prof. dr. G.J.M. Zijlmans

prof. dr. G.J.M. Zijlmans

Full Professor
prof. dr. G.J.M. Zijlmans
  • Neurology & Neurosurgery

Research Programs




Maeike Zijlmans is a neurologist and principle investigator at the UMC Utrecht Brain Center and Stichting Epilepsie Instellingen Nederland (SEIN). She finished her PhD with honors in May 2011 (prof van Huffelen, Utrecht, and prof Gotman, Montreal). Her thesis is about new presurgical techniques to characterize the focus of epilepsy. These techniques included EEG-fMRI, magnetoencephalography (MEG), special EEG electrodes and 3 T MRI. She stayed at the Montreal Neurological Institute for one year where she studied the use of high frequency oscillations (HFOs) in depth EEG in presurgical epilepsy patients.  She applied the acquired knowledge at the UMC Utrecht to record HFOs with corticography during surgery. This work ultimately led to the conduct of a prospective randomized controlled trial 'the HFO trial' comparing the use of HFOs to spikes as electrical biomarkers for epileptic tissue during epilepsy surgery. Results are expected to be published in 2022. Another part of the thesis concerned quality of life and coping style in epilepsy.  In 2013 she started her work as clinical researcher. She is now leading the 'epilab' which focusses on advanced technologies to recognize epileptic brain tissue. Her research group consists of a post-doctoral fellow, 7 PhD students (+3 finished) and several master students. She obtained an ERC starting grant in 2019 for the project 'the Core and Effects of Epilepsy'. The group studies how to delineate epileptic brain tissue from healthy cortex with optimal signal recording and analysis in a large dataset of retrospectively gathered highly sampled intra-operative electrocorticography and by prospectively recording high denisity electrocorticography. The group is trying to improve the clinical yield of the HFO-signal using different signal analytic methods, like high frequent network analysis and machine learning. Her ultimate goal is to find a way to direct the neurosurgeon directly to the epileptogenic tissue. Also, the clinical yield is studied to predict cognitive outcome and to compare HFOs to other disease markers like in tumours. Part of the research group works on related issues like the non-invasive identification of HFOs with EEG and MEG, and finding alterative biomarkers with metabolic MRI. Allied research focuses on stress-related epilepsy, psychogenic non-epileptic seizures and effect of surgery on patient well being.

Research line

Advance diagnostics for epilepsy surgery

Most recent key publications

1: Zijlmans M, Zweiphenning WJEM, van Klink NEC. Changing concepts in presurgical assessment for epilepsy surgery. Nat Rev Neurol 2019;15:594-606.

2: van 't Klooster MA, van Klink NEC, Zweiphenning WJEM, Leijten FSS, Zelmann R, Ferrier CH, van Rijen PC, Otte WM, Braun KPJ, Huiskamp GJM, Zijlmans M. Tailoring epilepsy surgery with fast ripples in the intraoperative electrocorticogram. Ann Neurol. 2017 May;81(5):664-676

3: Zijlmans M, Jiruska P, Zelmann R, Leijten FS, Jefferys JG, Gotman J. High-frequency oscillations as a new biomarker in epilepsy. Ann Neurol. 2012 Feb;71(2):169-78.

4: Zijlmans M, Jacobs J, Zelmann R, Dubeau F, Gotman J. High-frequency oscillations mirror disease activity in patients with epilepsy. Neurology. 2009

5: Zijlmans M, Huiskamp G, Hersevoort M, Seppenwoolde JH, van Huffelen AC, Leijten FS. EEG-fMRI in the preoperative work-up for epilepsy surgery. Brain. 2007 Sep;130(Pt 9):2343-53.

Side Activities

Neurologist at Stichting Epilepsie Instellingen Nederland (SEIN)

Advisor scientific board of EpilepsieNL

Fellowship and Awards

1: ILAE European Young investigators award 2022

2: ERC starting grant 803880

3: For-woman-in-science award LÓreal UNESCO

4: ZonMW veni personal grant

5: BCRM young talent grant and prize

6: Dutch Epilepsy Foundation research grant (2011, 2015)

7: Hersenstichting Prize for scientific work

8: Amsterdam Neurologists Prize for clinical research

9: Dutch Epilepsy Foundation Reseach prize

Research Output (114)

Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial):a randomised, single-blind, adaptive non-inferiority trial

Zweiphenning Willemiek, Klooster Maryse A.van t., van Klink Nicole E.C., Leijten Frans S.S., Ferrier Cyrille H., Gebbink Tineke, Huiskamp Geertjan, van Zandvoort Martine J.E., van Schooneveld Monique M.J., Bourez M., Goemans Sophie, Straumann Sven, van Rijen Peter C., Gosselaar Peter H., van Eijsden Pieter, Otte Willem M., van Diessen Eric, Braun Kees P.J., Zijlmans Maeike, Bloemen-Carlier Eltje M., Cibulková Veronika, de Munnink Renee, van der Salm Sandra, Eijkemans Martinus J.C., Ophorst-van Eck Janine M., Velders Anouk, van Asch Charlotte J.J., Zwemmer Jack, van Regteren-van Griethuysen Renate, Smeding Henriette, van der Berg Lydia, de Bresser Jeroen, de Kort Gérard A.P., Dankbaar Jan Willem, Nov 2022, In: The Lancet. Neurology. 21 , p. 982-993 12 p.

Tailored epilepsy surgery with high frequency oscillations versus spikes in intra-operative electrocorticography: Results of the RCT HFO trial

Klooster M. Van ' T., Zweiphenning W., Van Klink N., Leijten F., Ferrier C., Gebbink T., Huiskamp G., Van Zandvoort M., Van Schooneveld M., Bourez M., Goemans S., Straumann S., Van Rijen P., Gosselaar P., Van Eijsden P., Otte W., Van Diessen E., Braun K., Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 19-20

The analogy between structural networks obtained from diffusion weighted imaging and effective networks derived from single pulse electrical stimulation in people with epilepsy

Jelsma S., Van Blooijs D., Van Putten M., Raemaekers M., Zijlmans M., Van Klink N. Sep 2022, In: Epilepsia. 63 , p. 50-50

7T metabolic MRI in focal epilepsy

Jacobs S. M., Shams Z., Wiegers E. C., Wijnen J. P., Klomp D. W., Versteeg E., Siero J. C. W., Muhlebner A., Van Hecke W., Robe P. A., Zijlmans M., Van der Kolk A. G. Sep 2022, In: Epilepsia. 63 , p. 34-35

Deep learning and electrocorticography to tailor epilepsy surgery

Hoogteijling S., Schaft E., Huiskamp G., Straumann S., Smits P., Demuru M., van Rijen P., Leijten F., Gebbink T., van Putten M., Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 104-104

Dynamic properties of HFOs and spikes in the intra-operative electrocortigram in patients with focal cortical dysplasia

Schaft E., Sun D., van't Klooster M., van Blooijs D., Smits P., Zweiphenning W., Gosselaar P., Ferrier C., Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 103-103

Protocol for multicenter comparison of interictal high frequency oscillations as a predictor of seizure freedom

Dimakopoulos V., Gotman J., Stacey W., Benar C., Bartolomei F., Von Ellenrieder N., Jacobs J., Cimbalnik J., Worrell G., Sperling M., Zijlmans M., Imbach L., Frauscher B., Sarnthein J. Sep 2022, In: Epilepsia. 63 , p. 165-165

The spatial relationship between the MRI lesion and intraoperative electrocorticography in focal epilepsy surgery

Straumann S., Schaft E., Noordmans H. J., Dankbaar J. W., Otte W., Steenis J. Van, Smits P., Zweiphenning W., Eijsden P. Van, Gebbink T., Mariani L., Klooseter M. Van't, Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 177-177

Be Aware: the safety of temporarily pausing propofol to enable intraoperative electrocorticography during epilepsy surgery under general anesthesia

Sun D., van ' t Klooster M., Ringeling E., Schaft E., Van Rijen P., Leijten F., Demuru M., Robe P., Kappen T., Hoff R., Zijlmans M. Sep 2022, In: Epilepsia. 63 , p. 175-175 1 p.

Accurate differentiation between physiological and pathological ripples recorded with scalp-EEG

Mooij Anne H., Huiskamp Geertjan J.M., Aarts Emmeke, Ferrier Cyrille H., Braun Kees P.J., Zijlmans Maeike 30 Aug 2022, In: Clinical Neurophysiology. 143 , p. 172-181 10 p.

All research output

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