prof. dr. N.M. (Nico) Wulffraat

prof. dr. N.M. (Nico) Wulffraat

Professor Emeritus
prof. dr. N.M. (Nico) Wulffraat
  • Immuno/Rheumatology ERN



Nico Wulffraat is professor of pediatric Rheumatology at the department of pediatrics, University Medical Center, Utrecht, The Netherlands. He obtained his MD and PhD (1987) at the Free University Hospital Amsterdam. He trained as a paediatrician from 1988 untill 1993 in Utrecht. He was fellow pediatric immunology and rheumatology from 1993 to 1995 in the WKZ. Since 1995 he worked as a consultant in pediatric immunology-rheumatology. Since 2010 he is the head of this subunit. From 1997-2004 he was also coordinator of the pediatric allogeneic and autologous stem cell transplantations for immune deficiencies, metabolic disorders and autoimmune diseases. He is PI of several investigator initiated trials of immunisations in children with rheumatic diseases including MMR, HPV and Men C, prevention of MTX side effects, and application of Mesenchymal Stem cells in refractory GvHD and JIA. He is coordinator of a FP7 consortium for pharmacovigilance of biologics used in JIA (PHARMACHILD). Also he leads the EHHC project SHARE that aims at documenting standards of care and treatment recommendations for pediatric rheumatic diseases throughout Europe.

Since 2008 he became supervisor of the postgraduate clinical fellowship pediatric rheumatology and since 2009 head of pediatric immunology and rheumatology. In 2014, he was appointed as head of pediatric Rheumatology, Immunology, hematology and infectious diseases.

He has co-authored 220 Pubmed cited papers in international journals on pediatric rheumatology and immunology and 12 chapters in books.

Side Activities


Gezondheidsraad advies CVS

ZonMW commissie programma translationeel onderzoek en adulte stamcellen, adviesgroep medische producten (2009-2016)

Evaluatie beoordeling NFU expertise centra

Council PRES (2004-2010)

Council PRINTO National representative for NL (2001-2014)

ERN RITA HCP Member Representative (2017) and since 2019 ERN RITA coordinator

Reviewer for all major rheumatology Journals, Blood, Lancet, NEJM


Member of EBMT working party for autoimmune diseases (Chair R Saccardi, Florence Italy)

Member of the ZONWM programme committee Translational Adult Stem cell research

Member of Advisory working group consisting of external experts for RIVM (Corona related) (2021- )

Member of the European Medicines Agency (EMA) expert group for pediatric rheumatology

Member of the ZONMW programme committee Priority medicines for children

Member of the advisory council Ter Meulen Fonds

Member of the Drug Safety Monitoring board of the adalumimab trial for uveitis (NHS, England)

Member of the board for the Dutch pediatric rheumatology society, for education and research (2001-2010)

Member of the board for Utrecht pediatric postgraduate courses (1999-2010)

Member of the Scientific Advisory Council of the Dutch League for Rheumatology (Nationaal Reumafonds, 2006-2009)

Member of the Utrecht study group for the development of the electronic patient file into clinical paractise (2005-2009)

Member of the EBMT working party for inborn errors and immunodeficiencies (1996-2008)

Potential Conflicts of Interest

Dr. Wulffraat has regular interaction with pharmaceutical and other industrial partners. These activities were continued until 2018 . Since then he is the chair of the European rare Diseases Network (RITA) and receives grants from the EU to sustain this network. As per may 2022 he will receive a part time salary for this. ERN RITA has supported international clinical practice guidelines. UMCU has received incidental funding (up to €10,000 as multi sponsoring per event as  support for research and educational activities deployed by the Pediatric Rheumatology European Society. This is a non-for profit organization. He has received support from the Dutch medical Insurance company het Zilveren Kruis for a study on the use of an App (as a medical device) specifically for patients with chronic arthritis

Fellowship and Awards

FP7 Grant Pharmachild


Div. ZON MW Grants



AbbVie (bijdrage Reuma2Go)

Roche (bijdrage Reuma2Go)

ERN coordinator RITA

ZonMW grant Chronic Fatique QFS and JIA

Research Output (664)

The protective effect of COVID-19 vaccines on developing multisystem inflammatory syndrome in children (MIS-C):a systematic literature review and meta-analysis

Hamad Saied Mohamad, van der Griend Laura, van Straalen Joeri W, Wulffraat Nico M, Vastert Sebastiaan, Jansen Marc H A 7 Aug 2023, In: Pediatric rheumatology online journal. 21 , p. 1-10

Long-term immunoprotection after live attenuated measles-mumps-rubella booster vaccination in children with juvenile idiopathic arthritis

Hamad Saied Mohamad, van Straalen Joeri W, de Roock Sytze, de Joode-Smink Gerrie C J, Verduyn Lunel Frans M, Swart Joost F, Wulffraat Nico M, Jansen Marc H A 27 Jul 2023, In: Vaccine. 41 , p. 5477-5482 6 p.

Meningococcal ACWY conjugate vaccine immunogenicity in adolescents with primary or secondary immune deficiencies, a prospective observational cohort study

Ohm Milou, van Straalen Joeri W, de Joode-Smink Gerrie, van Montfrans Joris, Bartels Marije, van Wildenbeest Joanne G, Lindemans Caroline A, Wennink Roos Aw, de Boer Joke H, Sanders Elisabeth Am, Verduyn-Lunel Frans M, Berbers Guy Am, Wulffraat Nico M, Jansen Marc H A 20 Jul 2023, In: Pediatric rheumatology online journal. 21 , p. 1-6

Withdrawing biologics in non-systemic JIA:what matters to pediatric rheumatologists?

van Til Janine A, Kip Michelle M A, Schatorjé Ellen J H, Currie Gillian, Twilt Marinka, Benseler Susanne M, Swart Joost F, Vastert Sebastiaan J, Wulffraat Nico, Yeung Rae S M, Groothuis-Oudshoorn C G M Karin, Warta Sanne, Marshall Deborah A, IJzerman Maarten J, 11 Jul 2023, In: Pediatric rheumatology online journal. 21 , p. 1-10

Clinically Established Temporomandibular Involvement in Adults With Juvenile Idiopathic Arthritis

de Sonnaville Willemijn F C, Speksnijder Caroline M, Zuithoff Nicolaas P A, Heijstek Marloes W, Wulffraat Nico M, Steenks Michel H, Rosenberg Antoine J W P 1 Jul 2023, In: The Journal of rheumatology. 50 , p. 1462-1470 9 p.

What matters most to pediatric rheumatologists in deciding whether to discontinue biologics in a child with juvenile idiopathic arthritis?:A best-worst scaling survey

Currie Gillian R, Groothuis-Oudshoorn Catherina G M, Twilt Marinka, Kip Michelle M A, IJzerman Maarten J, Benseler Susanne M, Swart Joost F, Vastert Sebastiaan J, Wulffraat Nico M, Yeung Rae, Marshall Deborah A 19 May 2023, In: Clinical Rheumatology. 42 , p. 2173-2180 8 p.

Meningococcal ACWY conjugate vaccine immunogenicity and safety in adolescents with juvenile idiopathic arthritis and inflammatory bowel disease:A prospective observational cohort study

Ohm Milou, van Straalen Joeri W, Zijlstra Marieke, de Joode-Smink Gerrie, Jasmijn Sellies Anne, Swart Joost F, Vastert Sebastiaan J, van Montfrans Joris M, Bartels Marije, van Royen-Kerkhof Annet, Wildenbeest Joanne G, Lindemans Caroline A, Wolters Victorien, Wennink Roos A W, de Boer Joke H, Knol Mirjam J, Heijstek Marloes W, Sanders Elisabeth A M, Verduyn-Lunel Frans M, Berbers Guy A M, Wulffraat Nico M, Jansen Marc H A 15 May 2023, In: Vaccine. 41 , p. 3782-3789 8 p.

Safety of Measles-Mumps-Rubella booster vaccination in patients with juvenile idiopathic arthritis:A long-term follow-up study

Hamad Saied Mohamad, van Straalen Joeri W, de Roock Sytze, de Joode-Smink Gerrie C J, Swart Joost F, Wulffraat Nico M, Jansen Marc H A 7 Apr 2023, In: Vaccine. 41 , p. 2976-2981 6 p.

Methotrexate therapy associated with a reduced rate of new-onset uveitis in patients with biological-naïve juvenile idiopathic arthritis

van Straalen Joeri W, Akay Görkem, Kouwenberg Carlyn V, de Roock Sytze, Kalinina Ayuso Viera, Wulffraat Nico M, de Boer Joke, Swart Joost F Apr 2023, In: RMD Open. 9 , p. 1-8

Juvenile idiopathic arthritis patients with positive family history of autoimmune thyroid disease might benefit from serological screening:analysis of the international Pharmachild registry

van Straalen Joeri W, Baas Laurie, Giancane Gabriella, Grebenkina Lyudmila, Brunner Jurgen, Vega-Cornejo Gabriel, Chasnyk Vyacheslav G, Harel Liora, Appenzeller Simone, Gervais Elisabeth, de Roock Sytze, Wulffraat Nico M, Ruperto Nicolino, Swart Joost F, 21 Feb 2023, In: Pediatric rheumatology online journal. 21 9 p.

All research output

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