prof. dr. F.H. Rutten

prof. dr. F.H. Rutten

Full Professor
prof. dr. F.H. Rutten
  • Julius Center, dept. General Practice & Nursing Science
  • Julius Center Research Program Cardiovascular Epidemiology

Research Programs

Circulatory Health



I hold a position as professor in general practice. I lead a research group focusing on the management of cardiovascular disease in primary care, from early detection of disease and risk-stratification to risk-based treatment.

My teaching activities cover being involved in educational programs at the bachelor (CRU) and master (Summa) level at the medical school, and also being involved in the specialty training and post-graduate training courses of general practitioners. I am a member of the steering committee of the Dutch 'kaderopleiding hart- en vaatziekten' for general practitioners and actively participate in its teaching program.

My research group has contributed to improving the diagnosis of heart failure and deep venous thrombosis in the primary care setting, and our studies have been used as building blocks for diagnostic algorithms recommended by the (inter)national guidelines regarding these diseases. By showing that unrecognized heart failure is common in patients with chronic obstructive pulmonary disease (COPD) and also in type 2 diabetes, our work has helped revolutionize clinical practice. I contributed to the development of guidelines on heart failure, atrial fibrillation, left ventricular hypertrophy and Non-ST elevated Acute Coronary Syndrome for the European Society of Cardiology, and also to the educational practice guideline documents on heart failure and atrial fibrillation for the European Primary Care Cardiovascular Society. Over the years I have been actively involved in working groups of the Heart Failure Association of the European Society of Cardiology, and was instrumental in translating the interactive website '' to Dutch, making it understandable for patients and their carers.

Within the UMC Utrecht, I am member of the coreteam of the theme ('speerpunt') Circulatory Health.

I managed to acquire ample funding for the clinical research activities of our research group. In 2017 I became the successful recipient of a research grant of Cardiovascular Research Netherlands (CVON), with myself being the main applicant of a consortium that will focus on early diagnosis of heart failure, atrial fibrillation and coronary artery disease in patients who participate in primary care disease management programs for COPD or type 2 diabetes. The aim is to facilitate early treatment and improve prognosis by preventing acute cardiovascular events such as acute heart failure, stroke and acute coronary syndrome.

I am coordinator of the Research Programme Cardiovascular Health of the Julius Center for Health Sciences and Primary Care of the UMC Utrecht. In addition I am member of the leadership team of the Julius Center, chair of research of the department of general practice, and board member of the management team of the department of General Practice within the Julius Center.

I collaborate with other departments of the Julius Center (epidemiology, public health and nursing sciences) and the clinical departments of Cardiology, Vascular Surgery, Vascular Medicine and renal disease, as well as with the department of imaging.

Side Activities

2018- Member of the Advisory Board of the European Primary Care Cardiovascular Society

2017- Board Member of the research consortium of Dutch General Practitioners ('Consortium Onderzoek Huisartsgeneeskunde, COH') and of the University Network Research (UNH-R)

2015-2022 Board Member of the Scientific Advisory Committee of the Netherlands Heart Foundation

2014-2018 Editorial Board Member of Family Practice

2012- Board Member and supervisor of General Practioners' 'Kaderopleiding hart- en vaatziekten'

1992-2018 General Practitioner, part-time, in Rhenen 

2018- Free-lance General Practitioner no more than one day a week

2021- Editorial Board Member Frontiers of cardiovascular epidemiology

2019- Vice chair of the ZonMw research programme 'Early detection of disease'

2021- Coordinator Research 'Kaderhuisartsen hart- en vaatziekten'

2021- Chair of the authorisation committee of the Dutch GP college (autorisatiecommissie NHG)

Fellowship and Awards

2014   Utrecht General Practitioner of the year award

2017-  Fellow of the European Society of Cardiology

2018   The Dr. Carel Bakx award for achievements in cardiovascular research in primary care

Research Output (331)

Plasma Proteomic Patterns Show Sex Differences in Early Concentric Left Ventricular Remodeling

van Ommen Anne-Mar, Diez Benavente Ernest, Onland-Moret N Charlotte, Valstar Gideon B, Cramer Maarten J, Rutten Frans H, Teske Arco J, Menken Roxana, Hofstra Leonard, Tulevski Igor I, Sweitzer Nancy, Somsen G Aernout, den Ruijter Hester M 29 Jun 2023, In: Circulation. Heart Failure. 16 , p. 615-629 15 p.

Clinical consequences of off-label reduced dosing of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation:a systematic review and meta-analysis

Joosten Linda P T, van Maanen Rosanne, van den Dries Carline J, Rutten Frans H, Hoes Arno W, Granger Christopher B, Hemels Martin E W, Geersing Geert-Jan, van Doorn Sander 11 May 2023, In: Open Heart. 10 8 p.

Home monitoring by pulse oximetry of primary care patients with COVID-19:a pilot randomised controlled trial

Smit Karin, Venekamp Roderick P., Krol Loeke, Geersing Geert Jan, Schoonhoven Lisette, Kaasjager Karin, Rutten Frans H, Zwart Dorien May 2023, In: British Journal of General Practice. 73 , p. e356-e363

Evaluation of SGLT-2 inhibitor treatment in type 2 diabetes patients with very high cardiovascular risk

Hart Huberta E., Kievits Olivier, Rutten Frans H., Hollander Monika H. Apr 2023, In: Primary Care Diabetes. 17 , p. 190-194 5 p.

Stepwise treatment of uncontrolled HyperTensioN (Stepwise-HTN):Study design of a cluster randomised controlled trial in primary care

Kiliç Birsen, Biermans Marion C.J., Rutten Frans H., Deinum Jaap, Spiering Wilko, van der Wel Mark C., de Grauw Wim J.C., Bots Michiel L., Hollander Monika Mar 2023, In: Contemporary Clinical Trials. 126

Patterns in the Use of Heart Failure Telemonitoring:Post Hoc Analysis of the e-Vita Heart Failure Trial

Brons Maaike, Klooster Iris ten, Gemert-Pijnen Lisette van, Jaarsma Tiny, Asselbergs Folkert W., Oerlemans Marish I.F.J., Koudstaal Stefan, Rutten Frans H. 31 Jan 2023, In: JMIR Cardio. 7

A systematic review and meta-analysis of diagnostic delay in pulmonary embolism

van Maanen R, Trinks-Roerdink E M, Rutten F H, Geersing G J 31 Dec 2022, In: European Journal of General Practice. 28 , p. 165-172 8 p.

Diastolic dysfunction and sex-specific progression to HFpEF:current gaps in knowledge and future directions

van Ommen A M L N, Canto E Dal, Cramer Maarten J, Rutten F H, Onland-Moret N C, Ruijter H M den 27 Dec 2022, In: BMC Medicine. 20 , p. 1-16

Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls

van der Sluijs Koen M, Bakker Esmée A, Schuijt Tim, Joseph Jayaraj, Kavousi Maryam, Geersing Geert-Jan, Rutten Frans H, Hartman Yvonne A W, Thijssen Dick H J, Eijsvogels Thijs M H 2 Dec 2022, In: American Journal of Physiology-Heart and Circulatory Physiology. 324 , p. H47-H56

Development and validation of a prediction rule for patients suspected of acute coronary syndrome in primary care: a cross-sectional study

Wouters Loes T. C. M., Zwart Dorien L. M., Erkelens Daphne C. A., Adriaansen Elisabeth J. M., den Ruijter Hester M., De Groot Esther, Damoiseaux Roger A. M. J., Hoes Arno W., van Smeden Maarten, Rutten Frans H. 5 Oct 2022, In: BMJ Open. 12

All research output

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