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prof. dr. E.M. (Elly) Hol

prof. dr. E.M. (Elly) Hol

Full Professor
prof. dr. E.M. (Elly) Hol
  • Translational Neuroscience

Research Programs

Biography

Biography

Elly Hol is professor of “Glia biology of brain diseases” at the Utrecht University and a member of the Academia Europaea. She is head of the department of Translational Neuroscience at the University Medical Center Utrecht Brain Center. Her research is focused on the role of glial cells in brain diseases. The overall aim is to elucidate the molecular and functional changes in glia that contribute to the pathogenesis of neurological and psychiatric diseases. Her work is translational and includes studies on glial cells in human post-mortem brain tissue, in human cell models, and in mouse models for brain diseases. Elly was trained as a medical biologist with a specialization in molecular neurobiology. After her PhD in Utrecht, she obtained a Max-Planck Fellowship to work at the Max-Planck-Institute for Psychiatry in Martinsried. In 1997, she started as a post-doc at the Netherlands Institute for Neuroscience in Amsterdam, and between 2003 and 2013 she headed the group “Astrocyte Biology & Neurodegeneration”. She was appointed professor of "Biology of glia and neural stem cells” at the University of Amsterdam in 2012. As of 2013 she works as a principal investigator at the department of translational neuroscience, UMC Utrecht Brain Center. She is in the editorial board of Glia, chair of the scientific advisory board of Parkinson Nederland, chair of GliaNed, director of the Neuroscience Master and PhD program of the Utrecht University Graduate School of Life Sciences, and director of education Division Neuroscience at the UMCU.

Side Activities

Board member, Stichting vrienden van het Herseninstituut

Chair Scientific Advisory Board, Parkinson Nederland

Member Scientific Advisory Board, Alzheimer Nederland

Member Scientific advisory board EndParalysis Foundation

Member editorial board, Glia (scientific journal)

Fellowship and Awards

  • 2019 NWO Gravitation grant
  • 2019 member of the Academia Europaea
  • Nominated by NWO for AcademiaNet - Expert Database for Outstanding Female Scientists and Scholars.
  • 2009 VICI (NWO-ALW)
  • 2000 Hersenstichting fellowship
  • 1995 Max-Planck Fellowship

Research Output (189)

The Role of Astrocytes in Synapse Loss in Alzheimer's Disease:A Systematic Review

Hulshof Lianne A., van Nuijs Danny, Hol Elly M., Middeldorp Jinte 16 Jun 2022, In: Frontiers in Cellular Neuroscience. 16 , p. 1-17

GFAP Alternative Splicing and the Relevance for Disease - A Focus on Diffuse Gliomas

van Asperen Jessy V, Robe Pierre A J T, Hol Elly M 9 Jun 2022, In: ASN neuro. 14 , p. 1-18

Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model

Berdenis van Berlekom Amber, Kübler Raphael, Hoogeboom Jeske W, Vonk Daniëlle, Sluijs Jacqueline A, Pasterkamp R Jeroen, Middeldorp Jinte, Kraneveld Aletta D, Garssen Johan, Kahn René S, Hol Elly M, de Witte Lot D, Boks Marco P 2 May 2022, In: Nutrients. 14 , p. 1-19

Both male and female APPswe/PSEN1dE9 mice are impaired in spatial memory and cognitive flexibility at 9 months of age

Hulshof Lianne A., Frajmund Leon A., van Nuijs Danny, van der Heijden Denise C.N., Middeldorp Jinte, Hol Elly M. May 2022, In: Neurobiology of Aging. 113 , p. 28-38 11 p.

Calcium signaling in individual APP/PS1 mouse dentate gyrus astrocytes increases ex vivo with Aβ pathology and age without affecting astrocyte network activity

Huffels Christiaan F M, Osborn Lana M, Cappaert Natalie L M, Hol Elly M 16 Mar 2022, In: Journal of Neuroscience Research. 100 , p. 1281-1295 15 p.

Microglial transcriptomics meets genetics:new disease leads

Hol Elly M, Pasterkamp R Jeroen 28 Feb 2022, In: Nature Reviews Neurology. 18 , p. 191-192 2 p.

The neurovascular unit in leukodystrophies:towards solving the puzzle

Zarekiani Parand, Nogueira Pinto Henrique, Hol Elly M, Bugiani Marianna, de Vries Helga E 28 Feb 2022, In: Fluids and barriers of the CNS. 19 , p. 1-19

Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors

Donega Vanessa, van der Geest Astrid T., Sluijs Jacqueline A., van Dijk Roland E., Wang Chi Chiu, Basak Onur, Pasterkamp R. Jeroen, Hol Elly M. 24 Feb 2022, In: Nature Communications. 13 , p. 1-12

GFAP splice variants fine-tune glioma cell invasion and tumour dynamics by modulating migration persistence

Uceda-Castro Rebeca, van Asperen Jessy V., Vennin Claire, Sluijs Jacqueline A., van Bodegraven Emma J., Margarido Andreia S., Robe Pierre A.J., van Rheenen Jacco, Hol Elly M. 10 Jan 2022, In: Scientific Reports. 12 14 p.

All research output

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