

Pawluczkowycz A.W., Beurskens F.J., Beum P.V., Lindorfer M.A., van de Winkel J.G.J., Parren P.W.H.I., Taylor R.P. 2009, In: Journal of Immunology. 183 , p. 749-758 10 p.

FcgammaRIIa genotype is associated with acute coronary syndromes as first manifestation of coronary artery disease

Raaz D., Herrmann M., Ekici A.B., Klinghammer L., Lausen B., Voll R.E., Leusen J.H.W., van de Winkel J.G.J., Daniel W.G., Reis A., Garlichs C.D. 2009, In: Atherosclerosis. 205 , p. 512-516 5 p.

Inside-out regulation of Fc alpha RI (CD89) depends on PP2A

Bakema J.E., Bakker J., de Haij S., Honing H., Bracke M., Koenderman L., Vidarsson G., van de Winkel J.G.J., Leusen J.H.W. 15 Sep 2008, In: Journal of Immunology. 181 , p. 4080-4088 9 p.

Protein 4.1G binds to a unique motif within the Fc gamma RI cytoplasmic tail

Beekman J.M., Bakema J.E., van der Poel C.E., van der Linden J.A., van de Winkel J.G.J., Leusen J.H.W. Apr 2008, In: Molecular Immunology. 45 , p. 2069-2075 7 p.

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