dr. J.J.C. (Joost) Verhoeff

Associate Professor - medical
dr. J.J.C. (Joost) Verhoeff
  • Radiotherapy (research)
  • Department of Radiotherapy

Research Programs

Strategic Program Cancer



My lab's mission is to redefine Standard Radiotherapy

As radiation oncologists, we want to treat cancer patients with high precision radiotherapy. The UMC Utrecht has the right team and right machinery for this (2x MRI-linac, 10x CT-linac). My lab's goal is to provide the best cancer treatment for each patient. Some patients want to live as long as possible regardless of treatment side effects, others want quality of life. To find balance is key.

The UMC Utrecht department of radiation oncology is a terrific place to do clinical research, as it is even the birthplace of the MRI-linac. Next, the Radiation Oncology department harbours 2 1.5T MRI systems, a 3.0T MRI. a 7.0T MRI and a MRI/PET scanner.

Joost Verhoeff subspecialized in treatment of brain tumors and lung cancer. About half of his time he spends on research as associate professor.


Brain tumors:

- Increasing quality of life by shorter but better focused radiation treatment

- Increasing overall survival by combining better treatment modalities

- Principal Investigator of ZonMW funded GOLD trial (dutch info), 30x2Gy+TMZ versus 6x6Gy+TMZ for primary GBM (responsible researcher drs. Arthur van der Boog)

- Principal Investigator of KWF funded RISinG trial (Dutch info), 10x3.4Gy versus 4x7.5Gy for recurrent GBM (responsible researcher drs. Arthur van der Boog)


Brain metastases:

- Finding best treatments for each specific patient: personalized medicine.

- Increasing quality of life by incorporating MR-guided treatment post operative (MRI-linac)

- Coimbra brain metastasis prospective cohort (website) (responsible researcher drs. Fia Cialdella)


Lung cancer:

- Better predicting patient survival and toxicity by smart analyses

- Increasing quality of life by incorporating MR-guided treatment (MR-Linac)

- U-color prospective cohort, for all lung cancer patients that receive radiotherapy


Cardiac Ablative SBRT:

- In collaboration with 30 other European hospitals we develop strategies to treat Ventricular Tachycardia in the framework (Principal Investigator, EU H2020 grant).



- Szabolcs David PhD (brain tumors, imaging)

- Jacqueline Pomp MD PhD, radiation oncologist, (lung cancer and deep learning)

- Peter van Rossum MD PhD MSc, resident radiation oncologist (MRI-linac, epidemiology, lung cancer)


PhD students:

- Steven Nagtegaal MD (brain tumors, cognitive changes)

- Wouter van Amsterdam MD (deep learning, lung cancer)

- Eva van Grinsven MSc (neuro-psychology, brain tumors)

- Arthur van der Boog BS (brain tumors, clinical trials)

- Belle van Duin MD (melanoma, imaging, pathology)

- Fia Cialdella MD (brain metastases, neuro-oncology)


Residents radiation oncology performing research:

- Laura Merckel MD PhD (MRI-linac lung cancer)
- Marnix Rading MD (lung cancer)
- Joyce Lodeweges MD (lung cancer)
- Max Peters MD PhD MSc (epidemiology, lung cancer)- Pim Damen MD (immunotherapies)
- Janneke van der Stap NP (lung cancer)


Students (medical, biomedical, informatics):

- Victor Wasser (brain tumor imaging)
- Salah Gasle (brain tumor imaging)
- Michelle Sierts (MR-Linac for brain tumors)
- Karlijn Smitt (brain tumors)
- Mathijs Tomassen (lung cancer)
- Hugo van Joolingen (lung cancer)
- Anne van der Tuin (MR-Linac for lung cancer)
- Eva Swinkels (lung cancer)
- Lucie Egberink (lung cancer)
- Sjors Witteveen (lung cancer)
- Hajo Boersma (psychiatric disorders and radiotherapy)

Former group members (medical, biomedical, informatics):

- Bas Arends (deep learning for spine tumor treatment)
- Jasper Hennecken (spinal imaging)
- Céline Bogers (lung cancer)
- Eliza van Wulfften Palthe (brain metastases)
- Anouk Steennis (brain tumors)
- Ali Ghannam (brain metastases cohort)
- Emma Nessen (brain metastases)
- Marc Pijper (lung cancer)
- Cathalijne Post (brain tumors)
- Robin Schuijlenburg (brain tumors)
- Merel Kraak (lung cancer)
- Suzanne Vellinga (lung cancer)
- Netanja Harlianto (lung cancer)
- Yannic Hanekamp (Covid treatment)
- Sjors Wagemakers (pain meassurement)
- Max van Essen (brain tumors)
- Chris Hammerstein (survival analyses)



Full list of publications on PubMed: click here (automatic list is incomplete)

Research Output (72)

Sarcoma of the Heart Treated with Stereotactic MR-Guided Online Adaptive Radiation Therapy

Pomp Jacquelien, van Asselen Bram, Tersteeg Robbert H A, Vink Aryan, Hassink Rutger J, van der Kaaij Niels P, van Aarnhem Guido E E H L, Verhoeff Joost J C 2 apr 2021, In: Case Reports in Oncology. 14 , p. 453-458 6 p.

Prophylactic cranial irradiation in patients with small cell lung cancer in The Netherlands:A population-based study

Tomassen Mathijs L, Aarts Mieke J, Peters Max, van Lindert Anne, De Ruysscher Dirk K M, Verhoeff Joost J C, van Rossum Peter S N mrt 2021, In: Clinical and translational radiation oncology. 27 , p. 157-163 7 p.

Combining radiotherapy and focused ultrasound for pain palliation of cancer induced bone pain; a stage I/IIa study according to the IDEAL framework

Bartels Marcia M T J, Verpalen Inez M, Ferrer Cyril J, Slotman Derk J, Phernambucq Erik C J, Verhoeff Joost J C, Eppinga Wietse S C, Braat Manon N G J A, van den Hoed Rolf D, van 't Veer-Ten Kate Miranda, de Boer Erwin, Naber Harry R, Nijholt Ingrid M, Bartels Lambertus W, Bos Clemens, Moonen Chrit T W, Boomsma Martijn F, Verkooijen Helena M mrt 2021, In: Clinical and translational radiation oncology. 27 , p. 57-63 7 p.

Impact of the COVID-19 pandemic on quality of life and emotional wellbeing in patients with bone metastases treated with radiotherapy:a prospective cohort study

Bartels M M T J, Gal R, van der Velden J M, Verhoeff J J C, Verlaan J J, Verkooijen H M 25 feb 2021, In: Clinical & Experimental Metastasis. 38 , p. 209-217 9 p.

Dose-dependent volume loss in subcortical deep grey matter structures after cranial radiotherapy

Nagtegaal Steven H J, David Szabolcs, Philippens Marielle E P, Snijders Tom J, Leemans Alexander, Verhoeff Joost J C jan 2021, In: Clinical and translational radiation oncology. 26 , p. 35-41 7 p.

Initial Clinical Experience of MR-Guided Radiotherapy for Non-Small Cell Lung Cancer

Crockett Cathryn B, Samson Pamela, Chuter Robert, Dubec Michael, Faivre-Finn Corinne, Green Olga L, Hackett Sara L, McDonald Fiona, Robinson Clifford, Shiarli Anna-Maria, Straza Michael W, Verhoeff Joost J C, Werner-Wasik Maria, Vlacich Gregory, Cobben David 2021, In: Frontiers in oncology. 11 , p. 617681

Immunomodulation Through Low-Dose Radiation for Severe COVID-19:Lessons From the Past and New Developments

Hanekamp Yannic N, Giordano James, Hanekamp Jaap C, Khan Mohammad K, Limper Maarten, Venema Constantijn S, Vergunst Samuel D, Verhoeff Joost J C, Calabrese Edward J 22 sep 2020, In: Dose-response : a publication of International Hormesis Society. 18

Age, pathology and CA-125 are prognostic factors for survival in patients with brain metastases from gynaecological tumours

Nagtegaal S H J, Hulsbergen A F C, van Dorst E B L, Kavouridis V K, Jessurun C A C, Broekman M L D, Smith T R, Verhoeff J J C sep 2020, In: Clinical and translational radiation oncology. 24 , p. 11-15 5 p.

Glioma consensus contouring recommendations from a MR-Linac International Consortium Research Group and evaluation of a CT-MRI and MRI-only workflow

Tseng Chia-Lin, Stewart James, Whitfield Gillian, Verhoeff Joost J C, Bovi Joseph, Soliman Hany, Chung Caroline, Myrehaug Sten, Campbell Mikki, Atenafu Eshetu G, Heyn Chinthaka, Das Sunit, Perry James, Ruschin Mark, Sahgal Arjun 29 aug 2020, In: Journal of Neuro-Oncology. 149 , p. 305-314 10 p.

Predicting incomplete resection in non-small cell lung cancer preoperatively:a validated nomogram

Rasing Marnix J A, Peters Max, Moreno Amy C, Hofman Erik F N, Herder Gerarda J M, Welvaart Pim W N, Schramel Franz M N H, Lodeweges Joyce E, Lin Steven H, Verhoeff Joost J C, van Rossum Peter S N 31 jul 2020, In: Annals of Thoracic Surgery. 111 , p. 1052-1058 7 p.

All research output

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