prof. dr. F.H. Rutten

Full Professor

  • Department of General Practice
  • Julius Center Research Program Cardiovascular Epidemiology

prof. dr. F.H. Rutten

Research Programs


I hold a position as professor in general practice. I lead a research group focusing on the management of cardiovascular disease in primary care, from early detection of disease and risk-stratification to risk-based treatment.

My teaching activities cover being involved in educational programs at the bachelor (CRU) and master (Summa) level at the medical school, and also being involved in the specialty training and post-graduate training courses of general practitioners. I am a member of the steering committee of the Dutch 'kaderopleiding hart- en vaatziekten' for general practitioners and actively participate in its teaching program.

My research group has contributed to improving the diagnosis of heart failure and deep venous thrombosis in the primary care setting, and our studies have been used as building blocks for diagnostic algorithms recommended by the (inter)national guidelines regarding these diseases. By showing that unrecognized heart failure is common in patients with chronic obstructive pulmonary disease (COPD) and also in type 2 diabetes, our work has helped revolutionize clinical practice. I contributed to the development of guidelines on heart failure, atrial fibrillation and left ventricular hypertrophy for the European Society of Cardiology, and also to the educational practice guideline documents on heart failure and atrial fibrillation for the European Primary Care Cardiovascular Society. Currently I participate in the European Society of Cardiology taskforce on Non-ST elevated Acute Coronary Syndrome. Over the years I have been actively involved in working groups of the Heart Failure Association of the European Society of Cardiology, and was instrumental in translating the interactive website '' to Dutch, making it understandable for patients and their carers.

Within the UMC Utrecht, I am a principal investigator on heart failure within the theme ('speerpunt') Circulatory Health, and I managed to acquire ample funding for the clinical research activities of our research group. In 2017 I became the successful recipient of a research grant of Cardiovascular Research Netherlands (CVON), with myself being the main applicant of a consortium that will focus on early diagnosis of heart failure, atrial fibrillation and coronary artery diisease in patients who participate in primary care disease management programs for COPD or type 2 diabetes. The aim is to facilitate early treatment and improve prognosis by preventing acute cardiovascular events such as acute heart failure, stroke and acute coronary syndrome.

I am member of the task force for strategic planning of the Research Programme Cardiovascular Epidemiology of the Julius Center for Health Sciences and Primary Care of the UMC Utrecht. In addition I am member of the research team of the Julius Center, chair of research of the department of general practice, and board member of the management team of the department of General Practice within the Julius Center.

I collaborate with other departments of the Julius Center (epidemiology, public health and nursing sciences) and the clinical departments of Cardiology, Vascular Surgery, Vascular Medicine and renal disease, as well as with the department of imaging.

Side Activities

  • 2018- Member of the Advisory Board of the European Primary Care Cardiovascular Society

    2017- Board Member of the 'Interfacultair Overleg Huisartsgeneeskunde, Research (IOH-R)'

    2015- Board Member of the Scientific Advisory Committee of the Netherlands Heart Foundation

    2014-2018 Editorial Board Member of Family Practice

    2012- Board Member and supervisor of General Practioners' 'Kaderopleiding hart- en vaatziekten'

    1992-2018 General Practitioner, part-time, in Rhenen 

Fellowship and Awards

  • 2014   Utrecht General Practitioner of the year award

    2017-  Fellow of the European Society of Cardiology

    2018   The Dr. Carel Bakx award for achievements in cardiovascular research in primary care

Research Output (266)

Sex Differences in Symptom Presentation in Acute Coronary Syndromes:A Systematic Review and Meta-analysis

van Oosterhout Roos E M, de Boer Annemarijn R, Maas Angela H E M, Rutten Frans H, Bots Michiel L, Peters Sanne A E 5 mei 2020, In: Journal of the American Heart Association. 9 72 p.

"Tinkering and overruling the computer decision support system:Working strategies of telephone triage-nurses who assess the urgency of callers suspected of having an acute cardiac event."

Wouters Loes T, Zwart Dorien L, Erkelens Daphne C, Huijsmans Marlies, Hoes Arno W, Damoiseaux Roger A, Rutten Frans H, de Groot Esther apr 2020, In: Journal of Clinical Nursing. 29 , p. 1175-1186 12 p.

Man-vrouwverschillen in de optimale dosering van medicatie voor hartfalen:De 'one-size-fits-all'-aanpak van richtlijnen lijkt aan herziening toe

Groenewegen Amy, Mosterd Arend, Rutten Frans H. 17 mrt 2020, In: Nederlands Tijdschrift voor Geneeskunde. 164 3 p.

How to diagnose heart failure with preserved ejection fraction:the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)

Pieske Burkert, Tschöpe Carsten, de Boer Rudolf A, Fraser Alan G, Anker Stefan D, Donal Erwan, Edelmann Frank, Fu Michael, Guazzi Marco, Lam Carolyn S P, Lancellotti Patrizio, Melenovsky Vojtech, Morris Daniel A, Nagel Eike, Pieske-Kraigher Elisabeth, Ponikowski Piotr, Solomon Scott D, Vasan Ramachandran S, Rutten Frans H, Voors Adriaan A, Ruschitzka Frank, Paulus Walter J, Seferovic Petar, Filippatos Gerasimos 5 mrt 2020, In: European Journal of Heart Failure. 22 , p. 391-412 22 p.

Integrated management of atrial fibrillation in primary care:results of the ALL-IN cluster randomized trial

van den Dries Carline J, van Doorn Sander, Rutten Frans H, Oudega Ruud, van de Leur Sjef J C M, Elvan Arif, Oude Grave Lisa, Bilo Henk J G, Moons Karel G M, Hoes Arno W, Geersing Geert-Jan 29 feb 2020, In: European heart journal. 41 , p. 2836-2844 9 p.

Accounting for time-dependent treatment use when developing a prognostic model from observational data:A review of methods

Pajouheshnia Romin, Schuster Noah A., Groenwold Rolf H.H., Rutten Frans H., Moons Karel G.M., Peelen Linda M. 1 feb 2020, In: Statistica Neerlandica. 74 , p. 38-51 14 p.

Opportunistic screening versus usual care for diagnosing atrial fibrillation in general practice:a cluster randomised controlled trial

Kaasenbrood Femke, Hollander Monika, de Bruijn Steven Hm, Dolmans Carlijn Pe, Tieleman Robert G, Hoes Arno W, Rutten Frans H 27 jan 2020, In: British Journal of General Practice. 70 , p. e427-e433 7 p.

Mortality after hospital admission for heart failure:improvement over time, equally strong in women as in men

Buddeke J, Valstar G B, van Dis I, Visseren F L J, Rutten F H, den Ruijter H M, Vaartjes I, Bots M L, 10 jan 2020, In: BMC Public Health. 20 10 p.

Age at menarche and heart failure risk:The EPIC-NL study

Plompen Mitchell V L, van der Schouw Yvonne T, Rutten Frans H, Verschuren W M Monique, Boer Jolanda M A, Asselbergs Folkert W, Onland-Moret N Charlotte jan 2020, In: Maturitas. 131 , p. 34-39 6 p.

Safety of switching from vitamin K antagonist to non-vitamin K antagonist oral anticoagulant in frail elderly with atrial fibrillation:rationale and design of the FRAIL-AF randomised controlled trial

Joosten Linda P T, van Doorn Sander, Hoes Arno W, Nierman Melchior C, Wiersma Nynke M, Koek Huiberdina L, Hemels Martin E W, Huisman Menno V, Roes Kit C, van den Bor Rutger M, Buding Wim F, Rutten Frans H, Geersing Geert-Jan 29 dec 2019, In: BMJ Open. 9

All Research Output (266)