Associate Professor P.M. van Hasselt
Associate Professor - medical
- Metabolic diseases patient care
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Biography
2020-present Research Manager WKZ
2019-present Associate Professor (Universitair hoofddocent UHD)
2017-present Head of subspecialty Metabolic diseases (from August 2018)
2017-2020 Head of Cluster C (subspecialties Endocrinology, Metabolic diseases, MDL, Nephrology) at WKZ
2015-present 'Opleider' at department of Metabolic Diseases
2009-present Staff member at department of Metabolic Diseases
2007-present Pediatrician for Metabolic Diseases, Wilhelmina Children’s Hospital, Utrecht.
2004-2009 PhD “Vitamin K prophylaxis revisited – focus on risk factors”. Utrecht University. Promotors: Prof.Dr. R. Berger and Prof.dr. J.J.L. Kimpen
2004-2007 Subspecialty training (fellowship) for Metabolic Diseases, Wilhelmina Children’s Hospital. Head: Dr. T.J. de Koning
1999-2004 Pediatric specialty training. Wilhelmina Children’s Hospital, Utrecht and Isala Clinics, Zwolle. Head: Prof.dr. J.J.L. Kimpen
1998-1999 Physician-researcher at Netherlands Institute of Neuroscience, Amsterdam. Head: Prof R. Buis;
1997-1998 Physician at Department of Neonatology, Wilhelmina Children’s Hospital, Utrecht
1994-1997 Artsexamen (MD), University of Groningen
1989-1994 Doctoral Medicine (MSc), University of Groningen
1988-1989 Freshman-year at Wittenburg University, Springfield OH, USA (supported by scholarship through NACEE, now known as Fulbright Center)
Research Output (134)
Prime editing for functional repair in patient-derived disease models
Schene Imre F, Joore Indi P, Oka Rurika, Mokry Michal, van Vugt Anke H M, van Boxtel Ruben, van der Doef Hubert P J, van der Laan Luc J W, Verstegen Monique M A, van Hasselt Peter M, Nieuwenhuis Edward E S, Fuchs Sabine A 1 dec 2020, In: Nature Communications. 11 , p. 5352
Quantifying lymphocyte vacuolization serves as a measure of CLN3 disease severity
Kuper Willemijn F E, Oostendorp Marlies, van den Broek Brigitte T A, van Veghel Karin, Nonkes Lourens J P, Nieuwenhuis Edward E S, Fuchs Sabine A, Veenendaal Tineke, Klumperman Judith, Huisman Albert, Nierkens Stefan, van Hasselt Peter M jul 2020, In: JIMD Reports. 54 , p. 87-97 11 p.
Hurdles in treating Hurler disease:potential routes to achieve a "real" cure
van den Broek Brigitte T A, van Doorn Jaap, Hegeman Charlotte V, Nierkens Stefan, Lindemans Caroline A, Verhoeven-Duif Nanda, Boelens Jaap Jan, van Hasselt Peter M 23 jun 2020, In: Blood Advances. 4 , p. 2837-2849 13 p.
Cross-omics:Integrating genomics with metabolomics in clinical diagnostics
Kerkhofs Marten H.P.M., Haijes Hanneke A., Marcel Willemsen A., Van Gassen Koen L.I., Van Der Ham Maria, Gerrits Johan, De Sain-Van Der Velden Monique G.M., Prinsen Hubertus C.M.T., Van Deutekom Hanneke W.M., Van Hasselt Peter M., Verhoeven-Duif Nanda M., Jans Judith J.M. 18 mei 2020, In: Metabolites. 10 15 p.
Untargeted metabolomics for metabolic diagnostic screening with automated data interpretation using a knowledge-based algorithm
Haijes Hanneke A., van der Ham Maria, Prinsen Hubertus C.M.T., Broeks Melissa H., van Hasselt Peter M., de Sain-Van der Velden Monique G.M., Verhoeven-Duif Nanda M., Jans Judith J.M. 1 feb 2020, In: International journal of molecular sciences. 21 12 p.
Metachromatic leukodystrophy and transplantation:remyelination, no cross-correction
Wolf Nicole I., Breur Marjolein, Plug Bonnie, Beerepoot Shanice, Westerveld Aimee S.R., van Rappard Diane F., de Vries Sharon I., Kole Maarten H.P., Vanderver Adeline, van der Knaap Marjo S., Lindemans Caroline A., van Hasselt Peter M., Boelens Jaap J., Matzner Ulrich, Gieselmann Volkmar, Bugiani Marianna 22 jan 2020, In: Annals of Clinical and Translational Neurology. 7 , p. 169-180 12 p.
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis
Gomez-Giro Gemma, Arias-Fuenzalida Jonathan, Jarazo Javier, Zeuschner Dagmar, Ali Muhammad, Possemis Nina, Bolognin Silvia, Halder Rashi, Jäger Christian, Kuper Willemijn F.E., Van Hasselt Peter M., Zaehres Holm, Del Sol Antonio, Van Der Putten Herman, Schöler Hans R., Schwamborn Jens C. 30 dec 2019, In: Acta neuropathologica communications. 7
Emotional and behavioral problems, quality of life and metabolic control in NTBC-treated Tyrosinemia type 1 patients
van Vliet Kimber, van Ginkel Willem G., Jahja Rianne, Daly Anne, MacDonald Anita, De Laet Corinne, Vara Roshni, Rahman Yusof, Cassiman David, Eyskens Francois, Timmer Corrie, Mumford Nicky, Bierau Jörgen, van Hasselt Peter M., Gissen Paul, Goyens Philippe J., McKiernan Patrick J., Wilcox Gisela, Morris Andrew A.M., Jameson Elisabeth A., Huijbregts Stephan C.J., van Spronsen Francjan J. 4 dec 2019, In: Orphanet Journal of Rare Diseases. 14 9 p.
Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission
Guo Hui, Li Ying, Shen Lu, Wang Tianyun, Jia Xiangbin, Liu Lijuan, Xu Tao, Ou Mengzhu, Hoekzema Kendra, Wu Huidan, Gillentine Madelyn A., Liu Cenying, Ni Hailun, Peng Pengwei, Zhao Rongjuan, Zhang Yu, Phornphutkul Chanika, Stegmann Alexander P.A., Prada Carlos E., Hopkin Robert J., Shieh Joseph T., McWalter Kirsty, Monaghan Kristin G., van Hasselt Peter M., van Gassen Koen, Bai Ting, Long Min, Han Lin, Quan Yingting, Chen Meilin, Zhang Yaowen, Li Kuokuo, Zhang Qiumeng, Tan Jieqiong, Zhu Tengfei, Liu Yaning, Pang Nan, Peng Jing, Scott Daryl A., Lalani Seema R., Azamian Mahshid, Mancini Grazia M.S., Adams Darius J., Kvarnung Malin, Lindstrand Anna, Nordgren Ann, Pevsner Jonathan, Osei-Owusu Ikeoluwa A., Romano Corrado, Calabrese Giuseppe 25 sep 2019, In: Science advances. 5
Glutaminase deficiency caused by short tandem repeat expansion in GLS
Rumping Lynne, Jans Judith J., Van Hasselt Peter M. 19 sep 2019, In: New England Journal of Medicine. 381 , p. 1185-1185 1 p.