prof. dr. C.K. (Kors) van der Ent
prof. dr. C.K. (Kors) van der Ent
- Pulmonology patient care
- Strategic theme Child Health
Research Programs
Biography
Biography
The research interests of professor Kors van der Ent focus on the themes Cystic Fibrosis and other bronchusobstructive diseseases in young children. He is the leader of the national HIT-CF program which focuses on the development and personalised application of new drugs influencing the basis genetic defect in patients with CF. This program includes both mechanistic studies in collaboration with the Hubrecht lab and the Byvoet Center as well as studies into host pathogen interaction in collaboration with the veterinary faculty of the Utrecht University. Clinical studies are performed in close collaboration with other CF-centres throughout Europe. Furthermore, he was the founder of the Whistler birth cohort, in which thousands of children are followed from birth to study determinants of the development of respiratory diseases. These cohorts mirror normal development to understand mechanisms in disease.
Kors van der Ent has special interest in innovation and valorisation in medical care and believes in creation of hospital networks to build the future medical care system for children. He successfully developed new devices to measure neonatal lung function, which were launched to the market. He also developed the Luchtwegportaal, an interactive web-based system to collect patient data regarding respiratory diseases in many hospitals in The Netherlands.
Side Activities
Chairman of Cystic Fibrosis Center Utrecht
Chairman of Dutch Cystic Fibrosis Research Network
Member of Medical Advisory Board Dutch Cystic Fibrosis Committee
Member of Research committee Wilhelmina Children’s Hospital Utrecht
Member of Medical Ethical Committee University Medical Center Utrecht
Medical advisor of Sioux CCM
Board Member of Malawi Mission Work Team
Chair of CoreNetwork CF of European Refence Network of Excellence for rare lung diseases (ERN-LUNG) 2015-now
Member steering committee Clinical Trial Office UMC Utrecht 2017-now
Coordinator of European HIT-CF program 2018-now
Board member of Lung Alliance Netherlands (LAN) 2020-now
Reviewer for Am J Resp Crit Care Med, European Respir J and many others
Reviewer for the expertise centra voor zeldzame ziekte voor de NFU 2021 - heden
Chair of therapeutic foundation 2021 - heden
Potential Conflicts of Interest
Dr. van der Ent reports grants from GSK, grants from Nutricia, grants from TEVA, grants from Gilead, grants from Vertex, grants from ProQR, grants from Proteostasis, grants from Galapagos NV, grants from Eloxx and grants from Santhera, all paid to UMCU; In addition, Dr. van der Ent has a patent 10006904 with royalties paid.
Fellowship and Awards
European CF young investigator meeting award 2011. A functional CFTR assay using primary cystic fibrosis organoids
European CF basic science meeting award 2011. Treatment with VX809 and VX770 in rectal CF organoids expressing uncommon CFTR genotypes
European CF basic science meeting award 2012. Characterizing altered inflammatory signaling in CFTR-defective
bronchial epithelial cells
National symposium Dutch CF foundation award 2011. Complement mediated phagocytosis is reduced in CF monocytes.
Research Output (589)
Rodenburg Lisa W, Metzemaekers Mieke, van der Windt Isabelle S, Smits Shannon M A, den Hertog-Oosterhoff Loes A, Kruisselbrink Evelien, Brunsveld Jesse E, Michel Sabine, de Winter-de Groot Karin M, van der Ent Cornelis K, Stadhouders Ralph, Beekman Jeffrey M, Amatngalim Gimano D 30 Oct 2023, In: Scientific Reports. 13
Lefferts Juliet W, Bierlaagh Marlou C, Kroes Suzanne, Nieuwenhuijze Natascha D A, Sonneveld van Kooten Heleen N, Niemöller Paul J, Verburg Tibo F, Janssens Hettie M, Muilwijk Danya, van Beuningen Sam F B, van der Ent Cornelis K, Beekman Jeffrey M Oct 2023, In: International Journal of Molecular Sciences. 24 14 p.
Noordstar Johannes J, Hulzebos Erik H J, van der Ent Cornelis K, Suijker Monique H, Bartels Marije 1 Aug 2023, In: Journal of Pediatric Hematology/oncology. 45 , p. e710-e715
Muilwijk Danya, van Paridon Tessa J., van der Heijden Doris C., Faber-Bisschop Brenda M., Zomer-van Ommen Domenique D., Heijerman Harry G.M., van der Ent Cornelis K. Aug 2023, In: EClinicalMedicine. 62
Kristensen Maartje, de Koff Emma M, Chu Mei Ling, Groendijk Simone, Tramper-Stranders Gerdien A, de Winter-de Groot Karin M, Janssens Hettie M, Tiddens Harm A, van Westreenen Mireille, Sanders Elisabeth A M, Arets Bert H G M, van der Ent Cornelis K, Prevaes Sabine M P J, Bogaert Debby Jun 2023, In: Microbiology spectrum. 11 , p. 1-8
Aalbers Bente L., Mohamed Hoesein Firdaus A.A., Hofland Regina W., Bronsveld Inez, Kruijswijk Marian A., Schotman Suzan, Slingerland Corlien W., Panhuis Hannah, van der Ent C. Kors, Heijerman Harry G.M. 24 May 2023, In: Pediatric Pulmonology. 58 , p. 2317-2322 6 p.
van der Heijden Els, van den Bor Rutger M, van der Ent Cornelis K, Nijhof Sanne L, van der Laan Sabine E I 1 May 2023, In: ERJ Open Research. 9 11 p.
Lefferts J. W., Boersma V., Nieuwenhuijze N. D.A., Suen S. W.F., Hajo K., Collantes N. Sanchez, Vermeulen C., Groeneweg T., Hagemeijer M. C., de Jonge H. R., van der Ent C. K., Splinter E., Beekman J. M. May 2023, In: Journal of Cystic Fibrosis. 22 , p. 538-547 10 p.
Biemans Camille F M, Nijhof Sanne L, Gorter Jan Willem, Stevens Gonneke J W M, van de Putte Elise, Hoefnagels Johanna W, van den Berg Anemone, van der Ent Cornelis K, Dudink Jeroen, Verschuren Olaf W 26 Apr 2023, In: European Journal of Pediatrics. 182 , p. 3139-3146 8 p.
Alexandridis Dionysis, Nijhof Sanne L, van der Rijst Vincent G, van der Neut Damian Y, Spijkerman Renske, Stevens Gonneke W J M, Bakkes Sander C J, Lesscher Heidi M B, van den Eijnden Regina J J M, van der Ent Cornelis K, van den Berg Gerrit, Peeters Margot 17 Apr 2023, In: Frontiers in Public Health. 11 10 p.