dr. N. (Niels) EijkelkampAssociate Professor
- Laboratory for Translational Immunology (LTI)
Niels Eijkelkamp (18-07-1980) is PI at the laboratory of translational immunology. His research focusses on chronic pain, a major debilitating disease that affects >20% of the population. He aims to unravel mechanisms and to identify novel treatments of chronic pain by elucidating the role of the immune system and its interactions with the nervous system in chronic pain. His group is one of the very few groups in the Netherlands studying the mechanisms underlying pain.
His group uses different experimental approaches to unravel molecular pain mechansims and identify novel treatment approaches with the ultimate aim to translate these basic research findings to chronic pain patients such as children with Juvenile Idiopathic arthritis and adults with chronic inflammatory disease and osteoarthtis.
Eijkelkamp graduated in 2003 with honors in Medical Biology (University of Utrecht). In 2009 he completed his PhD under supervision of Dr. Heijnen with his thesis entitled ‘GRK gatekeeper of pain and inflammation’. Prior to his PhD he worked for 1 year on stress and wound healing in the team led by Dr. Sheridan at the Ohio State University. As PostDoc he had a joint appointment at the UMCU and University of Illinois at Urbana-Champaign to work on the role of GRKs in pain. Finally, he worked for 2 years on sensory transduction and signalling pathways in chronic pain in the laboratory of Dr. Wood at the University College London. Since 2013 he started his own group at the UMCU.
Member of the editorial board of Brain, Behaviour & Immunity
Fellowship and Awards
2019: Health Holland.
2019: TTW(NWO). 750k. It takes two to stop chronic pain: an innovative treatment with endogenous regulatory immune molecules.
2018: Dutch arthritis foundation (ReumaNL). 240k Identification of inflammatory mediators in spinal liquor in relation to synovial nerve sprouting and pain in osteoarthritis.
2018: H2020-MSCA-ITN-2018 – BonepainII. 560k. An innovative European PhD training network in bone pain.
2017: WKZ child Health Boost Grant. 20k co-applicant. Juvenile Idiopathic Arthritis, when does it hurt?
2015 Dutch arthritis foundation. 80k. Identification of inflammatory mediators in spinal liquor in relation to synovial nerve sprouting and pain in osteoarthritis.
2014 H2020-MSCA-ITN-2014 – Bonepain. 260k. Create an innovative European PhD training network in bone pain.
2013 Life science Seed grant Utrecht university. 100k. Title: Regulating neuroinflammation and sensory neuron function using a fusion protein of IL-4 and IL-10: a novel therapeutic strategy to block chronic pain.
2010-2012 Rubicon fellowship of the Netherlands Organisation of Scientific Research (NWO). 90k. to perform research at the laboratory of Molecular Nociception of Prof Wood at the Wolfson Institute for Biomedical Research at University College of London, London, UK. Title: Novel mechanisms of chronic pain: regulated trafficking of sodium channels by GRK2.
Research Output (65)
Asiri Mohammed M H, Engelsman Sjoukje, Eijkelkamp Niels, Höppener Jo W M 26 jun 2020, In: Cells. 9 32 p.
Steen-Louws Cristine, Boross Peter, Prado Judith, Meeldijk Jan, Langenhorst Jurgen B, Huitema Alwin D R, den Hartog Marcel T, Boon Louis, Lafeber Floris P J G, Hack C Erik, Eijkelkamp Niels, Popov-Celeketic Jelena dec 2019, In: Pharmaceutical Research. 37
Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model
Rudnik-Jansen Imke, Schrijver Karin, Woike Nina, Tellegen Anna, Versteeg Sabine, Thies Jens, Emans Pieter, Mihov George, Eijkelkamp Niels, Tryfonidou Marianna, Creemers Laura dec 2019, In: Drug delivery. 26 , p. 226-236 11 p.
Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration
Małecki Jędrzej, Willemen Hanneke L D M, Pinto Rita, Ho Angela Y Y, Moen Anders, Eijkelkamp Niels, Falnes Pål Ø 18 jun 2019, In: Journal of Biological Chemistry. 294 , p. 11654-11664 11 p.
Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems
Rudnik-Jansen Imke, Woike Nina, de Jong Suzanne, Versteeg Sabine, Kik Marja, Emans Pieter, Mihov George, Thies Jens, Eijkelkamp Niels, Tryfonidou Marianna, Creemers Laura 6 feb 2019, In: Pharmaceutics. 11
Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA; An exploratory study
Van Helvoort E. M., Popov-Celeketic J., Eijkelkamp N., Coeleveld K., Tryfonidou M. A., Wijne C. D., Hack C. E., Lafeber F. P.J.G., Mastbergen S. C. 1 jan 2019, In: PLoS ONE. 14 18 p.
Sensory signaling pathways in inflammatory and neuropathic pain
Willemen Hanneke L.D.M., Eijkelkamp Niels 2019,
Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase
Małecki Je drzej M., Willemen Hanneke L.D.M., Pinto Rita, Ho Angela Y.Y., Moen Anders, Kjønstad Ingrid F., Burgering Boudewijn M.T., Zwartkruis Fried, Eijkelkamp Niels, Falnes Pål 10 dec 2018, In: Journal of Biological Chemistry. 294 , p. 1128-1141 14 p.
Relaxin receptor deficiency promotes vascular inflammation and impairs outward remodeling in arteriovenous fistulas
Bezhaeva Taisiya, De Vries Margreet R., Geelhoed Wouter J., Van Der Veer Eric P., Versteeg Sabine, Van Alem Carla M.A., Voorzaat Bram M., Eijkelkamp Niels, Van Der Bogt Koen E., Agoulnik Alexander I., Van Zonneveld Anton Jan, Quax Paul H.A., Rotmans Joris I. 1 nov 2018, In: FASEB Journal. 32 , p. 6293-6304 12 p.
IL4-10 fusion protein has chondroprotective, anti-inflammatory and potentially analgesic effects in the treatment of osteoarthritis
Steen-Louws C., Popov-Celeketic J., Mastbergen S. C., Coeleveld K., Hack C. E., Eijkelkamp N., Tryfonidou M., Spruijt S., van Roon J. A.G., Lafeber F. P.J.G. 1 aug 2018, In: Osteoarthritis and Cartilage. 26 , p. 1127-1135 9 p.