dr. S.J. (Bas) Vastert

dr. S.J. (Bas) Vastert

Associate Professor - medical
dr. S.J. (Bas) Vastert
  • Center for Translational Immunology (CTI) Research
  • Rheumatology Research 1
  • Immunology

Research Programs

Child Health



Bas is a pediatric rheumatologist in the “EULAR center of excellence in rheumatology" Wilhelmina Children’s Hospital Utrecht. Besides being an esteemed clinician in the field of Pediatric Rheumatology, he has developed into a translational researcher, with a PhD on mechanisms of disease and therapy in severe JIA in 2013. From 2015, he has been starting a translational research group together with Jorg van Loosdregt, molecular biologist. They currently supervise 5 PhD students, 1 post-doc and 2 technicians together, within the Center of Translational Immunology in Utrecht (v Loosdregt-Vastert group). Their labgroup aims to translate cutting edge science into clinical benefit for patients and their research focusses on systemic JIA and on development of novel treatment strategies for JIA. Bas is currently leading a multi-center prospective trial implementing a biomarker driven stop-strategy for rIL-1RA therapy in systemic JIA in the Netherlands (the ESTIS trial).

In addition, as a designated Young Investigator, Bas is the Dutch lead for all translational laboratory studies within UCAN CAN DU (major infrastructural research project 2017-2021 in Canada and the Netherlands).

Key words: Translational research in childhood arthritis, biology of systemic JIA, (regulation of) auto-inflammation, regulation of autoimmune inflammation, epigenetics.

Side Activities

  • member editoreal board van Pediatric Rheumatology Online Journal
  • associate editor Rheumatology

Fellowship and Awards

- 2007: Young investigator Meeting, Pediatric rheumatology European Society: Award for best basic abstract .

- 2014: Wilhelmina Research Fund (co-applicant), € 150 000 : Dissecting the complex role of S100-proteins in systemic juvenile idiopathic arthritis.

- 2015: ZonMW Rational Pharmacotherapy grant, € 340 000 : Biomarker guided treatment and stop strategy for rIL-1RA therapy in systemic JIA.

- 2016-2019: Wilhelmina Kinderziekenhuis Fonds, Rosenberg foundation / Vrienden WKZ (€340 000): Modulation of Treg in JIA by Nicotinamide. Principal Investigator, no overlap.

- 2016-2021: ZonMW grant, Rational Pharmacotherapy for implementation of biomarker guided tapering strategy of rIL-1RA in systemic JIA (€340 000 + €190 000 contribution Sobi). Principal Investigator, clinical trial, no overlap.

- 2017-2021: UCAN CAN DU: (8,0 mln Can$). Canada – Netherlands Personalized Medicine Network in Childhood Arthritis and Rheumatic diseases. Young Investigator, NL lead for laboratory studies within UCAN CAN DU. (PI: R. Yeung, NM Wulffraat, co-PI JF Swart, S. Benseler).   


Research Output (156)

The protective effect of COVID-19 vaccines on developing multisystem inflammatory syndrome in children (MIS-C):a systematic literature review and meta-analysis

Hamad Saied Mohamad, van der Griend Laura, van Straalen Joeri W, Wulffraat Nico M, Vastert Sebastiaan, Jansen Marc H A 7 Aug 2023, In: Pediatric rheumatology online journal. 21 , p. 1-10

Withdrawing biologics in non-systemic JIA:what matters to pediatric rheumatologists?

van Til Janine A, Kip Michelle M A, Schatorjé Ellen J H, Currie Gillian, Twilt Marinka, Benseler Susanne M, Swart Joost F, Vastert Sebastiaan J, Wulffraat Nico, Yeung Rae S M, Groothuis-Oudshoorn C G M Karin, Warta Sanne, Marshall Deborah A, IJzerman Maarten J, 11 Jul 2023, In: Pediatric rheumatology online journal. 21 , p. 1-10

Biobanking and consenting to research:a qualitative thematic analysis of young people’s perspectives in the North East of England

van der Velden Fabian J.S., Lim Emma, Gills Lily, Broadey Jasmin, Hayes Louise, Roberts Eve, Courtney Jack, Ball Joanne, Herberg Jethro, Galassini Rachel, Emonts Marieke, Levin Michael, Cunnington Aubrey, Kaforou Myrsini, Wright Victoria, Bellos Evangelos, Broderick Claire, Channon-Wells Samuel, Cooray Samantha, De Tisham, D’Souza Giselle, Elorrieta Leire Estramiana, Estrada-Rivadeneyra Diego, Habgood-Coote Dominic, Hamilton Shea, Jackson Heather, Kavanagh James, Marjaneh Mahdi Moradi, Nichols Samuel, Nijman Ruud, Patel Harsita, Pennisi Ivana, Powell Oliver, Reid Ruth, Shah Priyen, Vito Ortensia, Whittaker Elizabeth, Wilson Clare, Womersley Rebecca, Abdulla Amina, Darnell Sarah, Nagelkerke Sietse, van der Flier Michiel, Tissing Wim J.E., Vastert Sebastiaan J., Vijlbrief Daniel C., Bont Louis J., Wolfs Tom F.W., Beudeker Coco R., Hulsmann Sanne C., 5 Jul 2023, In: BMC Medical Ethics. 24 , p. 1-11

N<sup>6</sup>-Methyladenosine Directly Regulates CD40L Expression in CD4<sup>+</sup> T Lymphocytes

van Vroonhoven Ellen C.N., Picavet Lucas W., Scholman Rianne C., van den Dungen Noortje A.M., Mokry Michal, Evers Anouk, Lebbink Robert J., Calis Jorg J.A., Vastert Sebastiaan J., van Loosdregt Jorg Jul 2023, In: Biology. 12 11 p.

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Ho Antonia, Orton Richard, Tayler Rachel, Asamaphan Patawee, Herder Vanessa, Davis Chris, Tong Lily, Smollett Katherine, Manali Maria, Allan Jay, Rawlik Konrad, McDonald Sarah E., Vink Elen, Pollock Louisa, Gannon Louise, Evans Clair, McMenamin Jim, Roy Kirsty, Marsh Kimberly, Divala Titus, Holden Matthew T.G., Lockhart Michael, Yirrell David, Currie Sandra, O’Leary Maureen, Henderson David, Shepherd Samantha J., Jackson Celia, Gunson Rory, MacLean Alasdair, McInnes Neil, Bradley-Stewart Amanda, Battle Richard, Hollenbach Jill A., Henderson Paul, Odam Miranda, Chikowore Primrose, Oosthuyzen Wilna, van den Berg J. M.Merlijn, Nagelkerke Sietse, van der Flier Michiel, Tissing Wim J.E., Wösten-van Asperen Roelie M., Vastert Sebastiaan J., Vijlbrief Daniel C., Bont Louis J., Wolfs Tom F.W., Beudeker Coco R., Tempel Dennie, van Keulen Danielle, , 30 May 2023, In: Nature. 617 , p. 555-563 9 p.

What matters most to pediatric rheumatologists in deciding whether to discontinue biologics in a child with juvenile idiopathic arthritis?:A best-worst scaling survey

Currie Gillian R, Groothuis-Oudshoorn Catherina G M, Twilt Marinka, Kip Michelle M A, IJzerman Maarten J, Benseler Susanne M, Swart Joost F, Vastert Sebastiaan J, Wulffraat Nico M, Yeung Rae, Marshall Deborah A 19 May 2023, In: Clinical Rheumatology. 42 , p. 2173-2180 8 p.

Genomic investigations of unexplained acute hepatitis in children

Morfopoulou Sofia, Buddle Sarah, Torres Montaguth Oscar Enrique, Atkinson Laura, Guerra-Assunção José Afonso, Moradi Marjaneh Mahdi, Zennezini Chiozzi Riccardo, Storey Nathaniel, Campos Luis, Hutchinson J. Ciaran, Counsell John R., Pollara Gabriele, Roy Sunando, Venturini Cristina, Antinao Diaz Juan F., Siam Ala’a, Tappouni Luke J., Asgarian Zeinab, Ng Joanne, Hanlon Killian S., Lennon Alexander, McArdle Andrew, Czap Agata, Rosenheim Joshua, Andrade Catarina, Anderson Glenn, Lee Jack C.D., Williams Rachel, Williams Charlotte A., Tutill Helena, Nagelkerke Sietse, van der Flier Michiel, Tissing Wim J.E., Wösten-van Asperen Roelie M., Vastert Sebastiaan J., Vijlbrief Daniel C., Bont Louis J., Wolfs Tom F.W., Beudeker Coco R., Tempel Dennie, van Keulen Danielle, de Groot Ronald, van der Flier Michiel, van Aerde Koen, Heidema J., Miedema C. J., Jongerius Ilse, van den Berg J. M., Schonenberg D., Zandstra Judith, , , 18 May 2023, In: Nature. 617 , p. 564-573 10 p.

Meningococcal ACWY conjugate vaccine immunogenicity and safety in adolescents with juvenile idiopathic arthritis and inflammatory bowel disease:A prospective observational cohort study

Ohm Milou, van Straalen Joeri W, Zijlstra Marieke, de Joode-Smink Gerrie, Jasmijn Sellies Anne, Swart Joost F, Vastert Sebastiaan J, van Montfrans Joris M, Bartels Marije, van Royen-Kerkhof Annet, Wildenbeest Joanne G, Lindemans Caroline A, Wolters Victorien, Wennink Roos A W, de Boer Joke H, Knol Mirjam J, Heijstek Marloes W, Sanders Elisabeth A M, Verduyn-Lunel Frans M, Berbers Guy A M, Wulffraat Nico M, Jansen Marc H A 15 May 2023, In: Vaccine. 41 , p. 3782-3789 8 p.

Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

Mijnheer Gerdien, Servaas Nila Hendrika, Leong Jing Yao, Boltjes Arjan, Spierings Eric, Chen Phyllis, Lai Liyun, Petrelli Alessandra, Vastert Sebastiaan, de Boer Rob J, Albani Salvatore, Pandit Aridaman, van Wijk Femke 23 Jan 2023, In: eLife. 12

Epigenetic changes in inflammatory arthritis monocytes contribute to disease and can be targeted by JAK inhibition

Peeters Janneke G C, Boltjes Arjan, Scholman Rianne C, Vervoort Stephin J, Coffer Paul J, Mokry Michal, Vastert Sebastiaan J, van Wijk Femke, van Loosdregt Jorg 10 Jan 2023, In: Rheumatology (Oxford, England). 62 , p. 2887-2897 11 p.

All research output

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