prof. dr. C.K. (Kors) van der Ent

prof. dr. C.K. (Kors) van der Ent

Full Professor
prof. dr. C.K. (Kors) van der Ent
  • Pulmonology patient care
  • Strategic theme Child Health



The research interests of professor Kors van der Ent focus on the themes Cystic Fibrosis and other bronchusobstructive diseseases in young children. He is the leader of the national HIT-CF program which focuses on the development and personalised application of new drugs influencing the basis genetic defect in patients with CF. This program includes both mechanistic studies in collaboration with the Hubrecht lab and the Byvoet Center as well as studies into host pathogen interaction in collaboration with the veterinary faculty of the Utrecht University. Clinical studies are performed in close collaboration with other CF-centres throughout Europe. Furthermore, he was the founder of the Whistler birth cohort, in which thousands of children are followed from birth to study determinants of the development of respiratory diseases. These cohorts mirror normal development to understand mechanisms in disease.

Kors van der Ent has special interest in innovation and valorisation in medical care and believes in creation of hospital networks to build the future medical care system for children. He successfully developed new devices to measure neonatal lung function, which were launched to the market. He also developed the Luchtwegportaal, an interactive web-based system to collect patient data regarding respiratory diseases in many hospitals in The Netherlands.

Side Activities

Chairman of Cystic Fibrosis Center Utrecht

Chairman of Dutch Cystic Fibrosis Research Network

Member of Medical Advisory Board Dutch Cystic Fibrosis Committee

Member of Research committee Wilhelmina Children’s Hospital Utrecht

Member of Medical Ethical Committee University Medical Center Utrecht

Medical advisor of Sioux CCM

Board Member of Malawi Mission Work Team

Chair of CoreNetwork CF of European Refence Network of Excellence for rare lung diseases (ERN-LUNG) 2015-now

Member steering committee Clinical Trial Office UMC Utrecht 2017-now

Coordinator of European HIT-CF program 2018-now

Board member of Lung Alliance Netherlands (LAN) 2020-now

Reviewer for Am J Resp Crit Care Med, European Respir J and many others

Reviewer for the expertise centra voor zeldzame ziekte voor de NFU 2021 - heden

Chair of therapeutic foundation 2021 - heden


Potential Conflicts of Interest

Dr. van der Ent reports grants from GSK, grants from Nutricia, grants from TEVA, grants from Gilead, grants from Vertex, grants from ProQR, grants from Proteostasis, grants from Galapagos NV, grants from Eloxx and grants from Santhera, all paid to UMCU; In addition, Dr. van der Ent has a patent 10006904 with royalties paid.

Fellowship and Awards

European CF young investigator meeting award 2011. A functional CFTR assay using primary cystic fibrosis organoids

European CF basic science meeting award 2011. Treatment with VX809 and VX770 in rectal CF organoids expressing  uncommon CFTR genotypes

European CF basic science meeting award 2012. Characterizing altered inflammatory signaling in CFTR-defective

bronchial epithelial cells

National symposium Dutch CF foundation award 2011. Complement mediated phagocytosis is reduced in CF monocytes.

Research Output (590)

Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis

Rodenburg Lisa W, Metzemaekers Mieke, van der Windt Isabelle S, Smits Shannon M A, den Hertog-Oosterhoff Loes A, Kruisselbrink Evelien, Brunsveld Jesse E, Michel Sabine, de Winter-de Groot Karin M, van der Ent Cornelis K, Stadhouders Ralph, Beekman Jeffrey M, Amatngalim Gimano D 30 Oct 2023, In: Scientific Reports. 13

CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes.

Lefferts Juliet W, Bierlaagh Marlou C, Kroes Suzanne, Nieuwenhuijze Natascha D A, Sonneveld van Kooten Heleen N, Niemöller Paul J, Verburg Tibo F, Janssens Hettie M, Muilwijk Danya, van Beuningen Sam F B, van der Ent Cornelis K, Beekman Jeffrey M Oct 2023, In: International Journal of Molecular Sciences. 24 14 p.

Organized Sports Activities Are Safe for Children With Sickle Cell Disease:A Pilot Intervention Study

Noordstar Johannes J, Hulzebos Erik H J, van der Ent Cornelis K, Suijker Monique H, Bartels Marije 1 Aug 2023, In: Journal of Pediatric Hematology/oncology. 45 , p. e710-e715

Development and validation of a novel personalized electronic patient-reported outcome measure to assess quality of life (Q-LIFE):a prospective observational study in people with Cystic Fibrosis

Muilwijk Danya, van Paridon Tessa J., van der Heijden Doris C., Faber-Bisschop Brenda M., Zomer-van Ommen Domenique D., Heijerman Harry G.M., van der Ent Cornelis K. Aug 2023, In: EClinicalMedicine. 62

Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders

Dreyer Henriette H.M., van Tuyll van Serooskerken Eleonora Sofie, Rodenburg Lisa W., Bittermann Arnold J.N., Arets Hubertus G.M., Reuling Ellen M.B.P., Verweij Johannes W., Haarman Eric G., van der Zee David C., Tytgat Stefaan H.A.J., van der Ent Cornelis K., Beekman Jeffrey M., Amatngalim Gimano D., Lindeboom Maud Y.A. 5 Jun 2023, In: Children (Basel, Switzerland). 10 , p. 1-9 9 p.

16S rRNA-Based Microbiota Profiling Assists Conventional Culture Analysis of Airway Samples from Pediatric Cystic Fibrosis Patients

Kristensen Maartje, de Koff Emma M, Chu Mei Ling, Groendijk Simone, Tramper-Stranders Gerdien A, de Winter-de Groot Karin M, Janssens Hettie M, Tiddens Harm A, van Westreenen Mireille, Sanders Elisabeth A M, Arets Bert H G M, van der Ent Cornelis K, Prevaes Sabine M P J, Bogaert Debby Jun 2023, In: Microbiology spectrum. 11 , p. 1-8

Radiological and long-term clinical response to elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis with advanced lung disease

Aalbers Bente L., Mohamed Hoesein Firdaus A.A., Hofland Regina W., Bronsveld Inez, Kruijswijk Marian A., Schotman Suzan, Slingerland Corlien W., Panhuis Hannah, van der Ent C. Kors, Heijerman Harry G.M. 24 May 2023, In: Pediatric Pulmonology. 58 , p. 2317-2322 6 p.

The RISE study protocol:resilience impacted by positive stressful events for people with cystic fibrosis

van der Heijden Els, van den Bor Rutger M, van der Ent Cornelis K, Nijhof Sanne L, van der Laan Sabine E I 1 May 2023, In: ERJ Open Research. 9 11 p.

Targeted locus amplification reveals heterogeneity between and within CFTR genotypes and association with CFTR function in patient-derived intestinal organoids

Lefferts J. W., Boersma V., Nieuwenhuijze N. D.A., Suen S. W.F., Hajo K., Collantes N. Sanchez, Vermeulen C., Groeneweg T., Hagemeijer M. C., de Jonge H. R., van der Ent C. K., Splinter E., Beekman J. M. May 2023, In: Journal of Cystic Fibrosis. 22 , p. 538-547 10 p.

Self-reported quantity and quality of sleep in children and adolescents with a chronic condition compared to healthy controls

Biemans Camille F M, Nijhof Sanne L, Gorter Jan Willem, Stevens Gonneke J W M, van de Putte Elise, Hoefnagels Johanna W, van den Berg Anemone, van der Ent Cornelis K, Dudink Jeroen, Verschuren Olaf W 26 Apr 2023, In: European Journal of Pediatrics. 182 , p. 3139-3146 8 p.

All research output

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